Kinetics, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate in healthy adult subjects

Regulatory Toxicology and Pharmacology

Volumn 63, Issue 3, 2012, Pages 401-408

  Clarke, Kieran ^a   Tchabanenko, Kirill ^a,e   Pawlosky, Robert ^b   Carter, Emma ^a   Todd King, M ^b   Musa Veloso, Kathy ^c   Ho, Manki ^c   Roberts, Ashley ^c   Robertson, Jeremy ^a   VanItallie, Theodore B ^d   Veech, Richard L ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^c Intertek Cantox   (Canada)

^d Columbia University ^*  (United States)

^e QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Hydroxybutyrate; (R) 3 hydroxybutyl (R) 3 hydroxybutyrate; Acetoacetate; Ketone; Kinetics; Safety; Tolerability

Indexed keywords

1,3 BUTANEDIOL; 3 HYDROXYBUTYL 3 HYDROXYBUTYRATE; 3 HYDROXYBUTYRIC ACID; ACETOACETIC ACID; KETONE DERIVATIVE; UNCLASSIFIED DRUG;

ABDOMINAL DISTENSION; ABDOMINAL PAIN; ADULT; ANXIETY; ARTICLE; BEVERAGE; BLOOD LEVEL; CLINICAL TRIAL; CONSTIPATION; DECREASED APPETITE; DIARRHEA; DIET SUPPLEMENTATION; DIZZINESS; DYSPNEA; EUPHORIA; FATIGUE; FEMALE; FLATULENCE; HALF LIFE TIME; HEADACHE; HEART PALPITATION; HUMAN; HUMAN EXPERIMENT; HYDROLYSIS; INSOMNIA; LETHARGY; MALE; NAUSEA; NORMAL HUMAN; OCCULT BLOOD; PRIORITY JOURNAL; RHINITIS; SAFETY; SOMNOLENCE; THORAX PAIN; VOMITING;

ADOLESCENT; ADULT; DIETARY SUPPLEMENTS; FEMALE; HUMANS; HYDROXYBUTYRATES; KETONES; KINETICS; MALE; MIDDLE AGED; YOUNG ADULT;

EID: 84862236426     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2012.04.008     Document Type: Article

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