A novel immunomodulatory effect of ugonin U in human neutrophils via stimulation of phospholipase C

Free Radical Biology and Medicine

Volumn 72, Issue , 2014, Pages 222-231

  Chen, Chun Yu ^a,b,c   Liaw, Chih Chuang ^d   Chen, Yi Hsuan ^a   Chang, Wen Yi ^a   Chung, Pei Jen ^a   Hwang, Tsong Long ^a  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^d NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

Flavonoid; Free radicals; Helminthostachys zeylanica; Neutrophils; Phospholipase C; Superoxide; Ugonin U

Indexed keywords

ELASTASE; FLAVONOID; FORMYLPEPTIDE RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL TRISPHOSPHATE; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE C; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; SUPEROXIDE; UGONIN U; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; PLANT EXTRACT;

ARTICLE; CELL STIMULATION; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ENZYME PHOSPHORYLATION; HELMINTHOSTACHYS ZEYLANICA; HOST RESISTANCE; HUMAN; HUMAN CELL; IMMUNOMODULATION; LEUKOCYTE ACTIVATION; MEDICINAL PLANT; PRIORITY JOURNAL; RESPIRATORY BURST; DRUG EFFECTS; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNOLOGY; METABOLISM; NEUTROPHIL; RHIZOME; WESTERN BLOTTING;

ANTI-INFLAMMATORY AGENTS; BLOTTING, WESTERN; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLAVONOIDS; FLOW CYTOMETRY; HUMANS; NEUTROPHIL ACTIVATION; NEUTROPHILS; PLANT EXTRACTS; PLANTS, MEDICINAL; RESPIRATORY BURST; RHIZOME; TYPE C PHOSPHOLIPASES;

EID: 84900848929     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.04.018     Document Type: Article

References (48)

1. L. Fialkow, Y. Wang, and G.P. Downey Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function Free Radic. Biol. Med. 42 2007 153 164 (Pubitemid 46001554)
2. V. Kumar, and A. Sharma Neutrophils: Cinderella of innate immune system Int. Immunopharmacol. 10 2010 1325 1334
3. S.D. Kobayashi, J.M. Voyich, and F.R. DeLeo Regulation of the neutrophil-mediated inflammatory response to infection Microbes Infect. 5 2003 1337 1344 (Pubitemid 37410247)
4. B.H. Segal, M.J. Grimm, A.N. Khan, W. Han, and T.S. Blackwell Regulation of innate immunity by NADPH oxidase Free Radic. Biol. Med. 53 2012 72 80
5. Y.F. Huang, S.Y. Liu, C.L. Yen, P.W. Yang, and C.C. Shieh Thapsigargin and flavin adenine dinucleotide ex vivo treatment rescues trafficking-defective gp91phox in chronic granulomatous disease leukocytes Free Radic. Biol. Med. 47 2009 932 940
6. A.C. Battersby, C.M. Cale, D. Goldblatt, and A.R. Gennery Clinical manifestations of disease in X-linked carriers of chronic granulomatous disease J. Clin. Immunol. 29 2013 29
7. D. Roos, and M. de Boer Molecular diagnosis of chronic granulomatous disease Clin. Exp. Immunol. 10 2013 12202
8. G.H. Bae, H.Y. Lee, Y.S. Jung, J.W. Shim, S.D. Kim, S.H. Baek, J.Y. Kwon, J.S. Park, and Y.S. Bae Identification of novel peptides that stimulate human neutrophils Exp. Mol. Med. 44 2012 130 137
9. R.D. Ye, F. Boulay, J.M. Wang, C. Dahlgren, C. Gerard, M. Parmentier, C.N. Serhan, and P.M. Murphy International union of basic and clinical pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family Pharmacol. Rev. 61 2009 119 161
10. Y. Kobayashi The role of chemokines in neutrophil biology Front. Biosci. 13 2008 2400 2407 (Pubitemid 351599693)
11. K. Futosi, S. Fodor, and A. Mocsai Neutrophil cell surface receptors and their intracellular signal transduction pathways Int. Immunopharmacol. 17 2013 638 650
12. Y.S. Bae, T.G. Lee, J.C. Park, J.H. Hur, Y. Kim, K. Heo, J.Y. Kwak, P.G. Suh, and S.H. Ryu Identification of a compound that directly stimulates phospholipase C activity Mol. Pharmacol. 63 2003 1043 1050 (Pubitemid 36529922)
13. O. Myhre, E. Mariussen, T. Reistad, O.A. Voie, H. Aarnes, and F. Fonnum Effects of polychlorinated biphenyls on the neutrophil NADPH oxidase system Toxicol. Lett. 187 2009 144 148
14. J.M. Strizki, S. Xu, N.E. Wagner, L. Wojcik, J. Liu, Y. Hou, M. Endres, A. Palani, S. Shapiro, J.W. Clader, W.J. Greenlee, J.R. Tagat, S. McCombie, K. Cox, A.B. Fawzi, C.C. Chou, C. Pugliese-Sivo, L. Davies, M.E. Moreno, D.D. Ho, A. Trkola, C.A. Stoddart, J.P. Moore, G.R. Reyes, and B.M. Baroudy SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo Proc. Natl. Acad. Sci. USA 98 2001 12718 12723 (Pubitemid 33020012)
15. G.R. Rosania, J. Merlie Jr, N. Gray, Y.T. Chang, P.G. Schultz, and R. Heald A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts Proc. Natl. Acad. Sci. USA 96 1999 4797 4802 (Pubitemid 29214491)
16. C.H. Lee, Y.L. Huang, J.F. Liao, and W.F. Chiou Ugonin K promotes osteoblastic differentiation and mineralization by activation of p38 MAPK- and ERK-mediated expression of Runx2 and osterix Eur. J. Pharmacol. 668 2011 383 389
17. C.H. Lee, Y.L. Huang, J.F. Liao, and W.F. Chiou Ugonin K-stimulated osteogenesis involves estrogen receptor-dependent activation of non-classical Src signaling pathway and classical pathway Eur. J. Pharmacol. 676 2012 26 33
18. Y.C. Huang, T.L. Hwang, Y.L. Yang, S.H. Wu, M.H. Hsu, J.P. Wang, S.C. Chen, L.J. Huang, and C.C. Liaw Acetogenin and prenylated flavonoids from Helminthostachys zeylanica with inhibitory activity on superoxide generation and elastase release by neutrophils Planta Med. 76 2010 447 453
19. Y.C. Huang, T.L. Hwang, C.S. Chang, Y.L. Yang, C.N. Shen, W.Y. Liao, S.C. Chen, and C.C. Liaw Anti-inflammatory flavonoids from the rhizomes of Helminthostachys zeylanica J. Nat. Prod. 72 2009 1273 1278
20. Y.L. Huang, P.Y. Yeh, C.C. Shen, and C.C. Chen Antioxidant flavonoids from the rhizomes of Helminthostachys zeylanica Phytochemistry 64 2003 1277 1283
21. S.R. Suja, P.G. Latha, P. Pushpangadan, and S. Rajasekharan Evaluation of hepatoprotective effects of Helminthostachys zeylanica (L.) Hook against carbon tetrachloride-induced liver damage in Wistar rats J. Ethnopharmacol. 92 2004 61 66 (Pubitemid 38510264)
22. K. Yamauchi, T. Mitsunaga, and I. Batubara Novel quercetin glucosides from Helminthostachys zeylanica root and acceleratory activity of melanin biosynthesis J. Nat. Med. 67 2013 369 374
23. A. Pandey, and K.S. Bhargavan Antiviral activity of crude extracts of some pteridophytes Indian J. Forestry 3 1980 132 133
24. C.C. Chen, Y.L. Huang, P.Y. Yeh, and J.C. Ou Cyclized geranyl stilbenes from the rhizomes of Helminthostachys zeylanica Planta Med. 69 2003 964 967
25. T.L. Hwang, G.L. Li, Y.H. Lan, Y.C. Chia, P.W. Hsieh, Y.H. Wu, and Y.C. Wu Potent inhibition of superoxide anion production in activated human neutrophils by isopedicin, a bioactive component of the Chinese medicinal herb Fissistigma oldhamii Free Radic. Biol. Med. 46 2009 520 528
26. S.C. Yang, P.J. Chung, C.M. Ho, C.Y. Kuo, M.F. Hung, Y.T. Huang, W.Y. Chang, Y.W. Chang, K.H. Chan, and T.L. Hwang Propofol inhibits superoxide production, elastase release, and chemotaxis in formyl peptide-activated human neutrophils by blocking formyl peptide receptor 1 J. Immunol. 190 2013 6511 6519
27. T.-L. Hwang, H.-W. Hung, S.-H. Kao, C.-M. Teng, C.-C. Wu, and S.J.-S. Cheng Soluble guanylyl cyclase activator YC-1 inhibits human neutrophil functions through a cGMP-independent but cAMP-dependent pathway Mol. Pharmacol. 64 2003 1419 1427 (Pubitemid 37532232)
28. T.L. Hwang, Y.L. Leu, S.H. Kao, M.C. Tang, and H.L. Chang Viscolin, a new chalcone from Viscum coloratum, inhibits human neutrophil superoxide anion and elastase release via a cAMP-dependent pathway Free Radic. Biol. Med. 41 2006 1433 1441
29. H.-P. Yu, P.-W. Hsieh, Y.-J. Chang, P.-J. Chung, L.-M. Kuo, and T.-L. Hwang 2-(2-Fluorobenzamido)benzoate ethyl ester (EFB-1) inhibits superoxide production by human neutrophils and attenuates hemorrhagic shock-induced organ dysfunction in rats Free Radic. Biol. Med. 50 2011 1737 1748
30. A. Seyoum, K. Asres, and F.K. El-Fiky Structure-radical scavenging activity relationships of flavonoids Phytochemistry 67 2006 2058 2070 (Pubitemid 44301284)
31. L. Harvath, R.R. Aksamit, and R.E. Cunningham Assay for chemoattractant binding Methods Mol. Biol. 115 1999 299 308
32. E. Trinquet, R. Bouhelal, and M. Dietz Monitoring Gq-coupled receptor response through inositol phosphate quantification with the IP-One assay Expert Opin. Drug Discovery 6 2011 981 994
33. Y.C. Wu, M. Sureshbabu, Y.C. Fang, Y.H. Wu, Y.H. Lan, F.R. Chang, Y.W. Chang, and T.L. Hwang Potent inhibition of human neutrophil activations by bractelactone, a novel chalcone from Fissistigma bracteolatum Toxicol. Appl. Pharmacol. 266 2013 399 407
34. E. Middleton Jr, C. Kandaswami, and T.C. Theoharides The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer Pharmacol. Rev. 52 2000 673 751
35. B.M. Babior, J.D. Lambeth, and W. Nauseef The neutrophil NADPH oxidase Arch. Biochem. Biophys. 397 2002 342 344 (Pubitemid 34852301)
36. P.M. Dang, A. Fontayne, J. Hakim, J. El Benna, and A. Perianin Protein kinase C zeta phosphorylates a subset of selective sites of the NADPH oxidase component p47phox and participates in formyl peptide-mediated neutrophil respiratory burst J. Immunol. 166 2001 1206 1213 (Pubitemid 32060281)
37. Q. Chen, D.W. Powell, M.J. Rane, S. Singh, W. Butt, J.B. Klein, and K.R. McLeish Akt phosphorylates p47phox and mediates respiratory burst activity in human neutrophils J. Immunol. 170 2003 5302 5308 (Pubitemid 36554765)
38. C. Dewas, P.M. Dang, M.A. Gougerot-Pocidalo, and J. El-Benna TNF-alpha induces phosphorylation of p47(phox) in human neutrophils: partial phosphorylation of p47phox is a common event of priming of human neutrophils by TNF-alpha and granulocyte-macrophage colony-stimulating factor J. Immunol. 171 2003 4392 4398 (Pubitemid 37238718)
39. K. Waki, O. Inanami, T. Yamamori, and M. Kuwabara Extracellular signal-regulated kinase 1/2 is involved in the activation of NADPH oxidase induced by FMLP receptor but not by complement receptor 3 in rat neutrophils Free Radic. Res. 37 2003 665 671 (Pubitemid 36603676)
40. K. Waki, O. Inanami, T. Yamamori, H. Nagahata, and M. Kuwabara Involvement of protein kinase Cdelta in the activation of NADPH oxidase and the phagocytosis of neutrophils Free Radic. Res. 40 2006 359 367 (Pubitemid 43336040)
41. S. Patel, J. Vemula, S. Konikkat, M.K. Barthwal, and M. Dikshit Ion channel modulators mediated alterations in NO-induced free radical generation and neutrophil membrane potential Free Radic. Res. 43 2009 514 521
42. J. El Benna, J. Han, J.W. Park, E. Schmid, R.J. Ulevitch, and B.M. Babior Activation of p38 in stimulated human neutrophils: phosphorylation of the oxidase component p47phox by p38 and ERK but not by JNK Arch. Biochem. Biophys. 334 1996 395 400 (Pubitemid 26347324)
43. S. Brechard, and E.J. Tschirhart Regulation of superoxide production in neutrophils: role of calcium influx J. Leukocyte Biol. 84 2008 1223 1237
44. M.J. Berridge, P. Lipp, and M.D. Bootman The versatility and universality of calcium signalling Nat. Rev. Mol. Cell Biol. 1 2000 11 21
45. 2+ entry channels J. Cell. Biochem. 99 2006 1503 1516 (Pubitemid 44845711)
46. M.X. Zhu, J. Ma, J. Parrington, P.J. Calcraft, A. Galione, and A.M. Evans Calcium signaling via two-pore channels: local or global, that is the question Am. J. Physiol. Cell Physiol. 298 2010 C430 C441
47. S.G. Rhee Regulation of phosphoinositide-specific phospholipase C Annu. Rev. Biochem. 70 2001 281 312 (Pubitemid 32662212)
48. F.R. Sheppard, M.R. Kelher, E.E. Moore, N.J. McLaughlin, A. Banerjee, and C.C. Silliman Structural organization of the neutrophil NADPH oxidase: phosphorylation and translocation during priming and activation J. Leukocyte Biol. 78 2005 1025 1042 (Pubitemid 41572466)