Impairment of the blood-nerve and blood-brain barriers in apolipoprotein E knockout mice

Experimental Neurology

Volumn 169, Issue 1, 2001, Pages 13-22

  Fullerton, Stephanie M ^a   Shirman, Gregory A ^a   Strittmatter, Warren J ^a   Matthew, William D ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Alzheimer's disease; Apolipoprotein E (apoE); Blood brain barrier; Blood nerve barrier; Cerebellum; Evans blue; Immunoglobulin G; Knockout; Sciatic nerve; Spinal cord

Indexed keywords

APOLIPOPROTEIN E; EVANS BLUE; IMMUNOGLOBULIN G;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD NERVE BARRIER; CEREBELLUM; CONTROLLED STUDY; KNOCKOUT MOUSE; MALE; MOUSE; NERVE INJURY; NERVOUS TISSUE; NONHUMAN; NONMYELINATED NERVE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SCIATIC NERVE; SPINAL CORD;

EID: 0035022053     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2001.7631     Document Type: Article

References (85)

1. Anticytokine nature of natural human immunoglobulin: One possible mechanism of intravenous immunoglobulin therapy
2. Intravenous immunoglobulin in multiple sclerosis: Clinical and neuroradiologic results and implications for possible mechanisms of action
3. ApoE genotype and survival from intracerebral hemorrhage
4. Permeation of proteins from the blood into peripheral nerves and ganglia
5. Is the pial microvessel a good model for blood-brain barrier studies?
6. The blood-nerve barrier: Enzymes, transporters and receptors - A comparison with the blood-brain barrier
7. Regional cerebral bloodflow in apolipoprotein E-deficient and wild-type mice during focal cerebral ischemia
8. Neural induction of the blood-brain barrier: Still an enigma
9. The neurobiology of apolipoproteins and their receptors in the CNS and Alzheimer's disease
10. Stable expression and secretion of apolipoprotein E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth
11. Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system
12. Evolution of neuropathologic abnormalities associated with blood-brain barrier breakdown in transgenic mice expressing interleukin-6 in astrocytes
13. Permeable endothelium and the interstitial space of the brain
14. Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central nervous system
15. Perineurium originates from fibroblasts: Demonstration in vitro with a retroviral marker
16. Binding of a high reactive heparin to human apolipoprotein E: Identification of two heparin-binding domains
17. Inhibition of lymphocyte proliferation by synthetic peptides homologous to human plasma apolipoproteins B and E
18. Development of endothelial paracellular clefts and their tight junctions in the pial microvessels of the rat
19. Vital staining, serum albumin and the blood-brain barrier
20. Apolipoprotein E knock-out mice are highly susceptible to endotoxemia and Klebsiella pneumoniae infection
21. The upregulation of the low density lipoprotein receptor at the blood-brain barrier: Intercommunication between brain capillary endothelial cells and astrocytes
22. The blood-brain barrier in neuroinflammatory disease
23. Nitric oxide synthase activity is elevated in brain microvessels in Alzheimer's disease
24. Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets
25. Uptake of plasma IgG by CNS motoneurons: Comparison of antineuronal and normal IgG
26. Apolipoprotein E genotype related difference in brain lesions of multiple sclerosis
27. Altered angioarchitecture in selected areas of brains with Alzheimer's disease
28. Peripheral sensory nerve defects in apolipoprotein E knockout mice
29. Apolipoprotein E binds to and potentiates the biological activity of ciliary neurotrophic factor
30. Glutamate GluR3 antibodies and the death of cortical cells
31. The difference in vascular volume between the cerebrum and cerebellum is the pia mater
32. Reevaluating the role of astrocytes in blood-brain barrier induction
33. Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line
34. Interaction of apolipoprotein E with laminin increases neuronal adhesion and alters neurite morphology
35. Apolipoprotein E epsilon-4 associated with chronic traumatic brain injury in boxing
36. Astrocytes induce blood-brain barrier properties in endothelial cells
37. Low density lipoprotein-receptors in primary cultures of rat glial cells
38. Impaired blood-brain barrier function in angiotensinogen deficient mice
39. Differential degeneration of the cerebral microvasculature in Alzheimer's disease
40. Increased collagen content of cerebral microvessels in Alzheimer's disease
41. Cerebral vessels in aging and Alzheimer's disease
42. Apolipoprotein E alleles and brain vascular pathology in Alzheimer's disease
43. Vascular permeability in the peripheral autonomic and somatic nervous systems: Controversial aspects and comparisons with the blood-brain barrier
44. Immunoglobulins induce increased myelin debris clearance by mouse macrophage
45. Apolipoprotein E suppresses glial secretion of TNFα
46. Apolipoprotein E deficient mice have increased susceptibility to focal cerebral ischemia
47. Endogenous apolipoprotein E suppresses LPS-stimulated microglial nitric oxide production
48. Reduced levels of antioxidants in the brains of apolipoprotein E-deficient mice following closed head injury
49. Difference between the peripheral and central nervous system in permeability to sodium fluorescein
50. Thickening of the basement membrane of cortical capillaries in Alzheimer's disease
51. The distribution of serum albumin in rat peripheral nerve
52. A physiological barrier distal to the anatomic blood-brain barrier in a model of transvascular delivery
53. Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro
54. The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization
55. Predictors of cognitive decline after cardiac operation
56. Medical progress: Multiple sclerosis
57. Inhibition of blood-brain barrier disruption in experimental allergic encephalomyelitis by short-term therapy with dexamethasone or cyclosporin A
58. Effect of an anticholinesterase compound on the ultrastructure and function of the rat blood-brain barrier: A review and experiment
59. The demyelinating potential of antibodies to myelin oligodendrocytes glycoprotein is related to their ability to fix complement
60. Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells
61. Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E lipoproteins
62. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
63. Apolipoprotein E and the apolipoprotein E-deficient mouse
64. Macromolecular permeability across the blood-nerve and blood-brain barriers
65. Regulation of the microenvironment of the peripheral nerve: Role of the blood-nerve barrier
66. Apolipoprotein E-deficient mice have impaired innate immune responses to Listeria monocytogenes in vivo
67. Association of apolipoprotein E allele E4 with late-onset familial and sporadic Alzheimer's disease
68. Increased blood-brain barrier permeability following acute short-term swimming exercise in conscious normotensive young rats
69. Denervated sheath cells secrete a new protein after nerve injury
70. Apolipoprotein E epsilon-4 and the risk of dementia with stroke. A population based investigation
71. Apolipoprotein E genotypes and outcome after post-traumatic coma
72. Macrophages in the peripheral nervous system and astroglia in the central nervous system of rat commonly express apolipoprotein E during development but differ in their response to injury
73. Multiple sclerosis: In situ evidence for antibody and complement mediated demyelination
74. Preliminary report of a genetic basis for cognitive decline after cardiac operations
75. Association of apolipoprotein E polymorphisms with outcome after head injury
76. Protein complexes and the impermeability of the blood-brain barrier to dyes
77. Rapid regression of atherosclerosis induced by liver-directed gene transfer of apoE in apoE-deficient mice
78. Immunocytochemical evaluation of blood-brain barrier to endogenous albumin in scrapie-infected mice
79. Blood-nerve transfer of albumin and its implications for the endoneurial microenvironment
80. Permeability of the blood-brain and blood-spinal cord barriers to neurotrophins
81. Permeability of the blood-brain barrier to neurotrophins
82. Human apolipoprotein E. Determination of the heparin binding sites of apolipoprotein E3
83. Antibodies have the intrinsic capacity to destroy antigens
84. Transport of proteins across normal cerebral arterioles
85. Changes in the permeability of the blood-brain barrier in acute hyperammonemia. Effect of dexamethasone