Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 43, 2014, Pages 15514-15519

  Yu, Jiujiu ^a   Nagasu, Hajime ^a   Murakami, Tomohiko ^a,d   Hoang, Hai ^a   Broderick, Lori ^b,c   Hoffman, Hal M ^b,c   Horng, Tiffany ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c RADY CHILDREN'S HOSPITAL   (United States)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

Inflammasomes; Mitochondrial damage; Mitophagy; Pyroptosis

Indexed keywords

CASPASE 8; INFLAMMASOME; INTERLEUKIN 1BETA CONVERTING ENZYME; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR PYRIN DOMAIN CONTAIN PROTEIN 3; PARKIN; REACTIVE OXYGEN METABOLITE; SYNAPSIN II; UNCLASSIFIED DRUG; AIM2 PROTEIN, MOUSE; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; DNA BINDING PROTEIN; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW DERIVED MACROPHAGE; CELL DAMAGE; CELL DEATH; CELL DIFFERENTIATION; CELL PERMEABILIZATION; CELL STRESS; CINCA SYNDROME; CONTROLLED STUDY; DNA FRAGMENTATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; MITOCHONDRION SWELLING; MITOPHAGY; NONHUMAN; OLIGOMERIZATION; ANIMAL; APOPTOSIS; C57BL MOUSE; ENZYMOLOGY; METABOLISM; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; PATHOLOGY; PERMEABILITY; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CARRIER PROTEINS; CASPASE 1; CRYOPYRIN-ASSOCIATED PERIODIC SYNDROMES; DNA-BINDING PROTEINS; HUMANS; INFLAMMASOMES; MICE, INBRED C57BL; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; MITOCHONDRIAL MEMBRANES; PERMEABILITY; SIGNAL TRANSDUCTION; UBIQUITIN-PROTEIN LIGASES;

EID: 84908544666     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1414859111     Document Type: Article

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