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Volumn 281, Issue 1, 2018, Pages 88-98

Metabolic regulation of NLRP3

Author keywords

Glycolysis; Inflammasome; Inflammation; Krebs cycle; Metabolism; NLRP3

Indexed keywords

CRYOPYRIN; HEXOKINASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PKM2 PROTEIN; PROTEIN; UNCLASSIFIED DRUG; CHOLESTEROL; INFLAMMASOME; INTERLEUKIN 1BETA CONVERTING ENZYME; KETONE BODY; PALMITIC ACID; REACTIVE OXYGEN METABOLITE; URIC ACID;

EID: 85037994658     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/imr.12608     Document Type: Review
Times cited : (246)

References (86)
  • 1
    • 84892528401 scopus 로고    scopus 로고
    • Innate immune system cells in atherosclerosis
    • Chavez-Sanchez L, Espinosa-Luna JE, Chavez-Rueda K, et al. Innate immune system cells in atherosclerosis. Arch Med Res. 2014;45:1-14. https://doi.org/10.1016/j.arcmed.2013.11.007.
    • (2014) Arch Med Res , vol.45 , pp. 1-14
    • Chavez-Sanchez, L.1    Espinosa-Luna, J.E.2    Chavez-Rueda, K.3
  • 2
    • 84879498251 scopus 로고    scopus 로고
    • Adipose tissue macrophages in the development of obesity- induced inflammation, insulin resistance and type 2 diabetes
    • Lee J. Adipose tissue macrophages in the development of obesity- induced inflammation, insulin resistance and type 2 diabetes. Arch Pharm Res. 2013;36:208-222. https://doi.org/10.1007/s12272-013-0023-8.
    • (2013) Arch Pharm Res , vol.36 , pp. 208-222
    • Lee, J.1
  • 3
    • 84949660664 scopus 로고    scopus 로고
    • Inflammaging and anti-inflammaging: The role of cytokines in extreme longevity
    • Minciullo PL, Catalano A, Mandraffino G, et al. Inflammaging and anti-inflammaging: the role of cytokines in extreme longevity. Arch Immunol Ther Exp (Warsz). 2016;64:111-126. https://doi.org/10.1007/s00005-015-0377-3.
    • (2016) Arch Immunol Ther Exp (Warsz) , vol.64 , pp. 111-126
    • Minciullo, P.L.1    Catalano, A.2    Mandraffino, G.3
  • 4
    • 84865297442 scopus 로고    scopus 로고
    • The inflammation highway: Metabolism accelerates inflammatory traffic in obesity
    • Johnson AR, Milner JJ, Makowski L. The inflammation highway: metabolism accelerates inflammatory traffic in obesity. Immunol Rev. 2012;249:218-238. https://doi.org/10.1111/j.1600-065X.2012.01151.x.
    • (2012) Immunol Rev , vol.249 , pp. 218-238
    • Johnson, A.R.1    Milner, J.J.2    Makowski, L.3
  • 5
    • 84952306311 scopus 로고    scopus 로고
    • The interplay between inflammation and metabolism in rheumatoid arthritis
    • Chimenti MS, Triggianese P, Conigliaro P, et al. The interplay between inflammation and metabolism in rheumatoid arthritis. Cell Death Dis. 2015;6:e1887. https://doi.org/10.1038/cddis.2015.246.
    • (2015) Cell Death Dis , vol.6
    • Chimenti, M.S.1    Triggianese, P.2    Conigliaro, P.3
  • 6
    • 84896332642 scopus 로고    scopus 로고
    • Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes
    • Lu A, Magupalli VG, Ruan J, et al. Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes. Cell. 2014;156:1193-1206. https://doi.org/10.1016/j.cell.2014.02.008.
    • (2014) Cell , vol.156 , pp. 1193-1206
    • Lu, A.1    Magupalli, V.G.2    Ruan, J.3
  • 7
    • 0036671894 scopus 로고    scopus 로고
    • The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    • Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell. 2002;10:417-426.
    • (2002) Mol Cell , vol.10 , pp. 417-426
    • Martinon, F.1    Burns, K.2    Tschopp, J.3
  • 8
    • 1642285783 scopus 로고    scopus 로고
    • NALP3 forms an IL-1beta- processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder
    • Agostini L, Martinon F, Burns K, et al. NALP3 forms an IL-1beta- processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity. 2004;20:319-325.
    • (2004) Immunity , vol.20 , pp. 319-325
    • Agostini, L.1    Martinon, F.2    Burns, K.3
  • 9
    • 75649096002 scopus 로고    scopus 로고
    • Thioredoxin-interacting protein links oxidative stress to inflammasome activation
    • Zhou R, Tardivel A, Thorens B, et al. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol. 2010;11:136-140. https://doi.org/10.1038/ni.1831.
    • (2010) Nat Immunol , vol.11 , pp. 136-140
    • Zhou, R.1    Tardivel, A.2    Thorens, B.3
  • 10
    • 79751512463 scopus 로고    scopus 로고
    • The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
    • Vandanmagsar B, Youm YH, Ravussin A, et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med. 2011;17:179-188. https://doi.org/10.1038/nm.2279.
    • (2011) Nat Med , vol.17 , pp. 179-188
    • Vandanmagsar, B.1    Youm, Y.H.2    Ravussin, A.3
  • 11
    • 84962219519 scopus 로고    scopus 로고
    • Human monocytes engage an alternative inflammasome pathway
    • Gaidt MM, Ebert TS, Chauhan D, et al. Human monocytes engage an alternative inflammasome pathway. Immunity. 2016;44:833-846. https://doi.org/10.1016/j.immuni.2016.01.012.
    • (2016) Immunity , vol.44 , pp. 833-846
    • Gaidt, M.M.1    Ebert, T.S.2    Chauhan, D.3
  • 12
    • 80455176839 scopus 로고    scopus 로고
    • Non-canonical inflammasome activation targets caspase-11
    • Kayagaki N, Warming S, Lamkanfi M, et al. Non-canonical inflammasome activation targets caspase-11. Nature. 2011;479:117-121. https://doi.org/10.1038/nature10558.
    • (2011) Nature , vol.479 , pp. 117-121
    • Kayagaki, N.1    Warming, S.2    Lamkanfi, M.3
  • 13
    • 84942856523 scopus 로고    scopus 로고
    • Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
    • Kayagaki N, Stowe IB, Lee BL, et al. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature. 2015;526:666-671. https://doi.org/10.1038/nature15541.
    • (2015) Nature , vol.526 , pp. 666-671
    • Kayagaki, N.1    Stowe, I.B.2    Lee, B.L.3
  • 14
    • 84901316606 scopus 로고    scopus 로고
    • Cellular mechanisms and physiological consequences of redox-dependent signalling
    • Holmstrom KM, Finkel T. Cellular mechanisms and physiological consequences of redox-dependent signalling. Nat Rev Mol Cell Biol. 2014;15:411-421. https://doi.org/10.1038/nrm3801.
    • (2014) Nat Rev Mol Cell Biol , vol.15 , pp. 411-421
    • Holmstrom, K.M.1    Finkel, T.2
  • 15
    • 84899636261 scopus 로고    scopus 로고
    • Reversible cysteine oxidation in hydrogen peroxide sensing and signal transduction
    • Garcia-Santamarina S, Boronat S, Hidalgo E. Reversible cysteine oxidation in hydrogen peroxide sensing and signal transduction. Biochemistry. 2014;53:2560-2580. https://doi.org/10.1021/bi401700f.
    • (2014) Biochemistry , vol.53 , pp. 2560-2580
    • Garcia-Santamarina, S.1    Boronat, S.2    Hidalgo, E.3
  • 16
    • 85011597266 scopus 로고    scopus 로고
    • Glutathione and glutathione transferase omega 1 as key posttranslational regulators in macrophages
    • Hughes MM, McGettrick AF, O’Neill LA. Glutathione and glutathione transferase omega 1 as key posttranslational regulators in macrophages. Microbiol Spectr. 2017;5:789-801. https://doi.org/10.1128/microbiolspec.MCHD-0044-2016.
    • (2017) Microbiol Spectr , vol.5 , pp. 789-801
    • Hughes, M.M.1    McGettrick, A.F.2    O’Neill, L.A.3
  • 17
    • 85026881072 scopus 로고    scopus 로고
    • Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling
    • Hughes MM, Lavrencic P, Coll RC, et al. Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling. Proc Natl Acad Sci U S A. 2017;114:E6480-6489. https://doi.org/10.1073/pnas.1701868114.
    • (2017) Proc Natl Acad Sci U S A , vol.114 , pp. E6480-E6489
    • Hughes, M.M.1    Lavrencic, P.2    Coll, R.C.3
  • 18
    • 47849120473 scopus 로고    scopus 로고
    • Superoxide dismutase 1 regulates caspase-1 and endotoxic shock
    • Meissner F, Molawi K, Zychlinsky A. Superoxide dismutase 1 regulates caspase-1 and endotoxic shock. Nat Immunol. 2008;9:866-872. https://doi.org/10.1038/ni.1633.
    • (2008) Nat Immunol , vol.9 , pp. 866-872
    • Meissner, F.1    Molawi, K.2    Zychlinsky, A.3
  • 19
    • 43049091172 scopus 로고    scopus 로고
    • Inhibition of caspase-3 activity and activation by protein glutathionylation
    • Huang Z, Pinto JT, Deng H, et al. Inhibition of caspase-3 activity and activation by protein glutathionylation. Biochem Pharmacol. 2008;75:2234-2244. https://doi.org/10.1016/j.bcp.2008.02.026.
    • (2008) Biochem Pharmacol , vol.75 , pp. 2234-2244
    • Huang, Z.1    Pinto, J.T.2    Deng, H.3
  • 20
    • 85021799413 scopus 로고    scopus 로고
    • A mechanistic insight into curcumin modulation of the IL-1beta secretion and NLRP3 S-glutathionylation induced by needle-like cationic cellulose nanocrystals in myeloid cells
    • Guglielmo A, Sabra A, Elbery M, et al. A mechanistic insight into curcumin modulation of the IL-1beta secretion and NLRP3 S-glutathionylation induced by needle-like cationic cellulose nanocrystals in myeloid cells. Chem Biol Interact. 2017;274:1-12. https://doi.org/10.1016/j.cbi.2017.06.028.
    • (2017) Chem Biol Interact , vol.274 , pp. 1-12
    • Guglielmo, A.1    Sabra, A.2    Elbery, M.3
  • 21
    • 84949595485 scopus 로고    scopus 로고
    • NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component
    • Shi H, Wang Y, Li X, et al. NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component. Nat Immunol. 2016;17:250-258. https://doi.org/10.1038/ni.3333.
    • (2016) Nat Immunol , vol.17 , pp. 250-258
    • Shi, H.1    Wang, Y.2    Li, X.3
  • 22
    • 84958971929 scopus 로고    scopus 로고
    • NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
    • He Y, Zeng MY, Yang D, et al. NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. Nature. 2016;530:354-357. https://doi.org/10.1038/nature16959.
    • (2016) Nature , vol.530 , pp. 354-357
    • He, Y.1    Zeng, M.Y.2    Yang, D.3
  • 23
    • 84879596906 scopus 로고    scopus 로고
    • K(+) efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter
    • Munoz-Planillo R, Kuffa P, Martinez-Colon G, et al. K(+) efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity. 2013;38:1142-1153. https://doi.org/10.1016/j.immuni.2013.05.016.
    • (2013) Immunity , vol.38 , pp. 1142-1153
    • Munoz-Planillo, R.1    Kuffa, P.2    Martinez-Colon, G.3
  • 24
    • 85025154002 scopus 로고    scopus 로고
    • The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1beta transcription and activate the NLRP3 inflammasome
    • Domingo-Fernandez R, Coll RC, Kearney J, et al. The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1beta transcription and activate the NLRP3 inflammasome. J Biol Chem. 2017;292:12077-12087. https://doi.org/10.1074/jbc.M117.797126.
    • (2017) J Biol Chem , vol.292 , pp. 12077-12087
    • Domingo-Fernandez, R.1    Coll, R.C.2    Kearney, J.3
  • 25
    • 85026857565 scopus 로고    scopus 로고
    • CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation
    • Tang T, Lang X, Xu C, et al. CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation. Nat Commun. 2017;8:202. https://doi.org/10.1038/s41467-017-00227-x.
    • (2017) Nat Commun , vol.8 , pp. 202
    • Tang, T.1    Lang, X.2    Xu, C.3
  • 26
    • 85025690240 scopus 로고    scopus 로고
    • AIM2 engages active but unprocessed caspase-1 to induce noncanonical activation of the NLRP3 inflammasome
    • Cunha LD, Silva ALN, Ribeiro JM, et al. AIM2 engages active but unprocessed caspase-1 to induce noncanonical activation of the NLRP3 inflammasome. Cell Rep. 2017;20:794-805. https://doi.org/10.1016/j.celrep.2017.06.086.
    • (2017) Cell Rep , vol.20 , pp. 794-805
    • Cunha, L.D.1    Silva, A.2    Ribeiro, J.M.3
  • 27
    • 85018275618 scopus 로고    scopus 로고
    • The RNA-binding protein Tristetraprolin (TTP) is a critical negative regulator of the NLRP3 inflammasome
    • Haneklaus M, O’Neil JD, Clark AR, et al. The RNA-binding protein Tristetraprolin (TTP) is a critical negative regulator of the NLRP3 inflammasome. J Biol Chem. 2017;292:6869-6881. https://doi.org/10.1074/jbc.M116.772947.
    • (2017) J Biol Chem , vol.292 , pp. 6869-6881
    • Haneklaus, M.1    O’Neil, J.D.2    Clark, A.R.3
  • 28
    • 75649151031 scopus 로고    scopus 로고
    • Cysteine oxidation enhanced by iron in tristetraprolin, a zinc finger peptide
    • Lee SJ, Michel SL. Cysteine oxidation enhanced by iron in tristetraprolin, a zinc finger peptide. Inorg Chem. 2010;49:1211-1219. https://doi.org/10.1021/ic9024298.
    • (2010) Inorg Chem , vol.49 , pp. 1211-1219
    • Lee, S.J.1    Michel, S.L.2
  • 29
    • 84900848929 scopus 로고    scopus 로고
    • A novel immunomodulatory effect of ugonin U in human neutrophils via stimulation of phospholipase C
    • Chen CY, Liaw CC, Chen YH, et al. A novel immunomodulatory effect of ugonin U in human neutrophils via stimulation of phospholipase C. Free Radic Biol Med. 2014;72:222-231. https://doi.org/10.1016/j.freeradbiomed.2014.04.018.
    • (2014) Free Radic Biol Med , vol.72 , pp. 222-231
    • Chen, C.Y.1    Liaw, C.C.2    Chen, Y.H.3
  • 30
    • 85007400766 scopus 로고    scopus 로고
    • Ugonin U stimulates NLRP3 inflammasome activation and enhances inflammasome-mediated pathogen clearance
    • Chen CY, Yang CH, Tsai YF, et al. Ugonin U stimulates NLRP3 inflammasome activation and enhances inflammasome-mediated pathogen clearance. Redox Biol. 2017;11:263-274. https://doi.org/10.1016/j.redox.2016.12.018.
    • (2017) Redox Biol , vol.11 , pp. 263-274
    • Chen, C.Y.1    Yang, C.H.2    Tsai, Y.F.3
  • 31
    • 84961290384 scopus 로고    scopus 로고
    • UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis
    • Moon JS, Lee S, Park MA, et al. UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis. J Clin Invest. 2015;125:665-680. https://doi.org/10.1172/jci78253.
    • (2015) J Clin Invest , vol.125 , pp. 665-680
    • Moon, J.S.1    Lee, S.2    Park, M.A.3
  • 32
    • 84979543880 scopus 로고    scopus 로고
    • NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages
    • Moon JS, Nakahira K, Chung KP, et al. NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages. Nat Med. 2016;22:1002-1012. https://doi.org/10.1038/nm.4153.
    • (2016) Nat Med , vol.22 , pp. 1002-1012
    • Moon, J.S.1    Nakahira, K.2    Chung, K.P.3
  • 33
    • 84876285741 scopus 로고    scopus 로고
    • Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha
    • Tannahill GM, Curtis AM, Adamik J, et al. Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha. Nature. 2013;496:238-242. https://doi.org/10.1038/nature11986.
    • (2013) Nature , vol.496 , pp. 238-242
    • Tannahill, G.M.1    Curtis, A.M.2    Adamik, J.3
  • 34
    • 84969142199 scopus 로고    scopus 로고
    • Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death
    • Sanman LE, Qian Y, Eisele NA, et al. Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death. Elife. 2016;5:e13663. https://doi.org/10.7554/eLife.13663.
    • (2016) Elife , vol.5
    • Sanman, L.E.1    Qian, Y.2    Eisele, N.A.3
  • 35
    • 84937513657 scopus 로고    scopus 로고
    • MTORC1-induced HK1-dependent glycolysis regulates NLRP3 inflammasome activation
    • Moon JS, Hisata S, Park MA, et al. mTORC1-induced HK1-dependent glycolysis regulates NLRP3 inflammasome activation. Cell Rep. 2015;12:102-115. https://doi.org/10.1016/j.celrep.2015.05.046.
    • (2015) Cell Rep , vol.12 , pp. 102-115
    • Moon, J.S.1    Hisata, S.2    Park, M.A.3
  • 36
    • 84958280606 scopus 로고    scopus 로고
    • Intracellular ATP decrease mediates NLRP3 inflammasome activation upon nigericin and crystal stimulation
    • Nomura J, So A, Tamura M, et al. Intracellular ATP decrease mediates NLRP3 inflammasome activation upon nigericin and crystal stimulation. J Immunol. 2015;195:5718-5724. https://doi.org/10.4049/jimmunol.1402512.
    • (2015) J Immunol , vol.195 , pp. 5718-5724
    • Nomura, J.1    So, A.2    Tamura, M.3
  • 37
    • 9744221185 scopus 로고    scopus 로고
    • Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak
    • Majewski N, Nogueira V, Bhaskar P, et al. Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol Cell. 2004;16:819-830. https://doi.org/10.1016/j.molcel.2004.11.014.
    • (2004) Mol Cell , vol.16 , pp. 819-830
    • Majewski, N.1    Nogueira, V.2    Bhaskar, P.3
  • 38
    • 25444524850 scopus 로고    scopus 로고
    • Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity
    • Hahn-Windgassen A, Nogueira V, Chen CC, et al. Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. J Biol Chem. 2005;280:32081-32089. https://doi.org/10.1074/jbc.M502876200.
    • (2005) J Biol Chem , vol.280 , pp. 32081-32089
    • Hahn-Windgassen, A.1    Nogueira, V.2    Chen, C.C.3
  • 39
    • 84978483985 scopus 로고    scopus 로고
    • Hexokinase is an innate immune receptor for the detection of bacterial peptidoglycan
    • Wolf AJ, Reyes CN, Liang W, et al. Hexokinase is an innate immune receptor for the detection of bacterial peptidoglycan. Cell. 2016;166:624-636. https://doi.org/10.1016/j.cell.2016.05.076.
    • (2016) Cell , vol.166 , pp. 624-636
    • Wolf, A.J.1    Reyes, C.N.2    Liang, W.3
  • 40
    • 79957567239 scopus 로고    scopus 로고
    • Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1
    • Luo W, Hu H, Chang R, et al. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell. 2011;145:732-744. https://doi.org/10.1016/j.cell.2011.03.054.
    • (2011) Cell , vol.145 , pp. 732-744
    • Luo, W.1    Hu, H.2    Chang, R.3
  • 41
    • 84920591180 scopus 로고    scopus 로고
    • Pyruvate kinase M2 regulates Hif-1alpha activity and IL-1beta induction and is a critical determinant of the warburg effect in LPS-activated macrophages
    • Palsson-McDermott EM, Curtis AM, Goel G, et al. Pyruvate kinase M2 regulates Hif-1alpha activity and IL-1beta induction and is a critical determinant of the warburg effect in LPS-activated macrophages. Cell Metab. 2015;21:65-80. https://doi.org/10.1016/j.cmet.2014.12.005.
    • (2015) Cell Metab , vol.21 , pp. 65-80
    • Palsson-Mcdermott, E.M.1    Curtis, A.M.2    Goel, G.3
  • 42
    • 84992597199 scopus 로고    scopus 로고
    • PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
    • Xie M, Yu Y, Kang R, et al. PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation. Nat Commun. 2016;7:13280. https://doi.org/10.1038/ncomms13280.
    • (2016) Nat Commun , vol.7 , pp. 13280
    • Xie, M.1    Yu, Y.2    Kang, R.3
  • 43
    • 0034610328 scopus 로고    scopus 로고
    • Caspase-1 and -3 are sequentially activated in motor neuron death
    • Pasinelli P. Caspase-1 and -3 are sequentially activated in motor neuron death. Proc Natl Acad Sci U S A. 2000;97:13901-13906.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 13901-13906
    • Pasinelli, P.1
  • 44
    • 84885167222 scopus 로고    scopus 로고
    • Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging
    • Youm YH, Grant RW, McCabe LR, et al. Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging. Cell Metab. 2013;18:519-532. https://doi.org/10.1016/j.cmet.2013.09.010.
    • (2013) Cell Metab , vol.18 , pp. 519-532
    • Youm, Y.H.1    Grant, R.W.2    McCabe, L.R.3
  • 45
    • 80053087484 scopus 로고    scopus 로고
    • Inflammasome is a central player in the induction of obesity and insulin resistance
    • Stienstra R, van Diepen JA, Tack CJ, et al. Inflammasome is a central player in the induction of obesity and insulin resistance. Proc Natl Acad Sci U S A. 2011;108:15324-15329. https://doi.org/10.1073/pnas.1100255108.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 15324-15329
    • Stienstra, R.1    Van Diepen, J.A.2    Tack, C.J.3
  • 46
    • 84924415042 scopus 로고    scopus 로고
    • A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
    • Coll RC, Robertson AA, Chae JJ, et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med. 2015;21:248-255. https://doi.org/10.1038/nm.3806.
    • (2015) Nat Med , vol.21 , pp. 248-255
    • Coll, R.C.1    Robertson, A.A.2    Chae, J.J.3
  • 48
    • 85026749851 scopus 로고    scopus 로고
    • Sulfonylureas as concomitant insulin secretagogues and NLRP3 inflammasome inhibitors
    • Hill JR, Coll RC, Sue N, et al. Sulfonylureas as concomitant insulin secretagogues and NLRP3 inflammasome inhibitors. ChemMedChem. 2017;12:1449-1457. https://doi.org/10.1002/cmdc.201700270.
    • (2017) Chemmedchem , vol.12 , pp. 1449-1457
    • Hill, J.R.1    Coll, R.C.2    Sue, N.3
  • 49
    • 85027019757 scopus 로고    scopus 로고
    • The NLRP3 inflammasome contributes to sarcopenia and lower muscle glycolytic potential in old mice
    • McBride MJ, Foley KP, D’Souza DM, et al. The NLRP3 inflammasome contributes to sarcopenia and lower muscle glycolytic potential in old mice. Am J Physiol Endocrinol Metab. 2017;313:E222-e232. https://doi.org/10.1152/ajpendo.00060.2017.
    • (2017) Am J Physiol Endocrinol Metab , vol.313 , pp. E222-e232
    • McBride, M.J.1    Foley, K.P.2    D’Souza, D.M.3
  • 50
    • 37549002511 scopus 로고    scopus 로고
    • The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock
    • Shao W, Yeretssian G, Doiron K, et al. The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock. J Biol Chem. 2007;282:36321-36329. https://doi.org/10.1074/jbc.M708182200.
    • (2007) J Biol Chem , vol.282 , pp. 36321-36329
    • Shao, W.1    Yeretssian, G.2    Doiron, K.3
  • 51
    • 79955038882 scopus 로고    scopus 로고
    • Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling
    • Wen H, Gris D, Lei Y, et al. Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol. 2011;12:408-415. https://doi.org/10.1038/ni.2022.
    • (2011) Nat Immunol , vol.12 , pp. 408-415
    • Wen, H.1    Gris, D.2    Lei, Y.3
  • 52
    • 84924356420 scopus 로고    scopus 로고
    • The ketone metabolite beta-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease
    • Youm YH, Nguyen KY, Grant RW, et al. The ketone metabolite beta-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med. 2015;21:263-269. https://doi.org/10.1038/nm.3804.
    • (2015) Nat Med , vol.21 , pp. 263-269
    • Youm, Y.H.1    Nguyen, K.Y.2    Grant, R.W.3
  • 53
    • 85029226840 scopus 로고    scopus 로고
    • The ketone metabolite beta-hydroxybutyrate attenuates oxidative stress in spinal cord injury by suppression of class I histone deacetylases
    • Kong G, Huang Z, Ji W, et al. The ketone metabolite beta-hydroxybutyrate attenuates oxidative stress in spinal cord injury by suppression of class I histone deacetylases. J Neurotrauma. 2017;34:2645-2655. https://doi.org/10.1089/neu.2017.5192.
    • (2017) J Neurotrauma , vol.34 , pp. 2645-2655
    • Kong, G.1    Huang, Z.2    Ji, W.3
  • 54
    • 85027181129 scopus 로고    scopus 로고
    • Beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses
    • Yamanashi T, Iwata M, Kamiya N, et al. Beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses. Sci Rep. 2017;7:7677. https://doi.org/10.1038/s41598-017-08055-1.
    • (2017) Sci Rep , vol.7 , pp. 7677
    • Yamanashi, T.1    Iwata, M.2    Kamiya, N.3
  • 55
    • 85014089976 scopus 로고    scopus 로고
    • Beta-Hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares
    • Goldberg EL, Asher JL, Molony RD, et al. beta-Hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares. Cell Rep. 2017;18:2077-2087. https://doi.org/10.1016/j.celrep.2017.02.004.
    • (2017) Cell Rep , vol.18 , pp. 2077-2087
    • Goldberg, E.L.1    Asher, J.L.2    Molony, R.D.3
  • 56
    • 84899934630 scopus 로고    scopus 로고
    • Nlrp3 is a key modulator of diet-induced nephropathy and renal cholesterol accumulation
    • Bakker PJ, Butter LM, Kors L, et al. Nlrp3 is a key modulator of diet-induced nephropathy and renal cholesterol accumulation. Kidney Int. 2014;85:1112-1122. https://doi.org/10.1038/ki.2013.503.
    • (2014) Kidney Int , vol.85 , pp. 1112-1122
    • Bakker, P.J.1    Butter, L.M.2    Kors, L.3
  • 57
    • 1242269851 scopus 로고    scopus 로고
    • Regulation of bile acid synthesis: Pathways, nuclear receptors, and mechanisms
    • Chiang JY. Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms. J Hepatol. 2004;40:539-551. https://doi.org/10.1016/j.jhep.2003.11.006.
    • (2004) J Hepatol , vol.40 , pp. 539-551
    • Chiang, J.Y.1
  • 58
    • 84994887772 scopus 로고    scopus 로고
    • Bile acids control inflammation and metabolic disorder through inhibition of NLRP3 inflammasome
    • Guo C, Xie S, Chi Z, et al. Bile acids control inflammation and metabolic disorder through inhibition of NLRP3 inflammasome. Immunity. 2016;45:944. https://doi.org/10.1016/j.immuni.2016.10.009.
    • (2016) Immunity , vol.45 , pp. 944
    • Guo, C.1    Xie, S.2    Chi, Z.3
  • 59
    • 84929643541 scopus 로고    scopus 로고
    • Prostaglandin E2 inhibits NLRP3 inflammasome activation through EP4 receptor and intracellular cyclic AMP in human macrophages
    • Sokolowska M, Chen LY, Liu Y, et al. Prostaglandin E2 inhibits NLRP3 inflammasome activation through EP4 receptor and intracellular cyclic AMP in human macrophages. J Immunol. 2015;194:5472-5487. https://doi.org/10.4049/jimmunol.1401343.
    • (2015) J Immunol , vol.194 , pp. 5472-5487
    • Sokolowska, M.1    Chen, L.Y.2    Liu, Y.3
  • 60
    • 85018476034 scopus 로고    scopus 로고
    • The induction of Pro-IL- 1beta by lipopolysaccharide requires endogenous prostaglandin E2 production
    • Zaslona Z, Palsson-McDermott EM, Menon D, et al. The induction of Pro-IL- 1beta by lipopolysaccharide requires endogenous prostaglandin E2 production. J Immunol. 2017;198:3558-3564. https://doi.org/10.4049/jimmunol.1602072.
    • (2017) J Immunol , vol.198 , pp. 3558-3564
    • Zaslona, Z.1    Palsson-Mcdermott, E.M.2    Menon, D.3
  • 61
    • 84939625498 scopus 로고    scopus 로고
    • Metformin inhibits the production of reactive oxygen species from NADH: Ubiquinone oxidoreductase to limit induction of interleukin-1beta (IL-1beta) and boosts interleukin-10 (IL-10) in lipopolysaccharide (LPS)-activated macrophages
    • Kelly B, Tannahill GM, Murphy MP, et al. Metformin inhibits the production of reactive oxygen species from NADH: ubiquinone oxidoreductase to limit induction of interleukin-1beta (IL-1beta) and boosts interleukin-10 (IL-10) in lipopolysaccharide (LPS)-activated macrophages. J Biol Chem. 2015;290:20348-20359. https://doi.org/10.1074/jbc.M115.662114.
    • (2015) J Biol Chem , vol.290 , pp. 20348-20359
    • Kelly, B.1    Tannahill, G.M.2    Murphy, M.P.3
  • 62
    • 84990845578 scopus 로고    scopus 로고
    • Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages
    • Mills EL, Kelly B, Logan A, et al. Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages. Cell. 2016;167:457-470. https://doi.org/10.1016/j.cell.2016.08.064.
    • (2016) Cell , vol.167 , pp. 457-470
    • Mills, E.L.1    Kelly, B.2    Logan, A.3
  • 63
    • 84862777872 scopus 로고    scopus 로고
    • Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
    • Shimada K, Crother TR, Karlin J, et al. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity. 2012;36:401-414. https://doi.org/10.1016/j.immuni.2012.01.009.
    • (2012) Immunity , vol.36 , pp. 401-414
    • Shimada, K.1    Crother, T.R.2    Karlin, J.3
  • 64
    • 84964829186 scopus 로고    scopus 로고
    • Succinate/NLRP3 inflammasome induces synovial fibroblast activation: Therapeutical effects of clematichinenoside AR on arthritis
    • Li Y, Zheng JY, Liu JQ, et al. Succinate/NLRP3 inflammasome induces synovial fibroblast activation: therapeutical effects of clematichinenoside AR on arthritis. Front Immunol. 2016;7:532. https://doi.org/10.3389/fimmu.2016.00532.
    • (2016) Front Immunol , vol.7 , pp. 532
    • Li, Y.1    Zheng, J.Y.2    Liu, J.Q.3
  • 65
    • 84969540589 scopus 로고    scopus 로고
    • Dimethyl fumarate ameliorates dextran sulfate sodium-induced murine experimental colitis by activating Nrf2 and suppressing NLRP3 inflammasome activation
    • Liu X, Zhou W, Zhang X, et al. Dimethyl fumarate ameliorates dextran sulfate sodium-induced murine experimental colitis by activating Nrf2 and suppressing NLRP3 inflammasome activation. Biochem Pharmacol. 2016;112:37-49. https://doi.org/10.1016/j.bcp.2016.05.002.
    • (2016) Biochem Pharmacol , vol.112 , pp. 37-49
    • Liu, X.1    Zhou, W.2    Zhang, X.3
  • 66
    • 80053349020 scopus 로고    scopus 로고
    • The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus
    • Zhao Y, Yang J, Shi J, et al. The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature. 2011;477:596-600. https://doi.org/10.1038/nature10510.
    • (2011) Nature , vol.477 , pp. 596-600
    • Zhao, Y.1    Yang, J.2    Shi, J.3
  • 67
    • 84922311780 scopus 로고    scopus 로고
    • Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5
    • Matusiak M, Van Opdenbosch N, Vande Walle L, et al. Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5. Proc Natl Acad Sci U S A. 2015;112:1541-1546. https://doi.org/10.1073/pnas.1417945112.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 1541-1546
    • Matusiak, M.1    Van Opdenbosch, N.2    Vande Walle, L.3
  • 68
    • 77955390094 scopus 로고    scopus 로고
    • Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella
    • Broz P, Newton K, Lamkanfi M, et al. Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella. J Exp Med. 2010;207:1745-1755. https://doi.org/10.1084/jem.20100257.
    • (2010) J Exp Med , vol.207 , pp. 1745-1755
    • Broz, P.1    Newton, K.2    Lamkanfi, M.3
  • 69
    • 84897932260 scopus 로고    scopus 로고
    • Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome
    • Wynosky-Dolfi MA, Snyder AG, Philip NH, et al. Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome. J Exp Med. 2014;211:653-668. https://doi.org/10.1084/jem.20130627.
    • (2014) J Exp Med , vol.211 , pp. 653-668
    • Wynosky-Dolfi, M.A.1    Snyder, A.G.2    Philip, N.H.3
  • 70
    • 85028983668 scopus 로고    scopus 로고
    • Dectin-1 activation during Leishmania amazonensis phagocytosis prompts Syk-dependent reactive oxygen species production to trigger inflammasome assembly and restriction of parasite replication
    • Lima-Junior DS, Mineo TWP, Calich VLG, et al. Dectin-1 activation during Leishmania amazonensis phagocytosis prompts Syk-dependent reactive oxygen species production to trigger inflammasome assembly and restriction of parasite replication. J Immunol. 2017;199:2055-2068. https://doi.org/10.4049/jimmunol.1700258.
    • (2017) J Immunol , vol.199 , pp. 2055-2068
    • Lima-Junior, D.S.1    Mineo, T.2    Calich, V.3
  • 71
    • 43249125839 scopus 로고    scopus 로고
    • Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
    • Dostert C, Petrilli V, Van Bruggen R, et al. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science. 2008;320:674-677. https://doi.org/10.1126/science.1156995.
    • (2008) Science , vol.320 , pp. 674-677
    • Dostert, C.1    Petrilli, V.2    Van Bruggen, R.3
  • 72
    • 78651393239 scopus 로고    scopus 로고
    • A role for mitochondria in NLRP3 inflammasome activation
    • Zhou R, Yazdi AS, Menu P, et al. A role for mitochondria in NLRP3 inflammasome activation. Nature. 2011;469:221-225. https://doi.org/10.1038/nature09663.
    • (2011) Nature , vol.469 , pp. 221-225
    • Zhou, R.1    Yazdi, A.S.2    Menu, P.3
  • 73
    • 84882614243 scopus 로고    scopus 로고
    • Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation
    • Iyer SS, He Q, Janczy JR, et al. Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation. Immunity. 2013;39:311-323. https://doi.org/10.1016/j.immuni.2013.08.001.
    • (2013) Immunity , vol.39 , pp. 311-323
    • Iyer, S.S.1    He, Q.2    Janczy, J.R.3
  • 74
    • 84885437002 scopus 로고    scopus 로고
    • The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity
    • Park S, Juliana C, Hong S, et al. The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity. J Immunol. 2013;191:4358-4366. https://doi.org/10.4049/jimmunol.1301170.
    • (2013) J Immunol , vol.191 , pp. 4358-4366
    • Park, S.1    Juliana, C.2    Hong, S.3
  • 75
    • 84908544666 scopus 로고    scopus 로고
    • Inflammasome activation leads to Caspase-1- dependent mitochondrial damage and block of mitophagy
    • Yu J, Nagasu H, Murakami T, et al. Inflammasome activation leads to Caspase-1- dependent mitochondrial damage and block of mitophagy. Proc Natl Acad Sci U S A. 2014;111:15514-15519. https://doi.org/10.1073/pnas.1414859111.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 15514-15519
    • Yu, J.1    Nagasu, H.2    Murakami, T.3
  • 76
    • 84887446052 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation
    • Heid ME, Keyel PA, Kamga C, et al. Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation. J Immunol. 2013;191:5230-5238. https://doi.org/10.4049/jimmunol.1301490.
    • (2013) J Immunol , vol.191 , pp. 5230-5238
    • Heid, M.E.1    Keyel, P.A.2    Kamga, C.3
  • 77
    • 84994910645 scopus 로고    scopus 로고
    • K+ efflux-independent NLRP3 inflammasome activation by small molecules targeting mitochondria
    • Gross CJ, Mishra R, Schneider KS, et al. K+ efflux-independent NLRP3 inflammasome activation by small molecules targeting mitochondria. Immunity. 2016;45:761-773. https://doi.org/10.1016/j.immuni.2016.08.010.
    • (2016) Immunity , vol.45 , pp. 761-773
    • Gross, C.J.1    Mishra, R.2    Schneider, K.S.3
  • 78
    • 85018784717 scopus 로고    scopus 로고
    • Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages
    • Ip WKE, Hoshi N, Shouval DS, et al. Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages. Science. 2017;356:513-519. https://doi.org/10.1126/science.aal3535.
    • (2017) Science , vol.356 , pp. 513-519
    • Ip, W.1    Hoshi, N.2    Shouval, D.S.3
  • 79
    • 84862236426 scopus 로고    scopus 로고
    • Kinetics, safety and tolerability of (R)-3- hydroxybutyl (R)-3- hydroxybutyrate in healthy adult subjects
    • Clarke K, Tchabanenko K, Pawlosky R, et al. Kinetics, safety and tolerability of (R)-3- hydroxybutyl (R)-3- hydroxybutyrate in healthy adult subjects. Regul Toxicol Pharmacol. 2012;63:401-408. https://doi.org/10.1016/j.yrtph.2012.04.008.
    • (2012) Regul Toxicol Pharmacol , vol.63 , pp. 401-408
    • Clarke, K.1    Tchabanenko, K.2    Pawlosky, R.3
  • 80
    • 84948172262 scopus 로고    scopus 로고
    • An ester of beta-hydroxybutyrate regulates cholesterol biosynthesis in rats and a cholesterol biomarker in humans
    • Kemper MF, Srivastava S, Todd King M, et al. An ester of beta-hydroxybutyrate regulates cholesterol biosynthesis in rats and a cholesterol biomarker in humans. Lipids. 2015;50:1185-1193. https://doi.org/10.1007/s11745-015-4085-x.
    • (2015) Lipids , vol.50 , pp. 1185-1193
    • Kemper, M.F.1    Srivastava, S.2    Todd King, M.3
  • 81
    • 84858376953 scopus 로고    scopus 로고
    • Mitochondria: In sickness and in health
    • Nunnari J, Suomalainen A. Mitochondria: in sickness and in health. Cell. 2012;148:1145-1159. https://doi.org/10.1016/j.cell.2012.02.035.
    • (2012) Cell , vol.148 , pp. 1145-1159
    • Nunnari, J.1    Suomalainen, A.2
  • 82
    • 84955620567 scopus 로고    scopus 로고
    • High glucose and lipopolysaccharide prime NLRP3 Inflammasome via ROS/TXNIP pathway in mesangial cells
    • Feng H, Gu J, Gou F, et al. High glucose and lipopolysaccharide prime NLRP3 Inflammasome via ROS/TXNIP pathway in mesangial cells. J Diabetes Res. 2016. https://doi.org/10.1155/2016/6973175
    • (2016) J Diabetes Res
    • Feng, H.1    Gu, J.2    Gou, F.3
  • 83
    • 84991329273 scopus 로고    scopus 로고
    • TRPM2 regulates TXNIP-mediated NLRP3 inflammasome activation via interaction with p47 phox under high glucose in human monocytic cells
    • Tseng HH, Vong CT, Kwan YW, et al. TRPM2 regulates TXNIP-mediated NLRP3 inflammasome activation via interaction with p47 phox under high glucose in human monocytic cells. Sci Rep. 2016;6. https://doi.org/10.1038/srep35016
    • (2016) Sci Rep , pp. 6
    • Tseng, H.H.1    Vong, C.T.2    Kwan, Y.W.3
  • 84
    • 85022088701 scopus 로고    scopus 로고
    • Chronic inflammation triggered by the NLRP3 inflammasome in myeloid cells promotes growth plate dysplasia by mesenchymal cells
    • Wang C, Xu CX, Alippe Y, et al. Chronic inflammation triggered by the NLRP3 inflammasome in myeloid cells promotes growth plate dysplasia by mesenchymal cells. Sci Rep. 2017;7:4880. https://doi.org/10.1038/s41598-017-05033-5
    • (2017) Sci Rep , vol.7 , pp. 4880
    • Wang, C.1    Xu, C.X.2    Alippe, Y.3
  • 85
    • 84978468846 scopus 로고    scopus 로고
    • Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation
    • Lampropoulou V, Sergushichev A, Bambouskova M, et al. Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation. Cell Metab. 2016;24:158-166. https://doi.org/10.1016/j.cmet.2016.06.004
    • (2016) Cell Metab , vol.24 , pp. 158-166
    • Lampropoulou, V.1    Sergushichev, A.2    Bambouskova, M.3
  • 86
    • 85012254007 scopus 로고    scopus 로고
    • Combined NADPH and the NOX inhibitor apocynin provides greater anti-inflammatory and neuroprotective effects in a mouse model of stroke
    • Qin YY, Li M, Feng X, et al. Combined NADPH and the NOX inhibitor apocynin provides greater anti-inflammatory and neuroprotective effects in a mouse model of stroke. Free Radic Biol Med. 2017;104: 333-345. https://doi.org/10.1016/j.freeradbiomed.2017.01.034
    • (2017) Free Radic Biol Med , vol.104 , pp. 333-345
    • Qin, Y.Y.1    Li, M.2    Feng, X.3


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