The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity

Journal of Immunology

Volumn 191, Issue 8, 2013, Pages 4358-4366

  Park, Sangjun ^a   Juliana, Christine ^b   Hong, Sujeong ^a   Datta, Pinaki ^b   Hwang, Inhwa ^a   Fernandes Alnemri, Teresa ^b   Yu, Je Wook ^a,b   Alnemri, Emad S ^b  

^a Yonsei University College of Medicine   (South Korea)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA CONVERTING ENZYME; MITOCHONDRIAL ANTIVIRAL SIGNALING PROTEIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DAMAGE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; MACROPHAGE; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SENDAI VIRUS INFECTION; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BONE MARROW CELLS; CARRIER PROTEINS; CASPASE 1; CELL LINE; ENZYME ACTIVATION; HEK293 CELLS; HUMANS; INFLAMMASOMES; MACROPHAGES; MICE; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; RESPIROVIRUS INFECTIONS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SENDAI VIRUS; SIGNAL TRANSDUCTION;

EID: 84885437002     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1301170     Document Type: Article

References (31)

1. Tschopp, J., and K. Schroder. 2010. NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production? Nat. Rev. Immunol. 10: 210-215.
2. Franchi, L., R. Muñoz-Planillo, and G. Núñez. 2012. Sensing and reacting to microbes through the inflammasomes. Nat. Immunol. 13: 325-332.
3. Wen, H., J. P. Ting, and L. A. O'Neill. 2012. A role for the NLRP3 inflammasome in metabolic diseases-did Warburg miss inflammation? Nat. Immunol. 13: 352-357.
4. Strowig, T., J. Henao-Mejia, E. Elinav, and R. Flavell. 2012. Inflammasomes in health and disease. Nature 481: 278-286.
5. Aksentijevich, I., C. D Putnam, E. F. Remmers, J. L. Mueller, J. Le, R. D. Kolodner, Z. Moak, M. Chuang, F. Austin, R. Goldbach-Mansky, et al. 2007. The clinical continuum of cryopyrinopathies: novel CIAS1 mutations in North American patients and a new cryopyrin model. Arthritis Rheum. 56: 1273-1285.
6. Bauernfeind, F. G., G. Horvath, A. Stutz, E. S. Alnemri, K. MacDonald, D. Speert, T. Fernandes-Alnemri, J. Wu, B. G. Monks, K. A. Fitzgerald, et al. 2009. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J. Immunol. 183: 787-791.
7. Juliana, C., T. Fernandes-Alnemri, S. Kang, A. Farias, F. Qin, and E. S. Alnemri. 2012. Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation. J. Biol. Chem. 287: 36617-36622.
8. Haneklaus, M., L. A. O'Neill, and R. C. Coll. 2013. Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments. Curr. Opin. Immunol. 25: 40-45.
9. Zhou, R., A. S. Yazdi, P. Menu, and J. Tschopp. 2011. A role for mitochondria in NLRP3 inflammasome activation. Nature 469: 221-225.
10. Zhou, R., A. Tardivel, B. Thorens, I. Choi, and J. Tschopp. 2010. Thioredoxininteracting protein links oxidative stress to inflammasome activation. Nat. Immunol. 11: 136-140.
11. Py, B. F., M. S. Kim, H. Vakifahmetoglu-Norberg, and J. Yuan. 2013. Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity. Mol. Cell 49: 331-338.
12. Lopez-Castejon, G., N. M. Luheshi, V. Compan, S. High, R. C. Whitehead, S. Flitsch, A. Kirov, I. Prudovsky, E. Swanton, and D. Brough. 2013. Deubiquitinases regulate the activity of caspase-1 and interleukin-1b secretion via assembly of the inflammasome. J. Biol. Chem. 288: 2721-2733.
13. Kawai, T., K. Takahashi, S. Sato, C. Coban, H. Kumar, H. Kato, K. J. Ishii, O. Takeuchi, and S. Akira. 2005. IPS-1, an adaptor triggering RIG-I-And Mda5-mediated type I interferon induction. Nat. Immunol. 6: 981-988.
14. Meylan, E., J. Curran, K. Hofmann, D. Moradpour, M. Binder, R. Bartenschlager, and J. Tschopp. 2005. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437: 1167-1172.
15. Seth, R. B., L. Sun, C. K. Ea, and Z. J. Chen. 2005. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell 122: 669-682.
16. Xu, L. G., Y. Y. Wang, K. J. Han, L. Y. Li, Z. Zhai, and H. B. Shu. 2005. VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol. Cell 19: 727-740.
17. Yoneyama, M., and T. Fujita. 2009. RNA recognition and signal transduction by RIG-I-like receptors. Immunol. Rev. 227: 54-65.
18. Hou, F., L. Sun, H. Zheng, B. Skaug, Q. X. Jiang, and Z. J. Chen. 2011. MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response. Cell 146: 448-461.
19. Shimada, K., T. R. Crother, J. Karlin, J. Dagvadorj, N. Chiba, S. Chen, V. K. Ramanujan, A. J. Wolf, L. Vergnes, D. M. Ojcius, et al. 2012. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity 36: 401-414.
20. Nakahira, K., J. A. Haspel, V. A. Rathinam, S. J. Lee, T. Dolinay, H. C. Lam, J. A. Englert, M. Rabinovitch, M. Cernadas, H. P. Kim, et al. 2011. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat. Immunol. 12: 222-230.
21. Fernandes-Alnemri, T., J. W. Yu, C. Juliana, L. Solorzano, S. Kang, J. Wu, P. Datta, M. McCormick, L. Huang, E. McDermott, et al. 2010. The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. Nat. Immunol. 11: 385-393.
22. Fernandes-Alnemri, T., J. Wu, J. W. Yu, P. Datta, B. Miller, W. Jankowski, S. Rosenberg, J. Zhang, and E. S. Alnemri. 2007. The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death Differ. 14: 1590-1604.
23. Fernandes-Alnemri, T., J. W. Yu, P. Datta, J. Wu, and E. S. Alnemri. 2009. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 458: 509-513.
24. Yu, J. W., T. Fernandes-Alnemri, P. Datta, J. Wu, C. Juliana, L. Solorzano, M. McCormick, Z. Zhang, and E. S. Alnemri. 2007. Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants. Mol. Cell 28: 214-227.
25. Juliana, C., T. Fernandes-Alnemri, J. Wu, P. Datta, L. Solorzano, J. W. Yu, R. Meng, A. A. Quong, E. Latz, C. P. Scott, and E. S. Alnemri. 2010. Antiinflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome. J. Biol. Chem. 285: 9792-9802.
26. Hornung, V., F. Bauernfeind, A. Halle, E. O. Samstad, H. Kono, K. L. Rock, K. A. Fitzgerald, and E. Latz. 2008. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat. Immunol. 9: 847-856.
27. Duncan, J. A., D. T. Bergstralh, Y. Wang, S. B. Willingham, Z. Ye, A. G. Zimmermann, and J. P. Ting. 2007. Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling. Proc. Natl. Acad. Sci. USA 104: 8041-8046.
28. Moore, C. B., D. T. Bergstralh, J. A. Duncan, Y. Lei, T. E. Morrison, A. G. Zimmermann, M. A. Accavitti-Loper, V. J. Madden, L. Sun, Z. Ye, et al. 2008. NLRX1 is a regulator of mitochondrial antiviral immunity. Nature 451: 573-577.
29. Guarda, G., M. Braun, F. Staehli, A. Tardivel, C. Mattmann, I. Fö rster, M. Farlik, T. Decker, R. A. Du Pasquier, P. Romero, and J. Tschopp. 2011. Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity 34: 213-223.
30. Subramanian, N., K. Natarajan, M. R. Clatworthy, Z. Wang, and R. N. Germain. 2013. The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation. Cell 153: 348-361.
31. Nakai, K., and P. Horton. 1999. PSORT: a program for detecting sorting signals in proteins and predicting their subcellular localization. Trends Biochem. Sci. 24: 34-36.