-
1
-
-
84873968168
-
Delineation of the clinical, molecular and cellular aspects of novel JAM3 mutations underlying the autosomal recessive hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts
-
Akawi, N.A., F.E. Canpolat, S.M. White, J. Quilis-Esquerra, M. Morales Sanchez, M.J. Gamundi, G.H. Mochida, C.A. Walsh, B.R. Ali, and L. Al-Gazali. 2013. Delineation of the clinical, molecular and cellular aspects of novel JAM3 mutations underlying the autosomal recessive hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Hum. Mutat. 34:498-505. https ://doi.org /10.1002 /humu.22263
-
(2013)
Hum. Mutat
, vol.34
, pp. 498-505
-
-
Akawi, N.A.1
Canpolat, F.E.2
White, S.M.3
Quilis-Esquerra, J.4
Morales Sanchez, M.5
Gamundi, M.J.6
Mochida, G.H.7
Walsh, C.A.8
Ali, B.R.9
Al-Gazali, L.10
-
2
-
-
84920686030
-
Human apolipoprotein E ε4 expression impairs cerebral vascularization and blood-brain barrier function in mice
-
Alata, W., Y. Ye, I. St-Amour, M. Vandal, and F. Calon. 2015. Human apolipoprotein E ε4 expression impairs cerebral vascularization and blood-brain barrier function in mice. J. Cereb. Blood Flow Metab. 35:86-94. https ://doi.org /10.1038 /jcbfm.2014.172
-
(2015)
J. Cereb. Blood Flow Metab
, vol.35
, pp. 86-94
-
-
Alata, W.1
Ye, Y.2
St-Amour, I.3
Vandal, M.4
Calon, F.5
-
3
-
-
85017463063
-
Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis
-
Andreone, B.J., B.W. Chow, A. Tata, B. Lacoste, A. Ben-Zvi, K. Bullock, A.A. Deik, D.D. Ginty, C.B. Clish, and C. Gu. 2017. Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis. Neuron. 94:581-594. https ://doi.org /10.1016 /j.neuron.2017.03.043
-
(2017)
Neuron
, vol.94
, pp. 581-594
-
-
Andreone, B.J.1
Chow, B.W.2
Tata, A.3
Lacoste, B.4
Ben-Zvi, A.5
Bullock, K.6
Deik, A.A.7
Ginty, D.D.8
Clish, C.B.9
Gu, C.10
-
4
-
-
62249133805
-
Spatial correlations between beta-amyloid (Abeta) deposits and blood vessels in familial Alzheimer's disease
-
Armstrong, R.A. 2008. Spatial correlations between beta-amyloid (Abeta) deposits and blood vessels in familial Alzheimer's disease. Folia Neuropathol. 46:241-248
-
(2008)
Folia Neuropathol
, vol.46
, pp. 241-248
-
-
Armstrong, R.A.1
-
5
-
-
78649467527
-
Pericytes regulate the blood-brain barrier
-
Armulik, A., G. Genové, M. Mäe, M.H. Nisancioglu, E. Wallgard, C. Niaudet, L. He, J. Norlin, P. Lindblom, K. Strittmatter, et al. 2010. Pericytes regulate the blood-brain barrier. Nature. 468:557-561. https ://doi.org /10.1038 /nature09522
-
(2010)
Nature
, vol.468
, pp. 557-561
-
-
Armulik, A.1
Genové, G.2
Mäe, M.3
Nisancioglu, M.H.4
Wallgard, E.5
Niaudet, C.6
He, L.7
Norlin, J.8
Lindblom, P.9
Strittmatter, K.10
-
6
-
-
84992206113
-
Relation of cerebral vessel disease to Alzheimer's disease dementia and cognitive function in elderly people: a cross-sectional study
-
Arvanitakis, Z., A.W. Capuano, S.E. Leurgans, D.A. Bennett, and J.A. Schneider. 2016. Relation of cerebral vessel disease to Alzheimer's disease dementia and cognitive function in elderly people: a cross-sectional study. Lancet Neurol. 15:934-943. https ://doi.org /10.1016 /S1474-4422(16)30029-1
-
(2016)
Lancet Neurol
, vol.15
, pp. 934-943
-
-
Arvanitakis, Z.1
Capuano, A.W.2
Leurgans, S.E.3
Bennett, D.A.4
Schneider, J.A.5
-
7
-
-
85002525199
-
Glymphatic solute transport does not require bulk flow
-
Asgari, M., D. de Zélicourt, and V. Kurtcuoglu. 2016. Glymphatic solute transport does not require bulk flow. Sci. Rep. 6:38635. https ://doi.org /10.1038 /srep38635
-
(2016)
Sci. Rep
, vol.6
, pp. 38635
-
-
Asgari, M.1
de Zélicourt, D.2
Kurtcuoglu, V.3
-
8
-
-
85007287595
-
Cerebrospinal fluid aquaporin-4-immunoglobulin G disrupts blood brain barrier
-
Asgari, N., C.T. Berg, M.T. Mørch, R. Khorooshi, and T. Owens. 2015. Cerebrospinal fluid aquaporin-4-immunoglobulin G disrupts blood brain barrier. Ann. Clin. Transl. Neurol. 2:857-863. https ://doi.org /10.1002 /acn3.221
-
(2015)
Ann. Clin. Transl. Neurol
, vol.2
, pp. 857-863
-
-
Asgari, N.1
Berg, C.T.2
Mørch, M.T.3
Khorooshi, R.4
Owens, T.5
-
9
-
-
84961216596
-
Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases
-
Bakker, E.N.T.P., B.J. Bacskai, M. Arbel-Ornath, R. Aldea, B. Bedussi, A.W.J. Morris, R.O. Weller, and R.O. Carare. 2016. Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases. Cell. Mol. Neurobiol. 36:181-194. https ://doi.org /10.1007 / s10571-015-0273-8
-
(2016)
Cell. Mol. Neurobiol
, vol.36
, pp. 181-194
-
-
Bakker, E.N.T.P.1
Bacskai, B.J.2
Arbel-Ornath, M.3
Aldea, R.4
Bedussi, B.5
Morris, A.W.J.6
Weller, R.O.7
Carare, R.O.8
-
10
-
-
84867581572
-
The vascular factor in Alzheimer's disease: a study in Golgi technique and electron microscopy
-
Baloyannis, S.J., and I.S. Baloyannis. 2012. The vascular factor in Alzheimer's disease: a study in Golgi technique and electron microscopy. J. Neurol. Sci. 322:117-121. https ://doi.org /10.1016 /j.jns.2012.07.010
-
(2012)
J. Neurol. Sci
, vol.322
, pp. 117-121
-
-
Baloyannis, S.J.1
Baloyannis, I.S.2
-
11
-
-
84865529158
-
Clinical and biomarker changes in dominantly inherited Alzheimer's disease
-
Bateman, R.J., C. Xiong, T.L.S. Benzinger, A.M. Fagan, A. Goate, N.C. Fox, D.S. Marcus, N.J. Cairns, X. Xie, T.M. Blazey, et al. Dominantly Inherited Alzheimer Network. 2012. Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N. Engl. J. Med. 367:795-804. https ://doi.org /10.1056 /NEJMoa1202753
-
(2012)
N. Engl. J. Med
, vol.367
, pp. 795-804
-
-
Bateman, R.J.1
Xiong, C.2
Benzinger, T.L.S.3
Fagan, A.M.4
Goate, A.5
Fox, N.C.6
Marcus, D.S.7
Cairns, N.J.8
Xie, X.9
Blazey, T.M.10
-
12
-
-
78751501329
-
Noninvasive magnetic resonance imaging detection of cerebral amyloid angiopathy-related microvascular alterations using superparamagnetic iron oxide particles in APP transgenic mouse models of Alzheimer's disease: application to passive Abeta immunotherapy
-
Beckmann, N., C. Gérard, D. Abramowski, C. Cannet, and M. Staufenbiel. 2011. Noninvasive magnetic resonance imaging detection of cerebral amyloid angiopathy-related microvascular alterations using superparamagnetic iron oxide particles in APP transgenic mouse models of Alzheimer's disease: application to passive Abeta immunotherapy. J. Neurosci. 31:1023-1031. https ://doi.org /10.1523 /JNE URO SCI.4936-10.2011
-
(2011)
J. Neurosci
, vol.31
, pp. 1023-1031
-
-
Beckmann, N.1
Gérard, C.2
Abramowski, D.3
Cannet, C.4
Staufenbiel, M.5
-
13
-
-
59649110562
-
SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells
-
Bell, R.D., R. Deane, N. Chow, X. Long, A. Sagare, I. Singh, J.W. Streb, H. Guo, A. Rubio, W. Van Nostrand, et al. 2009. SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells. Nat. Cell Biol. 11:143-153. https ://doi.org /10.1038 /ncb1819
-
(2009)
Nat. Cell Biol
, vol.11
, pp. 143-153
-
-
Bell, R.D.1
Deane, R.2
Chow, N.3
Long, X.4
Sagare, A.5
Singh, I.6
Streb, J.W.7
Guo, H.8
Rubio, A.9
Van Nostrand, W.10
-
14
-
-
78049279739
-
Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging
-
Bell, R.D., E.A. Winkler, A.P. Sagare, I. Singh, B. LaRue, R. Deane, and B.V. Zlokovic. 2010. Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron. 68:409-427. https ://doi.org /10.1016 /j.neuron.2010.09.043
-
(2010)
Neuron
, vol.68
, pp. 409-427
-
-
Bell, R.D.1
Winkler, E.A.2
Sagare, A.P.3
Singh, I.4
LaRue, B.5
Deane, R.6
Zlokovic, B.V.7
-
15
-
-
84861418194
-
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A
-
Bell, R.D., E.A. Winkler, I. Singh, A.P. Sagare, R. Deane, Z. Wu, D.M. Holtzman, C. Betsholtz, A. Armulik, J. Sallstrom, et al. 2012. Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature. 485:512-516
-
(2012)
Nature
, vol.485
, pp. 512-516
-
-
Bell, R.D.1
Winkler, E.A.2
Singh, I.3
Sagare, A.P.4
Deane, R.5
Wu, Z.6
Holtzman, D.M.7
Betsholtz, C.8
Armulik, A.9
Sallstrom, J.10
-
16
-
-
84888089112
-
Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease
-
Benzinger, T.L.S., T. Blazey, C.R. Jack Jr., R.A. Koeppe, Y. Su, C. Xiong, M.E. Raichle, A.Z. Snyder, B.M. Ances, R.J. Bateman, et al. 2013. Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 110:E4502-E4509. https ://doi.org /10.1073 /pnas.1317918110
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. E4502-E4509
-
-
Benzinger, T.L.S.1
Blazey, T.2
Jack, C.R.3
Koeppe, R.A.4
Su, Y.5
Xiong, C.6
Raichle, M.E.7
Snyder, A.Z.8
Ances, B.M.9
Bateman, R.J.10
-
17
-
-
84901269974
-
Mfsd2a is critical for the formation and function of the blood-brain barrier
-
Ben-Zvi, A., B. Lacoste, E. Kur, B.J. Andreone, Y. Mayshar, H. Yan, and C. Gu. 2014. Mfsd2a is critical for the formation and function of the blood-brain barrier. Nature. 509:507-511. https ://doi.org /10.1038 /nature13324
-
(2014)
Nature
, vol.509
, pp. 507-511
-
-
Ben-Zvi, A.1
Lacoste, B.2
Kur, E.3
Andreone, B.J.4
Mayshar, Y.5
Yan, H.6
Gu, C.7
-
18
-
-
84901267568
-
Physiology: Double function at the blood-brain barrier
-
Betsholtz, C. 2014. Physiology: Double function at the blood-brain barrier. Nature. 509:432-433. https ://doi.org /10.1038 /nature13339
-
(2014)
Nature
, vol.509
, pp. 432-433
-
-
Betsholtz, C.1
-
19
-
-
84944881561
-
Lack of Widespread BBB Disruption in Alzheimer's Disease Models: Focus on Therapeutic Antibodies
-
Bien-Ly, N., C.A. Boswell, S. Jeet, T.G. Beach, K. Hoyte, W. Luk, V. Shihadeh, S. Ulufatu, O. Foreman, Y. Lu, et al. 2015. Lack of Widespread BBB Disruption in Alzheimer's Disease Models: Focus on Therapeutic Antibodies. Neuron. 88:289-297. https ://doi.org /10.1016 /j.neuron.2015.09.036
-
(2015)
Neuron
, vol.88
, pp. 289-297
-
-
Bien-Ly, N.1
Boswell, C.A.2
Jeet, S.3
Beach, T.G.4
Hoyte, K.5
Luk, W.6
Shihadeh, V.7
Ulufatu, S.8
Foreman, O.9
Lu, Y.10
-
20
-
-
80052330506
-
Amyloid triggers extensive cerebral angiogenesis causing blood brain barrier permeability and hypervascularity in Alzheimer's disease
-
Biron, K.E., D.L. Dickstein, R. Gopaul, and W.A. Jefferies. 2011. Amyloid triggers extensive cerebral angiogenesis causing blood brain barrier permeability and hypervascularity in Alzheimer's disease. PLoS One. 6:e23789. https ://doi.org /10.1371 /journal.pone.0023789
-
(2011)
PLoS One
, vol.6
-
-
Biron, K.E.1
Dickstein, D.L.2
Gopaul, R.3
Jefferies, W.A.4
-
21
-
-
84944903063
-
Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy
-
Blair, L.J., H.D. Frauen, B. Zhang, B.A. Nordhues, S. Bijan, Y.-C. Lin, F. Zamudio, L.D. Hernandez, J.J. Sabbagh, M.-L.B. Selenica, and C.A. Dickey. 2015. Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy. Acta Neuropathol. Commun. 3:8. https ://doi.org /10.1186 /s40478-015-0186-2
-
(2015)
Acta Neuropathol. Commun
, vol.3
, pp. 8
-
-
Blair, L.J.1
Frauen, H.D.2
Zhang, B.3
Nordhues, B.A.4
Bijan, S.5
Lin, Y.-C.6
Zamudio, F.7
Hernandez, L.D.8
Sabbagh, J.J.9
Selenica, M.-L.B.10
Dickey, C.A.11
-
22
-
-
33645454579
-
Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy
-
Boekhoorn, K., D. Terwel, B. Biemans, P. Borghgraef, O. Wiegert, G.J.A. Ramakers, K. de Vos, H. Krugers, T. Tomiyama, H. Mori, et al. 2006. Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy. J. Neurosci. 26:3514-3523. https ://doi.org /10.1523 /JNE URO SCI.5425-05.2006
-
(2006)
J. Neurosci
, vol.26
, pp. 3514-3523
-
-
Boekhoorn, K.1
Terwel, D.2
Biemans, B.3
Borghgraef, P.4
Wiegert, O.5
Ramakers, G.J.A.6
de Vos, K.7
Krugers, H.8
Tomiyama, T.9
Mori, H.10
-
23
-
-
0000517316
-
Drainage of cerebral interstitial fluid into deep cervical lymph of the rabbit
-
Bradbury, M.W., H.F. Cserr, and R.J. Westrop. 1981. Drainage of cerebral interstitial fluid into deep cervical lymph of the rabbit. Am. J. Physiol. 240:F329-F336
-
(1981)
Am. J. Physiol
, vol.240
, pp. F329-F336
-
-
Bradbury, M.W.1
Cserr, H.F.2
Westrop, R.J.3
-
24
-
-
84865609374
-
High prevalence of cerebral microbleeds at 7Tesla MRI in patients with early Alzheimer's disease
-
Brundel, M., S.M. Heringa, J. de Bresser, H.L. Koek, J.J.M. Zwanenburg, L. Jaap Kappelle, P.R. Luijten, and G.J. Biessels. 2012. High prevalence of cerebral microbleeds at 7Tesla MRI in patients with early Alzheimer's disease. J. Alzheimers Dis. 31:259-263
-
(2012)
J. Alzheimers Dis
, vol.31
, pp. 259-263
-
-
Brundel, M.1
Heringa, S.M.2
de Bresser, J.3
Koek, H.L.4
Zwanenburg, J.J.M.5
Jaap Kappelle, L.6
Luijten, P.R.7
Biessels, G.J.8
-
25
-
-
85009754974
-
The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer's disease of humans and mice
-
Cacciottolo, M., A. Christensen, A. Moser, J. Liu, C.J. Pike, C. Smith, M.J. LaDu, P.M. Sullivan, T.E. Morgan, E. Dolzhenko, et al. Alzheimer's Disease Neuroimaging Initiative. 2016. The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer's disease of humans and mice. Neurobiol. Aging. 37:47-57. https ://doi.org /10.1016 /j.neurobiolaging.2015.10.010
-
(2016)
Neurobiol. Aging
, vol.37
, pp. 47-57
-
-
Cacciottolo, M.1
Christensen, A.2
Moser, A.3
Liu, J.4
Pike, C.J.5
Smith, C.6
LaDu, M.J.7
Sullivan, P.M.8
Morgan, T.E.9
Dolzhenko, E.10
-
26
-
-
79959772357
-
Human apoE isoforms differentially regulate brain amyloid-β peptide clearance
-
Castellano, J.M., J. Kim, F.R. Stewart, H. Jiang, R.B. DeMattos, B.W. Patterson, A.M. Fagan, J.C. Morris, K.G. Mawuenyega, C. Cruchaga, et al. 2011. Human apoE isoforms differentially regulate brain amyloid-β peptide clearance. Sci. Transl. Med. 3:89ra57. https ://doi.org /10.1126 / scitranslmed.3002156
-
(2011)
Sci. Transl. Med
, vol.3
-
-
Castellano, J.M.1
Kim, J.2
Stewart, F.R.3
Jiang, H.4
DeMattos, R.B.5
Patterson, B.W.6
Fagan, A.M.7
Morris, J.C.8
Mawuenyega, K.G.9
Cruchaga, C.10
-
27
-
-
84956741655
-
The brain as immunoprecipitator of serum autoantibodies against N-Methyl-Daspartate receptor subunit NR1
-
Castillo-Gomez, E., A. Kästner, J. Steiner, A. Schneider, B. Hettling, G. Poggi, K. Ostehr, M. Uhr, A.R. Asif, M. Matzke, et al. 2016. The brain as immunoprecipitator of serum autoantibodies against N-Methyl-Daspartate receptor subunit NR1. Ann. Neurol. 79:144-151. https ://doi.org /10.1002 /ana.24545
-
(2016)
Ann. Neurol
, vol.79
, pp. 144-151
-
-
Castillo-Gomez, E.1
Kästner, A.2
Steiner, J.3
Schneider, A.4
Hettling, B.5
Poggi, G.6
Ostehr, K.7
Uhr, M.8
Asif, A.R.9
Matzke, M.10
-
28
-
-
67649389481
-
-
Chabriat, H., A. Joutel, M. Dichgans, E. Tournier-Lasserve, and M.-G. Bousser. 2009. Cadasil. Lancet Neurol. 8:643-653. https ://doi.org /10.1016 /S1474-4422(09)70127-9
-
(2009)
Cadasil Lancet Neurol
, vol.8
, pp. 643-653
-
-
Chabriat, H.1
Joutel, A.2
Dichgans, M.3
Tournier-Lasserve, E.4
Bousser, M.-G.5
-
29
-
-
0034700480
-
A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease
-
Chen, G., K.S. Chen, J. Knox, J. Inglis, A. Bernard, S.J. Martin, A. Justice, L. McConlogue, D. Games, S.B. Freedman, and R.G. Morris. 2000. A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease. Nature. 408:975-979. https ://doi.org /10.1038 /35046031
-
(2000)
Nature
, vol.408
, pp. 975-979
-
-
Chen, G.1
Chen, K.S.2
Knox, J.3
Inglis, J.4
Bernard, A.5
Martin, S.J.6
Justice, A.7
McConlogue, L.8
Games, D.9
Freedman, S.B.10
Morris, R.G.11
-
30
-
-
85018927792
-
Depletion of coagulation factor XII ameliorates brain pathology and cognitive impairment in Alzheimer disease mice
-
Chen, Z.-L., A.S. Revenko, P. Singh, A.R. MacLeod, E.H. Norris, and S. Strickland. 2017. Depletion of coagulation factor XII ameliorates brain pathology and cognitive impairment in Alzheimer disease mice. Blood. 129:2547-2556. https ://doi.org /10.1182 /blood-2016-11-753202
-
(2017)
Blood
, vol.129
, pp. 2547-2556
-
-
Chen, Z.-L.1
Revenko, A.S.2
Singh, P.3
MacLeod, A.R.4
Norris, E.H.5
Strickland, S.6
-
31
-
-
27644489474
-
P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model
-
Cirrito, J.R., R. Deane, A.M. Fagan, M.L. Spinner, M. Parsadanian, M.B. Finn, H. Jiang, J.L. Prior, A. Sagare, K.R. Bales, et al. 2005. P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. J. Clin. Invest. 115:3285-3290. https ://doi.org /10.1172 /JCI25247
-
(2005)
J. Clin. Invest
, vol.115
, pp. 3285-3290
-
-
Cirrito, J.R.1
Deane, R.2
Fagan, A.M.3
Spinner, M.L.4
Parsadanian, M.5
Finn, M.B.6
Jiang, H.7
Prior, J.L.8
Sagare, A.9
Bales, K.R.10
-
32
-
-
85023776723
-
Pericytes Extend Survival of ALS SOD1 Mice and Induce the Expression of Antioxidant Enzymes in the Murine Model and in IPSCs Derived Neuronal Cells from an ALS Patient
-
Coatti, G.C., M. Frangini, M.C. Valadares, J.P. Gomes, N.O. Lima, N. Cavaçana, A.F. Assoni, M.V. Pelatti, A. Birbrair, A.C.P. de Lima, et al. 2017. Pericytes Extend Survival of ALS SOD1 Mice and Induce the Expression of Antioxidant Enzymes in the Murine Model and in IPSCs Derived Neuronal Cells from an ALS Patient. Stem Cell Rev. 13:686-698. https ://doi.org /10.1007 /s12015-017-9752-2
-
(2017)
Stem Cell Rev
, vol.13
, pp. 686-698
-
-
Coatti, G.C.1
Frangini, M.2
Valadares, M.C.3
Gomes, J.P.4
Lima, N.O.5
Cavaçana, N.6
Assoni, A.F.7
Pelatti, M.V.8
Birbrair, A.9
de Lima, A.C.P.10
-
33
-
-
84926254510
-
APOE2 enhances neuroprotection against Alzheimer's disease through multiple molecular mechanisms
-
Conejero-Goldberg, C., J.J. Gomar, T. Bobes-Bascaran, T.M. Hyde, J.E. Kleinman, M.M. Herman, S. Chen, P. Davies, and T.E. Goldberg. 2014. APOE2 enhances neuroprotection against Alzheimer's disease through multiple molecular mechanisms. Mol. Psychiatry. 19:1243-1250. https :// doi.org /10.1038 /mp.2013.194
-
(2014)
Mol. Psychiatry
, vol.19
, pp. 1243-1250
-
-
Conejero-Goldberg, C.1
Gomar, J.J.2
Bobes-Bascaran, T.3
Hyde, T.M.4
Kleinman, J.E.5
Herman, M.M.6
Chen, S.7
Davies, P.8
Goldberg, T.E.9
-
34
-
-
78649962844
-
Brain fuel metabolism, aging, and Alzheimer's disease
-
Cunnane, S., S. Nugent, M. Roy, A. Courchesne-Loyer, E. Croteau, S. Tremblay, A. Castellano, F. Pifferi, C. Bocti, N. Paquet, et al. 2011. Brain fuel metabolism, aging, and Alzheimer's disease. Nutrition. 27:3-20. https ://doi.org /10.1016 /j.nut.2010.07.021
-
(2011)
Nutrition
, vol.27
, pp. 3-20
-
-
Cunnane, S.1
Nugent, S.2
Roy, M.3
Courchesne-Loyer, A.4
Croteau, E.5
Tremblay, S.6
Castellano, A.7
Pifferi, F.8
Bocti, C.9
Paquet, N.10
-
35
-
-
78649487239
-
Pericytes are required for blood-brain barrier integrity during embryogenesis
-
Daneman, R., L. Zhou, A.A. Kebede, and B.A. Barres. 2010. Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature. 468:562-566. https ://doi.org /10.1038 /nature09513
-
(2010)
Nature
, vol.468
, pp. 562-566
-
-
Daneman, R.1
Zhou, L.2
Kebede, A.A.3
Barres, B.A.4
-
36
-
-
84870815173
-
Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation
-
Davalos, D., J.K. Ryu, M. Merlini, K.M. Baeten, N. Le Moan, M.A. Petersen, T.J. Deerinck, D.S. Smirnoff, C. Bedard, H. Hakozaki, et al. 2012. Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation. Nat. Commun. 3:1227. https ://doi.org /10.1038 /ncomms2230
-
(2012)
Nat. Commun
, vol.3
, pp. 1227
-
-
Davalos, D.1
Ryu, J.K.2
Merlini, M.3
Baeten, K.M.4
Le Moan, N.5
Petersen, M.A.6
Deerinck, T.J.7
Smirnoff, D.S.8
Bedard, C.9
Hakozaki, H.10
-
37
-
-
2442594971
-
Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor
-
Davis, J., F. Xu, R. Deane, G. Romanov, M.L. Previti, K. Zeigler, B.V. Zlokovic, and W.E. Van Nostrand. 2004. Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor. J. Biol. Chem. 279:20296-20306. https ://doi.org /10.1074 /jbc.M312946200
-
(2004)
J. Biol. Chem
, vol.279
, pp. 20296-20306
-
-
Davis, J.1
Xu, F.2
Deane, R.3
Romanov, G.4
Previti, M.L.5
Zeigler, K.6
Zlokovic, B.V.7
Van Nostrand, W.E.8
-
38
-
-
0037703255
-
RAGE mediates amyloidbeta peptide transport across the blood-brain barrier and accumulation in brain
-
Deane, R., S. Du Yan, R.K. Submamaryan, B. LaRue, S. Jovanovic, E. Hogg, D. Welch, L. Manness, C. Lin, J. Yu, et al. 2003. RAGE mediates amyloidbeta peptide transport across the blood-brain barrier and accumulation in brain. Nat. Med. 9:907-913. https ://doi.org /10.1038 /nm890
-
(2003)
Nat. Med
, vol.9
, pp. 907-913
-
-
Deane, R.1
Du Yan, S.2
Submamaryan, R.K.3
LaRue, B.4
Jovanovic, S.5
Hogg, E.6
Welch, D.7
Manness, L.8
Lin, C.9
Yu, J.10
-
39
-
-
4043061467
-
LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms
-
Deane, R., Z. Wu, A. Sagare, J. Davis, S. Du Yan, K. Hamm, F. Xu, M. Parisi, B. LaRue, H.W. Hu, et al. 2004. LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron. 43:333-344. https ://doi.org /10.1016 /j.neuron.2004.07.017
-
(2004)
Neuron
, vol.43
, pp. 333-344
-
-
Deane, R.1
Wu, Z.2
Sagare, A.3
Davis, J.4
Du Yan, S.5
Hamm, K.6
Xu, F.7
Parisi, M.8
LaRue, B.9
Hu, H.W.10
-
40
-
-
57449084208
-
apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain
-
Deane, R., A. Sagare, K. Hamm, M. Parisi, S. Lane, M.B. Finn, D.M. Holtzman, and B.V. Zlokovic. 2008. apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J. Clin. Invest. 118:4002-4013. https ://doi.org /10.1172 /JCI36663
-
(2008)
J. Clin. Invest
, vol.118
, pp. 4002-4013
-
-
Deane, R.1
Sagare, A.2
Hamm, K.3
Parisi, M.4
Lane, S.5
Finn, M.B.6
Holtzman, D.M.7
Zlokovic, B.V.8
-
41
-
-
84859723641
-
A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease
-
Deane, R., I. Singh, A.P. Sagare, R.D. Bell, N.T. Ross, B. LaRue, R. Love, S. Perry, N. Paquette, R.J. Deane, et al. 2012. A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. J. Clin. Invest. 122:1377-1392. https ://doi.org /10.1172 /JCI58642
-
(2012)
J. Clin. Invest
, vol.122
, pp. 1377-1392
-
-
Deane, R.1
Singh, I.2
Sagare, A.P.3
Bell, R.D.4
Ross, N.T.5
LaRue, B.6
Love, R.7
Perry, S.8
Paquette, N.9
Deane, R.J.10
-
42
-
-
84904100818
-
Activity of P-Glycoprotein, α β-Amyloid Transporter at the Blood-Brain Barrier, Is Compromised in Patients with Mild Alzheimer Disease
-
Deo, A.K., S. Borson, J.M. Link, K. Domino, J.F. Eary, B. Ke, T.L. Richards, D.A. Mankoff, S. Minoshima, F. O'Sullivan, et al. 2014. Activity of P-Glycoprotein, α β-Amyloid Transporter at the Blood-Brain Barrier, Is Compromised in Patients with Mild Alzheimer Disease. J. Nucl. Med. 55:1106-1111. https ://doi.org /10.2967 /jnumed.113.130161
-
(2014)
J. Nucl. Med
, vol.55
, pp. 1106-1111
-
-
Deo, A.K.1
Borson, S.2
Link, J.M.3
Domino, K.4
Eary, J.F.5
Ke, B.6
Richards, T.L.7
Mankoff, D.A.8
Minoshima, S.9
O'Sullivan, F.10
-
43
-
-
0035788767
-
Variable expression of presenilin 1 is not a major determinant of risk for late-onset Alzheimer's disease
-
Dermaut, B., G. Roks, J. Theuns, R. Rademakers, J.J. Houwing-Duistermaat, S. Serneels, A. Hofman, M.M. Breteler, M. Cruts, C. Van Broeckhoven, and C.M. van Duijn. 2001. Variable expression of presenilin 1 is not a major determinant of risk for late-onset Alzheimer's disease. J. Neurol. 248:935-939. https ://doi.org /10.1007 /s004150170044
-
(2001)
J. Neurol
, vol.248
, pp. 935-939
-
-
Dermaut, B.1
Roks, G.2
Theuns, J.3
Rademakers, R.4
Houwing-Duistermaat, J.J.5
Serneels, S.6
Hofman, A.7
Breteler, M.M.8
Cruts, M.9
Van Broeckhoven, C.10
van Duijn, C.M.11
-
44
-
-
84995952495
-
Exercise Does Not Protect against Peripheral and Central Effects of a High Cholesterol Diet Given Ad libitum in Old ApoE(-/-) Mice
-
Di Cataldo, V., A. Géloën, J.-B. Langlois, F. Chauveau, B. Thézé, V. Hubert, M. Wiart, E.N. Chirico, J. Rieusset, H. Vidal, et al. 2016. Exercise Does Not Protect against Peripheral and Central Effects of a High Cholesterol Diet Given Ad libitum in Old ApoE(-/-) Mice. Front. Physiol. 7:453. https :// doi.org /10.3389 /fphys.2016.00453
-
(2016)
Front. Physiol
, vol.7
, pp. 453
-
-
Di Cataldo, V.1
Géloën, A.2
Langlois, J.-B.3
Chauveau, F.4
Thézé, B.5
Hubert, V.6
Wiart, M.7
Chirico, E.N.8
Rieusset, J.9
Vidal, H.10
-
45
-
-
22244445780
-
Progression of cerebral amyloid angiopathy in transgenic mouse models of Alzheimer disease
-
Domnitz, S.B., E.M. Robbins, A.W. Hoang, M. Garcia-Alloza, B.T. Hyman, G.W. Rebeck, S.M. Greenberg, B.J. Bacskai, and M.P. Frosch. 2005. Progression of cerebral amyloid angiopathy in transgenic mouse models of Alzheimer disease. J. Neuropathol. Exp. Neurol. 64:588-594. https ://doi.org /10.1097 /01.jnen.0000171644.00180.fc
-
(2005)
J. Neuropathol. Exp. Neurol
, vol.64
, pp. 588-594
-
-
Domnitz, S.B.1
Robbins, E.M.2
Hoang, A.W.3
Garcia-Alloza, M.4
Hyman, B.T.5
Rebeck, G.W.6
Greenberg, S.M.7
Bacskai, B.J.8
Frosch, M.P.9
-
46
-
-
16044366039
-
Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1
-
Duff, K., C. Eckman, C. Zehr, X. Yu, C.M. Prada, J. Perez-tur, M. Hutton, L. Buee, Y. Harigaya, D. Yager, et al. 1996. Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature. 383:710-713. https ://doi.org /10.1038 /383710a0
-
(1996)
Nature
, vol.383
, pp. 710-713
-
-
Duff, K.1
Eckman, C.2
Zehr, C.3
Yu, X.4
Prada, C.M.5
Perez-tur, J.6
Hutton, M.7
Buee, L.8
Harigaya, Y.9
Yager, D.10
-
47
-
-
84922175753
-
Analysis of a compartmental model of amyloid beta production, irreversible loss and exchange in humans
-
Elbert, D.L., B.W. Patterson, and R.J. Bateman. 2015. Analysis of a compartmental model of amyloid beta production, irreversible loss and exchange in humans. Math. Biosci. 261:48-61. https ://doi.org /10.1016 /j.mbs.2014.11.004
-
(2015)
Math. Biosci
, vol.261
, pp. 48-61
-
-
Elbert, D.L.1
Patterson, B.W.2
Bateman, R.J.3
-
48
-
-
85009754057
-
The movers and shapers in immune privilege of the CNS
-
Engelhardt, B., P. Vajkoczy, and R.O. Weller. 2017. The movers and shapers in immune privilege of the CNS. Nat. Immunol. 18:123-131. https ://doi.org /10.1038 /ni.3666
-
(2017)
Nat. Immunol
, vol.18
, pp. 123-131
-
-
Engelhardt, B.1
Vajkoczy, P.2
Weller, R.O.3
-
49
-
-
84951569058
-
Hypertension enhances Aβ-induced neurovascular dysfunction, promotes β-secretase activity, and leads to amyloidogenic processing of APP
-
Faraco, G., L. Park, P. Zhou, W. Luo, S.M. Paul, J. Anrather, and C. Iadecola. 2016. Hypertension enhances Aβ-induced neurovascular dysfunction, promotes β-secretase activity, and leads to amyloidogenic processing of APP. J. Cereb. Blood Flow Metab. 36:241-252. https ://doi.org /10.1038 / jcbfm.2015.79
-
(2016)
J. Cereb. Blood Flow Metab
, vol.36
, pp. 241-252
-
-
Faraco, G.1
Park, L.2
Zhou, P.3
Luo, W.4
Paul, S.M.5
Anrather, J.6
Iadecola, C.7
-
50
-
-
0035047718
-
Cerebral microvascular pathology in aging and Alzheimer's disease
-
Farkas, E., and P.G. Luiten. 2001. Cerebral microvascular pathology in aging and Alzheimer's disease. Prog. Neurobiol. 64:575-611. https ://doi.org /10.1016 /S0301-0082(00)00068-X
-
(2001)
Prog. Neurobiol
, vol.64
, pp. 575-611
-
-
Farkas, E.1
Luiten, P.G.2
-
51
-
-
84926361649
-
Associations between biomarkers and age in the presenilin 1. E280A autosomal dominant Alzheimer disease kindred: a cross-sectional study
-
Fleisher, A.S., K. Chen, Y.T. Quiroz, L.J. Jakimovich, M. Gutierrez Gomez, C.M. Langois, J.B.S. Langbaum, A. Roontiva, P. Thiyyagura, W. Lee, et al. 2015. Associations between biomarkers and age in the presenilin 1. E280A autosomal dominant Alzheimer disease kindred: a cross-sectional study. JAMA Neurol. 72:316-324. https ://doi.org /10.1001 /jamaneurol.2014.3314
-
(2015)
JAMA Neurol
, vol.72
, pp. 316-324
-
-
Fleisher, A.S.1
Chen, K.2
Quiroz, Y.T.3
Jakimovich, L.J.4
Gutierrez Gomez, M.5
Langois, C.M.6
Langbaum, J.B.S.7
Roontiva, A.8
Thiyyagura, P.9
Lee, W.10
-
52
-
-
0035022053
-
Impairment of the blood-nerve and blood-brain barriers in apolipoprotein e knockout mice
-
Fullerton, S.M., G.A. Shirman, W.J. Strittmatter, and W.D. Matthew. 2001. Impairment of the blood-nerve and blood-brain barriers in apolipoprotein e knockout mice. Exp. Neurol. 169:13-22. https ://doi.org /10.1006 /exnr.2001.7631
-
(2001)
Exp. Neurol
, vol.169
, pp. 13-22
-
-
Fullerton, S.M.1
Shirman, G.A.2
Strittmatter, W.J.3
Matthew, W.D.4
-
53
-
-
73949119034
-
Age-related vascular pathology in transgenic mice expressing presenilin 1-associated familial Alzheimer's disease mutations
-
Gama Sosa, M.A., R.D. Gasperi, A.B. Rocher, A.C.-J. Wang, W.G.M. Janssen, T. Flores, G.M. Perez, J. Schmeidler, D.L. Dickstein, P.R. Hof, and G.A. Elder. 2010. Age-related vascular pathology in transgenic mice expressing presenilin 1-associated familial Alzheimer's disease mutations. Am. J. Pathol. 176:353-368. https ://doi.org /10.2353 /ajpath.2010.090482
-
(2010)
Am. J. Pathol
, vol.176
, pp. 353-368
-
-
Gama Sosa, M.A.1
Gasperi, R.D.2
Rocher, A.B.3
Wang, A.C.-J.4
Janssen, W.G.M.5
Flores, T.6
Perez, G.M.7
Schmeidler, J.8
Dickstein, D.L.9
Hof, P.R.10
Elder, G.A.11
-
54
-
-
34250658083
-
Ultrastructure of blood-brain barrier and blood-spinal cord barrier in SOD1 mice modeling ALS
-
Garbuzova-Davis, S., E. Haller, S. Saporta, I. Kolomey, S.V. Nicosia, and P.R. Sanberg. 2007a. Ultrastructure of blood-brain barrier and blood-spinal cord barrier in SOD1 mice modeling ALS. Brain Res. 1157:126-137. https ://doi.org /10.1016 /j.brainres.2007.04.044
-
(2007)
Brain Res
, vol.1157
, pp. 126-137
-
-
Garbuzova-Davis, S.1
Haller, E.2
Saporta, S.3
Kolomey, I.4
Nicosia, S.V.5
Sanberg, P.R.6
-
55
-
-
49849094080
-
Evidence of compromised blood-spinal cord barrier in early and late symptomatic SOD1 mice modeling ALS
-
Garbuzova-Davis, S., S. Saporta, E. Haller, I. Kolomey, S.P. Bennett, H. Potter, and P.R. Sanberg. 2007b. Evidence of compromised blood-spinal cord barrier in early and late symptomatic SOD1 mice modeling ALS. PLoS One. 2:e1205. https ://doi.org /10.1371 /journal.pone.0001205
-
(2007)
PLoS One
, vol.2
-
-
Garbuzova-Davis, S.1
Saporta, S.2
Haller, E.3
Kolomey, I.4
Bennett, S.P.5
Potter, H.6
Sanberg, P.R.7
-
56
-
-
84996565805
-
Imaging matrix metalloproteinase activity in multiple sclerosis as a specific marker of leukocyte penetration of the blood-brain barrier
-
Gerwien, H., S. Hermann, X. Zhang, E. Korpos, J. Song, K. Kopka, A. Faust, C. Wenning, C.C. Gross, L. Honold, et al. 2016. Imaging matrix metalloproteinase activity in multiple sclerosis as a specific marker of leukocyte penetration of the blood-brain barrier. Sci. Transl. Med. 8:364ra152. https ://doi.org /10.1126 /scitranslmed.aaf8020
-
(2016)
Sci. Transl. Med
, vol.8
-
-
Gerwien, H.1
Hermann, S.2
Zhang, X.3
Korpos, E.4
Song, J.5
Kopka, K.6
Faust, A.7
Wenning, C.8
Gross, C.C.9
Honold, L.10
-
57
-
-
84955186682
-
Pericytes are involved in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
-
Ghosh, M., M. Balbi, F. Hellal, M. Dichgans, U. Lindauer, and N. Plesnila. 2015. Pericytes are involved in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Ann. Neurol. 78:887-900. https ://doi.org /10.1002 /ana.24512
-
(2015)
Ann. Neurol
, vol.78
, pp. 887-900
-
-
Ghosh, M.1
Balbi, M.2
Hellal, F.3
Dichgans, M.4
Lindauer, U.5
Plesnila, N.6
-
58
-
-
33644649803
-
Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease
-
Girouard, H., and C. Iadecola. 2006. Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease. J. Appl. Physiol. 100:328-335. https ://doi.org /10.1152 /japplphysiol.00966.2005
-
(2006)
J. Appl. Physiol
, vol.100
, pp. 328-335
-
-
Girouard, H.1
Iadecola, C.2
-
59
-
-
84929377699
-
Activated protein C: biased for translation
-
Griffin, J.H., B.V. Zlokovic, and L.O. Mosnier. 2015. Activated protein C: biased for translation. Blood. 125:2898-2907. https ://doi.org /10.1182 / blood-2015-02-355974
-
(2015)
Blood
, vol.125
, pp. 2898-2907
-
-
Griffin, J.H.1
Zlokovic, B.V.2
Mosnier, L.O.3
-
60
-
-
84933040235
-
Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome
-
Guemez-Gamboa, A., L.N. Nguyen, H. Yang, M.S. Zaki, M. Kara, T. Ben-Omran, N. Akizu, R.O. Rosti, B. Rosti, E. Scott, et al. 2015. Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome. Nat. Genet. 47:809-813. https ://doi.org /10.1038 /ng.3311
-
(2015)
Nat. Genet
, vol.47
, pp. 809-813
-
-
Guemez-Gamboa, A.1
Nguyen, L.N.2
Yang, H.3
Zaki, M.S.4
Kara, M.5
Ben-Omran, T.6
Akizu, N.7
Rosti, R.O.8
Rosti, B.9
Scott, E.10
-
61
-
-
84969375554
-
Correction World Stroke Organization. Stroke and potentially preventable dementias proclamation: updated World Stroke Day proclamation
-
Hachinski, V. 2016. Correction. World Stroke Organization. Stroke and potentially preventable dementias proclamation: updated World Stroke Day proclamation. Stroke. 47:e37
-
(2016)
Stroke
, vol.47
-
-
Hachinski, V.1
-
62
-
-
34247325468
-
ApoE deficiency leads to a progressive age-dependent blood-brain barrier leakage
-
Hafezi-Moghadam, A., K.L. Thomas, and D.D. Wagner. 2007. ApoE deficiency leads to a progressive age-dependent blood-brain barrier leakage. Am. J. Physiol. Cell Physiol. 292:C1256-C1262. https ://doi.org /10.1152 / ajpcell.00563.2005
-
(2007)
Am. J. Physiol. Cell Physiol
, vol.292
, pp. C1256-C1262
-
-
Hafezi-Moghadam, A.1
Thomas, K.L.2
Wagner, D.D.3
-
63
-
-
84923264800
-
Apolipoprotein E, carbon dioxide vasoreactivity, and cognition in older adults: effect of hypertension
-
Hajjar, I., F. Sorond, and L.A. Lipsitz. 2015. Apolipoprotein E, carbon dioxide vasoreactivity, and cognition in older adults: effect of hypertension. J. Am. Geriatr. Soc. 63:276-281. https ://doi.org /10.1111 /jgs.13235
-
(2015)
J. Am. Geriatr. Soc
, vol.63
, pp. 276-281
-
-
Hajjar, I.1
Sorond, F.2
Lipsitz, L.A.3
-
64
-
-
84883796045
-
Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein ε4 carriers and blood-brain barrier breakdown
-
Halliday, M.R., N. Pomara, A.P. Sagare, W.J. Mack, B. Frangione, and B.V. Zlokovic. 2013. Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein ε4 carriers and blood-brain barrier breakdown. JAMA Neurol. 70:1198-1200. https ://doi.org /10.1001 /jamaneurol.2013.3841
-
(2013)
JAMA Neurol
, vol.70
, pp. 1198-1200
-
-
Halliday, M.R.1
Pomara, N.2
Sagare, A.P.3
Mack, W.J.4
Frangione, B.5
Zlokovic, B.V.6
-
65
-
-
84951568640
-
Accelerated pericyte degeneration and bloodbrain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease
-
Halliday, M.R., S.V. Rege, Q. Ma, Z. Zhao, C.A. Miller, E.A. Winkler, and B.V. Zlokovic. 2016. Accelerated pericyte degeneration and bloodbrain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease. J. Cereb. Blood Flow Metab. 36:216-227. https ://doi.org /10.1038 /jcbfm.2015.44
-
(2016)
J. Cereb. Blood Flow Metab
, vol.36
, pp. 216-227
-
-
Halliday, M.R.1
Rege, S.V.2
Ma, Q.3
Zhao, Z.4
Miller, C.A.5
Winkler, E.A.6
Zlokovic, B.V.7
-
66
-
-
84920889270
-
Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity
-
Hammer, C., B. Stepniak, A. Schneider, S. Papiol, M. Tantra, M. Begemann, A.-L. Sirén, L.A. Pardo, S. Sperling, S. Mohd Jofrry, et al. 2014. Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity. Mol. Psychiatry. 19:1143-1149. https ://doi.org /10.1038 /mp.2013.110
-
(2014)
Mol. Psychiatry
, vol.19
, pp. 1143-1149
-
-
Hammer, C.1
Stepniak, B.2
Schneider, A.3
Papiol, S.4
Tantra, M.5
Begemann, M.6
Sirén, A.-L.7
Pardo, L.A.8
Sperling, S.9
Mohd Jofrry, S.10
-
67
-
-
70349558522
-
Genome-wide association study identifies variants at CLU and PIC ALM associated with Alzheimer's disease
-
Harold, D., R. Abraham, P. Hollingworth, R. Sims, A. Gerrish, M.L. Hamshere, J.S. Pahwa, V. Moskvina, K. Dowzell, A. Williams, et al. 2009. Genome-wide association study identifies variants at CLU and PIC ALM associated with Alzheimer's disease. Nat. Genet. 41:1088-1093. https ://doi.org /10.1038 /ng.440
-
(2009)
Nat. Genet
, vol.41
, pp. 1088-1093
-
-
Harold, D.1
Abraham, R.2
Hollingworth, P.3
Sims, R.4
Gerrish, A.5
Hamshere, M.L.6
Pahwa, J.S.7
Moskvina, V.8
Dowzell, K.9
Williams, A.10
-
68
-
-
84991383345
-
Analysis of the brain mural cell transcriptome
-
He, L., M. Vanlandewijck, E. Raschperger, M. Andaloussi Mäe, B. Jung, T. Lebouvier, K. Ando, J. Hofmann, A. Keller, and C. Betsholtz. 2016. Analysis of the brain mural cell transcriptome. Sci. Rep. 6:35108. https :// doi.org /10.1038 /srep35108
-
(2016)
Sci. Rep
, vol.6
, pp. 35108
-
-
He, L.1
Vanlandewijck, M.2
Raschperger, E.3
Andaloussi Mäe, M.4
Jung, B.5
Lebouvier, T.6
Ando, K.7
Hofmann, J.8
Keller, A.9
Betsholtz, C.10
-
69
-
-
84887259294
-
Multiple microbleeds are related to cerebral network disruptions in patients with early Alzheimer's disease
-
Heringa, S.M., Y.D. Reijmer, A. Leemans, H.L. Koek, L.J. Kappelle, and G.J. Biessels. Utrecht Vascular Cognitive Impairment (VCI) Study Group. 2014. Multiple microbleeds are related to cerebral network disruptions in patients with early Alzheimer's disease. J. Alzheimers Dis. 38:211-221
-
(2014)
J. Alzheimers Dis
, vol.38
, pp. 211-221
-
-
Heringa, S.M.1
Reijmer, Y.D.2
Leemans, A.3
Koek, H.L.4
Kappelle, L.J.5
Biessels, G.J.6
-
70
-
-
0006440758
-
[The hexosephosphatase system; partition of activity of glucose-6-phosphatase in the tissues]
-
(Paris)
-
Hers, H.G., and C. De Duve. 1950. [The hexosephosphatase system; partition of activity of glucose-6-phosphatase in the tissues]. Bull. Soc. Chim. Biol. (Paris). 32:20-29
-
(1950)
Bull. Soc. Chim. Biol
, vol.32
, pp. 20-29
-
-
Hers, H.G.1
De Duve, C.2
-
71
-
-
84924273728
-
Mechanisms of fluid movement into, through and out of the brain: evaluation of the evidence
-
Hladky, S.B., and M.A. Barrand. 2014. Mechanisms of fluid movement into, through and out of the brain: evaluation of the evidence. Fluids Barriers CNS. 11:26. https ://doi.org /10.1186 /2045-8118-11-26
-
(2014)
Fluids Barriers CNS
, vol.11
, pp. 26
-
-
Hladky, S.B.1
Barrand, M.A.2
-
72
-
-
85029502411
-
Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow
-
Holter, K.E., B. Kehlet, A. Devor, T.J. Sejnowski, A.M. Dale, S.W. Omholt, O.P. Ottersen, E.A. Nagelhus, K.-A. Mardal, and K.H. Pettersen. 2017. Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow. Proc. Natl. Acad. Sci. USA. 114:9894-9899. https ://doi.org /10.1073 /pnas.1706942114
-
(2017)
Proc. Natl. Acad. Sci. USA
, vol.114
, pp. 9894-9899
-
-
Holter, K.E.1
Kehlet, B.2
Devor, A.3
Sejnowski, T.J.4
Dale, A.M.5
Omholt, S.W.6
Ottersen, O.P.7
Nagelhus, E.A.8
Mardal, K.-A.9
Pettersen, K.H.10
-
73
-
-
0034123538
-
Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model
-
Holtzman, D.M., A.M. Fagan, B. Mackey, T. Tenkova, L. Sartorius, S.M. Paul, K. Bales, K.H. Ashe, M.C. Irizarry, and B.T. Hyman. 2000. Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model. Ann. Neurol. 47:739-747. https ://doi.org /10.1002 /1531-8249(200006)47 :6<739::AID-ANA6>3.0.CO;2-8
-
(2000)
Ann. Neurol
, vol.47
, pp. 739-747
-
-
Holtzman, D.M.1
Fagan, A.M.2
Mackey, B.3
Tenkova, T.4
Sartorius, L.5
Paul, S.M.6
Bales, K.7
Ashe, K.H.8
Irizarry, M.C.9
Hyman, B.T.10
-
74
-
-
84863504256
-
Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease
-
Holtzman, D.M., J. Herz, and G. Bu. 2012. Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. Cold Spring Harb. Perspect. Med. 2:a006312. https ://doi.org /10.1101 /cshperspect.a006312
-
(2012)
Cold Spring Harb. Perspect. Med
, vol.2
-
-
Holtzman, D.M.1
Herz, J.2
Bu, G.3
-
75
-
-
0029742199
-
Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
-
Hsiao, K., P. Chapman, S. Nilsen, C. Eckman, Y. Harigaya, S. Younkin, F. Yang, and G. Cole. 1996. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science. 274:99-102. https ://doi.org /10.1126 /science.274.5284.99
-
(1996)
Science
, vol.274
, pp. 99-102
-
-
Hsiao, K.1
Chapman, P.2
Nilsen, S.3
Eckman, C.4
Harigaya, Y.5
Younkin, S.6
Yang, F.7
Cole, G.8
-
76
-
-
0021893778
-
Metabolic fluxes between [14C]2-deoxy-D-glucose and [14C]2-deoxy-D-glucose-6-phosphate in brain in vivo
-
Huang, M.T., and R.L. Veech. 1985. Metabolic fluxes between [14C]2-deoxy-D-glucose and [14C]2-deoxy-D-glucose-6-phosphate in brain in vivo. J. Neurochem. 44:567-573. https ://doi.org /10.1111 /j.1471-4159.1985.tb05450.x
-
(1985)
J. Neurochem
, vol.44
, pp. 567-573
-
-
Huang, M.T.1
Veech, R.L.2
-
77
-
-
85019686113
-
A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease
-
Huang, K.-L., E. Marcora, A.A. Pimenova, A.F. Di Narzo, M. Kapoor, S.C. Jin, O. Harari, S. Bertelsen, B.P. Fairfax, J. Czajkowski, et al. 2017. A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease. Nat. Neurosci. 20:1052-1061. https ://doi.org /10.1038 /nn.4587
-
(2017)
Nat. Neurosci
, vol.20
, pp. 1052-1061
-
-
Huang, K.-L.1
Marcora, E.2
Pimenova, A.A.3
Di Narzo, A.F.4
Kapoor, M.5
Jin, S.C.6
Harari, O.7
Bertelsen, S.8
Fairfax, B.P.9
Czajkowski, J.10
-
78
-
-
84881181605
-
The APOE ε4/ε4 genotype potentiates vascular fibrin(ogen) deposition in amyloid-laden vessels in the brains of Alzheimer's disease patients
-
Hultman, K., S. Strickland, and E.H. Norris. 2013. The APOE ε4/ε4 genotype potentiates vascular fibrin(ogen) deposition in amyloid-laden vessels in the brains of Alzheimer's disease patients. J. Cereb. Blood Flow Metab. 33:1251-1258. https ://doi.org /10.1038 /jcbfm.2013.76
-
(2013)
J. Cereb. Blood Flow Metab
, vol.33
, pp. 1251-1258
-
-
Hultman, K.1
Strickland, S.2
Norris, E.H.3
-
79
-
-
84888019151
-
The pathobiology of vascular dementia
-
Iadecola, C. 2013. The pathobiology of vascular dementia. Neuron. 80:844-866. https ://doi.org /10.1016 /j.neuron.2013.10.008
-
(2013)
Neuron
, vol.80
, pp. 844-866
-
-
Iadecola, C.1
-
80
-
-
85031027137
-
The neurovascular unit coming of age: a journey through neurovascular coupling in health and disease
-
Iadecola, C. 2017. The neurovascular unit coming of age: a journey through neurovascular coupling in health and disease. Neuron. 96:17-42. https :// doi.org /10.1016 /j.neuron.2017.07.030
-
(2017)
Neuron
, vol.96
, pp. 17-42
-
-
Iadecola, C.1
-
81
-
-
84865123660
-
A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β
-
Iliff, J.J., M. Wang, Y. Liao, B.A. Plogg, W. Peng, G.A. Gundersen, H. Benveniste, G.E. Vates, R. Deane, S.A. Goldman, et al. 2012. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci. Transl. Med. 4:147ra111. https ://doi.org /10.1126 /scitranslmed.3003748
-
(2012)
Sci. Transl. Med
, vol.4
-
-
Iliff, J.J.1
Wang, M.2
Liao, Y.3
Plogg, B.A.4
Peng, W.5
Gundersen, G.A.6
Benveniste, H.7
Vates, G.E.8
Deane, R.9
Goldman, S.A.10
-
82
-
-
84975882747
-
Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis
-
Iturria-Medina, Y., R.C. Sotero, P.J. Toussaint, J.M. Mateos-Pérez, and A.C. Evans. Alzheimer's Disease Neuroimaging Initiative. 2016. Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis. Nat. Commun. 7:11934. https ://doi.org /10.1038 /ncomms11934
-
(2016)
Nat. Commun
, vol.7
, pp. 11934
-
-
Iturria-Medina, Y.1
Sotero, R.C.2
Toussaint, P.J.3
Mateos-Pérez, J.M.4
Evans, A.C.5
-
83
-
-
84889794517
-
Progranulin deficiency promotes post-ischemic blood-brain barrier disruption
-
Jackman, K., T. Kahles, D. Lane, L. Garcia-Bonilla, T. Abe, C. Capone, K. Hochrainer, H. Voss, P. Zhou, A. Ding, et al. 2013. Progranulin deficiency promotes post-ischemic blood-brain barrier disruption. J. Neurosci. 33:19579-19589. https ://doi.org /10.1523 /JNE URO SCI.4318-13.2013
-
(2013)
J. Neurosci
, vol.33
, pp. 19579-19589
-
-
Jackman, K.1
Kahles, T.2
Lane, D.3
Garcia-Bonilla, L.4
Abe, T.5
Capone, C.6
Hochrainer, K.7
Voss, H.8
Zhou, P.9
Ding, A.10
-
84
-
-
84949316085
-
The Glymphatic System: A Beginner's Guide
-
Jessen, N.A., A.S.F. Munk, I. Lundgaard, and M. Nedergaard. 2015. The Glymphatic System: A Beginner's Guide. Neurochem. Res. 40:2583-2599. https ://doi.org /10.1007 /s11064-015-1581-6
-
(2015)
Neurochem. Res
, vol.40
, pp. 2583-2599
-
-
Jessen, N.A.1
Munk, A.S.F.2
Lundgaard, I.3
Nedergaard, M.4
-
85
-
-
85008490303
-
Spatial model of convective solute transport in brain extracellular space does not support a 'glymphatic' mechanism
-
Jin, B.-J., A.J. Smith, and A.S. Verkman. 2016. Spatial model of convective solute transport in brain extracellular space does not support a 'glymphatic' mechanism. J. Gen. Physiol. 148:489-501. https ://doi.org /10.1085 /jgp.201611684
-
(2016)
J. Gen. Physiol
, vol.148
, pp. 489-501
-
-
Jin, B.-J.1
Smith, A.J.2
Verkman, A.S.3
-
86
-
-
84920703987
-
Alzheimer's disease risk genes and mechanisms of disease pathogenesis
-
Karch, C.M., and A.M. Goate. 2015. Alzheimer's disease risk genes and mechanisms of disease pathogenesis. Biol. Psychiatry. 77:43-51. https :// doi.org /10.1016 /j.biopsych.2014.05.006
-
(2015)
Biol. Psychiatry
, vol.77
, pp. 43-51
-
-
Karch, C.M.1
Goate, A.M.2
-
87
-
-
84903627137
-
Alzheimer's disease genetics: from the bench to the clinic
-
Karch, C.M., C. Cruchaga, and A.M. Goate. 2014. Alzheimer's disease genetics: from the bench to the clinic. Neuron. 83:11-26. https ://doi.org /10.1016 /j.neuron.2014.05.041
-
(2014)
Neuron
, vol.83
, pp. 11-26
-
-
Karch, C.M.1
Cruchaga, C.2
Goate, A.M.3
-
88
-
-
84883463387
-
Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice
-
Keller, A., A. Westenberger, M.J. Sobrido, M. García-Murias, A. Domingo, R.L. Sears, R.R. Lemos, A. Ordoñez-Ugalde, G. Nicolas, J.E.G. da Cunha, et al. 2013. Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice. Nat. Genet. 45:1077-1082. https :// doi.org /10.1038 /ng.2723
-
(2013)
Nat. Genet
, vol.45
, pp. 1077-1082
-
-
Keller, A.1
Westenberger, A.2
Sobrido, M.J.3
García-Murias, M.4
Domingo, A.5
Sears, R.L.6
Lemos, R.R.7
Ordoñez-Ugalde, A.8
Nicolas, G.9
da Cunha, J.E.G.10
-
89
-
-
84922681924
-
Restoration of cerebral and systemic microvascular architecture in APP/PS1 transgenic mice following treatment with LiraglutideTM
-
Kelly, P., P.L. McClean, M. Ackermann, M.A. Konerding, C. Hölscher, and C.A. Mitchell. 2015. Restoration of cerebral and systemic microvascular architecture in APP/PS1 transgenic mice following treatment with LiraglutideTM. Microcirc. 22:133-145. https ://doi.org /10.1111 /micc.12186
-
(2015)
Microcirc
, vol.22
, pp. 133-145
-
-
Kelly, P.1
McClean, P.L.2
Ackermann, M.3
Konerding, M.A.4
Hölscher, C.5
Mitchell, C.A.6
-
90
-
-
85021150580
-
Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease
-
Kisler, K., A.R. Nelson, A. Montagne, and B.V. Zlokovic. 2017a. Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease. Nat. Rev. Neurosci. 18:419-434. https ://doi.org /10.1038 /nrn.2017.48
-
(2017)
Nat. Rev. Neurosci
, vol.18
, pp. 419-434
-
-
Kisler, K.1
Nelson, A.R.2
Montagne, A.3
Zlokovic, B.V.4
-
91
-
-
85010928380
-
Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain
-
Kisler, K., A.R. Nelson, S.V. Rege, A. Ramanathan, Y. Wang, A. Ahuja, D. Lazic, P.S. Tsai, Z. Zhao, Y. Zhou, et al. 2017b. Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain. Nat. Neurosci. 20:406-416. https ://doi.org /10.1038 /nn.4489
-
(2017)
Nat. Neurosci
, vol.20
, pp. 406-416
-
-
Kisler, K.1
Nelson, A.R.2
Rege, S.V.3
Ramanathan, A.4
Wang, Y.5
Ahuja, A.6
Lazic, D.7
Tsai, P.S.8
Zhao, Z.9
Zhou, Y.10
-
92
-
-
82555164994
-
Detection of cerebral microbleeds with quantitative susceptibility mapping in the ArcAbeta mouse model of cerebral amyloidosis
-
Klohs, J., A. Deistung, F. Schweser, J. Grandjean, M. Dominietto, C. Waschkies, R.M. Nitsch, I. Knuesel, J.R. Reichenbach, and M. Rudin. 2011. Detection of cerebral microbleeds with quantitative susceptibility mapping in the ArcAbeta mouse model of cerebral amyloidosis. J. Cereb. Blood Flow Metab. 31:2282-2292. https ://doi.org /10.1038 /jcbfm.2011.118
-
(2011)
J. Cereb. Blood Flow Metab
, vol.31
, pp. 2282-2292
-
-
Klohs, J.1
Deistung, A.2
Schweser, F.3
Grandjean, J.4
Dominietto, M.5
Waschkies, C.6
Nitsch, R.M.7
Knuesel, I.8
Reichenbach, J.R.9
Rudin, M.10
-
93
-
-
84856667645
-
Contrast-enhanced magnetic resonance microangiography reveals remodeling of the cerebral microvasculature in transgenic ArcAβ mice
-
Klohs, J., C. Baltes, F. Princz-Kranz, D. Ratering, R.M. Nitsch, I. Knuesel, and M. Rudin. 2012. Contrast-enhanced magnetic resonance microangiography reveals remodeling of the cerebral microvasculature in transgenic ArcAβ mice. J. Neurosci. 32:1705-1713. https ://doi.org /10.1523 /JNE URO SCI.5626-11.2012
-
(2012)
J. Neurosci
, vol.32
, pp. 1705-1713
-
-
Klohs, J.1
Baltes, C.2
Princz-Kranz, F.3
Ratering, D.4
Nitsch, R.M.5
Knuesel, I.6
Rudin, M.7
-
94
-
-
84879233445
-
Longitudinal Assessment of Amyloid Pathology in Transgenic ArcAβ Mice Using Multi-Parametric Magnetic Resonance Imaging
-
Klohs, J., I.W. Politano, A. Deistung, J. Grandjean, A. Drewek, M. Dominietto, R. Keist, F. Schweser, J.R. Reichenbach, R.M. Nitsch, et al. 2013. Longitudinal Assessment of Amyloid Pathology in Transgenic ArcAβ Mice Using Multi-Parametric Magnetic Resonance Imaging. PLoS One. 8:e66097. https ://doi.org /10.1371 /journal.pone.0066097
-
(2013)
PLoS One
, vol.8
-
-
Klohs, J.1
Politano, I.W.2
Deistung, A.3
Grandjean, J.4
Drewek, A.5
Dominietto, M.6
Keist, R.7
Schweser, F.8
Reichenbach, J.R.9
Nitsch, R.M.10
-
95
-
-
84862885703
-
Aβ1-42-RAGE interaction disrupts tight junctions of the bloodbrain barrier via Ca2+-calcineurin signaling
-
Kook, S.-Y., H.S. Hong, M. Moon, C.M. Ha, S. Chang, and I. Mook-Jung. 2012. Aβ1-42-RAGE interaction disrupts tight junctions of the bloodbrain barrier via Ca2+-calcineurin signaling. J. Neurosci. 32:8845-8854. https ://doi.org /10.1523 /JNE URO SCI.6102-11.2012
-
(2012)
J. Neurosci
, vol.32
, pp. 8845-8854
-
-
Kook, S.-Y.1
Hong, H.S.2
Moon, M.3
Ha, C.M.4
Chang, S.5
Mook-Jung, I.6
-
96
-
-
84941050887
-
Chronic Hypertension Leads to Neurodegeneration in the TgSwDI Mouse Model of Alzheimer's Disease
-
Kruyer, A., N. Soplop, S. Strickland, and E.H. Norris. 2015. Chronic Hypertension Leads to Neurodegeneration in the TgSwDI Mouse Model of Alzheimer's Disease. Hypertension. 66:175-182. https ://doi.org /10.1161 /HYP ERT ENS ION AHA.115.05524
-
(2015)
Hypertension
, vol.66
, pp. 175-182
-
-
Kruyer, A.1
Soplop, N.2
Strickland, S.3
Norris, E.H.4
-
97
-
-
25144503548
-
Dense-core plaques in Tg2576 and PSA PP mouse models of Alzheimer's disease are centered on vessel walls
-
Kumar-Singh, S., D. Pirici, E. McGowan, S. Serneels, C. Ceuterick, J. Hardy, K. Duff, D. Dickson, and C. Van Broeckhoven. 2005. Dense-core plaques in Tg2576 and PSA PP mouse models of Alzheimer's disease are centered on vessel walls. Am. J. Pathol. 167:527-543. https ://doi.org /10.1016 / S0002-9440(10)62995-1
-
(2005)
Am. J. Pathol
, vol.167
, pp. 527-543
-
-
Kumar-Singh, S.1
Pirici, D.2
McGowan, E.3
Serneels, S.4
Ceuterick, C.5
Hardy, J.6
Duff, K.7
Dickson, D.8
Van Broeckhoven, C.9
-
98
-
-
78549264026
-
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
-
Lambert, J.-C., S. Heath, G. Even, D. Campion, K. Sleegers, M. Hiltunen, O. Combarros, D. Zelenika, M.J. Bullido, B. Tavernier, et al. European Alzheimer's Disease Initiative Investigators. 2009. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat. Genet. 41:1094-1099. https ://doi.org /10.1038 /ng.439
-
(2009)
Nat. Genet
, vol.41
, pp. 1094-1099
-
-
Lambert, J.-C.1
Heath, S.2
Even, G.3
Campion, D.4
Sleegers, K.5
Hiltunen, M.6
Combarros, O.7
Zelenika, D.8
Bullido, M.J.9
Tavernier, B.10
-
99
-
-
84989168190
-
Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice
-
Lane-Donovan, C., W.M. Wong, M.S. Durakoglugil, C.R. Wasser, S. Jiang, X. Xian, and J. Herz. 2016. Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice. J. Neurosci. 36:10141-10150. https ://doi.org /10.1523 /JNE URO SCI.1054-16.2016
-
(2016)
J. Neurosci
, vol.36
, pp. 10141-10150
-
-
Lane-Donovan, C.1
Wong, W.M.2
Durakoglugil, M.S.3
Wasser, C.R.4
Jiang, S.5
Xian, X.6
Herz, J.7
-
100
-
-
77953913051
-
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations
-
Lee, J.-H., W.H. Yu, A. Kumar, S. Lee, P.S. Mohan, C.M. Peterhoff, D.M. Wolfe, M. Martinez-Vicente, A.C. Massey, G. Sovak, et al. 2010. Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell. 141:1146-1158. https ://doi.org /10.1016 /j.cell.2010.05.008
-
(2010)
Cell
, vol.141
, pp. 1146-1158
-
-
Lee, J.-H.1
Yu, W.H.2
Kumar, A.3
Lee, S.4
Mohan, P.S.5
Peterhoff, C.M.6
Wolfe, D.M.7
Martinez-Vicente, M.8
Massey, A.C.9
Sovak, G.10
-
101
-
-
0034426011
-
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
-
Lewis, J., E. McGowan, J. Rockwood, H. Melrose, P. Nacharaju, M. Van Slegtenhorst, K. Gwinn-Hardy, M. Paul Murphy, M. Baker, X. Yu, et al. 2000. Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nat. Genet. 25:402-405. https ://doi.org /10.1038 /78078
-
(2000)
Nat. Genet
, vol.25
, pp. 402-405
-
-
Lewis, J.1
McGowan, E.2
Rockwood, J.3
Melrose, H.4
Nacharaju, P.5
Van Slegtenhorst, M.6
Gwinn-Hardy, K.7
Paul Murphy, M.8
Baker, M.9
Yu, X.10
-
102
-
-
85002170011
-
Apolipoprotein E metabolism and functions in brain and its role in Alzheimer's disease
-
Liao, F., H. Yoon, and J. Kim. 2017. Apolipoprotein E metabolism and functions in brain and its role in Alzheimer's disease. Curr. Opin. Lipidol. 28:60-67
-
(2017)
Curr. Opin. Lipidol
, vol.28
, pp. 60-67
-
-
Liao, F.1
Yoon, H.2
Kim, J.3
-
103
-
-
84927516421
-
APOE4 enhances agedependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice
-
Liu, D.S., X.D. Pan, J. Zhang, H. Shen, N.C. Collins, A.M. Cole, K.P. Koster, M. Ben Aissa, X.M. Dai, M. Zhou, et al. 2015. APOE4 enhances agedependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice. Mol. Neurodegener. 10:7. https ://doi.org /10.1186 /s13024-015-0002-2
-
(2015)
Mol. Neurodegener
, vol.10
, pp. 7
-
-
Liu, D.S.1
Pan, X.D.2
Zhang, J.3
Shen, H.4
Collins, N.C.5
Cole, A.M.6
Koster, K.P.7
Ben Aissa, M.8
Dai, X.M.9
Zhou, M.10
-
104
-
-
84936871460
-
Structural and functional features of central nervous system lymphatic vessels
-
Louveau, A., I. Smirnov, T.J. Keyes, J.D. Eccles, S.J. Rouhani, J.D. Peske, N.C. Derecki, D. Castle, J.W. Mandell, K.S. Lee, et al. 2015. Structural and functional features of central nervous system lymphatic vessels. Nature. 523:337-341. https ://doi.org /10.1038 /nature14432
-
(2015)
Nature
, vol.523
, pp. 337-341
-
-
Louveau, A.1
Smirnov, I.2
Keyes, T.J.3
Eccles, J.D.4
Rouhani, S.J.5
Peske, J.D.6
Derecki, N.C.7
Castle, D.8
Mandell, J.W.9
Lee, K.S.10
-
105
-
-
57049187662
-
Pertussis toxin induces angiogenesis in brain microvascular endothelial cells
-
Lu, C., S. Pelech, H. Zhang, J. Bond, K. Spach, R. Noubade, E.P. Blankenhorn, and C. Teuscher. 2008. Pertussis toxin induces angiogenesis in brain microvascular endothelial cells. J. Neurosci. Res. 86:2624-2640. https :// doi.org /10.1002 /jnr.21716
-
(2008)
J. Neurosci. Res
, vol.86
, pp. 2624-2640
-
-
Lu, C.1
Pelech, S.2
Zhang, H.3
Bond, J.4
Spach, K.5
Noubade, R.6
Blankenhorn, E.P.7
Teuscher, C.8
-
106
-
-
84872713614
-
Apolipoprotein e sets the stage: response to injury triggers neuropathology
-
Mahley, R.W., and Y. Huang. 2012. Apolipoprotein e sets the stage: response to injury triggers neuropathology. Neuron. 76:871-885. https ://doi.org /10.1016 /j.neuron.2012.11.020
-
(2012)
Neuron
, vol.76
, pp. 871-885
-
-
Mahley, R.W.1
Huang, Y.2
-
107
-
-
0034975365
-
Amyloid angiopathy and variability in amyloid beta deposition is determined by mutation position in presenilin-1-linked Alzheimer's disease
-
Mann, D.M., S.M. Pickering-Brown, A. Takeuchi, and T. Iwatsubo. Members of the Familial Alzheimer's Disease Pathology Study Group. 2001. Amyloid angiopathy and variability in amyloid beta deposition is determined by mutation position in presenilin-1-linked Alzheimer's disease. Am. J. Pathol. 158:2165-2175. https ://doi.org /10.1016 /S0002-9440(10)64688-3
-
(2001)
Am. J. Pathol
, vol.158
, pp. 2165-2175
-
-
Mann, D.M.1
Pickering-Brown, S.M.2
Takeuchi, A.3
Iwatsubo, T.4
-
108
-
-
0025122107
-
Use of nonradioactive 2-deoxyglucose to study compartmentation of brain glucose metabolism and rapid regional changes in rate
-
McDougal, D.B. Jr., J.A. Ferrendelli, V. Yip, M.E. Pusateri, J.G. Carter, M.M. Chi, B. Norris, J. Manchester, and O.H. Lowry. 1990. Use of nonradioactive 2-deoxyglucose to study compartmentation of brain glucose metabolism and rapid regional changes in rate. Proc. Natl. Acad. Sci. USA. 87:1357-1361. https ://doi.org /10.1073 /pnas.87.4.1357
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 1357-1361
-
-
McDougal, D.B.1
Ferrendelli, J.A.2
Yip, V.3
Pusateri, M.E.4
Carter, J.G.5
Chi, M.M.6
Norris, B.7
Manchester, J.8
Lowry, O.H.9
-
109
-
-
85020540681
-
FTY720 Attenuates Infection-Induced Enhancement of Aβ Accumulation in APP/PS1 Mice by Modulating Astrocytic Activation
-
McManus, R.M., O.M. Finucane, M.M. Wilk, K.H.G. Mills, and M.A. Lynch. 2017. FTY720 Attenuates Infection-Induced Enhancement of Aβ Accumulation in APP/PS1 Mice by Modulating Astrocytic Activation. J. Neuroimmune Pharmacol. https ://doi.org /10.1007 /s11481-017-9753-6
-
(2017)
J. Neuroimmune Pharmacol
-
-
McManus, R.M.1
Finucane, O.M.2
Wilk, M.M.3
Mills, K.H.G.4
Lynch, M.A.5
-
110
-
-
0035716136
-
ApoE deficiency compromises the blood brain barrier especially after injury
-
Methia, N., P. André, A. Hafezi-Moghadam, M. Economopoulos, K.L. Thomas, and D.D. Wagner. 2001. ApoE deficiency compromises the blood brain barrier especially after injury. Mol. Med. 7:810-815
-
(2001)
Mol. Med
, vol.7
, pp. 810-815
-
-
Methia, N.1
André, P.2
Hafezi-Moghadam, A.3
Economopoulos, M.4
Thomas, K.L.5
Wagner, D.D.6
-
111
-
-
0016763145
-
The third circulation revisited
-
Milhorat, T.H. 1975. The third circulation revisited. J. Neurosurg. 42:628-645. https ://doi.org /10.3171 /jns.1975.42.6.0628
-
(1975)
J. Neurosurg
, vol.42
, pp. 628-645
-
-
Milhorat, T.H.1
-
112
-
-
79952499042
-
Disruption of neurovascular unit prior to motor neuron degeneration in amyotrophic lateral sclerosis
-
Miyazaki, K., Y. Ohta, M. Nagai, N. Morimoto, T. Kurata, Y. Takehisa, Y. Ikeda, T. Matsuura, and K. Abe. 2011. Disruption of neurovascular unit prior to motor neuron degeneration in amyotrophic lateral sclerosis. J. Neurosci. Res. 89:718-728. https ://doi.org /10.1002 /jnr.22594
-
(2011)
J. Neurosci. Res
, vol.89
, pp. 718-728
-
-
Miyazaki, K.1
Ohta, Y.2
Nagai, M.3
Morimoto, N.4
Kurata, T.5
Takehisa, Y.6
Ikeda, Y.7
Matsuura, T.8
Abe, K.9
-
113
-
-
84901913570
-
Ion transporters in brain endothelial cells that contribute to formation of brain interstitial fluid
-
Mokgokong, R., S. Wang, C.J. Taylor, M.A. Barrand, and S.B. Hladky. 2014. Ion transporters in brain endothelial cells that contribute to formation of brain interstitial fluid. Pflugers Arch. 466:887-901. https ://doi.org /10.1007 /s00424-013-1342-9
-
(2014)
Pflugers Arch
, vol.466
, pp. 887-901
-
-
Mokgokong, R.1
Wang, S.2
Taylor, C.J.3
Barrand, M.A.4
Hladky, S.B.5
-
114
-
-
84921326695
-
Bloodbrain barrier breakdown in the aging human hippocampus
-
Montagne, A., S.R. Barnes, M.D. Sweeney, M.R. Halliday, A.P. Sagare, Z. Zhao, A.W. Toga, R.E. Jacobs, C.Y. Liu, L. Amezcua, et al. 2015. Bloodbrain barrier breakdown in the aging human hippocampus. Neuron. 85:296-302. https ://doi.org /10.1016 /j.neuron.2014.12.032
-
(2015)
Neuron
, vol.85
, pp. 296-302
-
-
Montagne, A.1
Barnes, S.R.2
Sweeney, M.D.3
Halliday, M.R.4
Sagare, A.P.5
Zhao, Z.6
Toga, A.W.7
Jacobs, R.E.8
Liu, C.Y.9
Amezcua, L.10
-
115
-
-
84962173232
-
Brain imaging of neurovascular dysfunction in Alzheimer's disease
-
Montagne, A., D.A. Nation, J. Pa, M.D. Sweeney, A.W. Toga, and B.V. Zlokovic. 2016. Brain imaging of neurovascular dysfunction in Alzheimer's disease. Acta Neuropathol. 131:687-707. https ://doi.org /10.1007 /s00401-016-1570-0
-
(2016)
Acta Neuropathol
, vol.131
, pp. 687-707
-
-
Montagne, A.1
Nation, D.A.2
Pa, J.3
Sweeney, M.D.4
Toga, A.W.5
Zlokovic, B.V.6
-
116
-
-
84921991249
-
Recommendations of the Alzheimer's disease-related dementias conference
-
Montine, T.J., W.J. Koroshetz, D. Babcock, D.W. Dickson, W.R. Galpern, M.M. Glymour, S.M. Greenberg, M.L. Hutton, D.S. Knopman, A.N. Kuzmichev, et al. ADRD 2013 Conference Organizing Committee. 2014. Recommendations of the Alzheimer's disease-related dementias conference. Neurology. 83:851-860. https ://doi.org /10.1212 /WNL.0000000000000733
-
(2014)
Neurology
, vol.83
, pp. 851-860
-
-
Montine, T.J.1
Koroshetz, W.J.2
Babcock, D.3
Dickson, D.W.4
Galpern, W.R.5
Glymour, M.M.6
Greenberg, S.M.7
Hutton, M.L.8
Knopman, D.S.9
Kuzmichev, A.N.10
-
117
-
-
0034936960
-
Apolipoprotein E protects against neuropathology induced by a high-fat diet and maintains the integrity of the blood-brain barrier during aging
-
Mulder, M., A. Blokland, D.J. van den Berg, H. Schulten, A.H. Bakker, D. Terwel, W. Honig, E.R. de Kloet, L.M. Havekes, H.W. Steinbusch, and E.C. de Lange. 2001. Apolipoprotein E protects against neuropathology induced by a high-fat diet and maintains the integrity of the blood-brain barrier during aging. Lab. Invest. 81:953-960. https ://doi.org /10.1038 / labinvest.3780307
-
(2001)
Lab. Invest
, vol.81
, pp. 953-960
-
-
Mulder, M.1
Blokland, A.2
van den Berg, D.J.3
Schulten, H.4
Bakker, A.H.5
Terwel, D.6
Honig, W.7
de Kloet, E.R.8
Havekes, L.M.9
Steinbusch, H.W.10
de Lange, E.C.11
-
118
-
-
84953228317
-
Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease
-
Nelson, A.R., M.D. Sweeney, A.P. Sagare, and B.V. Zlokovic. 2016. Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease. Biochim. Biophys. Acta. 1862:887-900. https ://doi.org /10.1016 /j.bbadis.2015.12.016
-
(2016)
Biochim. Biophys. Acta
, vol.1862
, pp. 887-900
-
-
Nelson, A.R.1
Sweeney, M.D.2
Sagare, A.P.3
Zlokovic, B.V.4
-
119
-
-
84901260638
-
Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid
-
Nguyen, L.N., D. Ma, G. Shui, P. Wong, A. Cazenave-Gassiot, X. Zhang, M.R. Wenk, E.L.K. Goh, and D.L. Silver. 2014. Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. Nature. 509:503-506. https ://doi.org /10.1038 /nature13241
-
(2014)
Nature
, vol.509
, pp. 503-506
-
-
Nguyen, L.N.1
Ma, D.2
Shui, G.3
Wong, P.4
Cazenave-Gassiot, A.5
Zhang, X.6
Wenk, M.R.7
Goh, E.L.K.8
Silver, D.L.9
-
120
-
-
71849084133
-
Impaired blood-brain and blood-spinal cord barriers in mutant SOD1-linked ALS rat
-
Nicaise, C., D. Mitrecic, P. Demetter, R. De Decker, M. Authelet, A. Boom, and R. Pochet. 2009. Impaired blood-brain and blood-spinal cord barriers in mutant SOD1-linked ALS rat. Brain Res. 1301:152-162. https ://doi.org /10.1016 /j.brainres.2009.09.018
-
(2009)
Brain Res
, vol.1301
, pp. 152-162
-
-
Nicaise, C.1
Mitrecic, D.2
Demetter, P.3
De Decker, R.4
Authelet, M.5
Boom, A.6
Pochet, R.7
-
121
-
-
84873693930
-
Mutation of the PDG FRB gene as a cause of idiopathic basal ganglia calcification
-
Nicolas, G., C. Pottier, D. Maltête, S. Coutant, A. Rovelet-Lecrux, S. Legallic, S. Rousseau, Y. Vaschalde, L. Guyant-Maréchal, J. Augustin, et al. 2013. Mutation of the PDG FRB gene as a cause of idiopathic basal ganglia calcification. Neurology. 80:181-187. https ://doi.org /10.1212 /WNL.0b013e31827ccf34
-
(2013)
Neurology
, vol.80
, pp. 181-187
-
-
Nicolas, G.1
Pottier, C.2
Maltête, D.3
Coutant, S.4
Rovelet-Lecrux, A.5
Legallic, S.6
Rousseau, S.7
Vaschalde, Y.8
Guyant-Maréchal, L.9
Augustin, J.10
-
122
-
-
85018819806
-
Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-β signaling
-
Nikolakopoulou, A.M., Z. Zhao, A. Montagne, and B.V. Zlokovic. 2017. Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-β signaling. PLoS One. 12:e0176225. https ://doi.org /10.1371 /journal.pone.0176225
-
(2017)
PLoS One
, vol.12
-
-
Nikolakopoulou, A.M.1
Zhao, Z.2
Montagne, A.3
Zlokovic, B.V.4
-
123
-
-
79955953909
-
Apolipoprotein E regulates the integrity of tight junctions in an isoformdependent manner in an in vitro blood-brain barrier model
-
Nishitsuji, K., T. Hosono, T. Nakamura, G. Bu, and M. Michikawa. 2011. Apolipoprotein E regulates the integrity of tight junctions in an isoformdependent manner in an in vitro blood-brain barrier model. J. Biol. Chem. 286:17536-17542. https ://doi.org /10.1074 /jbc.M111.225532
-
(2011)
J. Biol. Chem
, vol.286
, pp. 17536-17542
-
-
Nishitsuji, K.1
Hosono, T.2
Nakamura, T.3
Bu, G.4
Michikawa, M.5
-
124
-
-
0036302636
-
Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein
-
Niwa, K., K. Kazama, L. Younkin, S.G. Younkin, G.A. Carlson, and C. Iadecola. 2002. Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein. Am. J. Physiol. Heart Circ. Physiol. 283:H315-H323. https ://doi.org /10.1152 /ajpheart.00022.2002
-
(2002)
Am. J. Physiol. Heart Circ. Physiol
, vol.283
, pp. H315-H323
-
-
Niwa, K.1
Kazama, K.2
Younkin, L.3
Younkin, S.G.4
Carlson, G.A.5
Iadecola, C.6
-
125
-
-
77956374543
-
Recessive mutations in the gene encoding the tight junction protein occludin cause band-like calcification with simplified gyration and polymicrogyria
-
O'Driscoll, M.C., S.B. Daly, J.E. Urquhart, G.C.M. Black, D.T. Pilz, K. Brockmann, M. McEntagart, G. Abdel-Salam, M. Zaki, N.I. Wolf, et al. 2010. Recessive mutations in the gene encoding the tight junction protein occludin cause band-like calcification with simplified gyration and polymicrogyria. Am. J. Hum. Genet. 87:354-364. https ://doi.org /10.1016 /j.ajhg.2010.07.012
-
(2010)
Am. J. Hum. Genet
, vol.87
, pp. 354-364
-
-
O'Driscoll, M.C.1
Daly, S.B.2
Urquhart, J.E.3
Black, G.C.M.4
Pilz, D.T.5
Brockmann, K.6
McEntagart, M.7
Abdel-Salam, G.8
Zaki, M.9
Wolf, N.I.10
-
126
-
-
33749521100
-
Intraneuronal betaamyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation
-
Oakley, H., S.L. Cole, S. Logan, E. Maus, P. Shao, J. Craft, A. Guillozet-Bongaarts, M. Ohno, J. Disterhoft, L. Van Eldik, et al. 2006. Intraneuronal betaamyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J. Neurosci. 26:10129-10140. https ://doi.org /10.1523 /JNE URO SCI.1202-06.2006
-
(2006)
J. Neurosci
, vol.26
, pp. 10129-10140
-
-
Oakley, H.1
Cole, S.L.2
Logan, S.3
Maus, E.4
Shao, P.5
Craft, J.6
Guillozet-Bongaarts, A.7
Ohno, M.8
Disterhoft, J.9
Van Eldik, L.10
-
127
-
-
84873672546
-
Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia
-
Ossenkoppele, R., W.M. van der Flier, M.D. Zwan, S.F. Adriaanse, R. Boellaard, A.D. Windhorst, F. Barkhof, A.A. Lammertsma, P. Scheltens, and B.N.M. van Berckel. 2013. Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia. Neurology. 80:359-365. https ://doi.org /10.1212 /WNL.0b013e31827f0889
-
(2013)
Neurology
, vol.80
, pp. 359-365
-
-
Ossenkoppele, R.1
van der Flier, W.M.2
Zwan, M.D.3
Adriaanse, S.F.4
Boellaard, R.5
Windhorst, A.D.6
Barkhof, F.7
Lammertsma, A.A.8
Scheltens, P.9
van Berckel, B.N.M.10
-
128
-
-
84929138470
-
Targeted delivery of protein and gene medicines through the blood-brain barrier
-
Pardridge, W.M. 2015. Targeted delivery of protein and gene medicines through the blood-brain barrier. Clin. Pharmacol. Ther. 97:347-361. https ://doi.org /10.1002 /cpt.18
-
(2015)
Clin. Pharmacol. Ther
, vol.97
, pp. 347-361
-
-
Pardridge, W.M.1
-
129
-
-
84987906247
-
Annexin A1 restores Aβ1-42-induced blood-brain barrier disruption through the inhibition of RhoA-ROCK signaling pathway
-
Park, J.-C., S.H. Baik, S.-H. Han, H.J. Cho, H. Choi, H.J. Kim, H. Choi, W. Lee, D.K. Kim, and I. Mook-Jung. 2017. Annexin A1 restores Aβ1-42-induced blood-brain barrier disruption through the inhibition of RhoA-ROCK signaling pathway. Aging Cell. 16:149-161. https ://doi.org /10.1111 /acel.12530
-
(2017)
Aging Cell
, vol.16
, pp. 149-161
-
-
Park, J.-C.1
Baik, S.H.2
Han, S.-H.3
Cho, H.J.4
Choi, H.5
Kim, H.J.6
Choi, H.7
Lee, W.8
Kim, D.K.9
Mook-Jung, I.10
-
130
-
-
84874263603
-
Innate immunity receptor CD36 promotes cerebral amyloid angiopathy
-
USA
-
Park, L., J. Zhou, P. Zhou, R. Pistick, S. El Jamal, L. Younkin, J. Pierce, A. Arreguin, J. Anrather, S.G. Younkin, et al. 2013a. Innate immunity receptor CD36 promotes cerebral amyloid angiopathy. Proc. Natl. Acad. Sci. USA. 110:3089-3094. https ://doi.org /10.1073 /pnas.1300021110
-
(2013)
Proc. Natl. Acad. Sci
, vol.110
, pp. 3089-3094
-
-
Park, L.1
Zhou, J.2
Zhou, P.3
Pistick, R.4
El Jamal, S.5
Younkin, L.6
Pierce, J.7
Arreguin, A.8
Anrather, J.9
Younkin, S.G.10
-
131
-
-
84872074083
-
Brain and circulating levels of Aβ1-40 differentially contribute to vasomotor dysfunction in the mouse brain
-
Park, L., P. Zhou, K. Koizumi, S. El Jamal, M.L. Previti, W.E. Van Nostrand, G. Carlson, and C. Iadecola. 2013b. Brain and circulating levels of Aβ1-40 differentially contribute to vasomotor dysfunction in the mouse brain. Stroke. 44:198-204. https ://doi.org /10.1161 /STR OKE AHA.112.670976
-
(2013)
Stroke
, vol.44
, pp. 198-204
-
-
Park, L.1
Zhou, P.2
Koizumi, K.3
El Jamal, S.4
Previti, M.L.5
Van Nostrand, W.E.6
Carlson, G.7
Iadecola, C.8
-
132
-
-
34547791784
-
Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease
-
Paul, J., S. Strickland, and J.P. Melchor. 2007. Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease. J. Exp. Med. 204:1999-2008. https ://doi.org /10.1084 /jem.20070304
-
(2007)
J. Exp. Med
, vol.204
, pp. 1999-2008
-
-
Paul, J.1
Strickland, S.2
Melchor, J.P.3
-
133
-
-
84978035447
-
Cerebral microbleeds in early Alzheimer's disease
-
Poliakova, T., O. Levin, A. Arablinskiy, E. Vasenina, and I. Zerr. 2016. Cerebral microbleeds in early Alzheimer's disease. J. Neurol. 263:1961-1968. https ://doi.org /10.1007 /s00415-016-8220-2
-
(2016)
J. Neurol
, vol.263
, pp. 1961-1968
-
-
Poliakova, T.1
Levin, O.2
Arablinskiy, A.3
Vasenina, E.4
Zerr, I.5
-
134
-
-
84880525521
-
Increased in vivo amyloid-β42 production, exchange, and loss in presenilin mutation carriers
-
Potter, R., B.W. Patterson, D.L. Elbert, V. Ovod, T. Kasten, W. Sigurdson, K. Mawuenyega, T. Blazey, A. Goate, R. Chott, et al. 2013. Increased in vivo amyloid-β42 production, exchange, and loss in presenilin mutation carriers. Sci. Transl. Med. 5:189ra77. https ://doi.org /10.1126 /scitranslmed.3005615
-
(2013)
Sci. Transl. Med
, vol.5
-
-
Potter, R.1
Patterson, B.W.2
Elbert, D.L.3
Ovod, V.4
Kasten, T.5
Sigurdson, W.6
Mawuenyega, K.7
Blazey, T.8
Goate, A.9
Chott, R.10
-
135
-
-
84874912869
-
Posterior cingulate glucose metabolism, hippocampal glucose metabolism, and hippocampal volume in cognitively normal, late-middle-aged persons at 3 levels of genetic risk for Alzheimer disease
-
Protas, H.D., K. Chen, J.B.S. Langbaum, A.S. Fleisher, G.E. Alexander, W. Lee, D. Bandy, M.J. de Leon, L. Mosconi, S. Buckley, et al. 2013. Posterior cingulate glucose metabolism, hippocampal glucose metabolism, and hippocampal volume in cognitively normal, late-middle-aged persons at 3 levels of genetic risk for Alzheimer disease. JAMA Neurol. 70:320-325. https ://doi.org /10.1001 /2013.jamaneurol.286
-
(2013)
JAMA Neurol
, vol.70
, pp. 320-325
-
-
Protas, H.D.1
Chen, K.2
Langbaum, J.B.S.3
Fleisher, A.S.4
Alexander, G.E.5
Lee, W.6
Bandy, D.7
de Leon, M.J.8
Mosconi, L.9
Buckley, S.10
-
136
-
-
0032168460
-
Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females
-
Raber, J., D. Wong, M. Buttini, M. Orth, S. Bellosta, R.E. Pitas, R.W. Mahley, and L. Mucke. 1998. Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females. Proc. Natl. Acad. Sci. USA. 95:10914-10919. https ://doi.org /10.1073 /pnas.95.18.10914
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 10914-10919
-
-
Raber, J.1
Wong, D.2
Buttini, M.3
Orth, M.4
Bellosta, S.5
Pitas, R.E.6
Mahley, R.W.7
Mucke, L.8
-
137
-
-
0347719366
-
Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia
-
Reiman, E.M., K. Chen, G.E. Alexander, R.J. Caselli, D. Bandy, D. Osborne, A.M. Saunders, and J. Hardy. 2004. Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia. Proc. Natl. Acad. Sci. USA. 101:284-289. https ://doi.org /10.1073 /pnas.2635903100
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 284-289
-
-
Reiman, E.M.1
Chen, K.2
Alexander, G.E.3
Caselli, R.J.4
Bandy, D.5
Osborne, D.6
Saunders, A.M.7
Hardy, J.8
-
138
-
-
85013379971
-
HPLC and TLC methods for analysis of [(18)F]FDG and its metabolites from biological samples
-
Rokka, J., T.J. Grönroos, T. Viljanen, O. Solin, and M. Haaparanta-Solin. 2017. HPLC and TLC methods for analysis of [(18)F]FDG and its metabolites from biological samples. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 1048:140-149. https ://doi.org /10.1016 /j.jchromb.2017.01.042
-
(2017)
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci
, vol.1048
, pp. 140-149
-
-
Rokka, J.1
Grönroos, T.J.2
Viljanen, T.3
Solin, O.4
Haaparanta-Solin, M.5
-
139
-
-
84890576583
-
Pericyte loss influences Alzheimer-like neurodegeneration in mice
-
Sagare, A.P., R.D. Bell, Z. Zhao, Q. Ma, E.A. Winkler, A. Ramanathan, and B.V. Zlokovic. 2013. Pericyte loss influences Alzheimer-like neurodegeneration in mice. Nat. Commun. 4:2932. https ://doi.org /10.1038 /ncomms3932
-
(2013)
Nat. Commun
, vol.4
, pp. 2932
-
-
Sagare, A.P.1
Bell, R.D.2
Zhao, Z.3
Ma, Q.4
Winkler, E.A.5
Ramanathan, A.6
Zlokovic, B.V.7
-
140
-
-
17744409878
-
Effect of APOE genotype on microvascular basement membrane in Alzheimer's disease
-
Salloway, S., T. Gur, T. Berzin, R. Tavares, B. Zipser, S. Correia, V. Hovanesian, J. Fallon, V. Kuo-Leblanc, D. Glass, et al. 2002. Effect of APOE genotype on microvascular basement membrane in Alzheimer's disease. J. Neurol. Sci. 203-204:183-187. https ://doi.org /10.1016 /S0022-510X(02)00288-5
-
(2002)
J. Neurol. Sci
, vol.203-204
, pp. 183-187
-
-
Salloway, S.1
Gur, T.2
Berzin, T.3
Tavares, R.4
Zipser, B.5
Correia, S.6
Hovanesian, V.7
Fallon, J.8
Kuo-Leblanc, V.9
Glass, D.10
-
141
-
-
84896855511
-
Hippocampus-related cognitive impairments in young apoE4 targeted replacement mice
-
Salomon-Zimri, S., A. Boehm-Cagan, O. Liraz, and D.M. Michaelson. 2014. Hippocampus-related cognitive impairments in young apoE4 targeted replacement mice. Neurodegener. Dis. 13:86-92. https ://doi.org /10.1159 /000354777
-
(2014)
Neurodegener. Dis
, vol.13
, pp. 86-92
-
-
Salomon-Zimri, S.1
Boehm-Cagan, A.2
Liraz, O.3
Michaelson, D.M.4
-
142
-
-
84938681719
-
Behavioral testing affects the phenotypic expression of APOE ε3 and APOE ε4 in targeted replacement mice and reduces the differences between them
-
Salomon-Zimri, S., O. Liraz, and D.M. Michaelson. 2015. Behavioral testing affects the phenotypic expression of APOE ε3 and APOE ε4 in targeted replacement mice and reduces the differences between them. Alzheimers Dement (Amst). 1:127-135
-
(2015)
Alzheimers Dement (Amst)
, vol.1
, pp. 127-135
-
-
Salomon-Zimri, S.1
Liraz, O.2
Michaelson, D.M.3
-
143
-
-
84876288324
-
Deficiency in mural vascular cells coincides with bloodbrain barrier disruption in Alzheimer's disease
-
Sengillo, J.D., E.A. Winkler, C.T. Walker, J.S. Sullivan, M. Johnson, and B.V. Zlokovic. 2013. Deficiency in mural vascular cells coincides with bloodbrain barrier disruption in Alzheimer's disease. Brain Pathol. 23:303-310. https ://doi.org /10.1111 /bpa.12004
-
(2013)
Brain Pathol
, vol.23
, pp. 303-310
-
-
Sengillo, J.D.1
Winkler, E.A.2
Walker, C.T.3
Sullivan, J.S.4
Johnson, M.5
Zlokovic, B.V.6
-
144
-
-
84951832103
-
Cerebral microbleeds as a biomarker in Alzheimer's disease? A review in the field
-
Shams, S., and L.-O. Wahlund. 2016. Cerebral microbleeds as a biomarker in Alzheimer's disease? A review in the field. Biomarkers Med. 10:9-18. https ://doi.org /10.2217 /bmm.15.101
-
(2016)
Biomarkers Med
, vol.10
, pp. 9-18
-
-
Shams, S.1
Wahlund, L.-O.2
-
145
-
-
84927562356
-
Cerebral microbleeds: different prevalence, topography, and risk factors depending on dementia diagnosis-the Karolinska Imaging Dementia Study
-
Shams, S., J. Martola, T. Granberg, X. Li, M. Shams, S.M. Fereshtehnejad, L. Cavallin, P. Aspelin, M. Kristoffersen-Wiberg, and L.O. Wahlund. 2015. Cerebral microbleeds: different prevalence, topography, and risk factors depending on dementia diagnosis-the Karolinska Imaging Dementia Study. AJNR Am. J. Neuroradiol. 36:661-666. https ://doi.org /10.3174 / ajnr.A4176
-
(2015)
AJNR Am. J. Neuroradiol
, vol.36
, pp. 661-666
-
-
Shams, S.1
Martola, J.2
Granberg, T.3
Li, X.4
Shams, M.5
Fereshtehnejad, S.M.6
Cavallin, L.7
Aspelin, P.8
Kristoffersen-Wiberg, M.9
Wahlund, L.O.10
-
146
-
-
85019070065
-
Plasminogen Deficiency Delays the Onset and Protects from Demyelination and Paralysis in Autoimmune Neuroinflammatory Disease
-
Shaw, M.A., Z. Gao, K.E. McElhinney, S. Thornton, M.J. Flick, A. Lane, J.L. Degen, J.K. Ryu, K. Akassoglou, and E.S. Mullins. 2017. Plasminogen Deficiency Delays the Onset and Protects from Demyelination and Paralysis in Autoimmune Neuroinflammatory Disease. J. Neurosci. 37:3776-3788. https ://doi.org /10.1523 /JNE URO SCI.2932-15.2017
-
(2017)
J. Neurosci
, vol.37
, pp. 3776-3788
-
-
Shaw, M.A.1
Gao, Z.2
McElhinney, K.E.3
Thornton, S.4
Flick, M.J.5
Lane, A.6
Degen, J.L.7
Ryu, J.K.8
Akassoglou, K.9
Mullins, E.S.10
-
147
-
-
78650371044
-
APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Aβ42
-
Sheline, Y.I., J.C. Morris, A.Z. Snyder, J.L. Price, Z. Yan, G. D'Angelo, C. Liu, S. Dixit, T. Benzinger, A. Fagan, et al. 2010. APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Aβ42. J. Neurosci. 30:17035-17040. https ://doi.org /10.1523 /JNE URO SCI.3987-10.2010
-
(2010)
J. Neurosci
, vol.30
, pp. 17035-17040
-
-
Sheline, Y.I.1
Morris, J.C.2
Snyder, A.Z.3
Price, J.L.4
Yan, Z.5
D'Angelo, G.6
Liu, C.7
Dixit, S.8
Benzinger, T.9
Fagan, A.10
-
148
-
-
0034521392
-
Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier
-
Shibata, M., S. Yamada, S.R. Kumar, M. Calero, J. Bading, B. Frangione, D.M. Holtzman, C.A. Miller, D.K. Strickland, J. Ghiso, and B.V. Zlokovic. 2000. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J. Clin. Invest. 106:1489-1499. https ://doi.org /10.1172 /JCI10498
-
(2000)
J. Clin. Invest
, vol.106
, pp. 1489-1499
-
-
Shibata, M.1
Yamada, S.2
Kumar, S.R.3
Calero, M.4
Bading, J.5
Frangione, B.6
Holtzman, D.M.7
Miller, C.A.8
Strickland, D.K.9
Ghiso, J.10
Zlokovic, B.V.11
-
149
-
-
85029231897
-
Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma
-
Smith, A.J., X. Yao, J.A. Dix, B.-J. Jin, and A.S. Verkman. 2017. Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma. eLife. 6:e27679. https ://doi.org /10.7554 /eLife.27679
-
(2017)
ELife
, vol.6
-
-
Smith, A.J.1
Yao, X.2
Dix, J.A.3
Jin, B.-J.4
Verkman, A.S.5
-
150
-
-
84924296638
-
Vascular contributions to cognitive impairment and dementia including Alzheimer's disease
-
Snyder, H.M., R.A. Corriveau, S. Craft, J.E. Faber, S.M. Greenberg, D. Knopman, B.T. Lamb, T.J. Montine, M. Nedergaard, C.B. Schaffer, et al. 2015. Vascular contributions to cognitive impairment and dementia including Alzheimer's disease. Alzheimers Dement. 11:710-717. https :// doi.org /10.1016 /j.jalz.2014.10.008
-
(2015)
Alzheimers Dement
, vol.11
, pp. 710-717
-
-
Snyder, H.M.1
Corriveau, R.A.2
Craft, S.3
Faber, J.E.4
Greenberg, S.M.5
Knopman, D.6
Lamb, B.T.7
Montine, T.J.8
Nedergaard, M.9
Schaffer, C.B.10
-
151
-
-
0017368491
-
The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat
-
Sokoloff, L., M. Reivich, C. Kennedy, M.H. Des Rosiers, C.S. Patlak, K.D. Pettigrew, O. Sakurada, and M. Shinohara. 1977. The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J. Neurochem. 28:897-916. https ://doi.org /10.1111 /j.1471-4159.1977.tb10649.x
-
(1977)
J. Neurochem
, vol.28
, pp. 897-916
-
-
Sokoloff, L.1
Reivich, M.2
Kennedy, C.3
Des Rosiers, M.H.4
Patlak, C.S.5
Pettigrew, K.D.6
Sakurada, O.7
Shinohara, M.8
-
152
-
-
0001477074
-
Substrate specificity of brain hexokinase
-
Sols, A., and R.K. Crane. 1954. Substrate specificity of brain hexokinase. J. Biol. Chem. 210:581-595
-
(1954)
J. Biol. Chem
, vol.210
, pp. 581-595
-
-
Sols, A.1
Crane, R.K.2
-
153
-
-
84946066133
-
APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction
-
Soto, I., L.C. Graham, H.J. Richter, S.N. Simeone, J.E. Radell, W. Grabowska, W.K. Funkhouser, M.C. Howell, and G.R. Howell. 2015. APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction. PLoS Biol. 13:e1002279. https ://doi.org /10.1371 /journal.pbio.1002279
-
(2015)
PLoS Biol
, vol.13
-
-
Soto, I.1
Graham, L.C.2
Richter, H.J.3
Simeone, S.N.4
Radell, J.E.5
Grabowska, W.6
Funkhouser, W.K.7
Howell, M.C.8
Howell, G.R.9
-
154
-
-
0347286867
-
Tissue-specific differences in 2-fluoro-2-deoxyglucose metabolism beyond FDG-6-P: a 19F NMR spectroscopy study in the rat
-
Southworth, R., C.R. Parry, H.G. Parkes, R.A. Medina, and P.B. Garlick. 2003. Tissue-specific differences in 2-fluoro-2-deoxyglucose metabolism beyond FDG-6-P: a 19F NMR spectroscopy study in the rat. NMR Biomed. 16:494-502. https ://doi.org /10.1002 /nbm.856
-
(2003)
NMR Biomed
, vol.16
, pp. 494-502
-
-
Southworth, R.1
Parry, C.R.2
Parkes, H.G.3
Medina, R.A.4
Garlick, P.B.5
-
155
-
-
84939536467
-
A balanced view of the cerebrospinal fluid composition and functions: Focus on adult humans
-
Spector, R., S. Robert Snodgrass, and C.E. Johanson. 2015. A balanced view of the cerebrospinal fluid composition and functions: Focus on adult humans. Exp. Neurol. 273:57-68. https ://doi.org /10.1016 /j.expneurol.2015.07.027
-
(2015)
Exp. Neurol
, vol.273
, pp. 57-68
-
-
Spector, R.1
Robert Snodgrass, S.2
Johanson, C.E.3
-
156
-
-
84956617728
-
Endothelial LRP1 transports amyloid-β(1-42) across the blood-brain barrier
-
Storck, S.E., S. Meister, J. Nahrath, J.N. Meißner, N. Schubert, A. Di Spiezio, S. Baches, R.E. Vandenbroucke, Y. Bouter, I. Prikulis, et al. 2016. Endothelial LRP1 transports amyloid-β(1-42) across the blood-brain barrier. J. Clin. Invest. 126:123-136. https ://doi.org /10.1172 /JCI81108
-
(2016)
J. Clin. Invest
, vol.126
, pp. 123-136
-
-
Storck, S.E.1
Meister, S.2
Nahrath, J.3
Meißner, J.N.4
Schubert, N.5
Di Spiezio, A.6
Baches, S.7
Vandenbroucke, R.E.8
Bouter, Y.9
Prikulis, I.10
-
157
-
-
84931036843
-
Reduced cerebrovascular reactivity in young adults carrying the APOE ε4 allele
-
Suri, S., C.E. Mackay, M.E. Kelly, M. Germuska, E.M. Tunbridge, G.B. Frisoni, P.M. Matthews, K.P. Ebmeier, D.P. Bulte, and N. Filippini. 2015. Reduced cerebrovascular reactivity in young adults carrying the APOE ε4 allele. Alzheimers Dement. 11:648-57.e1. https ://doi.org /10.1016 /j.jalz.2014.05.1755
-
(2015)
Alzheimers Dement
, vol.11
-
-
Suri, S.1
Mackay, C.E.2
Kelly, M.E.3
Germuska, M.4
Tunbridge, E.M.5
Frisoni, G.B.6
Matthews, P.M.7
Ebmeier, K.P.8
Bulte, D.P.9
Filippini, N.10
-
158
-
-
84934444613
-
Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease
-
Sweeney, M.D., A.P. Sagare, and B.V. Zlokovic. 2015. Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease. J. Cereb. Blood Flow Metab. 35:1055-1068. https :// doi.org /10.1038 /jcbfm.2015.76
-
(2015)
J. Cereb. Blood Flow Metab
, vol.35
, pp. 1055-1068
-
-
Sweeney, M.D.1
Sagare, A.P.2
Zlokovic, B.V.3
-
159
-
-
85014656015
-
Pericytes of the neurovascular unit: key functions and signaling pathways
-
Sweeney, M.D., S. Ayyadurai, and B.V. Zlokovic. 2016. Pericytes of the neurovascular unit: key functions and signaling pathways. Nat. Neurosci. 19:771-783. https ://doi.org /10.1038 /nn.4288
-
(2016)
Nat. Neurosci
, vol.19
, pp. 771-783
-
-
Sweeney, M.D.1
Ayyadurai, S.2
Zlokovic, B.V.3
-
160
-
-
84921734855
-
Cerebral vascular leak in a mouse model of amyloid neuropathology
-
Tanifum, E.A., Z.A. Starosolski, S.W. Fowler, J.L. Jankowsky, and A.V. Annapragada. 2014. Cerebral vascular leak in a mouse model of amyloid neuropathology. J. Cereb. Blood Flow Metab. 34:1646-1654. https ://doi.org /10.1038 /jcbfm.2014.125
-
(2014)
J. Cereb. Blood Flow Metab
, vol.34
, pp. 1646-1654
-
-
Tanifum, E.A.1
Starosolski, Z.A.2
Fowler, S.W.3
Jankowsky, J.L.4
Annapragada, A.V.5
-
161
-
-
84867608942
-
The genetics of Alzheimer disease
-
Tanzi, R.E. 2012. The genetics of Alzheimer disease. Cold Spring Harb. Perspect. Med. 2:a006296. https ://doi.org /10.1101 /cshperspect.a006296
-
(2012)
Cold Spring Harb. Perspect. Med
, vol.2
-
-
Tanzi, R.E.1
-
162
-
-
84938949776
-
Clearance systems in the brain-implications for Alzheimer disease
-
Tarasoff-Conway, J.M., R.O. Carare, R.S. Osorio, L. Glodzik, T. Butler, E. Fieremans, L. Axel, H. Rusinek, C. Nicholson, B.V. Zlokovic, et al. 2015. Clearance systems in the brain-implications for Alzheimer disease. Nat. Rev. Neurol. 11:457-470. https ://doi.org /10.1038 /nrneurol.2015.119
-
(2015)
Nat. Rev. Neurol
, vol.11
, pp. 457-470
-
-
Tarasoff-Conway, J.M.1
Carare, R.O.2
Osorio, R.S.3
Glodzik, L.4
Butler, T.5
Fieremans, E.6
Axel, L.7
Rusinek, H.8
Nicholson, C.9
Zlokovic, B.V.10
-
163
-
-
74949100133
-
APOE epsilon4 genotype and longitudinal changes in cerebral blood flow in normal aging
-
Thambisetty, M., L. Beason-Held, Y. An, M.A. Kraut, and S.M. Resnick. 2010. APOE epsilon4 genotype and longitudinal changes in cerebral blood flow in normal aging. Arch. Neurol. 67:93-98. https ://doi.org /10.1001 /archneurol.2009.913
-
(2010)
Arch. Neurol
, vol.67
, pp. 93-98
-
-
Thambisetty, M.1
Beason-Held, L.2
An, Y.3
Kraut, M.A.4
Resnick, S.M.5
-
164
-
-
85005896391
-
Clinical and multimodal biomarker correlates of ADNI neuropathological findings
-
Toledo, J.B., N.J. Cairns, X. Da, K. Chen, D. Carter, A. Fleisher, E. Householder, N. Ayutyanont, A. Roontiva, R.J. Bauer, et al. Alzheimer's Disease Neuroimaging Initiative (ADNI). 2013. Clinical and multimodal biomarker correlates of ADNI neuropathological findings. Acta Neuropathol. Commun. 1:65. https ://doi.org /10.1186 /2051-5960-1-65
-
(2013)
Acta Neuropathol. Commun
, vol.1
, pp. 65
-
-
Toledo, J.B.1
Cairns, N.J.2
Da, X.3
Chen, K.4
Carter, D.5
Fleisher, A.6
Householder, E.7
Ayutyanont, N.8
Roontiva, A.9
Bauer, R.J.10
-
165
-
-
3442894794
-
Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model
-
Ujiie, M., D.L. Dickstein, D.A. Carlow, and W.A. Jefferies. 2003. Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model. Microcirculation. 10:463-470. https ://doi.org /10.1038 /sj.mn.7800212
-
(2003)
Microcirculation
, vol.10
, pp. 463-470
-
-
Ujiie, M.1
Dickstein, D.L.2
Carlow, D.A.3
Jefferies, W.A.4
-
166
-
-
84863393540
-
Blood-brain barrier P-glycoprotein function in Alzheimer's disease
-
van Assema, D.M.E., M. Lubberink, M. Bauer, W.M. van der Flier, R.C. Schuit, A.D. Windhorst, E.F.I. Comans, N.J. Hoetjes, N. Tolboom, O. Langer, et al. 2012. Blood-brain barrier P-glycoprotein function in Alzheimer's disease. Brain. 135:181-189. https ://doi.org /10.1093 /brain /awr298
-
(2012)
Brain
, vol.135
, pp. 181-189
-
-
van Assema, D.M.E.1
Lubberink, M.2
Bauer, M.3
van der Flier, W.M.4
Schuit, R.C.5
Windhorst, A.D.6
Comans, E.F.I.7
Hoetjes, N.J.8
Tolboom, N.9
Langer, O.10
-
167
-
-
84992111543
-
Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease
-
van de Haar, H.J., S. Burgmans, J.F.A. Jansen, M.J.P. van Osch, M.A. van Buchem, M. Muller, P.A.M. Hofman, F.R.J. Verhey, and W.H. Backes. 2016a. Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease. Radiology. 281:527-535. https ://doi.org /10.1148 /radiol.2016152244
-
(2016)
Radiology
, vol.281
, pp. 527-535
-
-
van de Haar, H.J.1
Burgmans, S.2
Jansen, J.F.A.3
van Osch, M.J.P.4
van Buchem, M.A.5
Muller, M.6
Hofman, P.A.M.7
Verhey, F.R.J.8
Backes, W.H.9
-
168
-
-
84978946283
-
Neurovascular unit impairment in early Alzheimer's disease measured with magnetic resonance imaging
-
van de Haar, H.J., J.F.A. Jansen, M.J.P. van Osch, M.A. van Buchem, M. Muller, S.M. Wong, P.A.M. Hofman, S. Burgmans, F.R.J. Verhey, and W.H. Backes. 2016b. Neurovascular unit impairment in early Alzheimer's disease measured with magnetic resonance imaging. Neurobiol. Aging. 45:190-196. https ://doi.org /10.1016 /j.neurobiolaging.2016.06.006
-
(2016)
Neurobiol. Aging
, vol.45
, pp. 190-196
-
-
van de Haar, H.J.1
Jansen, J.F.A.2
van Osch, M.J.P.3
van Buchem, M.A.4
Muller, M.5
Wong, S.M.6
Hofman, P.A.M.7
Burgmans, S.8
Verhey, F.R.J.9
Backes, W.H.10
-
169
-
-
85022320223
-
Subtle blood-brain barrier leakage rate and spatial extent: Considerations for dynamic contrast-enhanced MRI
-
van de Haar, H.J., J.F.A. Jansen, C.R.L.P.N. Jeukens, S. Burgmans, M.A. van Buchem, M. Muller, P.A.M. Hofman, F.R.J. Verhey, M.J.P. van Osch, and W.H. Backes. 2017. Subtle blood-brain barrier leakage rate and spatial extent: Considerations for dynamic contrast-enhanced MRI. Med. Phys. 44:4112-4125. https ://doi.org /10.1002 /mp.12328
-
(2017)
Med. Phys
, vol.44
, pp. 4112-4125
-
-
van de Haar, H.J.1
Jansen, J.F.A.2
Jeukens, C.R.L.P.N.3
Burgmans, S.4
van Buchem, M.A.5
Muller, M.6
Hofman, P.A.M.7
Verhey, F.R.J.8
van Osch, M.J.P.9
Backes, W.H.10
-
170
-
-
84958225750
-
Functional Characterization of Germline Mutations in PDG FB and PDG FRB in Primary Familial Brain Calcification
-
Vanlandewijck, M., T. Lebouvier, M. Andaloussi Mäe, K. Nahar, S. Hornemann, D. Kenkel, S.I. Cunha, J. Lennartsson, A. Boss, C.-H. Heldin, et al. 2015. Functional Characterization of Germline Mutations in PDG FB and PDG FRB in Primary Familial Brain Calcification. PLoS One. 10:e0143407. https ://doi.org /10.1371 /journal.pone.0143407
-
(2015)
PLoS One
, vol.10
-
-
Vanlandewijck, M.1
Lebouvier, T.2
Andaloussi Mäe, M.3
Nahar, K.4
Hornemann, S.5
Kenkel, D.6
Cunha, S.I.7
Lennartsson, J.8
Boss, A.9
Heldin, C.-H.10
-
171
-
-
79951713725
-
Apolipoprotein E in Alzheimer's disease and other neurological disorders
-
Verghese, P.B., J.M. Castellano, and D.M. Holtzman. 2011. Apolipoprotein E in Alzheimer's disease and other neurological disorders. Lancet Neurol. 10:241-252. https ://doi.org /10.1016 /S1474-4422(10)70325-2
-
(2011)
Lancet Neurol
, vol.10
, pp. 241-252
-
-
Verghese, P.B.1
Castellano, J.M.2
Holtzman, D.M.3
-
172
-
-
0033850218
-
Mutational analysis of GLUT1 (SLC2A1) in Glut-1 deficiency syndrome
-
Wang, D., P. Kranz-Eble, and D.C. De Vivo. 2000. Mutational analysis of GLUT1 (SLC2A1) in Glut-1 deficiency syndrome. Hum. Mutat. 16:224-231. https ://doi.org /10.1002 /1098-1004(200009)16 :3<224::AID-HUMU5>3.0.CO;2-P
-
(2000)
Hum. Mutat
, vol.16
, pp. 224-231
-
-
Wang, D.1
Kranz-Eble, P.2
De Vivo, D.C.3
-
173
-
-
84994665914
-
Resveratrol defends blood-brain barrier integrity in experimental autoimmune encephalomyelitis mice
-
Wang, D., S.-P. Li, J.-S. Fu, S. Zhang, L. Bai, and L. Guo. 2016. Resveratrol defends blood-brain barrier integrity in experimental autoimmune encephalomyelitis mice. J. Neurophysiol. 116:2173-2179. https ://doi.org /10.1152 /jn.00510.2016
-
(2016)
J. Neurophysiol
, vol.116
, pp. 2173-2179
-
-
Wang, D.1
Li, S.-P.2
Fu, J.-S.3
Zhang, S.4
Bai, L.5
Guo, L.6
-
174
-
-
84880391350
-
Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration
-
Wardlaw, J.M., E.E. Smith, G.J. Biessels, C. Cordonnier, F. Fazekas, R. Frayne, R.I. Lindley, J.T. O'Brien, F. Barkhof, O.R. Benavente, et al. STandards for ReportIng Vascular changes on nEuroimaging (STR IVE v1). 2013. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol. 12:822-838. https ://doi.org /10.1016 /S1474-4422(13)70124-8
-
(2013)
Lancet Neurol
, vol.12
, pp. 822-838
-
-
Wardlaw, J.M.1
Smith, E.E.2
Biessels, G.J.3
Cordonnier, C.4
Fazekas, F.5
Frayne, R.6
Lindley, R.I.7
O'Brien, J.T.8
Barkhof, F.9
Benavente, O.R.10
-
175
-
-
84901029497
-
Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models
-
Webster, S.J., A.D. Bachstetter, P.T. Nelson, F.A. Schmitt, and L.J. Van Eldik. 2014. Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models. Front. Genet. 5:88. https ://doi.org /10.3389 /fgene.2014.00088
-
(2014)
Front. Genet
, vol.5
, pp. 88
-
-
Webster, S.J.1
Bachstetter, A.D.2
Nelson, P.T.3
Schmitt, F.A.4
Van Eldik, L.J.5
-
176
-
-
26244458965
-
Selective expression of presenilin 1 in neural progenitor cells rescues the cerebral hemorrhages and cortical lamination defects in presenilin 1-null mutant mice
-
Wen, P.H., R. De Gasperi, M.A.G. Sosa, A.B. Rocher, V.L. Friedrich Jr., P.R. Hof, and G.A. Elder. 2005. Selective expression of presenilin 1 in neural progenitor cells rescues the cerebral hemorrhages and cortical lamination defects in presenilin 1-null mutant mice. Development. 132:3873-3883. https ://doi.org /10.1242 /dev.01946
-
(2005)
Development
, vol.132
, pp. 3873-3883
-
-
Wen, P.H.1
De Gasperi, R.2
Sosa, M.A.G.3
Rocher, A.B.4
Friedrich, V.L.5
Hof, P.R.6
Elder, G.A.7
-
177
-
-
84896520534
-
Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALSmodel mice
-
Winkler, E.A., J.D. Sengillo, A.P. Sagare, Z. Zhao, Q. Ma, E. Zuniga, Y. Wang, Z. Zhong, J.S. Sullivan, J.H. Griffin, et al. 2014. Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALSmodel mice. Proc. Natl. Acad. Sci. USA. 111:E1035-E1042. https ://doi.org /10.1073 /pnas.1401595111
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. E1035-E1042
-
-
Winkler, E.A.1
Sengillo, J.D.2
Sagare, A.P.3
Zhao, Z.4
Ma, Q.5
Zuniga, E.6
Wang, Y.7
Zhong, Z.8
Sullivan, J.S.9
Griffin, J.H.10
-
178
-
-
84925594369
-
GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration
-
Winkler, E.A., Y. Nishida, A.P. Sagare, S.V. Rege, R.D. Bell, D. Perlmutter, J.D. Sengillo, S. Hillman, P. Kong, A.R. Nelson, et al. 2015. GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration. Nat. Neurosci. 18:521-530. https ://doi.org /10.1038 /nn.3966
-
(2015)
Nat. Neurosci
, vol.18
, pp. 521-530
-
-
Winkler, E.A.1
Nishida, Y.2
Sagare, A.P.3
Rege, S.V.4
Bell, R.D.5
Perlmutter, D.6
Sengillo, J.D.7
Hillman, S.8
Kong, P.9
Nelson, A.R.10
-
179
-
-
84866505159
-
Junctional adhesion molecule (JAM)-C deficient C57BL/6 mice develop a severe hydrocephalus
-
Wyss, L., J. Schäfer, S. Liebner, M. Mittelbronn, U. Deutsch, G. Enzmann, R.H. Adams, M. Aurrand-Lions, K.H. Plate, B.A. Imhof, and B. Engelhardt. 2012. Junctional adhesion molecule (JAM)-C deficient C57BL/6 mice develop a severe hydrocephalus. PLoS One. 7:e45619. https ://doi.org /10.1371 /journal.pone.0045619
-
(2012)
PLoS One
, vol.7
-
-
Wyss, L.1
Schäfer, J.2
Liebner, S.3
Mittelbronn, M.4
Deutsch, U.5
Enzmann, G.6
Adams, R.H.7
Aurrand-Lions, M.8
Plate, K.H.9
Imhof, B.A.10
Engelhardt, B.11
-
180
-
-
84885775321
-
Sleep drives metabolite clearance from the adult brain
-
Xie, L., H. Kang, Q. Xu, M.J. Chen, Y. Liao, M. Thiyagarajan, J. O'Donnell, D.J. Christensen, C. Nicholson, J.J. Iliff, et al. 2013. Sleep drives metabolite clearance from the adult brain. Science. 342:373-377. https ://doi.org /10.1126 /science.1241224
-
(2013)
Science
, vol.342
, pp. 373-377
-
-
Xie, L.1
Kang, H.2
Xu, Q.3
Chen, M.J.4
Liao, Y.5
Thiyagarajan, M.6
O'Donnell, J.7
Christensen, D.J.8
Nicholson, C.9
Iliff, J.J.10
-
181
-
-
85018848227
-
Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1
-
Yanagida, K., C.H. Liu, G. Faraco, S. Galvani, H.K. Smith, N. Burg, J. Anrather, T. Sanchez, C. Iadecola, and T. Hla. 2017. Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1. Proc. Natl. Acad. Sci. USA. 114:4531-4536. https ://doi.org /10.1073 /pnas.1618659114
-
(2017)
Proc. Natl. Acad. Sci. USA
, vol.114
, pp. 4531-4536
-
-
Yanagida, K.1
Liu, C.H.2
Faraco, G.3
Galvani, S.4
Smith, H.K.5
Burg, N.6
Anrather, J.7
Sanchez, T.8
Iadecola, C.9
Hla, T.10
-
182
-
-
84902167026
-
Incidence of cerebral microbleeds in preclinical Alzheimer disease
-
Yates, P.A., P.M. Desmond, P.M. Phal, C. Steward, C. Szoeke, O. Salvado, K.A. Ellis, R.N. Martins, C.L. Masters, D. Ames, et al. AIBL Research Group. 2014. Incidence of cerebral microbleeds in preclinical Alzheimer disease. Neurology. 82:1266-1273. https ://doi.org /10.1212 /WNL.0000000000000285
-
(2014)
Neurology
, vol.82
, pp. 1266-1273
-
-
Yates, P.A.1
Desmond, P.M.2
Phal, P.M.3
Steward, C.4
Szoeke, C.5
Salvado, O.6
Ellis, K.A.7
Martins, R.N.8
Masters, C.L.9
Ames, D.10
-
183
-
-
84924565530
-
Brain structure. Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
-
Zeisel, A., A.B. Muñoz-Manchado, S. Codeluppi, P. Lönnerberg, G. La Manno, A. Juréus, S. Marques, H. Munguba, L. He, C. Betsholtz, et al. 2015. Brain structure. Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq. Science. 347:1138-1142. https ://doi.org /10.1126 /science.aaa1934
-
(2015)
Science
, vol.347
, pp. 1138-1142
-
-
Zeisel, A.1
Muñoz-Manchado, A.B.2
Codeluppi, S.3
Lönnerberg, P.4
La Manno, G.5
Juréus, A.6
Marques, S.7
Munguba, H.8
He, L.9
Betsholtz, C.10
-
184
-
-
84939000054
-
Neutrophils promote Alzheimer's disease-like pathology and cognitive decline via LFA-1 integrin
-
Zenaro, E., E. Pietronigro, V. Della Bianca, G. Piacentino, L. Marongiu, S. Budui, E. Turano, B. Rossi, S. Angiari, S. Dusi, et al. 2015. Neutrophils promote Alzheimer's disease-like pathology and cognitive decline via LFA-1 integrin. Nat. Med. 21:880-886. https ://doi.org /10.1038 /nm.3913
-
(2015)
Nat. Med
, vol.21
, pp. 880-886
-
-
Zenaro, E.1
Pietronigro, E.2
Della Bianca, V.3
Piacentino, G.4
Marongiu, L.5
Budui, S.6
Turano, E.7
Rossi, B.8
Angiari, S.9
Dusi, S.10
-
185
-
-
84900992748
-
Blood-brain barrier: a dual life of MFSD2A?
-
Zhao, Z., and B.V. Zlokovic. 2014. Blood-brain barrier: a dual life of MFSD2A? Neuron. 82:728-730. https ://doi.org /10.1016 /j.neuron.2014.05.012
-
(2014)
Neuron
, vol.82
, pp. 728-730
-
-
Zhao, Z.1
Zlokovic, B.V.2
-
186
-
-
84947901598
-
Establishment and Dysfunction of the Blood-Brain Barrier
-
Zhao, Z., A.R. Nelson, C. Betsholtz, and B.V. Zlokovic. 2015a. Establishment and Dysfunction of the Blood-Brain Barrier. Cell. 163:1064-1078. https ://doi.org /10.1016 /j.cell.2015.10.067
-
(2015)
Cell
, vol.163
, pp. 1064-1078
-
-
Zhao, Z.1
Nelson, A.R.2
Betsholtz, C.3
Zlokovic, B.V.4
-
187
-
-
84933277693
-
Central role for PIC ALM in amyloid-β blood-brain barrier transcytosis and clearance
-
Zhao, Z., A.P. Sagare, Q. Ma, M.R. Halliday, P. Kong, K. Kisler, E.A. Winkler, A. Ramanathan, T. Kanekiyo, G. Bu, et al. 2015b. Central role for PIC ALM in amyloid-β blood-brain barrier transcytosis and clearance. Nat. Neurosci. 18:978-987. https ://doi.org /10.1038 /nn.4025
-
(2015)
Nat. Neurosci
, vol.18
, pp. 978-987
-
-
Zhao, Z.1
Sagare, A.P.2
Ma, Q.3
Halliday, M.R.4
Kong, P.5
Kisler, K.6
Winkler, E.A.7
Ramanathan, A.8
Kanekiyo, T.9
Bu, G.10
-
188
-
-
41149097086
-
ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration
-
Zhong, Z., R. Deane, Z. Ali, M. Parisi, Y. Shapovalov, M.K. O'Banion, K. Stojanovic, A. Sagare, S. Boillee, D.W. Cleveland, and B.V. Zlokovic. 2008. ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nat. Neurosci. 11:420-422. https ://doi.org /10.1038 /nn2073
-
(2008)
Nat. Neurosci
, vol.11
, pp. 420-422
-
-
Zhong, Z.1
Deane, R.2
Ali, Z.3
Parisi, M.4
Shapovalov, Y.5
O'Banion, M.K.6
Stojanovic, K.7
Sagare, A.8
Boillee, S.9
Cleveland, D.W.10
Zlokovic, B.V.11
-
189
-
-
70449433875
-
Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells
-
Zhong, Z., H. Ilieva, L. Hallagan, R. Bell, I. Singh, N. Paquette, M. Thiyagarajan, R. Deane, J.A. Fernandez, S. Lane, et al. 2009. Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. J. Clin. Invest. 119:3437-3449
-
(2009)
J. Clin. Invest
, vol.119
, pp. 3437-3449
-
-
Zhong, Z.1
Ilieva, H.2
Hallagan, L.3
Bell, R.4
Singh, I.5
Paquette, N.6
Thiyagarajan, M.7
Deane, R.8
Fernandez, J.A.9
Lane, S.10
-
190
-
-
34247343262
-
Microvascular injury and blood-brain barrier leakage in Alzheimer's disease
-
Zipser, B.D., C.E. Johanson, L. Gonzalez, T.M. Berzin, R. Tavares, C.M. Hulette, M.P. Vitek, V. Hovanesian, and E.G. Stopa. 2007. Microvascular injury and blood-brain barrier leakage in Alzheimer's disease. Neurobiol. Aging. 28:977-986. https ://doi.org /10.1016 /j.neurobiolaging.2006.05.016
-
(2007)
Neurobiol. Aging
, vol.28
, pp. 977-986
-
-
Zipser, B.D.1
Johanson, C.E.2
Gonzalez, L.3
Berzin, T.M.4
Tavares, R.5
Hulette, C.M.6
Vitek, M.P.7
Hovanesian, V.8
Stopa, E.G.9
-
191
-
-
38149090292
-
The blood-brain barrier in health and chronic neurodegenerative disorders
-
Zlokovic, B.V. 2008. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron. 57:178-201. https ://doi.org /10.1016 /j.neuron.2008.01.003
-
(2008)
Neuron
, vol.57
, pp. 178-201
-
-
Zlokovic, B.V.1
-
192
-
-
81555200043
-
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
-
Zlokovic, B.V. 2011. Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat. Rev. Neurosci. 12:723-738
-
(2011)
Nat. Rev. Neurosci
, vol.12
, pp. 723-738
-
-
Zlokovic, B.V.1
-
193
-
-
84876136764
-
Cerebrovascular effects of apolipoprotein E: implications for Alzheimer disease
-
Zlokovic, B.V. 2013. Cerebrovascular effects of apolipoprotein E: implications for Alzheimer disease. JAMA Neurol. 70:440-444. https ://doi.org /10.1001 /jamaneurol.2013.2152
-
(2013)
JAMA Neurol
, vol.70
, pp. 440-444
-
-
Zlokovic, B.V.1
-
194
-
-
79953161072
-
Cytoprotective protein C pathways and implications for stroke and neurological disorders
-
Zlokovic, B.V., and J.H. Griffin. 2011. Cytoprotective protein C pathways and implications for stroke and neurological disorders. Trends Neurosci. 34:198-209. https ://doi.org /10.1016 /j.tins.2011.01.005
-
(2011)
Trends Neurosci
, vol.34
, pp. 198-209
-
-
Zlokovic, B.V.1
Griffin, J.H.2
-
195
-
-
84895830747
-
Prevalence of cortical superficial siderosis in a memory clinic population
-
Zonneveld, H.I., J.D.C. Goos, M.P. Wattjes, N.D. Prins, P. Scheltens, W.M. van der Flier, J.P.A. Kuijer, M. Muller, and F. Barkhof. 2014. Prevalence of cortical superficial siderosis in a memory clinic population. Neurology. 82:698-704. https ://doi.org /10.1212 /WNL.0000000000000150
-
(2014)
Neurology
, vol.82
, pp. 698-704
-
-
Zonneveld, H.I.1
Goos, J.D.C.2
Wattjes, M.P.3
Prins, N.D.4
Scheltens, P.5
van der Flier, W.M.6
Kuijer, J.P.A.7
Muller, M.8
Barkhof, F.9
|