Antioxidants Rescue Mitochondrial Transport in Differentiated Alzheimer's Disease Trans-Mitochondrial Cybrid Cells

Journal of Alzheimer's Disease

Volumn 54, Issue 2, 2016, Pages 679-690

  Yu, Qing ^a,b   Fang, Du ^a   Swerdlow, Russell Howard ^c   Yu, Haiyang ^b   Chen, John Xi ^d   Yan, Shirley Shidu ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b SICHUAN UNIVERSITY   (China)

^c UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Alzheimer's disease; antioxidants; cybrid cells; mitochondrial dysfunction; mitochondrial transport

Indexed keywords

ADENOSINE TRIPHOSPHATE; ASCORBIC ACID; CYTOCHROME C OXIDASE; CYTOPROTECTIVE AGENT; PROBUCOL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ANTIOXIDANT; MITOCHONDRIAL DNA;

AGED; ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; BRAIN MITOCHONDRION; BRAIN NERVE CELL; CELL DENSITY; CELL MOTILITY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYBRID CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; NERVE CELL DIFFERENTIATION; NERVE FIBER TRANSPORT; OXIDATIVE STRESS; PRIORITY JOURNAL; THROMBOCYTE; CELL DIFFERENTIATION; CELL LINE; FEMALE; MALE; METABOLISM; MITOCHONDRION; PATHOLOGY; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANTIOXIDANTS; BIOLOGICAL TRANSPORT; CELL DIFFERENTIATION; CELL LINE; DNA, MITOCHONDRIAL; FEMALE; HUMANS; MALE; MITOCHONDRIA;

EID: 84986564696     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-160532     Document Type: Article

References (38)

1. Chan DC (2006) Mitochondria: Dynamic organelles in disease, aging, and development. Cell 125, 1241-1252.
2. Kann O, Kovacs R (2007) Mitochondria and neuronal activity. Am J Physiol Cell Physiol 292, C641-C657.
3. Chen H, Chan DC (2006) Critical dependence of neurons on mitochondrial dynamics. Curr Opin Cell Biol 18, 453-459.
4. Hollenbeck PJ (1996) The pattern and mechanism of mitochondrial transport in axons. Front Biosci 1, d91-d102.
5. Li Z, Okamoto K, Hayashi Y, Sheng M (2004) The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses. Cell 119, 873-887.
6. Tada T, ShengM(2006) Molecular mechanisms of dendritic spine morphogenesis. Curr Opin Neurobiol 16, 95-101.
7. Gan X, Huang S, Wu L, Wang Y, Hu G, Li G, Zhang H, Yu H, Swerdlow RH, Chen JX, Yan SS (2014) Inhibition of ERK-DLP1 signaling and mitochondrial division alleviates mitochondrial dysfunction in Alzheimer's disease cybrid cell. Biochim Biophys Acta 1842, 220-231.
8. Guo L, Du H, Yan S, Wu X, McKhann GM, Chen JX, Yan SS (2013) Cyclophilin D deficiency rescues axonal mitochondrial transport in Alzheimer's neurons. PLoS One 8, e54914.
9. Du H, Guo L, Fang F, Chen D, Sosunov AA, McKhann GM, Yan Y,Wang C, Zhang H, Molkentin JD, Gunn-Moore FJ, Vonsattel JP, Arancio O, Chen JX, Yan SD (2008) Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. Nat Med 14, 1097-1105.
10. Silva DF, Selfridge JE, Lu J, E L, Roy N, Hutfles L, Burns JM, Michaelis EK, Yan S, Cardoso SM, Swerdlow RH (2013) Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines. Hum Mol Genet 22, 3931-3946.
11. Baloyannis SJ (2006) Mitochondrial alterations in Alzheimer's disease. J Alzheimers Dis 9, 119-126.
12. Xie H, Guan J, Borrelli LA, Xu J, Serrano-Pozo A, Bacskai BJ (2013) Mitochondrial alterations near amyloid plaques in an Alzheimer's disease mouse model. J Neurosci 33, 17042-17051.
13. Cuadrado-Tejedor M, Cabodevilla JF, Zamarbide M, Gomez-Isla T, Franco R, Perez-Mediavilla A (2013) Agerelated mitochondrial alterations without neuronal loss in the hippocampus of a transgenic model of Alzheimer's disease. Curr Alzheimer Res 10, 390-405.
14. Wang X, Su B, Siedlak SL, Moreira PI, Fujioka H,Wang Y, Casadesus G, Zhu X (2008) Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc Natl Acad Sci U S A 105, 19318-19323.
15. Trimmer PA, Borland MK (2005) Differentiated Alzheimer's disease transmitochondrial cybrid cell lines exhibit reduced organelle movement. Antioxid Redox Signal 7, 1101-1109.
16. Trimmer PA, Swerdlow RH, Parks JK, Keeney P, Bennett JP Jr, Miller SW, Davis RE, Parker WD Jr (2000) Abnormal mitochondrial morphology in sporadic Parkinson's and Alzheimer's disease cybrid cell lines. Exp Neurol 162, 37-50.
17. King MP, Attardi G (1989) Human cells lacking mtDNA: Repopulation with exogenous mitochondria by complementation. Science 246, 500-503.
18. Cardoso SM, Santana I, Swerdlow RH, Oliveira CR (2004) Mitochondria dysfunction of Alzheimer's disease cybrids enhances Abeta toxicity. J Neurochem 89, 1417-1426.
19. Prince JA, Oreland L (1997) Staurosporine differentiated human SH-SY5Y neuroblastoma cultures exhibit transient apoptosis and trophic factor independence. Brain Res Bull 43, 515-523.
20. Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, PhelpsCH(2011) The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 7, 270-279.
21. Miller SW, Trimmer PA, Parker WD Jr, Davis RE (1996) Creation and characterization of mitochondrial DNA-depleted cell lines with "neuronal-like" properties. J Neurochem 67, 1897-1907.
22. Swerdlow RH (2007) Mitochondria in cybrids containing mtDNAfrom persons with mitochondriopathies. J Neurosci Res 85, 3416-3428.
23. Leskiewicz M, Regulska M, Budziszewska B, Jantas D, Jaworska-Feil L, Basta-Kaim A,Kubera M, LasonW(2008) Neurosteroids enhance the viability of staurosporine and doxorubicin treated differentiated human neuroblastoma SH-SY5Y cells. Pharmacol Rep 60, 685-691.
24. Trimmer PA, Schwartz KM, Borland MK, De Taboada L, Streeter J, Oron U (2009) Reduced axonal transport in Parkinson's disease cybrid neurites is restored by light therapy. Mol Neurodegener 4, 26.
25. Du H, Guo L, Yan S, Sosunov AA, McKhann GM, Yan SS (2010) Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model. Proc Natl Acad Sci U S A 107, 18670-18675.
26. Fang D, Wang Y, Zhang Z, Du H, Yan S, Sun Q, Zhong C, Wu L, Vangavaragu JR, Yan S, Hu G, Guo L, Rabinowitz M, Glaser E, Arancio O, Sosunov AA, McKhann GM, Chen JX, Yan SS (2015) Increased neuronal PreP activity reduces Abeta accumulation, attenuates neuroinflammation and improves mitochondrial and synaptic function in Alzheimer disease's mouse model. Hum Mol Genet 24, 5198-5210.
27. Fang D, Zhang Z, Li H, Yu Q, Douglas JT, Bratasz A, Kuppusamy P, Yan SS (2016) Increased electron paramagnetic resonance signal correlates with mitochondrial dysfunction and oxidative stress in an Alzheimer's disease mouse brain. J Alzheimers Dis 51, 571-580.
28. Borland MK, Trimmer PA, Rubinstein JD, Keeney PM, Mohanakumar K, Liu L, Bennett JP Jr (2008) Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells. Mol Neurodegener 3, 21.
29. Tsatmali M,Walcott EC, Crossin KL (2005) Newborn neurons acquire high levels of reactive oxygen species and increased mitochondrial proteins upon differentiation from progenitors. Brain Res 1040, 137-150.
30. Butterfield DA, Drake J, Pocernich C, Castegna A (2001) Evidence of oxidative damage in Alzheimer's disease brain: Central role for amyloid beta-peptide. Trends Mol Med 7, 548-554.
31. Reddy PH, Beal MF (2008) Amyloid beta, mitochondrial dysfunction and synaptic damage: Implications for cognitive decline in aging and Alzheimer's disease. Trends Mol Med 14, 45-53.
32. Kuzuya M, Kuzuya F (1993) Probucol as an antioxidant and antiatherogenic drug. Free Radic Biol Med 14, 67-77.
33. Arrigoni O, DeTullioMC(2002) Ascorbic acid: Much more than just an antioxidant. Biochim Biophys Acta 1569, 1-9.
34. Rao VK, Carlson EA, Yan SS (2014) Mitochondrial permeability transition pore is a potential drug target for neurodegeneration. Biochim Biophys Acta 1842, 1267-1272.
35. Du H, Guo L, Zhang W, Rydzewska M, Yan S (2011) Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model. Neurobiol Aging 32, 398-406.
36. Du H, Guo L, Wu X, Sosunov AA, McKhann GM, Chen JX, Yan SS (2014) Cyclophilin D deficiency rescues Abetaimpaired PKA/CREB signaling and alleviates synaptic degeneration. Biochim Biophys Acta 1842, 2517-2527.
37. Gan X,Wu L, Huang S, Zhong C, Shi H, Li G,Yu H, Howard Swerdlow R, Xi Chen J, Yan SS (2014) Oxidative stressmediated activation of extracellular signal-regulated kinase contributes to mild cognitive impairment-related mitochondrial dysfunction. Free Radic Biol Med 75, 230-240.
38. Borger E, Herrmann A, Mann DA, Spires-Jones T, Gunn-Moore F (2014) The calcium-binding protein EFhd2 modulates synapse formation in vitro and is linked to human dementia. J Neuropathol Exp Neurol 73, 1166-1182.