Selective expression of presenilin 1 in neural progenitor cells rescues the cerebral hemorrhages and cortical lamination defects in presenilin 1-null mutant mice

Development

Volumn 132, Issue 17, 2005, Pages 3873-3883

  Wen, Paul H ^a,b   De Gasperi, Rita ^a,b   Gama Sosa, Miguel A ^a,b   Rocher, Anne B ^a   Friedrich Jr , Victor L ^a   Hof, Patrick R ^a   Elder, Gregory A ^a,b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

CNS hemorrhages; Cortical development; Familial Alzheimer's disease; Neural progenitor cells; Presenilin 1 (PS1. Psent1); Transgenic mice; Vascular development

Indexed keywords

NESTIN; PRESENILIN 1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN BLOOD VESSEL; BRAIN CORTEX LESION; BRAIN DEVELOPMENT; BRAIN HEMORRHAGE; BRAIN NERVE CELL; CAUSE OF DEATH; CELL MIGRATION; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; EMBRYO; EMBRYO MORTALITY; ENDOTHELIUM CELL; ENHANCER REGION; GENE EXPRESSION; INTRON; MOUSE; MOUSE MUTANT; NEOCORTEX; NEURAL STEM CELL; NEUROECTODERM; NONHUMAN; PRIORITY JOURNAL; TELENCEPHALON; TRANSGENE; VASCULAR ENDOTHELIUM;

ANIMALS; CELL MOVEMENT; CEREBRAL CORTEX; CEREBRAL HEMORRHAGE; EMBRYO; EMBRYO LOSS; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; INTERMEDIATE FILAMENT PROTEINS; INTRONS; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; NEURONS; PRESENILIN-1; RATS; STEM CELLS; TELENCEPHALON;

ANIMALIA; MUS MUSCULUS;

EID: 26244458965     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.01946     Document Type: Article

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