메뉴 건너뛰기




Volumn 215, Issue 6, 2016, Pages 857-874

Atg8 family LC3/GAB ARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMYCIN A1; AUTOPHAGY RELATED PROTEIN; AUTOPHAGY RELATED PROTEIN 8 FAMILY; BAFILOMYCIN A1; GABARAP PROTEIN; LC3 PROTEIN; OLIGOMYCIN; PARKIN; PINK1 PROTEIN; PLEKHM1 PROTEIN; UNCLASSIFIED DRUG; WORTMANNIN; ACID; GABARAP PROTEIN, HUMAN; LIGHT CHAIN 3, HUMAN; MEMBRANE PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; PLEKHM1 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; UBIQUITIN PROTEIN LIGASE;

EID: 85009198548     PISSN: 00219525     EISSN: 15408140     Source Type: Journal    
DOI: 10.1083/jcb.201607039     Document Type: Article
Times cited : (485)

References (61)
  • 1
    • 84869222326 scopus 로고    scopus 로고
    • ATG8 family proteins act as scaffolds for assembly of the ULK complex: Sequence requirements for LC3-interacting region (LIR) motifs
    • Alemu, E.A., T. Lamark, K.M. Torgersen, A.B. Birgisdottir, K.B. Larsen, A. Jain, H. Olsvik, A. Øvervatn, V. Kirkin, and T. Johansen. 2012. ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs. J. Biol. Chem. 287:39275-39290. http://dx.doi.org/10.1074/jbc.M112.378109
    • (2012) J. Biol. Chem , vol.287 , pp. 39275-39290
    • Alemu, E.A.1    Lamark, T.2    Torgersen, K.M.3    Birgisdottir, A.B.4    Larsen, K.B.5    Jain, A.6    Olsvik, H.7    Øvervatn, A.8    Kirkin, V.9    Johansen, T.10
  • 2
    • 50249084987 scopus 로고    scopus 로고
    • Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
    • Axe, E.L., S.A. Walker, M. Manifava, P. Chandra, H.L. Roderick, A. Habermann, G. Griffiths, and N.T. Ktistakis. 2008. Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J. Cell Biol. 182:685-701. http://dx.doi.org/10.1083/jcb.200803137
    • (2008) J. Cell Biol , vol.182 , pp. 685-701
    • Axe, E.L.1    Walker, S.A.2    Manifava, M.3    Chandra, P.4    Roderick, H.L.5    Habermann, A.6    Griffiths, G.7    Ktistakis, N.T.8
  • 3
    • 77954237882 scopus 로고    scopus 로고
    • Network organization of the human autophagy system
    • Behrends, C., M.E. Sowa, S.P. Gygi, and J.W. Harper. 2010. Network organization of the human autophagy system. Nature. 466:68-76. http://dx.doi.org/10.1038/nature09204
    • (2010) Nature , vol.466 , pp. 68-76
    • Behrends, C.1    Sowa, M.E.2    Gygi, S.P.3    Harper, J.W.4
  • 4
    • 84883414890 scopus 로고    scopus 로고
    • The LIR motif: Crucial for selective autophagy
    • Birgisdottir, A.B., T. Lamark, and T. Johansen. 2013. The LIR motif: crucial for selective autophagy. J. Cell Sci. 126:3237-3247. http://dx.doi.org/10.1242/jcs.126128
    • (2013) J. Cell Sci , vol.126 , pp. 3237-3247
    • Birgisdottir, A.B.1    Lamark, T.2    Johansen, T.3
  • 5
    • 84928550400 scopus 로고    scopus 로고
    • ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes
    • Diao, J., R. Liu, Y. Rong, M. Zhao, J. Zhang, Y. Lai, Q. Zhou, L.M. Wilz, J. Li, S. Vivona, et al. 2015. ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes. Nature. 520:563-566. http: //dx.doi.org/10.1038/nature14147
    • (2015) Nature , vol.520 , pp. 563-566
    • Diao, J.1    Liu, R.2    Rong, Y.3    Zhao, M.4    Zhang, J.5    Lai, Y.6    Zhou, Q.7    Wilz, L.M.8    Li, J.9    Vivona, S.10
  • 6
    • 58149290220 scopus 로고    scopus 로고
    • An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure
    • Fujita, N., M. Hayashi-Nishino, H. Fukumoto, H. Omori, A. Yamamoto, T. Noda, and T. Yoshimori. 2008. An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure. Mol. Biol. Cell. 19:4651-4659. http://dx.doi.org/10.1091/mbc.E08-03-0312
    • (2008) Mol. Biol. Cell , vol.19 , pp. 4651-4659
    • Fujita, N.1    Hayashi-Nishino, M.2    Fukumoto, H.3    Omori, H.4    Yamamoto, A.5    Noda, T.6    Yoshimori, T.7
  • 7
    • 10944253145 scopus 로고    scopus 로고
    • Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages
    • Gutierrez, M.G., S.S. Master, S.B. Singh, G.A. Taylor, M.I. Colombo, and V. Deretic. 2004. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell. 119:753-766. http://dx.doi.org/10.1016/j.cell.2004.11.038
    • (2004) Cell , vol.119 , pp. 753-766
    • Gutierrez, M.G.1    Master, S.S.2    Singh, S.B.3    Taylor, G.A.4    Colombo, M.I.5    Deretic, V.6
  • 9
    • 84951930787 scopus 로고    scopus 로고
    • The PINK1-PARKIN mitochondrial ubiquitylation pathway drives a program of OPTN/NDP52 recruitment and TBK1 activation to promote mitophagy
    • Heo, J.M., A. Ordureau, J.A. Paulo, J. Rinehart, and J.W. Harper. 2015. The PINK1-PARKIN mitochondrial ubiquitylation pathway drives a program of OPTN/NDP52 recruitment and TBK1 activation to promote mitophagy. Mol. Cell. 60:7-20. http://dx.doi.org/10.1016/j.molcel.2015.08.016
    • (2015) Mol. Cell , vol.60 , pp. 7-20
    • Heo, J.M.1    Ordureau, A.2    Paulo, J.A.3    Rinehart, J.4    Harper, J.W.5
  • 11
    • 84857850213 scopus 로고    scopus 로고
    • Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy
    • Itakura, E., C. Kishi-Itakura, I. Koyama-Honda, and N. Mizushima. 2012a. Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy. J. Cell Sci. 125:1488-1499. http://dx.doi.org/10.1242/jcs.094110
    • (2012) J. Cell Sci , vol.125 , pp. 1488-1499
    • Itakura, E.1    Kishi-Itakura, C.2    Koyama-Honda, I.3    Mizushima, N.4
  • 12
    • 84870880174 scopus 로고    scopus 로고
    • The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes
    • Itakura, E., C. Kishi-Itakura, and N. Mizushima. 2012b. The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. Cell. 151:1256-1269. http://dx.doi.org/10.1016/j.cell.2012.11.001
    • (2012) Cell , vol.151 , pp. 1256-1269
    • Itakura, E.1    Kishi-Itakura, C.2    Mizushima, N.3
  • 13
    • 84971524977 scopus 로고    scopus 로고
    • GABARAP activates ULK1 and traffics from the centrosome dependent on Golgi partners WAC and GOLGA2/ GM130
    • Joachim, J., and S.A. Tooze. 2016. GABARAP activates ULK1 and traffics from the centrosome dependent on Golgi partners WAC and GOLGA2/ GM130. Autophagy. 12:892-893. http://dx.doi.org/10.1080/15548627.2016.1159368
    • (2016) Autophagy. , vol.12 , pp. 892-893
    • Joachim, J.1    Tooze, S.A.2
  • 14
    • 84899539731 scopus 로고    scopus 로고
    • PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity
    • Kane, L.A., M. Lazarou, A.I. Fogel, Y. Li, K. Yamano, S.A. Sarraf, S. Banerjee, and R.J. Youle. 2014. PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. J. Cell Biol. 205:143-153. http://dx.doi.org/10.1083/jcb.201402104
    • (2014) J. Cell Biol , vol.205 , pp. 143-153
    • Kane, L.A.1    Lazarou, M.2    Fogel, A.I.3    Li, Y.4    Yamano, K.5    Sarraf, S.A.6    Banerjee, S.7    Youle, R.J.8
  • 15
    • 80052145606 scopus 로고    scopus 로고
    • A sensitive and quantitative technique for detecting autophagic events based on lysosomal delivery
    • Katayama, H., T. Kogure, N. Mizushima, T. Yoshimori, and A. Miyawaki. 2011. A sensitive and quantitative technique for detecting autophagic events based on lysosomal delivery. Chem. Biol. 18:1042-1052. http://dx.doi.org/10.1016/j.chembiol.2011.05.013
    • (2011) Chem. Biol , vol.18 , pp. 1042-1052
    • Katayama, H.1    Kogure, T.2    Mizushima, N.3    Yoshimori, T.4    Miyawaki, A.5
  • 21
    • 84964294603 scopus 로고    scopus 로고
    • Autophagosome closure requires membrane scission
    • Knorr, R.L., R. Lipowsky, and R. Dimova. 2015. Autophagosome closure requires membrane scission. Autophagy. 11:2134-2137. http://dx.doi.org/10.1080/15548627.2015.1091552
    • (2015) Autophagy , vol.11 , pp. 2134-2137
    • Knorr, R.L.1    Lipowsky, R.2    Dimova, R.3
  • 25
    • 84888380983 scopus 로고    scopus 로고
    • The autophagosome: Origins unknown, biogenesis complex
    • Lamb, C.A., T. Yoshimori, and S.A. Tooze. 2013. The autophagosome: origins unknown, biogenesis complex. Nat. Rev. Mol. Cell Biol. 14:759-774. http://dx.doi.org/10.1038/nrm3696
    • (2013) Nat. Rev. Mol. Cell Biol , vol.14 , pp. 759-774
    • Lamb, C.A.1    Yoshimori, T.2    Tooze, S.A.3
  • 26
    • 84955513784 scopus 로고    scopus 로고
    • Lipid geometry and bilayer curvature modulate LC3/GABARAP-mediated model autophagosomal elongation
    • Landajuela, A., J.H. Hervas, Z. Antón, L.R. Montes, D. Gil, M. Valle, J.F. Rodriguez, F.M. Goñi, and A. Alonso. 2016. Lipid geometry and bilayer curvature modulate LC3/GABARAP-mediated model autophagosomal elongation. Biophys. J. 110:411-422. http://dx.doi.org/10.1016/j.bpj.2015.11.3524
    • (2016) Biophys. J , vol.110 , pp. 411-422
    • Landajuela, A.1    Hervas, J.H.2    Antón, Z.3    Montes, L.R.4    Gil, D.5    Valle, M.6    Rodriguez, J.F.7    Goñi, F.M.8    Alonso, A.9
  • 27
    • 34250164233 scopus 로고    scopus 로고
    • Analysis of the assembly profiles for mitochondrial-and nuclear-DNA-encoded subunits into complex I
    • Lazarou, M., M. McKenzie, A. Ohtake, D.R. Thorburn, and M.T. Ryan. 2007. Analysis of the assembly profiles for mitochondrial-and nuclear-DNA-encoded subunits into complex I. Mol. Cell. Biol. 27:4228-4237. http://dx.doi.org/10.1128/MCB.00074-07
    • (2007) Mol. Cell. Biol , vol.27 , pp. 4228-4237
    • Lazarou, M.1    McKenzie, M.2    Ohtake, A.3    Thorburn, D.R.4    Ryan, M.T.5
  • 29
    • 84892438559 scopus 로고    scopus 로고
    • The C. elegans LC3 acts downstream of GABARAP to degrade autophagosomes by interacting with the HOPS subunit VPS39
    • (published erratum appears in Dev. Cell2014. 30:110)
    • Manil-Ségalen, M., C. Lefebvre, C. Jenzer, M. Trichet, C. Boulogne, B. Satiat-Jeunemaitre, and R. Legouis. 2014. The C. elegans LC3 acts downstream of GABARAP to degrade autophagosomes by interacting with the HOPS subunit VPS39. Dev. Cell. 28:43-55. (published erratum appears in Dev. Cell2014. 30:110) http://dx.doi.org/10.1016/j.devcel.2013.11.022
    • (2014) Dev. Cell , vol.28 , pp. 43-55
    • Manil-Ségalen, M.1    Lefebvre, C.2    Jenzer, C.3    Trichet, M.4    Boulogne, C.5    Satiat-Jeunemaitre, B.6    Legouis, R.7
  • 30
    • 77951181836 scopus 로고    scopus 로고
    • PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
    • Matsuda, N., S. Sato, K. Shiba, K. Okatsu, K. Saisho, C.A. Gautier, Y.S. Sou, S. Saiki, S. Kawajiri, F. Sato, et al. 2010. PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J. Cell Biol. 189:211-221. http://dx.doi.org/10.1083/jcb.200910140
    • (2010) J. Cell Biol , vol.189 , pp. 211-221
    • Matsuda, N.1    Sato, S.2    Shiba, K.3    Okatsu, K.4    Saisho, K.5    Gautier, C.A.6    Sou, Y.S.7    Saiki, S.8    Kawajiri, S.9    Sato, F.10
  • 33
    • 84980027958 scopus 로고    scopus 로고
    • Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system
    • McLelland, G.L., S.A. Lee, H.M. McBride, and E.A. Fon. 2016. Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system. J. Cell Biol. 214:275-291. http://dx.doi.org/10.1083/jcb.201603105
    • (2016) J. Cell Biol , vol.214 , pp. 275-291
    • McLelland, G.L.1    Lee, S.A.2    McBride, H.M.3    Fon, E.A.4
  • 36
    • 34447099450 scopus 로고    scopus 로고
    • Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion
    • Nakatogawa, H., Y. Ichimura, and Y. Ohsumi. 2007. Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion. Cell. 130:165-178. http://dx.doi.org/10.1016/j.cell.2007.05.021
    • (2007) Cell , vol.130 , pp. 165-178
    • Nakatogawa, H.1    Ichimura, Y.2    Ohsumi, Y.3
  • 37
    • 58149314211 scopus 로고    scopus 로고
    • Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
    • Narendra, D., A. Tanaka, D.F. Suen, and R.J. Youle. 2008. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J. Cell Biol. 183:795-803. http://dx.doi.org/10.1083/jcb.200809125
    • (2008) J. Cell Biol , vol.183 , pp. 795-803
    • Narendra, D.1    Tanaka, A.2    Suen, D.F.3    Youle, R.J.4
  • 40
    • 34548259958 scopus 로고    scopus 로고
    • p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
    • Pankiv, S., T.H. Clausen, T. Lamark, A. Brech, J.A. Bruun, H. Outzen, A. Øvervatn, G. Bjørkøy, and T. Johansen. 2007. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J. Biol. Chem. 282:24131-24145. http://dx.doi.org/10.1074/jbc.M702824200
    • (2007) J. Biol. Chem , vol.282 , pp. 24131-24145
    • Pankiv, S.1    Clausen, T.H.2    Lamark, T.3    Brech, A.4    Bruun, J.A.5    Outzen, H.6    Øvervatn, A.7    Bjørkøy, G.8    Johansen, T.9
  • 41
    • 84887010498 scopus 로고    scopus 로고
    • Genome engineering using the CRISPR-Cas9 system
    • Ran, F.A., P.D. Hsu, J. Wright, V. Agarwala, D.A. Scott, and F. Zhang. 2013. Genome engineering using the CRISPR-Cas9 system. Nat. Protoc. 8:2281-2308. http://dx.doi.org/10.1038/nprot.2013.143
    • (2013) Nat. Protoc , vol.8 , pp. 2281-2308
    • Ran, F.A.1    Hsu, P.D.2    Wright, J.3    Agarwala, V.4    Scott, D.A.5    Zhang, F.6
  • 43
    • 84892859905 scopus 로고    scopus 로고
    • Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy
    • Rogov, V., V. Dötsch, T. Johansen, and V. Kirkin. 2014. Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy. Mol. Cell. 53:167-178. http://dx.doi.org/10.1016/j.molcel.2013.12.014
    • (2014) Mol. Cell , vol.53 , pp. 167-178
    • Rogov, V.1    Dötsch, V.2    Johansen, T.3    Kirkin, V.4
  • 45
    • 84899848892 scopus 로고    scopus 로고
    • Cargo binding to Atg19 unmasks additional Atg8 binding sites to mediate membrane-cargo apposition during selective autophagy
    • Sawa-Makarska, J., C. Abert, J. Romanov, B. Zens, I. Ibiricu, and S. Martens. 2014. Cargo binding to Atg19 unmasks additional Atg8 binding sites to mediate membrane-cargo apposition during selective autophagy. Nat. Cell Biol. 16:425-433. http://dx.doi.org/10.1038/ncb2935
    • (2014) Nat. Cell Biol , vol.16 , pp. 425-433
    • Sawa-Makarska, J.1    Abert, C.2    Romanov, J.3    Zens, B.4    Ibiricu, I.5    Martens, S.6
  • 46
    • 57549094368 scopus 로고    scopus 로고
    • The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice
    • Sou, Y.S., S. Waguri, J. Iwata, T. Ueno, T. Fujimura, T. Hara, N. Sawada, A. Yamada, N. Mizushima, Y. Uchiyama, et al. 2008. The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol. Biol. Cell. 19:4762-4775. http://dx.doi.org/10.1091/mbc.E08-03-0309
    • (2008) Mol. Biol. Cell , vol.19 , pp. 4762-4775
    • Sou, Y.S.1    Waguri, S.2    Iwata, J.3    Ueno, T.4    Fujimura, T.5    Hara, T.6    Sawada, N.7    Yamada, A.8    Mizushima, N.9    Uchiyama, Y.10
  • 47
    • 84901815187 scopus 로고    scopus 로고
    • Cargo recognition and trafficking in selective autophagy
    • Stolz, A., A. Ernst, and I. Dikic. 2014. Cargo recognition and trafficking in selective autophagy. Nat. Cell Biol. 16:495-501. http://dx.doi.org/10.1038/ncb2979
    • (2014) Nat. Cell Biol , vol.16 , pp. 495-501
    • Stolz, A.1    Ernst, A.2    Dikic, I.3
  • 48
    • 78650114245 scopus 로고    scopus 로고
    • Rubicon and PLEKHM1 negatively regulate the endocytic/ autophagic pathway via a novel Rab7-binding domain
    • Tabata, K., K. Matsunaga, A. Sakane, T. Sasaki, T. Noda, and T. Yoshimori. 2010. Rubicon and PLEKHM1 negatively regulate the endocytic/ autophagic pathway via a novel Rab7-binding domain. Mol. Biol. Cell.21:4162-4172. http://dx.doi.org/10.1091/mbc.E10-06-0495
    • (2010) Mol. Biol. Cell , vol.21 , pp. 4162-4172
    • Tabata, K.1    Matsunaga, K.2    Sakane, A.3    Sasaki, T.4    Noda, T.5    Yoshimori, T.6
  • 49
    • 84992154479 scopus 로고    scopus 로고
    • The ATG conjugation systems are important for degradation of the inner autophagosomal membrane
    • Tsuboyama, K., I. Koyama-Honda, Y. Sakamaki, M. Koike, H. Morishita, and N. Mizushima. 2016. The ATG conjugation systems are important for degradation of the inner autophagosomal membrane. Science. http://dx.doi.org/10.1126/science.aaf6136
    • (2016) Science
    • Tsuboyama, K.1    Koyama-Honda, I.2    Sakamaki, Y.3    Koike, M.4    Morishita, H.5    Mizushima, N.6
  • 51
    • 77951637036 scopus 로고    scopus 로고
    • Imaging type-III secretion reveals dynamics and spatial segregation of Salmonella effectors
    • Van Engelenburg, S.B., and A.E. Palmer. 2010. Imaging type-III secretion reveals dynamics and spatial segregation of Salmonella effectors. Nat. Methods. 7:325-330. http://dx.doi.org/10.1038/nmeth.1437
    • (2010) Nat. Methods , vol.7 , pp. 325-330
    • Van Engelenburg, S.B.1    Palmer, A.E.2
  • 52
    • 84857844643 scopus 로고    scopus 로고
    • Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets
    • Velikkakath, A.K., T. Nishimura, E. Oita, N. Ishihara, and N. Mizushima. 2012. Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets. Mol. Biol. Cell. 23:896-909. http://dx.doi.org/10.1091/mbc.E11-09-0785
    • (2012) Mol. Biol. Cell , vol.23 , pp. 896-909
    • Velikkakath, A.K.1    Nishimura, T.2    Oita, E.3    Ishihara, N.4    Mizushima, N.5
  • 55
    • 77953122645 scopus 로고    scopus 로고
    • LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis
    • Weidberg, H., E. Shvets, T. Shpilka, F. Shimron, V. Shinder, and Z. Elazar. 2010. LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis. EMBO J. 29:1792-1802. http://dx.doi.org/10.1038/emboj.2010.74
    • (2010) EMBO J , vol.29 , pp. 1792-1802
    • Weidberg, H.1    Shvets, E.2    Shpilka, T.3    Shimron, F.4    Shinder, V.5    Elazar, Z.6
  • 56
    • 79954544250 scopus 로고    scopus 로고
    • LC3 and GATE-16 N termini mediate membrane fusion processes required for autophagosome biogenesis
    • Weidberg, H., T. Shpilka, E. Shvets, A. Abada, F. Shimron, and Z. Elazar. 2011. LC3 and GATE-16 N termini mediate membrane fusion processes required for autophagosome biogenesis. Dev. Cell. 20:444-454. http://dx.doi.org/10.1016/j.devcel.2011.02.006
    • (2011) Dev. Cell , vol.20 , pp. 444-454
    • Weidberg, H.1    Shpilka, T.2    Shvets, E.3    Abada, A.4    Shimron, F.5    Elazar, Z.6
  • 57
    • 84908065760 scopus 로고    scopus 로고
    • Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation
    • Wong, Y.C., and E.L. Holzbaur. 2014. Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation. Proc. Natl. Acad. Sci. USA. 111:E4439-E4448. http://dx.doi.org/10.1073/pnas.1405752111
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. E4439-E4448
    • Wong, Y.C.1    Holzbaur, E.L.2
  • 58
    • 84953383938 scopus 로고    scopus 로고
    • Structural basis of the differential function of the two C. elegans Atg8 homologs, LGG-1 and LGG-2, in autophagy
    • Wu, F., Y. Watanabe, X.Y. Guo, X. Qi, P. Wang, H.Y. Zhao, Z. Wang, Y. Fujioka, H. Zhang, J.Q. Ren, et al. 2015. Structural basis of the differential function of the two C. elegans Atg8 homologs, LGG-1 and LGG-2, in autophagy. Mol. Cell. 60:914-929. http://dx.doi.org/10.1016/j.molcel.2015.11.019
    • (2015) Mol. Cell , vol.60 , pp. 914-929
    • Wu, F.1    Watanabe, Y.2    Guo, X.Y.3    Qi, X.4    Wang, P.5    Zhao, H.Y.6    Wang, Z.7    Fujioka, Y.8    Zhang, H.9    Ren, J.Q.10
  • 59
    • 0035874881 scopus 로고    scopus 로고
    • Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein
    • Xin, Y., L. Yu, Z. Chen, L. Zheng, Q. Fu, J. Jiang, P. Zhang, R. Gong, and S. Zhao. 2001. Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein. Genomics. 74:408-413. http://dx.doi.org/10.1006/geno.2001.6555
    • (2001) Genomics , vol.74 , pp. 408-413
    • Xin, Y.1    Yu, L.2    Chen, Z.3    Zheng, L.4    Fu, Q.5    Jiang, J.6    Zhang, P.7    Gong, R.8    Zhao, S.9
  • 60
    • 84898652320 scopus 로고    scopus 로고
    • Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy
    • Yamano, K., A.I. Fogel, C. Wang, A.M. van der Bliek, and R.J. Youle. 2014. Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy. eLife. 3:e01612. http://dx.doi.org/10.7554/eLife.01612
    • (2014) eLife , vol.3 , pp. e01612
    • Yamano, K.1    Fogel, A.I.2    Wang, C.3    van der Bliek, A.M.4    Youle, R.J.5
  • 61
    • 84902440389 scopus 로고    scopus 로고
    • A PCR based protocol for detecting indel mutations induced by TALENs and CRISPR/Cas9 in zebrafish
    • Yu, C., Y. Zhang, S. Yao, and Y. Wei. 2014. A PCR based protocol for detecting indel mutations induced by TALENs and CRISPR/Cas9 in zebrafish. PLoS One. 9:e98282. http://dx.doi.org/10.1371/journal.pone.0098282
    • (2014) PLoS One , vol.9 , pp. e98282
    • Yu, C.1    Zhang, Y.2    Yao, S.3    Wei, Y.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.