The Ketone Metabolite β-Hydroxybutyrate Attenuates Oxidative Stress in Spinal Cord Injury by Suppression of Class i Histone Deacetylases

Journal of Neurotrauma

Volumn 34, Issue 18, 2017, Pages 2645-2655

  Kong, Ganggang ^a   Huang, Zucheng ^a   Ji, Wei ^a   Wang, Xiaomeng ^b   Liu, Junhao ^a   Wu, Xiuhua ^a   Huang, Zhiping ^a   Li, Rong ^a   Zhu, Qingan ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b Department of Neurosurgery Longyan First Hospital   (China)

Author keywords

class I HDACs; FOXO3a; ketogenic diet; NADPH oxidase; SCI; OHB

Indexed keywords

3 HYDROXYBUTYRIC ACID; CATALASE; HISTONE DEACETYLASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE 8; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SMALL INTERFERING RNA; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR FKHRL1; HISTONE DEACETYLASE INHIBITOR; HYDROGEN PEROXIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; KETOGENIC DIET; MALE; NONHUMAN; OXIDATIVE STRESS; PC12 CELL LINE; PROTEIN CARBONYLATION; PROTEIN EXPRESSION; RAT; SPINAL CORD INJURY; UPREGULATION; ANIMAL; CERVICAL VERTEBRA; DRUG EFFECT; METABOLISM; SPRAGUE DAWLEY RAT;

3-HYDROXYBUTYRIC ACID; ANIMALS; CERVICAL VERTEBRAE; DIET, KETOGENIC; DOWN-REGULATION; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HYDROGEN PEROXIDE; MALE; NADPH OXIDASES; OXIDATIVE STRESS; PC12 CELLS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SPINAL CORD INJURIES; UP-REGULATION;

EID: 85029226840     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2017.5192     Document Type: Article

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