The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome

Journal of Biological Chemistry

Volumn 292, Issue 29, 2017, Pages 12077-12087

  Domingo Fernández, Raquel ^a   Coll, Rebecca C ^b   Kearney, Jay ^a   Breit, Samuel ^c   O’Neill, Luke A J ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BONE; CELL DEATH; CHEMICAL ACTIVATION; CHLORINE COMPOUNDS; PROTEINS;

CELL FRACTIONATION; CELLULAR MEMBRANES; CHLORIDE CHANNELS; INTRACELLULAR CHANNEL; MULTI-PROTEIN COMPLEX; MURINE MACROPHAGES; PATHOGEN-ASSOCIATED MOLECULAR PATTERNS; PRO-INFLAMMATORY CYTOKINES;

MACROPHAGES;

ADENOSINE TRIPHOSPHATE; CELL PROTEIN; CHLORIDE CHANNEL; CLIC1 PROTEIN; CLIC4 PROTEIN; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; CLIC PROTEIN, MOUSE; CLIC1 PROTEIN, MOUSE; IL1B PROTEIN, MOUSE; MITOCHONDRIAL PROTEIN; NLRP3 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL FRACTIONATION; CELL MEMBRANE TRANSPORT; CELL NUCLEUS; CONFOCAL MICROSCOPY; CONTROLLED STUDY; GENETIC TRANSFECTION; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; 129 MOUSE; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; CELL LINE; CYTOLOGY; DRUG EFFECTS; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; MACROPHAGE; METABOLISM; NUCLEOCYTOPLASMIC TRANSPORT; PYROPTOSIS; RAW 264.7 CELL LINE; RNA INTERFERENCE; SECRETION (PROCESS);

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; BONE MARROW CELLS; CELL LINE; CELLS, CULTURED; CHLORIDE CHANNELS; INFLAMMASOMES; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIAL PROTEINS; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PROTEIN TRANSPORT; PYROPTOSIS; RAW 264.7 CELLS; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

EID: 85025154002     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M117.797126     Document Type: Article

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