Resveratrol defends blood-brain barrier integrity in experimental autoimmune encephalomyelitis mice

Journal of Neurophysiology

Volumn 116, Issue 5, 2016, Pages 2173-2179

  Wang, Dong ^a   Li, Shi Ping ^a   Fu, Jin Sheng ^a   Zhang, Sheng ^b   Bai, Lin ^a   Guo, Li ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b XingTai People Hospital   (China)

Author keywords

Blood brain barrier; Encephalomyelitis; Multiple sclerosis; Resveratrol

Indexed keywords

ARGINASE 1; CLAUDIN 5; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 1BETA; MULTIPROTEIN COMPLEX; OCCLUDIN; PROTEIN ZO1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; RESVERATROL; TIGHT JUNCTION PROTEIN; VASCULAR CELL ADHESION MOLECULE 1; AUTACOID; NONSTEROID ANTIINFLAMMATORY AGENT; STILBENE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BASEMENT MEMBRANE; BLOOD BRAIN BARRIER; CELL ADHESION; CHEMOLUMINESCENCE; CLINICAL OUTCOME; COMPARATIVE STUDY; CONTROLLED STUDY; DEMYELINATION; DISEASE SEVERITY; DOSE RESPONSE; DOWN REGULATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FEMALE; GENE OVEREXPRESSION; IMMUNOCOMPETENT CELL; MOUSE; MULTIPLE SCLEROSIS; NERVE CELL LESION; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIGHT JUNCTION; TREATMENT DURATION; UPREGULATION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; C57BL MOUSE; DRUG EFFECTS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; METABOLISM;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BLOOD-BRAIN BARRIER; BRAIN; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; INFLAMMATION MEDIATORS; MICE; MICE, INBRED C57BL; STILBENES;

EID: 84994665914     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.00510.2016     Document Type: Article

References (28)

1. Chaudhary P, Marracci GH, Bourdette DN. Lipoic acid inhibits expression of ICAM-1 and VCAM-1 by CNS endothelial cells and T cell migration into the spinal cord in experimental autoimmune encephalomyelitis. J Neuroimmunol 175: 87-96, 2006.
2. Csiszar A. Anti-inflammatory effects of resveratrol: possible role in prevention of age-related cardiovascular disease. Ann NY Acad Sci 1215: 117-122, 2011.
3. Das S, Das DK. Anti-inflammatory responses of resveratrol. Inflamm Allergy Drug Targets 6: 168-173, 2007.
4. de la Lastra CA, Villegas I. Resveratrol as an anti-inflammatory and antiaging agent: Mechanisms and clinical implications. Mol Nutr Food Res 49: 405-430, 2005.
5. Eberle M, Ebel P, Mayer CA, Barthelmes J, Tafferner N, Ferreiros N, Ulshofer T, Henke M, Foerch C, de Bazo AM, Grosch S, Geisslinger G, Willecke K, Schiffmann S. Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils. Immunol Cell Biol 93: 825-836, 2015.
6. Fischer HJ, Schweingruber N, Luhder F, Reichardt HM. The potential role of T cell migration and chemotaxis as targets of glucocorticoids in multiple sclerosis and experimental autoimmune encephalomyelitis. Mol Cell Endocrinol 380: 99-107, 2013.
7. Flugel A, Matsumuro K, Neumann H, Klinkert WE, Birnbacher R, Lassmann H, Otten U, Wekerle H. Anti-inflammatory activity of nerve growth factor in experimental autoimmune encephalomyelitis: Inhibition of monocyte transendothelial migration. Eur J Immunol 31: 11-22, 2001.
8. Fonseca-Kelly Z, Nassrallah M, Uribe J, Khan RS, Dine K, Dutt M, Shindler KS. Resveratrol neuroprotection in a chronic mouse model of multiple sclerosis. Front Neurol 3: 84, 2012.
9. Gao Z, Wen Q, Xia Y, Yang J, Gao P, Zhang N, Li H, Zou S. Osthole augments therapeutic efficiency of neural stem cells-based therapy in experimental autoimmune encephalomyelitis. J Pharm Sci 124: 54-65, 2014.
10. + T cell subsets and exacerbate experimental autoimmune encephalomyelitis. Stem Cells 32: 2744-2755, 2014.
11. +) regulatory B cells in experimental autoimmune encephalomyelitis. Neuroimmunomodulation 20: 294-303, 2013.
12. Hou Y, Ryu CH, Park KY, Kim SM, Jeong CH, Jeun SS. Effective combination of human bone marrow mesenchymal stem cells and minocycline in experimental autoimmune encephalomyelitis mice. Stem Cell Res Ther 4: 77, 2013.
13. + cells, and decreased macrophage IL-6 expression. Int Immunopharmacol 9: 134-143, 2009.
14. Jones MV, Nguyen TT, Ewaleifoh O, Lebson L, Whartenby KA, Griffin JW, Calabresi PA. Accelerated axon loss in MOG35-55 experimental autoimmune encephalomyelitis (EAE) in myelin-associated glycoproteindeficient (MAGKO) mice. J Neuroimmunol 262: 53-61, 2013.
15. Kassis I, Petrou P, Halimi M, Karussis D. Mesenchymal stem cells (MSC) derived from mice with experimental autoimmune encephalomyelitis (EAE) suppress EAE and have similar biological properties with MSC from healthy donors. Immunol Lett 154: 70-76, 2013.
16. Labinskyy N, Csiszar A, Veress G, Stef G, Pacher P, Oroszi G, Wu J, Ungvari Z. Vascular dysfunction in aging: potential effects of resveratrol, an anti-inflammatory phytoestrogen. Curr Med Chem 13: 989-996, 2006.
17. Ma C, Wang Y, Dong L, Li M, Cai W. Anti-inflammatory effect of resveratrol through the suppression of NF-kappaB and JAK/STAT signaling pathways. Acta Biochim Biophys Sin (Shanghai) 47: 207-213, 2015.
18. Seo JE, Hasan M, Han JS, Kang MJ, Jung BH, Kwok SK, Kim HY, Kwon OS. Experimental autoimmune encephalomyelitis and age-related correlations of NADPH oxidase, MMP-9, and cell adhesion molecules: The increased disease severity and blood-brain barrier permeability in middle-aged mice. J Neuroimmunol 287: 43-53, 2015.
19. Shindler KS, Ventura E, Dutt M, Elliott P, Fitzgerald DC, Rostami A. Oral resveratrol reduces neuronal damage in a model of multiple sclerosis. J Neuroophthalmol 30: 328-339, 2010.
20. Svajger U, Jeras M. Anti-inflammatory effects of resveratrol and its potential use in therapy of immune-mediated diseases. Int Rev Immunol 31: 202-222, 2012.
21. Udenigwe CC, Ramprasath VR, Aluko RE, Jones PJ. Potential of resveratrol in anticancer and anti-inflammatory therapy. Nutr Rev 66: 445-454, 2008.
22. Vallejo S, Palacios E, Romacho T, Villalobos L, Peiró C, Sánchez-Ferrer CF. The interleukin-1 receptor antagonist anakinra improves endothelial dysfunction in streptozotocin-induced diabetic rats. Cardiovasc Diabetol 13: 158, 2014.
23. Wang XS, Fang HL, Chen Y, Liang SS, Zhu ZG, Zeng QY, Li J, Xu HQ, Shao B, He JC, Hou ST, Zheng RY. Idazoxan reduces blood-brain barrier damage during experimental autoimmune encephalomyelitis in mouse. Eur J Pharmacol 736: 70-76, 2014.
24. Wolburg H, Wolburg-Buchholz K, Engelhardt B. Involvement of tight junctions during transendothelial migration of mononuclear cells in experimental autoimmune encephalomyelitis. Ernst Schering Res Found Workshop 47: 17-38, 2004.
25. Wood LG, Wark PA, Garg ML. Antioxidant and anti-inflammatory effects of resveratrol in airway disease. Antioxid Redox Signal 13: 1535-1548, 2010.
26. Yang X, Yan J, Feng J. Treatment with tanshinone IIA suppresses disruption of the blood-brain barrier and reduces expression of adhesion molecules and chemokines in experimental autoimmune encephalomyelitis. Eur J Pharmacol 771: 18-28, 2016.
27. Zhang F, Liu J, Shi JS. Anti-inflammatory activities of resveratrol in the brain: role of resveratrol in microglial activation. Eur J Pharmacol 636: 1-7, 2010.
28. Zhang S, Kan QC, Xu Y, Zhang GX, Zhu L. Inhibitory effect of matrine on blood-brain barrier disruption for the treatment of experimental autoimmune encephalomyelitis. Mediators Inflamm 2013: 736085, 2013.