Plasminogen deficiency delays the onset and protects from demyelination and paralysis in autoimmune neuroinflammatory disease

Journal of Neuroscience

Volumn 37, Issue 14, 2017, Pages 3776-3788

  Shaw, Maureen A ^a   Gao, Zhen ^a   McElhinney, Kathryn E ^a   Thornton, Sherry ^b   Flick, Matthew J ^a   Lane, Adam ^a   Degen, Jay L ^a   Ryu, Jae Kyu ^c   Akassoglou, Katerina ^c,d   Mullins, Eric S ^a  

^a Division of Experimental Hematology and Cancer Biology   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c GLADSTONE INSTITUTE OF NEUROLOGICAL DISEASE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Fibrinogen; Fibrinolysis; Mice; Neuroinflammation; Plasminogen

Indexed keywords

CXCL1 CHEMOKINE; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 6; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; PLASMINOGEN; RANTES; TRANEXAMIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA; BLOOD BRAIN BARRIER; CELL PROLIFERATION ASSAY; CONTROLLED STUDY; CYTOLYSIS ASSAY; DEMYELINATION; DYING; ELECTRON MICROSCOPY; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FIBRINOGEN METABOLISM; HISTOLOGY; HISTOPATHOLOGY; MOUSE; MULTIPLE SCLEROSIS; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PARALYSIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DEFICIENCY; ROTAROD TREADMILL ASSAY; SPLEEN CELL; TREADMILL TEST; ZYMOGRAPHY; ANIMAL; C57BL MOUSE; CELL CULTURE; DEFICIENCY; DEMYELINATING DISEASES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY;

ANIMALS; CELLS, CULTURED; DEMYELINATING DISEASES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PARALYSIS; PLASMINOGEN;

EID: 85019070065     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2932-15.2017     Document Type: Article

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