Metformin inhibits the production of reactive oxygen species from NADH: Ubiquinone oxidoreductase to limit induction of interleukin-1β (IL-1β) and boosts interleukin-10 (IL-10) in lipopolysaccharide (LPS)-activated macrophages

Journal of Biological Chemistry

Volumn 290, Issue 33, 2015, Pages 20348-20359

  Kelly, Beth ^a   Tannahill, Gillian M ^a   Murphy, Michael P ^b   O'Neill, Luke A J ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOLOGY;

ACTIVATED MACROPHAGES; ANTI-DIABETIC DRUGS; ANTI-INFLAMMATORY ACTION; ANTI-INFLAMMATORY ACTIVITY; INFLAMMATORY SIGNALING; LIPOPOLYSACCHARIDES; MITOCHONDRIAL NADH; REACTIVE OXYGEN SPECIES;

DRUG PRODUCTS;

6,7 DIHYDRO 4 HYDROXY 3 (2' HYDROXY 1,1' BIPHENYL 4 YL) 6 OXOTHIENO[2,3 B]PYRIDINE 5 CARBONITRILE; ANTIOXIDANT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INTERLEUKIN 10; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; METFORMIN; MITOQ; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROTENONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ADENYLATE KINASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; C57BL MOUSE; DRUG EFFECTS; GENETICS; MACROPHAGE; METABOLISM;

ADENYLATE KINASE; ANIMALS; ELECTRON TRANSPORT COMPLEX I; INTERLEUKIN-10; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; METFORMIN; MICE; MICE, INBRED C57BL; REACTIVE OXYGEN SPECIES; ROTENONE;

EID: 84939625498     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.662114     Document Type: Article

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