메뉴 건너뛰기




Volumn 36, Issue 2, 2016, Pages 181-194

Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases

Author keywords

Cerebrospinal fluid; Cerebrovascular basement membranes; Interstitial fluid; Paravascular; Perivascular

Indexed keywords

AMYLOID BETA PROTEIN; AQUAPORIN 1; AQUAPORIN 4; GLYCOSAMINOGLYCAN; N ACETYLGALACTOSAMINE; N ACETYLGLUCOSAMINE;

EID: 84961216596     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-015-0273-8     Document Type: Review
Times cited : (287)

References (91)
  • 1
    • 2942623871 scopus 로고    scopus 로고
    • Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology
    • COI: 1:CAS:528:DC%2BD2cXks12qurk%3D, PID: 15186921
    • Abbott NJ (2004) Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology. Neurochem Int 45(4):545–552
    • (2004) Neurochem Int , vol.45 , Issue.4 , pp. 545-552
    • Abbott, N.J.1
  • 2
    • 84877747508 scopus 로고    scopus 로고
    • Blood–brain barrier structure and function and the challenges for CNS drug delivery
    • COI: 1:CAS:528:DC%2BC3sXnsFGis7w%3D, PID: 23609350
    • Abbott NJ (2013) Blood–brain barrier structure and function and the challenges for CNS drug delivery. J Inherit Metab Dis 36(3):437–449
    • (2013) J Inherit Metab Dis , vol.36 , Issue.3 , pp. 437-449
    • Abbott, N.J.1
  • 3
    • 0023912551 scopus 로고
    • The cranial arachnoid and pia mater in man: anatomical and ultrastructural observations
    • COI: 1:STN:280:DyaL1c3jtlWmtQ%3D%3D, PID: 3374751
    • Alcolado R, Weller R, Parrish E, Garrod D (1988) The cranial arachnoid and pia mater in man: anatomical and ultrastructural observations. Neuropathol Appl Neurobiol 14(1):1–17
    • (1988) Neuropathol Appl Neurobiol , vol.14 , Issue.1 , pp. 1-17
    • Alcolado, R.1    Weller, R.2    Parrish, E.3    Garrod, D.4
  • 5
    • 0023182521 scopus 로고
    • Nerve fibres and their terminals of the dura mater encephali of the rat
    • COI: 1:STN:280:DyaL2s7lsVersA%3D%3D, PID: 3826655
    • Andres K, Von Düring M, Muszynski K, Schmidt R (1987) Nerve fibres and their terminals of the dura mater encephali of the rat. Anat Embryol 175(3):289–301
    • (1987) Anat Embryol , vol.175 , Issue.3 , pp. 289-301
    • Andres, K.1    Von Düring, M.2    Muszynski, K.3    Schmidt, R.4
  • 9
    • 34247506244 scopus 로고    scopus 로고
    • Transport pathways for clearance of human Alzheimer’s amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system
    • COI: 1:CAS:528:DC%2BD2sXlvVSktro%3D, PID: 17077814
    • Bell RD, Sagare AP, Friedman AE, Bedi GS, Holtzman DM, Deane R, Zlokovic BV (2007) Transport pathways for clearance of human Alzheimer’s amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system. J Cereb Blood Flow Metab 27:909–918
    • (2007) J Cereb Blood Flow Metab , vol.27 , pp. 909-918
    • Bell, R.D.1    Sagare, A.P.2    Friedman, A.E.3    Bedi, G.S.4    Holtzman, D.M.5    Deane, R.6    Zlokovic, B.V.7
  • 10
    • 78049279739 scopus 로고    scopus 로고
    • Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging
    • COI: 1:CAS:528:DC%2BC3cXhtlKkt7vJ, PID: 21040844
    • Bell RD, Winkler EA, Sagare AP, Singh I, LaRue B, Deane R, Zlokovic BV (2010) Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron 68(3):409
    • (2010) Neuron , vol.68 , Issue.3 , pp. 409
    • Bell, R.D.1    Winkler, E.A.2    Sagare, A.P.3    Singh, I.4    LaRue, B.5    Deane, R.6    Zlokovic, B.V.7
  • 11
    • 77950647447 scopus 로고    scopus 로고
    • The influence of the relative timing of arterial and subarachnoid space pulse waves on spinal perivascular cerebrospinal fluid flow as a possible factor in syrinx development: laboratory investigation
    • PID: 19522574
    • Bilston LE, Stoodley MA, Fletcher DF (2010) The influence of the relative timing of arterial and subarachnoid space pulse waves on spinal perivascular cerebrospinal fluid flow as a possible factor in syrinx development: laboratory investigation. J Neurosurg 112(4):808–813
    • (2010) J Neurosurg , vol.112 , Issue.4 , pp. 808-813
    • Bilston, L.E.1    Stoodley, M.A.2    Fletcher, D.F.3
  • 12
    • 0034830873 scopus 로고    scopus 로고
    • Spinal and cranial contributions to total cerebrospinal fluid transport
    • COI: 1:CAS:528:DC%2BD3MXmvFWjurg%3D, PID: 11507008
    • Bozanovic-Sosic R, Mollanji R, Johnston MG (2001) Spinal and cranial contributions to total cerebrospinal fluid transport. Am J Physiol Regul Integr Comp Physiol 281:R909–R916
    • (2001) Am J Physiol Regul Integr Comp Physiol , vol.281 , pp. R909-R916
    • Bozanovic-Sosic, R.1    Mollanji, R.2    Johnston, M.G.3
  • 14
    • 84900033899 scopus 로고    scopus 로고
    • A new look at cerebrospinal fluid circulation
    • PID: 24817998
    • Brinker T, Stopa E, Morrison J, Klinge P (2014) A new look at cerebrospinal fluid circulation. Fluids Barriers CNS 11:10. doi:10.1186/2045-8118-11-10
    • (2014) Fluids Barriers CNS , vol.11 , pp. 10
    • Brinker, T.1    Stopa, E.2    Morrison, J.3    Klinge, P.4
  • 15
    • 40149099870 scopus 로고    scopus 로고
    • Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology
    • COI: 1:STN:280:DC%2BD1c7kslaqsA%3D%3D, PID: 18208483
    • Carare R, Bernardes-Silva M, Newman T, Page A, Nicoll J, Perry V, Weller R (2008) Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology. Neuropathol Appl Neurobiol 34(2):131–144
    • (2008) Neuropathol Appl Neurobiol , vol.34 , Issue.2 , pp. 131-144
    • Carare, R.1    Bernardes-Silva, M.2    Newman, T.3    Page, A.4    Nicoll, J.5    Perry, V.6    Weller, R.7
  • 18
    • 0017692459 scopus 로고
    • Flow of cerebral interstitial fluid as indicated by the removal of extracellular markers from rat caudate nucleus
    • PID: 590401
    • Cserr HF, Cooper D, Milhorat T (1977) Flow of cerebral interstitial fluid as indicated by the removal of extracellular markers from rat caudate nucleus. Exp Eye Res 25:461–473
    • (1977) Exp Eye Res , vol.25 , pp. 461-473
    • Cserr, H.F.1    Cooper, D.2    Milhorat, T.3
  • 19
    • 0019556901 scopus 로고
    • Efflux of radiolabeled polyethylene glycols and albumin from rat brain
    • COI: 1:CAS:528:DyaL3MXhslWltLs%3D
    • Cserr H, Cooper D, Suri P, Patlak C (1981) Efflux of radiolabeled polyethylene glycols and albumin from rat brain. Am J Physiol Ren Physiol 240(4):F319–F328
    • (1981) Am J Physiol Ren Physiol , vol.240 , Issue.4 , pp. F319-F328
    • Cserr, H.1    Cooper, D.2    Suri, P.3    Patlak, C.4
  • 20
    • 84885730661 scopus 로고    scopus 로고
    • Cerebrospinal fluid secretion by the choroid plexus
    • COI: 1:CAS:528:DC%2BC3sXhvVShtrvO, PID: 24137023
    • Damkier HH, Brown PD, Praetorius J (2013) Cerebrospinal fluid secretion by the choroid plexus. Physiol Rev 93(4):1847–1892. doi:10.1152/physrev.00004.2013
    • (2013) Physiol Rev , vol.93 , Issue.4 , pp. 1847-1892
    • Damkier, H.H.1    Brown, P.D.2    Praetorius, J.3
  • 21
    • 4644292545 scopus 로고    scopus 로고
    • Potential role of ABC transporters as a detoxification system at the blood-CSF barrier
    • PID: 15381334
    • de Lange EC (2004) Potential role of ABC transporters as a detoxification system at the blood-CSF barrier. Adv Drug Deliv Rev 56(12):1793–1809. doi:10.1016/j.addr.2004.07.009
    • (2004) Adv Drug Deliv Rev , vol.56 , Issue.12 , pp. 1793-1809
    • de Lange, E.C.1
  • 22
    • 0001588139 scopus 로고
    • Movement of the cerebrospinal fluid in human beings
    • Di Chiro G (1964) Movement of the cerebrospinal fluid in human beings. Nature (Lond) 204:290–291
    • (1964) Nature (Lond) , vol.204 , pp. 290-291
    • Di Chiro, G.1
  • 23
    • 80051762728 scopus 로고    scopus 로고
    • Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle
    • Engelhardt B, Coisne C (2011) Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle. Fluids Barriers CNS 8(4):10–1186
    • (2011) Fluids Barriers CNS , vol.8 , Issue.4 , pp. 10-1186
    • Engelhardt, B.1    Coisne, C.2
  • 24
    • 0027361074 scopus 로고
    • Cerebrospinal fluid flow measured by phase-contrast cine MR
    • COI: 1:STN:280:DyaK2c7gs1emuw%3D%3D, PID: 8279323
    • Enzmann DR, Pelc N (1993) Cerebrospinal fluid flow measured by phase-contrast cine MR. Am J Neuroradiol 14(6):1301–1307
    • (1993) Am J Neuroradiol , vol.14 , Issue.6 , pp. 1301-1307
    • Enzmann, D.R.1    Pelc, N.2
  • 25
    • 84964461338 scopus 로고    scopus 로고
    • Harding B, Copp A (2008) Malformations
    • Harding B, Copp A (2008) Malformations
  • 26
    • 79954623282 scopus 로고    scopus 로고
    • Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy
    • PID: 21259015
    • Hawkes CA, Härtig W, Kacza J, Schliebs R, Weller RO, Nicoll JA, Carare RO (2011) Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy. Acta Neuropathol 121(4):431–443
    • (2011) Acta Neuropathol , vol.121 , Issue.4 , pp. 431-443
    • Hawkes, C.A.1    Härtig, W.2    Kacza, J.3    Schliebs, R.4    Weller, R.O.5    Nicoll, J.A.6    Carare, R.O.7
  • 27
    • 84902687106 scopus 로고    scopus 로고
    • Failure of perivascular drainage of beta-amyloid in cerebral amyloid angiopathy
    • COI: 1:CAS:528:DC%2BC2cXhtVahtLnN, PID: 24946077
    • Hawkes CA, Jayakody N, Johnston DA, Bechmann I, Carare RO (2014) Failure of perivascular drainage of beta-amyloid in cerebral amyloid angiopathy. Brain Pathol 24(4):396–403. doi:10.1111/bpa.12159
    • (2014) Brain Pathol , vol.24 , Issue.4 , pp. 396-403
    • Hawkes, C.A.1    Jayakody, N.2    Johnston, D.A.3    Bechmann, I.4    Carare, R.O.5
  • 28
    • 84924273728 scopus 로고    scopus 로고
    • Mechanisms of fluid movement into, through and out of the brain: evaluation of the evidence
    • Hladky SB, Barrand MA (2014) Mechanisms of fluid movement into, through and out of the brain: evaluation of the evidence. Fluids Barriers CNS 11(1):1–32
    • (2014) Fluids Barriers CNS , vol.11 , Issue.1 , pp. 1-32
    • Hladky, S.B.1    Barrand, M.A.2
  • 29
    • 2942534217 scopus 로고    scopus 로고
    • Contribution of dead-space microdomains to tortuosity of brain extracellular space
    • PID: 15186912
    • Hrabětová S, Nicholson C (2004) Contribution of dead-space microdomains to tortuosity of brain extracellular space. Neurochem Int 45(4):467–477
    • (2004) Neurochem Int , vol.45 , Issue.4 , pp. 467-477
    • Hrabětová, S.1    Nicholson, C.2
  • 30
    • 18244420652 scopus 로고    scopus 로고
    • Dead-space microdomains hinder extracellular diffusion in rat neocortex during ischemia
    • COI: 1:CAS:528:DC%2BD3sXnsVGgu7k%3D, PID: 12967997
    • Hrabetova S, Hrabe J, Nicholson C (2003) Dead-space microdomains hinder extracellular diffusion in rat neocortex during ischemia. J Neurosci 23(23):8351–8359
    • (2003) J Neurosci , vol.23 , Issue.23 , pp. 8351-8359
    • Hrabetova, S.1    Hrabe, J.2    Nicholson, C.3
  • 31
    • 0025729615 scopus 로고
    • Distribution of extracellular tracers in perivascular spaces of the rat brain
    • COI: 1:STN:280:DyaK3Mzhs1Glsg%3D%3D, PID: 1713524
    • Ichimura T, Fraser PA, Cserr HF (1991) Distribution of extracellular tracers in perivascular spaces of the rat brain. Brain Res 545(1–2):103–113
    • (1991) Brain Res , vol.545 , Issue.1-2 , pp. 103-113
    • Ichimura, T.1    Fraser, P.A.2    Cserr, H.F.3
  • 33
    • 84874637845 scopus 로고    scopus 로고
    • Brain-wide pathway for waste clearance captured by contrast-enhanced MRI
    • COI: 1:CAS:528:DC%2BC3sXjvVyht7s%3D, PID: 23434588
    • Iliff JJ, Lee H, Yu M, Feng T, Logan J, Nedergaard M, Benveniste H (2013a) Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. J Clin Investig 123(3):1299–1309. doi:10.1172/JCI67677
    • (2013) J Clin Investig , vol.123 , Issue.3 , pp. 1299-1309
    • Iliff, J.J.1    Lee, H.2    Yu, M.3    Feng, T.4    Logan, J.5    Nedergaard, M.6    Benveniste, H.7
  • 34
    • 84887399490 scopus 로고    scopus 로고
    • Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain
    • COI: 1:CAS:528:DC%2BC3sXhvVWmu7%2FF, PID: 24227727
    • Iliff JJ, Wang M, Zeppenfeld DM, Venkataraman A, Plog BA, Liao Y, Deane R, Nedergaard M (2013b) Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain. J Neurosci 33(46):18190–18199. doi:10.1523/JNEUROSCI.1592-13.2013
    • (2013) J Neurosci , vol.33 , Issue.46 , pp. 18190-18199
    • Iliff, J.J.1    Wang, M.2    Zeppenfeld, D.M.3    Venkataraman, A.4    Plog, B.A.5    Liao, Y.6    Deane, R.7    Nedergaard, M.8
  • 35
    • 33749414503 scopus 로고    scopus 로고
    • Evidence of connections between cerebrospinal fluid and nasal lymphatic vessels in humans, non-human primates and other mammalian species
    • PID: 15679948
    • Johnston M, Zakharov A, Papaiconomou C, Salmasi G, Armstrong D (2004) Evidence of connections between cerebrospinal fluid and nasal lymphatic vessels in humans, non-human primates and other mammalian species. Cerebrospinal fluid research 1(1):2. doi:10.1186/1743-8454-1-2
    • (2004) Cerebrospinal fluid research , vol.1 , Issue.1 , pp. 2
    • Johnston, M.1    Zakharov, A.2    Papaiconomou, C.3    Salmasi, G.4    Armstrong, D.5
  • 36
    • 0027740941 scopus 로고
    • CSF drains directly from the subarachnoid space into nasal lymphatics in the rat. Anatomy, histology and immunological significance
    • COI: 1:STN:280:DyaK2c7ms12gug%3D%3D, PID: 7510047
    • Kida S, Pantazis A, Weller R (1993) CSF drains directly from the subarachnoid space into nasal lymphatics in the rat. Anatomy, histology and immunological significance. Neuropathol Appl Neurobiol 19(6):480–488
    • (1993) Neuropathol Appl Neurobiol , vol.19 , Issue.6 , pp. 480-488
    • Kida, S.1    Pantazis, A.2    Weller, R.3
  • 38
    • 84862903745 scopus 로고    scopus 로고
    • The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles
    • Lacolley P, Regnault V, Nicoletti A, Li Z, Michel J-B (2012) The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles. Cardiovasc Res. doi:10.1093/cvr/cvs135
    • (2012) Cardiovasc Res
    • Lacolley, P.1    Regnault, V.2    Nicoletti, A.3    Li, Z.4    Michel, J.-B.5
  • 39
    • 0028964629 scopus 로고
    • Morphology of cerebral arteries
    • COI: 1:CAS:528:DyaK2MXoslCnt7Y%3D, PID: 7630927
    • Lee RM (1995) Morphology of cerebral arteries. Pharmacol Ther 66(1):149–173
    • (1995) Pharmacol Ther , vol.66 , Issue.1 , pp. 149-173
    • Lee, R.M.1
  • 40
    • 67349209590 scopus 로고    scopus 로고
    • Aquaporin-4 maintains ependymal integrity in adult mice
    • COI: 1:CAS:528:DC%2BD1MXmvFymu7g%3D, PID: 19393298
    • Li X, Kong H, Wu W, Xiao M, Sun X, Hu G (2009) Aquaporin-4 maintains ependymal integrity in adult mice. Neuroscience 162(1):67–77. doi:10.1016/j.neuroscience.2009.04.044
    • (2009) Neuroscience , vol.162 , Issue.1 , pp. 67-77
    • Li, X.1    Kong, H.2    Wu, W.3    Xiao, M.4    Sun, X.5    Hu, G.6
  • 42
    • 57049154231 scopus 로고    scopus 로고
    • Ageing and dementia
    • Love S, Louis DN, Ellison DW, (eds), 1, Hodder Arnold, London
    • Lowe J, Mirra SS, Hyman BT, Dickson DW (2008) Ageing and dementia. In: Love S, Louis DN, Ellison DW (eds) Greenfield’s neuropathology, vol 1, 8th edn. Hodder Arnold, London, pp 1031–1152
    • (2008) Greenfield’s neuropathology , pp. 1031-1152
    • Lowe, J.1    Mirra, S.S.2    Hyman, B.T.3    Dickson, D.W.4
  • 44
    • 84887611153 scopus 로고    scopus 로고
    • Real-time in vivo imaging reveals the ability of monocytes to clear vascular amyloid beta
    • COI: 1:CAS:528:DC%2BC3sXhslCltLbL, PID: 24210819
    • Michaud JP, Bellavance MA, Prefontaine P, Rivest S (2013) Real-time in vivo imaging reveals the ability of monocytes to clear vascular amyloid beta. Cell Rep 5(3):646–653. doi:10.1016/j.celrep.2013.10.010
    • (2013) Cell Rep , vol.5 , Issue.3 , pp. 646-653
    • Michaud, J.P.1    Bellavance, M.A.2    Prefontaine, P.3    Rivest, S.4
  • 45
    • 0016763145 scopus 로고
    • The third circulation revisited
    • COI: 1:STN:280:DyaE2M7ptFWnsw%3D%3D, PID: 167134
    • Milhorat TH (1975) The third circulation revisited. J Neurosurg 42:628–642
    • (1975) J Neurosurg , vol.42 , pp. 628-642
    • Milhorat, T.H.1
  • 47
    • 84907222721 scopus 로고    scopus 로고
    • The cerebrovascular basement membrane: role in the clearance of β-amyloid and cerebral amyloid angiopathy
    • Morris AW, Carare RO, Schreiber S, Hawkes CA (2014) The cerebrovascular basement membrane: role in the clearance of β-amyloid and cerebral amyloid angiopathy. Frontiers in aging neuroscience 6
    • (2014) Frontiers in aging neuroscience , pp. 6
    • Morris, A.W.1    Carare, R.O.2    Schreiber, S.3    Hawkes, C.A.4
  • 49
    • 84885754029 scopus 로고    scopus 로고
    • Physiological roles of aquaporin-4 in brain
    • COI: 1:CAS:528:DC%2BC3sXhvVShtr3F, PID: 24137016
    • Nagelhus EA, Ottersen OP (2013) Physiological roles of aquaporin-4 in brain. Physiol Rev 93(4):1543–1562
    • (2013) Physiol Rev , vol.93 , Issue.4 , pp. 1543-1562
    • Nagelhus, E.A.1    Ottersen, O.P.2
  • 50
    • 33751161062 scopus 로고    scopus 로고
    • Quantification of cerebrospinal fluid transport across the cribriform plate into lymphatics in rats
    • COI: 1:CAS:528:DC%2BD28Xht1GnsbvL, PID: 16793937
    • Nagra G, Koh L, Zakharov A, Armstrong D, Johnston M (2006) Quantification of cerebrospinal fluid transport across the cribriform plate into lymphatics in rats. Am J Physiol Regul Integr Comp Physiol 291(5):R1383–R1389. doi:10.1152/ajpregu.00235.2006
    • (2006) Am J Physiol Regul Integr Comp Physiol , vol.291 , Issue.5 , pp. R1383-R1389
    • Nagra, G.1    Koh, L.2    Zakharov, A.3    Armstrong, D.4    Johnston, M.5
  • 51
    • 0027080279 scopus 로고
    • Quantitative analysis of extracellular space using the method of TMA+ iontophoresis and the issue of TMA + uptake
    • COI: 1:CAS:528:DyaK3sXjsFentQ%3D%3D, PID: 1295682
    • Nicholson C (1992) Quantitative analysis of extracellular space using the method of TMA+ iontophoresis and the issue of TMA + uptake. Can J Physiol Pharmacol 70(Suppl):S314–S322
    • (1992) Can J Physiol Pharmacol , vol.70 , pp. S314-S322
    • Nicholson, C.1
  • 52
    • 84871745687 scopus 로고    scopus 로고
    • Brain extracellular space as a diffusion barrier
    • PID: 23172993
    • Nicholson C, Kamali-Zare P, Tao L (2011) Brain extracellular space as a diffusion barrier. Comput Vis Sci 14(7):309–325
    • (2011) Comput Vis Sci , vol.14 , Issue.7 , pp. 309-325
    • Nicholson, C.1    Kamali-Zare, P.2    Tao, L.3
  • 53
    • 0026583226 scopus 로고
    • Circadian variation in human cerebrospinal fluid production measured by magnetic resonance imaging
    • COI: 1:STN:280:DyaK387isFGksg%3D%3D, PID: 1733335
    • Nilsson C, Stahlberg F, Thomsen C, Henriksen O, Herning M, Owman C (1992) Circadian variation in human cerebrospinal fluid production measured by magnetic resonance imaging. Am J Physiol 262(1 Pt 2):R20–R24
    • (1992) Am J Physiol , vol.262 , pp. R20-R24
    • Nilsson, C.1    Stahlberg, F.2    Thomsen, C.3    Henriksen, O.4    Herning, M.5    Owman, C.6
  • 55
    • 84906825339 scopus 로고    scopus 로고
    • Evidence for lymphatic Abeta clearance in Alzheimer’s transgenic mice
    • COI: 1:CAS:528:DC%2BC2cXhtlCjt77O, PID: 25102344
    • Pappolla M, Sambamurti K, Vidal R, Pacheco-Quinto J, Poeggeler B, Matsubara E (2014) Evidence for lymphatic Abeta clearance in Alzheimer’s transgenic mice. Neurobiol Dis 71:215–219. doi:10.1016/j.nbd.2014.07.012
    • (2014) Neurobiol Dis , vol.71 , pp. 215-219
    • Pappolla, M.1    Sambamurti, K.2    Vidal, R.3    Pacheco-Quinto, J.4    Poeggeler, B.5    Matsubara, E.6
  • 56
    • 33749860102 scopus 로고    scopus 로고
    • Bidirectional control of CNS capillary diameter by pericytes
    • COI: 1:CAS:528:DC%2BD28XhtVGkurrP, PID: 17036005
    • Peppiatt CM, Howarth C, Mobbs P, Attwell D (2006) Bidirectional control of CNS capillary diameter by pericytes. Nature 443(7112):700–704
    • (2006) Nature , vol.443 , Issue.7112 , pp. 700-704
    • Peppiatt, C.M.1    Howarth, C.2    Mobbs, P.3    Attwell, D.4
  • 57
    • 0030059065 scopus 로고    scopus 로고
    • Cerebrospinal fluid concentrations of soluble amyloid á-protein and apolipoprotein E in patients with Alzheimer’s disease. Correlations with amyloid load in the brain
    • COI: 1:STN:280:DyaK283isFOhsw%3D%3D, PID: 8639071
    • Pirttila T, McHta PD, Soininen H, Kim KS, Heinonen O, Paljarvi L, Kosunen O, Riekkinen P, Wisniewski HM (1996) Cerebrospinal fluid concentrations of soluble amyloid á-protein and apolipoprotein E in patients with Alzheimer’s disease. Correlations with amyloid load in the brain. Arch Neurol 53:189–193
    • (1996) Arch Neurol , vol.53 , pp. 189-193
    • Pirttila, T.1    McHta, P.D.2    Soininen, H.3    Kim, K.S.4    Heinonen, O.5    Paljarvi, L.6    Kosunen, O.7    Riekkinen, P.8    Wisniewski, H.M.9
  • 59
    • 0021959647 scopus 로고
    • Evidence for a ‘paravascular’ fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid space
    • COI: 1:STN:280:DyaL2M7itlyhtg%3D%3D, PID: 3971148
    • Rennels ML, Gregory TF, Blaumanis OR, Fujimoto K, Grady PA (1985) Evidence for a ‘paravascular’ fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid space. Brain Res 326(1):47–63
    • (1985) Brain Res , vol.326 , Issue.1 , pp. 47-63
    • Rennels, M.L.1    Gregory, T.F.2    Blaumanis, O.R.3    Fujimoto, K.4    Grady, P.A.5
  • 62
    • 0020407963 scopus 로고
    • Clearance of albumin from mouse subarachnoid space: a measure of CSF bulk flow
    • COI: 1:STN:280:DyaL3s%2FmtFSqtA%3D%3D, PID: 7144238
    • Rudick RA, Zirretta DK, Herndon RM (1982) Clearance of albumin from mouse subarachnoid space: a measure of CSF bulk flow. J Neurosci Methods 6(3):253–259
    • (1982) J Neurosci Methods , vol.6 , Issue.3 , pp. 253-259
    • Rudick, R.A.1    Zirretta, D.K.2    Herndon, R.M.3
  • 63
    • 80051796008 scopus 로고    scopus 로고
    • Colocalization of gadolinium-diethylene triamine pentaacetic acid with high-molecular-weight molecules after intracerebral convection-enhanced delivery in humans
    • PID: 21430586
    • Sampson JH, Brady M, Raghavan R, Mehta AI, Friedman AH, Reardon DA, Petry NA, Barboriak DP, Wong TZ, Zalutsky MR (2011) Colocalization of gadolinium-diethylene triamine pentaacetic acid with high-molecular-weight molecules after intracerebral convection-enhanced delivery in humans. Neurosurgery 69(3):668–676
    • (2011) Neurosurgery , vol.69 , Issue.3 , pp. 668-676
    • Sampson, J.H.1    Brady, M.2    Raghavan, R.3    Mehta, A.I.4    Friedman, A.H.5    Reardon, D.A.6    Petry, N.A.7    Barboriak, D.P.8    Wong, T.Z.9    Zalutsky, M.R.10
  • 64
    • 31744448129 scopus 로고    scopus 로고
    • Mechanisms to explain the reverse perivascular transport of solutes out of the brain
    • COI: 1:CAS:528:DC%2BD28XhtFSgsbw%3D, PID: 16112683
    • Schley D, Carare-Nnadi R, Please C, Perry V, Weller R (2006) Mechanisms to explain the reverse perivascular transport of solutes out of the brain. J Theor Biol 238(4):962–974
    • (2006) J Theor Biol , vol.238 , Issue.4 , pp. 962-974
    • Schley, D.1    Carare-Nnadi, R.2    Please, C.3    Perry, V.4    Weller, R.5
  • 65
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer’s disease: genes, proteins, and therapy
    • COI: 1:CAS:528:DC%2BD3MXislCrsLc%3D, PID: 11274343
    • Selkoe DJ (2001) Alzheimer’s disease: genes, proteins, and therapy. Physiol Rev 81(2):741–766
    • (2001) Physiol Rev , vol.81 , Issue.2 , pp. 741-766
    • Selkoe, D.J.1
  • 66
    • 84900563185 scopus 로고    scopus 로고
    • Gliotoxin-induced swelling of astrocytes hinders diffusion in brain extracellular space via formation of dead-space microdomains
    • PID: 24687699
    • Sherpa AD, van de Nes P, Xiao F, Weedon J, Hrabetova S (2014) Gliotoxin-induced swelling of astrocytes hinders diffusion in brain extracellular space via formation of dead-space microdomains. Glia 62(7):1053–1065. doi:10.1002/glia.22661
    • (2014) Glia , vol.62 , Issue.7 , pp. 1053-1065
    • Sherpa, A.D.1    van de Nes, P.2    Xiao, F.3    Weedon, J.4    Hrabetova, S.5
  • 68
    • 0028979854 scopus 로고
    • Amyloid beta -proteins 1-40 and 1-42(43) in the soluble fraction of extra- and intracranial blood vessels
    • COI: 1:CAS:528:DyaK2MXosl2lsLw%3D, PID: 7668828
    • Shinkai Y, Yoshimura M, Ito Y, Odaka A, Suzuki N, Yanagisawa K, Ihara Y (1995) Amyloid beta -proteins 1-40 and 1-42(43) in the soluble fraction of extra- and intracranial blood vessels. Ann Neurol 38(3):421–428
    • (1995) Ann Neurol , vol.38 , Issue.3 , pp. 421-428
    • Shinkai, Y.1    Yoshimura, M.2    Ito, Y.3    Odaka, A.4    Suzuki, N.5    Yanagisawa, K.6    Ihara, Y.7
  • 70
    • 19444384572 scopus 로고    scopus 로고
    • Mechanical, biochemical, and extracellular matrix effects on vascular smooth muscle cell phenotype
    • PID: 15894540
    • Stegemann JP, Hong H, Nerem RM (2005) Mechanical, biochemical, and extracellular matrix effects on vascular smooth muscle cell phenotype. J Appl Physiol 98(6):2321–2327
    • (2005) J Appl Physiol , vol.98 , Issue.6 , pp. 2321-2327
    • Stegemann, J.P.1    Hong, H.2    Nerem, R.M.3
  • 71
    • 55949130305 scopus 로고    scopus 로고
    • Diffusion in brain extracellular space
    • PID: 18923183
    • Syková E, Nicholson C (2008) Diffusion in brain extracellular space. Physiol Rev 88(4):1277–1340
    • (2008) Physiol Rev , vol.88 , Issue.4 , pp. 1277-1340
    • Syková, E.1    Nicholson, C.2
  • 72
    • 1842715270 scopus 로고
    • Drainage of interstitial fluid from different regions of rat brain
    • COI: 1:STN:280:DyaL2c3lsVSlsg%3D%3D, PID: 6742132
    • Szentistvanyi I, Patlak CS, Ellis RA, Cserr HF (1984) Drainage of interstitial fluid from different regions of rat brain. Am J Physiol 246:F835–F844
    • (1984) Am J Physiol , vol.246 , pp. F835-F844
    • Szentistvanyi, I.1    Patlak, C.S.2    Ellis, R.A.3    Cserr, H.F.4
  • 73
    • 8644244647 scopus 로고    scopus 로고
    • Diffusion of epidermal growth factor in rat brain extracellular space measured by integrative optical imaging
    • COI: 1:CAS:528:DC%2BD2cXhtVOqtLjP, PID: 15269225
    • Thorne RG, Hrabětová S, Nicholson C (2004a) Diffusion of epidermal growth factor in rat brain extracellular space measured by integrative optical imaging. J Neurophysiol 92(6):3471–3481
    • (2004) J Neurophysiol , vol.92 , Issue.6 , pp. 3471-3481
    • Thorne, R.G.1    Hrabětová, S.2    Nicholson, C.3
  • 74
    • 3242740239 scopus 로고    scopus 로고
    • Delivery of insulin-like growth factor-1 to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration
    • COI: 1:CAS:528:DC%2BD2cXlvVSqurg%3D, PID: 15262337
    • Thorne RG, Pronk GJ, Padmanabhan V, Frey WH (2004b) Delivery of insulin-like growth factor-1 to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience 127:481–496
    • (2004) Neuroscience , vol.127 , pp. 481-496
    • Thorne, R.G.1    Pronk, G.J.2    Padmanabhan, V.3    Frey, W.H.4
  • 76
    • 76749146826 scopus 로고    scopus 로고
    • The regulation of brain states by neuroactive substances distributed via the cerebrospinal fluid; a review
    • PID: 20157443
    • Veening JG, Barendregt HP (2010) The regulation of brain states by neuroactive substances distributed via the cerebrospinal fluid; a review. Cerebrospinal Fluid Res 7:1. doi:10.1186/1743-8454-7-1
    • (2010) Cerebrospinal Fluid Res , vol.7 , pp. 1
    • Veening, J.G.1    Barendregt, H.P.2
  • 77
    • 0029975660 scopus 로고    scopus 로고
    • Brain parenchymal and microvascular amyloid in Alzheimer’s disease
    • COI: 1:CAS:528:DyaK28XivFykurs%3D, PID: 8737932
    • Vinters HV, Wang ZZ, Secor DL (1996) Brain parenchymal and microvascular amyloid in Alzheimer’s disease. Brain Pathol 6(2):179–195
    • (1996) Brain Pathol , vol.6 , Issue.2 , pp. 179-195
    • Vinters, H.V.1    Wang, Z.Z.2    Secor, D.L.3
  • 78
    • 67650875881 scopus 로고    scopus 로고
    • Vascular extracellular matrix and arterial mechanics
    • COI: 1:CAS:528:DC%2BD1MXpslyjsLY%3D, PID: 19584318
    • Wagenseil JE, Mecham RP (2009) Vascular extracellular matrix and arterial mechanics. Physiol Rev 89(3):957–989
    • (2009) Physiol Rev , vol.89 , Issue.3 , pp. 957-989
    • Wagenseil, J.E.1    Mecham, R.P.2
  • 79
    • 0000015417 scopus 로고
    • The absorbtion of cerebrospinal fluid into the venous system
    • COI: 1:CAS:528:DyaB3sXhtFKitQ%3D%3D
    • Weed LH (1923) The absorbtion of cerebrospinal fluid into the venous system. Ame J Anat 31(3):191–221
    • (1923) Ame J Anat , vol.31 , Issue.3 , pp. 191-221
    • Weed, L.H.1
  • 80
    • 0031722421 scopus 로고    scopus 로고
    • Pathology of cerebrospinal fluid and interstitial fluid of the CNS: significance for Alzheimer disease, prion disorders and multiple sclerosis
    • COI: 1:STN:280:DyaK1M%2FgtVWkug%3D%3D, PID: 9786239
    • Weller RO (1998) Pathology of cerebrospinal fluid and interstitial fluid of the CNS: significance for Alzheimer disease, prion disorders and multiple sclerosis. J Neuropathol Exp Neurol 57(10):885–894
    • (1998) J Neuropathol Exp Neurol , vol.57 , Issue.10 , pp. 885-894
    • Weller, R.O.1
  • 81
    • 33644874975 scopus 로고    scopus 로고
    • Microscopic morphology and histology of the human meninges
    • COI: 1:STN:280:DC%2BD2M3pslShtg%3D%3D, PID: 15943078
    • Weller R (2005) Microscopic morphology and histology of the human meninges. Morphologie 89(284):22–34
    • (2005) Morphologie , vol.89 , Issue.284 , pp. 22-34
    • Weller, R.1
  • 82
    • 0031679480 scopus 로고    scopus 로고
    • Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer’s disease
    • COI: 1:CAS:528:DyaK1cXmtFKnurs%3D, PID: 9736023
    • Weller RO, Massey A, Newman TA, Hutchings M, Kuo YM, Roher AE (1998) Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer’s disease. Am J Pathol 153(3):725–733
    • (1998) Am J Pathol , vol.153 , Issue.3 , pp. 725-733
    • Weller, R.O.1    Massey, A.2    Newman, T.A.3    Hutchings, M.4    Kuo, Y.M.5    Roher, A.E.6
  • 83
    • 41149157623 scopus 로고    scopus 로고
    • perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD1cXmtFGqt7s%3D, PID: 18363936
    • Weller RO, Subash M, Preston SD, Mazanti I, Carare RO (2008) perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer’s disease. Brain Pathol 18:253–266
    • (2008) Brain Pathol , vol.18 , pp. 253-266
    • Weller, R.O.1    Subash, M.2    Preston, S.D.3    Mazanti, I.4    Carare, R.O.5
  • 84
    • 67349118757 scopus 로고    scopus 로고
    • Microvasculature changes and cerebral amyloid angiopathy in Alzheimer’s disease and their potential impact on therapy
    • COI: 1:CAS:528:DC%2BD1MXmt1ahu7c%3D, PID: 19234858
    • Weller RO, Boche D, Nicoll JA (2009a) Microvasculature changes and cerebral amyloid angiopathy in Alzheimer’s disease and their potential impact on therapy. Acta Neuropathol 118(1):87–102
    • (2009) Acta Neuropathol , vol.118 , Issue.1 , pp. 87-102
    • Weller, R.O.1    Boche, D.2    Nicoll, J.A.3
  • 85
    • 57049154546 scopus 로고    scopus 로고
    • Lymphatic drainage of the brain and the pathophysiology of neurological disease
    • COI: 1:CAS:528:DC%2BD1cXhsVeksrfK, PID: 19002474
    • Weller RO, Djuanda E, Yow HY, Carare RO (2009b) Lymphatic drainage of the brain and the pathophysiology of neurological disease. Acta Neuropathol 117:1–14
    • (2009) Acta Neuropathol , vol.117 , pp. 1-14
    • Weller, R.O.1    Djuanda, E.2    Yow, H.Y.3    Carare, R.O.4
  • 86
    • 40849102937 scopus 로고    scopus 로고
    • Time course of syringomyelia resolution following decompression of Chiari malformation Type I
    • PID: 18352779
    • Wetjen NM, Heiss JD, Oldfield EH (2008) Time course of syringomyelia resolution following decompression of Chiari malformation Type I. J Neurosurg Pediatr 1(2):118
    • (2008) J Neurosurg Pediatr , vol.1 , Issue.2 , pp. 118
    • Wetjen, N.M.1    Heiss, J.D.2    Oldfield, E.H.3
  • 87
    • 80055014830 scopus 로고    scopus 로고
    • Central nervous system pericytes in health and disease
    • COI: 1:CAS:528:DC%2BC3MXhtlOnurrM, PID: 22030551
    • Winkler EA, Bell RD, Zlokovic BV (2011) Central nervous system pericytes in health and disease. Nat Neurosci 14(11):1398–1405
    • (2011) Nat Neurosci , vol.14 , Issue.11 , pp. 1398-1405
    • Winkler, E.A.1    Bell, R.D.2    Zlokovic, B.V.3
  • 89
    • 0025363827 scopus 로고
    • Molecular architecture of basement membranes
    • COI: 1:CAS:528:DyaK3cXitlWgtLY%3D, PID: 2180767
    • Yurchenco PD, Schittny JC (1990) Molecular architecture of basement membranes. FASEB J 4(6):1577–1590
    • (1990) FASEB J , vol.4 , Issue.6 , pp. 1577-1590
    • Yurchenco, P.D.1    Schittny, J.C.2
  • 90
    • 0025353908 scopus 로고
    • Interrelationships of the pia mater and the perivascular (Virchow-Robin) spaces in the human cerebrum
    • COI: 1:STN:280:DyaK3M%2Fnt1Sktw%3D%3D, PID: 2254158
    • Zhang E, Inman C, Weller R (1990) Interrelationships of the pia mater and the perivascular (Virchow-Robin) spaces in the human cerebrum. J Anat 170:111
    • (1990) J Anat , vol.170 , pp. 111
    • Zhang, E.1    Inman, C.2    Weller, R.3
  • 91
    • 0026567020 scopus 로고
    • Directional and compartmentalised drainage of interstitial fluid and cerebrospinal fluid from the rat brain
    • COI: 1:STN:280:DyaK383hsVSksQ%3D%3D, PID: 1373020
    • Zhang E, Richards H, Kida S, Weller R (1992) Directional and compartmentalised drainage of interstitial fluid and cerebrospinal fluid from the rat brain. Acta Neuropathol 83(3):233–239
    • (1992) Acta Neuropathol , vol.83 , Issue.3 , pp. 233-239
    • Zhang, E.1    Richards, H.2    Kida, S.3    Weller, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.