메뉴 건너뛰기




Volumn 35, Issue 7, 2015, Pages 1055-1068

Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease

Author keywords

Alzheimer's disease; biomarkers; cerebrospinal fluid; dementia; neurovascular unit

Indexed keywords

BIOLOGICAL MARKER;

EID: 84934444613     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2015.76     Document Type: Review
Times cited : (97)

References (222)
  • 1
    • 84921290864 scopus 로고    scopus 로고
    • World Alzheimer report 2014: Dementia and risk reduction: An analysis of protective and modifiable factors
    • Prince M, Albanese E, Guerchet M, Prina M. World Alzheimer Report 2014: dementia and risk reduction: an analysis of protective and modifiable factors. Alzheimers Dis Int 2014, 1-99
    • (2014) Alzheimers Dis Int , pp. 1-99
    • Prince, M.1    Albanese, E.2    Guerchet, M.3    Prina, M.4
  • 2
    • 84897481309 scopus 로고    scopus 로고
    • 2014 Alzheimer's disease facts and figures
    • Alzheimer's Association
    • Alzheimer's Association. 2014 Alzheimer's disease facts and figures. Alzheimers Dement 2014; 10: e47-e92
    • (2014) Alzheimers Dement , vol.10 , pp. e47-e92
  • 4
    • 13544268809 scopus 로고    scopus 로고
    • Neurovascular mechanisms of Alzheimer's neurodegeneration
    • Zlokovic BV. Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends Neurosci 2005; 28: 202-208
    • (2005) Trends Neurosci , vol.28 , pp. 202-208
    • Zlokovic, B.V.1
  • 5
    • 38149090292 scopus 로고    scopus 로고
    • The blood-brain barrier in health and chronic neurodegenerative disorders
    • Zlokovic BV. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 2008; 57: 178-201
    • (2008) Neuron , vol.57 , pp. 178-201
    • Zlokovic, B.V.1
  • 6
    • 62949092903 scopus 로고    scopus 로고
    • The neurovascular unit in health and disease: Introduction
    • Lo EH, Rosenberg GA. The neurovascular unit in health and disease: introduction. Stroke 2009; 40: S2-S3
    • (2009) Stroke , vol.40 , pp. S2-S3
    • Lo, E.H.1    Rosenberg, G.A.2
  • 7
    • 80052400687 scopus 로고    scopus 로고
    • Vascular contributions to cognitive impairment and dementia: A statement for healthcare professionals from the American heart association/American stroke association
    • Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, Iadecola C, et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke 2011; 42: 2672-2713
    • (2011) Stroke , vol.42 , pp. 2672-2713
    • Gorelick, P.B.1    Scuteri, A.2    Black, S.E.3    Decarli, C.4    Greenberg, S.M.5    Iadecola, C.6
  • 8
    • 84880844965 scopus 로고    scopus 로고
    • Stroke research priorities meeting steering committee and the national advisory neurological disorders and stroke council national institute of neurological disorders and stroke research priority setting: A summary of the 2012 ninds stroke planning meeting report
    • Vickrey BG, Brott TG, Koroshetz WJ. Stroke Research Priorities Meeting Steering Committee and the National Advisory Neurological Disorders and Stroke Council, National Institute of Neurological Disorders and Stroke. Research priority setting: a summary of the 2012 NINDS Stroke Planning Meeting Report. Stroke 2013; 44: 2338-2342
    • (2013) Stroke , vol.44 , pp. 2338-2342
    • Vickrey, B.G.1    Brott, T.G.2    Koroshetz, W.J.3
  • 9
    • 84934445920 scopus 로고    scopus 로고
    • Bethesda Maryland (accessed 22 Jan 2014
    • Montine T. Conference and recommendations report to the NINDS Council. Bethesda, Maryland, 2013 http://www.ninds.nih.gov/funding/areas/neurodegen eration/workshops/adrd2013/ADRD-2013-Report-And-Memorandum-508comp. pdf (accessed 22 Jan 2014
    • (2013) Conference and Recommendations Report to the NINDS Council
    • Montine, T.1
  • 12
    • 81555200043 scopus 로고    scopus 로고
    • Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
    • Zlokovic BV. Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat Rev Neurosci 2011; 12: 723-738
    • (2011) Nat Rev Neurosci , vol.12 , pp. 723-738
    • Zlokovic, B.V.1
  • 13
    • 84888019151 scopus 로고    scopus 로고
    • The pathobiology of vascular dementia
    • Iadecola C. The pathobiology of vascular dementia. Neuron 2013; 80: 844-866
    • (2013) Neuron , vol.80 , pp. 844-866
    • Iadecola, C.1
  • 15
    • 2342614850 scopus 로고    scopus 로고
    • Neurovascular regulation in the normal brain and in Alzheimer's disease
    • Iadecola C. Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat Rev Neurosci 2004; 5: 347-360
    • (2004) Nat Rev Neurosci , vol.5 , pp. 347-360
    • Iadecola, C.1
  • 16
    • 34547173081 scopus 로고    scopus 로고
    • Current insights into molecular mechanisms of Alzheimer disease and their implications for therapeutic approaches
    • Van Broeck B, Van Broeckhoven C, Kumar-Singh S. Current insights into molecular mechanisms of Alzheimer disease and their implications for therapeutic approaches. Neurodegener Dis 2007; 4: 349-365
    • (2007) Neurodegener Dis , vol.4 , pp. 349-365
    • Van Broeck, B.1    Van Broeckhoven, C.2    Kumar-Singh, S.3
  • 17
    • 78650011841 scopus 로고    scopus 로고
    • Neurodegeneration and the neurovascular unit
    • Zlokovic BV. Neurodegeneration and the neurovascular unit. Nat Med 2010; 16: 1370-1371
    • (2010) Nat Med , vol.16 , pp. 1370-1371
    • Zlokovic, B.V.1
  • 19
    • 84867644303 scopus 로고    scopus 로고
    • Does vascular pathology contribute to Alzheimer changes
    • Kalaria RN, Akinyemi R, Ihara M. Does vascular pathology contribute to Alzheimer changes? J Neurol Sci 2012; 322: 141-147
    • (2012) J Neurol Sci , vol.322 , pp. 141-147
    • Kalaria, R.N.1    Akinyemi, R.2    Ihara, M.3
  • 20
    • 84876136764 scopus 로고    scopus 로고
    • Cerebrovascular effects of apolipoprotein e: Implications for Alzheimer disease
    • Zlokovic BV. Cerebrovascular effects of apolipoprotein E: implications for Alzheimer disease. JAMA Neurol 2013; 70: 440-444
    • (2013) JAMA Neurol , vol.70 , pp. 440-444
    • Zlokovic, B.V.1
  • 21
    • 84902652960 scopus 로고    scopus 로고
    • The pericyte: A forgotten cell type with important implications for Alzheimer's disease
    • Winkler EA, Sagare AP, Zlokovic BV. The pericyte: a forgotten cell type with important implications for Alzheimer's disease? Brain Pathol 2014; 24: 371-386
    • (2014) Brain Pathol , vol.24 , pp. 371-386
    • Winkler, E.A.1    Sagare, A.P.2    Zlokovic, B.V.3
  • 22
    • 1842528072 scopus 로고    scopus 로고
    • Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathology
    • Schneider JA, Wilson RS, Bienias JL, Evans DA, Bennett DA. Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathology. Neurology 2004; 62: 1148-1155
    • (2004) Neurology , vol.62 , pp. 1148-1155
    • Schneider, J.A.1    Wilson, R.S.2    Bienias, J.L.3    Evans, D.A.4    Bennett, D.A.5
  • 25
    • 84883402644 scopus 로고    scopus 로고
    • Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the national Alzheimer's coordinating centre
    • Toledo JB, Arnold SE, Raible K, Brettschneider J, Xie SX, Grossman M, et al. Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer's Coordinating Centre. Brain 2013; 136: 2697-2706
    • (2013) Brain , vol.136 , pp. 2697-2706
    • Toledo, J.B.1    Arnold, S.E.2    Raible, K.3    Brettschneider, J.4    Xie, S.X.5    Grossman, M.6
  • 26
    • 0022257648 scopus 로고
    • Blood-brain barrier permeability to leucine-enkephalin d-Alanine2-d-leucine5-enkephalin and their n-Terminal amino acid (tyrosine)
    • Zlokovic BV, Begley DJ, Chain-Eliash DG. Blood-brain barrier permeability to leucine-enkephalin, D-Alanine2-D-leucine5-enkephalin and their N-Terminal amino acid (tyrosine). Brain Res 1985; 336: 125-132
    • (1985) Brain Res , vol.336 , pp. 125-132
    • Zlokovic, B.V.1    Begley, D.J.2    Chain-Eliash, D.G.3
  • 27
    • 0022377737 scopus 로고
    • Permeability of the bloodcerebrospinal fluid and blood-brain barriers to thyrotropin-releasing hormone
    • Zloković BV, Segal MB, Begley DJ, Davson H, Rakić L. Permeability of the bloodcerebrospinal fluid and blood-brain barriers to thyrotropin-releasing hormone. Brain Res 1985; 358: 191-199
    • (1985) Brain Res , vol.358 , pp. 191-199
    • Zloković, B.V.1    Segal, M.B.2    Begley, D.J.3    Davson, H.4    Rakić, L.5
  • 28
    • 0028806803 scopus 로고
    • Cerebrovascular permeability to peptides: Manipulations of transport systems at the blood-brain barrier
    • Zlokovic BV. Cerebrovascular permeability to peptides: manipulations of transport systems at the blood-brain barrier. Pharm Res 1995; 12: 1395-1406
    • (1995) Pharm Res , vol.12 , pp. 1395-1406
    • Zlokovic, B.V.1
  • 29
    • 0023220909 scopus 로고
    • Transport of leucineenkephalin across the blood-brain barrier in the perfused Guinea pig brain
    • Zloković BV, Lipovac MN, Begley DJ, Davson H, Rakić L. Transport of leucineenkephalin across the blood-brain barrier in the perfused guinea pig brain. J Neurochem 1987; 49: 310-315
    • (1987) J Neurochem , vol.49 , pp. 310-315
    • Zloković, B.V.1    Lipovac, M.N.2    Begley, D.J.3    Davson, H.4    Rakić, L.5
  • 30
    • 0022371325 scopus 로고
    • Evidence for a lactate transport system in the sarcolemmal membrane of the perfused rabbit heart: Kinetics of unidirectional influx, carrier specificity and effects of glucagon
    • Mann GE, Zlokovic BV, Yudilevich DL. Evidence for a lactate transport system in the sarcolemmal membrane of the perfused rabbit heart: kinetics of unidirectional influx, carrier specificity and effects of glucagon. Biochim Biophys Acta 1985; 819: 241-248
    • (1985) Biochim Biophys Acta , vol.819 , pp. 241-248
    • Mann, G.E.1    Zlokovic, B.V.2    Yudilevich, D.L.3
  • 31
    • 78649487239 scopus 로고    scopus 로고
    • Pericytes are required for bloodbrain barrier integrity during embryogenesis
    • Daneman R, Zhou L, Kebede AA, Barres BA. Pericytes are required for bloodbrain barrier integrity during embryogenesis. Nature 2010; 468: 562-566
    • (2010) Nature , vol.468 , pp. 562-566
    • Daneman, R.1    Zhou, L.2    Kebede, A.A.3    Barres, B.A.4
  • 33
    • 78049279739 scopus 로고    scopus 로고
    • Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging
    • Bell RD, Winkler EA, Sagare AP, Singh I, LaRue B, Deane R, et al. Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron 2010; 68: 409-427
    • (2010) Neuron , vol.68 , pp. 409-427
    • Bell, R.D.1    Winkler, E.A.2    Sagare, A.P.3    Singh, I.4    Larue, B.5    Deane, R.6
  • 34
    • 84861418194 scopus 로고    scopus 로고
    • Apolipoprotein e controls cerebrovascular integrity via cyclophilin a
    • Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, et al. Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature 2012; 485: 512-516
    • (2012) Nature , vol.485 , pp. 512-516
    • Bell, R.D.1    Winkler, E.A.2    Singh, I.3    Sagare, A.P.4    Deane, R.5    Wu, Z.6
  • 35
    • 84867083056 scopus 로고    scopus 로고
    • Blood-spinal cord barrier pericyte reductions contribute to increased capillary permeability
    • Winkler EA, Sengillo JD, Bell RD, Wang J, Zlokovic BV. Blood-spinal cord barrier pericyte reductions contribute to increased capillary permeability. J Cereb Blood Flow Metab 2012; 32: 1841-1852
    • (2012) J Cereb Blood Flow Metab , vol.32 , pp. 1841-1852
    • Winkler, E.A.1    Sengillo, J.D.2    Bell, R.D.3    Wang, J.4    Zlokovic, B.V.5
  • 36
    • 0037000396 scopus 로고    scopus 로고
    • Cyclooxygenase-2-positive macrophages infiltrate the Alzheimer's disease brain and damage the blood-brain barrier
    • Fiala M, Liu QN, Sayre J, Pop V, Brahmandam V, Graves MC, et al. Cyclooxygenase-2-positive macrophages infiltrate the Alzheimer's disease brain and damage the blood-brain barrier. Eur J Clin Invest 2002; 32: 360-371
    • (2002) Eur J Clin Invest , vol.32 , pp. 360-371
    • Fiala, M.1    Liu, Q.N.2    Sayre, J.3    Pop, V.4    Brahmandam, V.5    Graves, M.C.6
  • 37
    • 17744409878 scopus 로고    scopus 로고
    • Effect of apoe genotype on microvascular basement membrane in Alzheimer's disease
    • Salloway S, Gur T, Berzin T, Tavares R, Zipser B, Correia S, et al. Effect of APOE genotype on microvascular basement membrane in Alzheimer's disease. J Neurol Sci 2002; 203-204: 183-187
    • (2002) J Neurol Sci , vol.203-204 , pp. 183-187
    • Salloway, S.1    Gur, T.2    Berzin, T.3    Tavares, R.4    Zipser, B.5    Correia, S.6
  • 39
    • 72849106266 scopus 로고    scopus 로고
    • A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer's disease brain
    • Ryu JK, McLarnon JG. A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer's disease brain. J Cell Mol Med 2009; 13: 2911-2925
    • (2009) J Cell Mol Med , vol.13 , pp. 2911-2925
    • Ryu, J.K.1    McLarnon, J.G.2
  • 40
    • 84881181605 scopus 로고    scopus 로고
    • The apoe e4/e4 genotype potentiates vascular fibrin(ogen) deposition in amyloid-laden vessels in the brains of Alzheimer's disease patients
    • Hultman K, Strickland S, Norris EH. The APOE e4/e4 genotype potentiates vascular fibrin(ogen) deposition in amyloid-laden vessels in the brains of Alzheimer's disease patients. J Cereb Blood Flow Metab 2013; 33: 1251-1258
    • (2013) J Cereb Blood Flow Metab , vol.33 , pp. 1251-1258
    • Hultman, K.1    Strickland, S.2    Norris, E.H.3
  • 41
    • 84876288324 scopus 로고    scopus 로고
    • Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's disease
    • Sengillo JD, Winkler EA, Walker CT, Sullivan JS, Johnson M, Zlokovic BV. Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's disease. Brain Pathol 2013; 23: 303-310
    • (2013) Brain Pathol , vol.23 , pp. 303-310
    • Sengillo, J.D.1    Winkler, E.A.2    Walker, C.T.3    Sullivan, J.S.4    Johnson, M.5    Zlokovic, B.V.6
  • 42
    • 0035047718 scopus 로고    scopus 로고
    • Cerebral microvascular pathology in aging and Alzheimer's disease
    • Farkas E, Luiten PG. Cerebral microvascular pathology in aging and Alzheimer's disease. Prog Neurobiol 2001; 64: 575-611
    • (2001) Prog Neurobiol , vol.64 , pp. 575-611
    • Farkas, E.1    Luiten, P.G.2
  • 43
    • 84867581572 scopus 로고    scopus 로고
    • The vascular factor in Alzheimer's disease: A study in golgi technique and electron microscopy
    • Baloyannis SJ, Baloyannis IS. The vascular factor in Alzheimer's disease: a study in Golgi technique and electron microscopy. J Neurol Sci 2012; 322: 117-121
    • (2012) J Neurol Sci , vol.322 , pp. 117-121
    • Baloyannis, S.J.1    Baloyannis, I.S.2
  • 44
    • 28044448943 scopus 로고    scopus 로고
    • Pericapillary haem-rich deposits: Evidence for microhaemorrhages in aging human cerebral cortex
    • Cullen KM, Kócsi Z, Stone J. Pericapillary haem-rich deposits: evidence for microhaemorrhages in aging human cerebral cortex. J Cereb Blood Flow Metab 2005; 25: 1656-1667
    • (2005) J Cereb Blood Flow Metab , vol.25 , pp. 1656-1667
    • Cullen, K.M.1    Kócsi, Z.2    Stone, J.3
  • 45
    • 70350548210 scopus 로고    scopus 로고
    • Patients with Alzheimer disease with multiple microbleeds: Relation with cerebrospinal fluid biomarkers and cognition
    • Goos JDC, Kester MI, Barkhof F, Klein M, Blankenstein MA, Scheltens P, et al. Patients with Alzheimer disease with multiple microbleeds: relation with cerebrospinal fluid biomarkers and cognition. Stroke 2009; 40: 3455-3460
    • (2009) Stroke , vol.40 , pp. 3455-3460
    • Goos, J.D.C.1    Kester, M.I.2    Barkhof, F.3    Klein, M.4    Blankenstein, M.A.5    Scheltens, P.6
  • 47
    • 84883168593 scopus 로고    scopus 로고
    • Increased iron levels and decreased tissue integrity in hippocampus of Alzheimer's disease detected in vivo with magnetic resonance imaging
    • Raven EP, Lu PH, Tishler TA, Heydari P, Bartzokis G. Increased iron levels and decreased tissue integrity in hippocampus of Alzheimer's disease detected in vivo with magnetic resonance imaging. J Alzheimers Dis 2013; 37: 127-136
    • (2013) J Alzheimers Dis , vol.37 , pp. 127-136
    • Raven, E.P.1    Lu, P.H.2    Tishler, T.A.3    Heydari, P.4    Bartzokis, G.5
  • 48
    • 61349102361 scopus 로고    scopus 로고
    • Blood-brain barrier permeability in Alzheimer's disease: A case-control mri study
    • Starr JM, Farrall AJ, Armitage P, McGurn B, Wardlaw J. Blood-brain barrier permeability in Alzheimer's disease: a case-control MRI study. Psychiatry Res 2009; 171: 232-241
    • (2009) Psychiatry Res , vol.171 , pp. 232-241
    • Starr, J.M.1    Farrall, A.J.2    Armitage, P.3    McGurn, B.4    Wardlaw, J.5
  • 49
    • 33748252298 scopus 로고    scopus 로고
    • Vascular volume and blood-brain barrier permeability measured by dynamic contrast enhanced mri in hippocampus and cerebellum of patients with mci and normal controls
    • Wang H, Golob EJ, Su M-Y. Vascular volume and blood-brain barrier permeability measured by dynamic contrast enhanced MRI in hippocampus and cerebellum of patients with MCI and normal controls. J Magn Reson Imaging 2006; 24: 695-700
    • (2006) J Magn Reson Imaging , vol.24 , pp. 695-700
    • Wang, H.1    Golob, E.J.2    Su, M.-Y.3
  • 50
    • 70449411152 scopus 로고    scopus 로고
    • Measurement of brain perfusion blood volume and blood-brain barrier permeability using dynamic contrast-enhanced t 1)-weighted mri at 3 tesla
    • Larsson HBW, Courivaud F, Rostrup E, Hansen AE. Measurement of brain perfusion, blood volume, and blood-brain barrier permeability, using dynamic contrast-enhanced T(1)-weighted MRI at 3 tesla. Magn Reson Med 2009; 62: 1270-1281
    • (2009) Magn Reson Med , vol.62 , pp. 1270-1281
    • Larsson, H.B.W.1    Courivaud, F.2    Rostrup, E.3    Hansen, A.E.4
  • 51
    • 84891289780 scopus 로고    scopus 로고
    • Abnormal blood-brain barrier permeability in normal appearing white matter in multiple sclerosis investigated by mri
    • Cramer SP, Simonsen H, Frederiksen JL, Rostrup E, Larsson HBW. Abnormal blood-brain barrier permeability in normal appearing white matter in multiple sclerosis investigated by MRI. Neuroimage Clin 2014; 4: 182-189
    • (2014) Neuroimage Clin , vol.4 , pp. 182-189
    • Cramer, S.P.1    Simonsen, H.2    Frederiksen, J.L.3    Rostrup, E.4    Larsson, H.B.W.5
  • 52
    • 79952776352 scopus 로고    scopus 로고
    • Quantitative measurement of blood-brain barrier permeability in human using dynamic contrast-enhanced mri with fast t1 mapping
    • Taheri S, Gasparovic C, Shah NJ, Rosenberg GA. Quantitative measurement of blood-brain barrier permeability in human using dynamic contrast-enhanced MRI with fast T1 mapping. Magn Reson Med 2011; 65: 1036-1042
    • (2011) Magn Reson Med , vol.65 , pp. 1036-1042
    • Taheri, S.1    Gasparovic, C.2    Shah, N.J.3    Rosenberg, G.A.4
  • 54
    • 0037703255 scopus 로고    scopus 로고
    • Rage mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain
    • Deane R, Du Yan S, Submamaryan RK, LaRue B, Jovanovic S, Hogg E, et al. RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat Med 2003; 9: 907-913
    • (2003) Nat Med , vol.9 , pp. 907-913
    • Deane, R.1    Du Yan, S.2    Submamaryan, R.K.3    Larue, B.4    Jovanovic, S.5    Hogg, E.6
  • 55
    • 34547791784 scopus 로고    scopus 로고
    • Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease
    • Paul J, Strickland S, Melchor JP. Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease. J Exp Med 2007; 204: 1999-2008
    • (2007) J Exp Med , vol.204 , pp. 1999-2008
    • Paul, J.1    Strickland, S.2    Melchor, J.P.3
  • 56
    • 84911885234 scopus 로고    scopus 로고
    • Increased permeability of the blood-brain barrier and Alzheimer's disease-like alterations in slit-2 transgenic mice
    • Li J-C, Han L, Wen Y-X, Yang Y-X, Li S, Li X-S, et al. Increased permeability of the blood-brain barrier and Alzheimer's disease-like alterations in slit-2 transgenic mice. J Alzheimers Dis 2014; 43: 535-548
    • (2014) J Alzheimers Dis , vol.43 , pp. 535-548
    • Li, J.-C.1    Han, L.2    Wen, Y.-X.3    Yang, Y.-X.4    Li, S.5    Li, X.-S.6
  • 57
    • 0032693981 scopus 로고    scopus 로고
    • Altered brain activation in cognitively intact individuals at high risk for Alzheimer's disease
    • Smith CD, Andersen AH, Kryscio RJ, Schmitt FA, Kindy MS, Blonder LX, et al. Altered brain activation in cognitively intact individuals at high risk for Alzheimer's disease. Neurology 1999; 53: 1391-1396
    • (1999) Neurology , vol.53 , pp. 1391-1396
    • Smith, C.D.1    Andersen, A.H.2    Kryscio, R.J.3    Schmitt, F.A.4    Kindy, M.S.5    Blonder, L.X.6
  • 60
    • 74949100133 scopus 로고    scopus 로고
    • Apoe epsilon4 genotype and longitudinal changes in cerebral blood flow in normal aging
    • Thambisetty M, Beason-Held L, An Y, Kraut MA, Resnick SM. APOE epsilon4 genotype and longitudinal changes in cerebral blood flow in normal aging. Arch Neurol 2010; 67: 93-98
    • (2010) Arch Neurol , vol.67 , pp. 93-98
    • Thambisetty, M.1    Beason-Held, L.2    An, Y.3    Kraut, M.A.4    Resnick, S.M.5
  • 61
    • 84908212297 scopus 로고    scopus 로고
    • Cerebral blood flow measured by arterial spin labeling mri as a preclinical marker of Alzheimer's disease
    • Wierenga CE, Hays CC, Zlatar ZZ. Cerebral blood flow measured by arterial spin labeling MRI as a preclinical marker of Alzheimer's disease. J Alzheimers Dis 2014; 42 Suppl 4: S411-S419
    • (2014) J Alzheimers Dis , vol.42 , pp. S411-S419
    • Wierenga, C.E.1    Hays, C.C.2    Zlatar, Z.Z.3
  • 62
    • 13844298168 scopus 로고    scopus 로고
    • Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling mr imaging: Initial experience
    • Johnson NA, Jahng G-H, Weiner MW, Miller BL, Chui HC, Jagust WJ, et al. Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: initial experience. Radiology 2005; 234: 851-859
    • (2005) Radiology , vol.234 , pp. 851-859
    • Johnson, N.A.1    Jahng, G.-H.2    Weiner, M.W.3    Miller, B.L.4    Chui, H.C.5    Jagust, W.J.6
  • 65
    • 84888304810 scopus 로고    scopus 로고
    • Age-related alteration in cerebral blood flow and energy failure is correlated with cognitive impairment in the senescence-Accelerated prone mouse strain 8 (samp8
    • Zhang X, Li G, Guo L, Nie K, Jia Y, Zhao L, et al. Age-related alteration in cerebral blood flow and energy failure is correlated with cognitive impairment in the senescence-Accelerated prone mouse strain 8 (SAMP8). Neurol Sci 2013; 34: 1917-1924
    • (2013) Neurol Sci , vol.34 , pp. 1917-1924
    • Zhang, X.1    Li, G.2    Guo, L.3    Nie, K.4    Jia, Y.5    Zhao, L.6
  • 67
    • 25144503548 scopus 로고    scopus 로고
    • Densecore plaques in tg2576 and psapp mouse models of Alzheimer's disease are centered on vessel walls
    • Kumar-Singh S, Pirici D, McGowan E, Serneels S, Ceuterick C, Hardy J, et al. Densecore plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls. Am J Pathol 2005; 167: 527-543
    • (2005) Am J Pathol , vol.167 , pp. 527-543
    • Kumar-Singh, S.1    Pirici, D.2    McGowan, E.3    Serneels, S.4    Ceuterick, C.5    Hardy, J.6
  • 68
    • 84902002905 scopus 로고    scopus 로고
    • Crystal structure of the human glucose transporter glut1
    • Deng D, Xu C, Sun P, Wu J, Yan C, Hu M, et al. Crystal structure of the human glucose transporter GLUT1. Nature 2014; 510: 121-125
    • (2014) Nature , vol.510 , pp. 121-125
    • Deng, D.1    Xu, C.2    Sun, P.3    Wu, J.4    Yan, C.5    Hu, M.6
  • 69
    • 84871379058 scopus 로고    scopus 로고
    • Plastic changes in the astrocyte glut1 glucose transporter and beta-Tubulin microtubule protein following voluntary exercise in mice
    • Allen A, Messier C. Plastic changes in the astrocyte GLUT1 glucose transporter and beta-Tubulin microtubule protein following voluntary exercise in mice. Behav Brain Res 2013; 240: 95-102
    • (2013) Behav Brain Res , vol.240 , pp. 95-102
    • Allen, A.1    Messier, C.2
  • 71
    • 0031050403 scopus 로고    scopus 로고
    • Distribution of glut1 glucose transporters in different brain structures compared to glucose utilization and capillary density of adult rat brains
    • Zeller K, Rahner-Welsch S, Kuschinsky W. Distribution of Glut1 glucose transporters in different brain structures compared to glucose utilization and capillary density of adult rat brains. J Cereb Blood Flow Metab 1997; 17: 204-209
    • (1997) J Cereb Blood Flow Metab , vol.17 , pp. 204-209
    • Zeller, K.1    Rahner-Welsch, S.2    Kuschinsky, W.3
  • 73
    • 84874912869 scopus 로고    scopus 로고
    • Posterior cingulate glucose metabolism, hippocampal glucose metabolism, and hippocampal volume in cognitively normal, late-middle-Aged persons at 3 levels of genetic risk for Alzheimer disease
    • Protas HD, Chen K, Langbaum JBS, Fleisher AS, Alexander GE, Lee W, et al. Posterior cingulate glucose metabolism, hippocampal glucose metabolism, and hippocampal volume in cognitively normal, late-middle-Aged persons at 3 levels of genetic risk for Alzheimer disease. JAMA Neurol 2013; 70: 320-325
    • (2013) JAMA Neurol , vol.70 , pp. 320-325
    • Protas, H.D.1    Chen, K.2    Langbaum, J.B.S.3    Fleisher, A.S.4    Alexander, G.E.5    Lee, W.6
  • 74
    • 84868159914 scopus 로고    scopus 로고
    • Amyloid and metabolic positron emission tomography imaging of cognitively normal adults with Alzheimer's parents
    • Mosconi L, Rinne JO, Tsui WH, Murray J, Li Y, Glodzik L, et al. Amyloid and metabolic positron emission tomography imaging of cognitively normal adults with Alzheimer's parents. Neurobiol Aging 2013; 34: 22-34
    • (2013) Neurobiol Aging , vol.34 , pp. 22-34
    • Mosconi, L.1    Rinne, J.O.2    Tsui, W.H.3    Murray, J.4    Li, Y.5    Glodzik, L.6
  • 75
    • 33947261376 scopus 로고    scopus 로고
    • Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer's disease
    • Mosconi L, Sorbi S, de Leon MJ, Li Y, Nacmias B, Myoung PS, et al. Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer's disease. J Nucl Med 2006; 47: 1778-1786
    • (2006) J Nucl Med , vol.47 , pp. 1778-1786
    • Mosconi, L.1    Sorbi, S.2    De Leon, M.J.3    Li, Y.4    Nacmias, B.5    Myoung, P.S.6
  • 76
    • 0036176504 scopus 로고    scopus 로고
    • Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein
    • Niwa K, Kazama K, Younkin SG, Carlson GA, Iadecola C. Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein. Neurobiol Dis 2002; 9: 61-68
    • (2002) Neurobiol Dis , vol.9 , pp. 61-68
    • Niwa, K.1    Kazama, K.2    Younkin, S.G.3    Carlson, G.A.4    Iadecola, C.5
  • 78
    • 0029874365 scopus 로고    scopus 로고
    • Diminished glucose transport and phosphorylation in Alzheimer's disease determined by dynamic fdg-pet
    • Piert M, Koeppe RA, Giordani B, Berent S, Kuhl DE. Diminished glucose transport and phosphorylation in Alzheimer's disease determined by dynamic FDG-PET. J Nucl Med 1996; 37: 201-208
    • (1996) J Nucl Med , vol.37 , pp. 201-208
    • Piert, M.1    Koeppe, R.A.2    Giordani, B.3    Berent, S.4    Kuhl, D.E.5
  • 79
    • 0028241915 scopus 로고
    • Decreased concentrations of glut1 and glut3 glucose transporters in the brains of patients with Alzheimer's disease
    • Simpson IA, Chundu KR, Davies-Hill T, Honer WG, Davies P. Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease. Ann Neurol 1994; 35: 546-551
    • (1994) Ann Neurol , vol.35 , pp. 546-551
    • Simpson, I.A.1    Chundu, K.R.2    Davies-Hill, T.3    Honer, W.G.4    Davies, P.5
  • 80
    • 0030690323 scopus 로고    scopus 로고
    • Glut-1 expression in the cerebra of patients with Alzheimer's disease
    • Mooradian AD, Chung HC, Shah GN. GLUT-1 expression in the cerebra of patients with Alzheimer's disease. Neurobiol Aging 1997; 18: 469-474
    • (1997) Neurobiol Aging , vol.18 , pp. 469-474
    • Mooradian, A.D.1    Chung, H.C.2    Shah, G.N.3
  • 81
    • 0024419325 scopus 로고
    • Reduced glucose transporter at the blood-brain barrier and in cerebral cortex in Alzheimer disease
    • Kalaria RN, Harik SI. Reduced glucose transporter at the blood-brain barrier and in cerebral cortex in Alzheimer disease. J Neurochem 1989; 53: 1083-1088
    • (1989) J Neurochem , vol.53 , pp. 1083-1088
    • Kalaria, R.N.1    Harik, S.I.2
  • 82
    • 0027933949 scopus 로고
    • Immunolabelling of hippocampal microvessel glucose transporter protein is reduced in Alzheimer's disease
    • Horwood N, Davies DC. Immunolabelling of hippocampal microvessel glucose transporter protein is reduced in Alzheimer's disease. Virchows Arch 1994; 425: 69-72
    • (1994) Virchows Arch , vol.425 , pp. 69-72
    • Horwood, N.1    Davies, D.C.2
  • 84
    • 33747448625 scopus 로고    scopus 로고
    • Studies on the first described Alzheimer's disease amyloid beta mutant, the Dutch variant
    • Levy E, Prelli F, Frangione B. Studies on the first described Alzheimer's disease amyloid beta mutant, the Dutch variant. J Alzheimers Dis 2006; 9: 329-339
    • (2006) J Alzheimers Dis , vol.9 , pp. 329-339
    • Levy, E.1    Prelli, F.2    Frangione, B.3
  • 86
    • 84887259294 scopus 로고    scopus 로고
    • Multiple microbleeds are related to cerebral network disruptions in patients with early Alzheimer's disease
    • Heringa SM, Reijmer YD, Leemans A, Koek HL, Kappelle LJ, Biessels GJ, et al. Multiple microbleeds are related to cerebral network disruptions in patients with early Alzheimer's disease. J Alzheimers Dis 2014; 38: 211-221
    • (2014) J Alzheimers Dis , vol.38 , pp. 211-221
    • Heringa, S.M.1    Reijmer, Y.D.2    Leemans, A.3    Koek, H.L.4    Kappelle, L.J.5    Biessels, G.J.6
  • 87
    • 0036323445 scopus 로고    scopus 로고
    • Alzheimer disease and cerebrovascular pathology: An update
    • Jellinger KA. Alzheimer disease and cerebrovascular pathology: an update. J Neural Transm 2002; 109: 813-836
    • (2002) J Neural Transm , vol.109 , pp. 813-836
    • Jellinger, K.A.1
  • 88
    • 4043061467 scopus 로고    scopus 로고
    • Lrp/amyloid betapeptide interaction mediates differential brain efflux of abeta isoforms
    • Deane R, Wu Z, Sagare A, Davis J, Du Yan S, Hamm K, et al. LRP/amyloid betapeptide interaction mediates differential brain efflux of Abeta isoforms. Neuron 2004; 43: 333-344
    • (2004) Neuron , vol.43 , pp. 333-344
    • Deane, R.1    Wu, Z.2    Sagare, A.3    Davis, J.4    Du Yan, S.5    Hamm, K.6
  • 89
    • 0036227489 scopus 로고    scopus 로고
    • Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood
    • Monro OR, Mackic JB, Yamada S, Segal MB, Ghiso J, Maurer C, et al. Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood. Neurobiol Aging 2002; 23: 405-412
    • (2002) Neurobiol Aging , vol.23 , pp. 405-412
    • Monro, O.R.1    MacKic, J.B.2    Yamada, S.3    Segal, M.B.4    Ghiso, J.5    Maurer, C.6
  • 90
    • 84864691664 scopus 로고    scopus 로고
    • Disruption of arterial perivascular drainage of amyloid-β from the brains of mice expressing the human apoe e4 allele
    • Hawkes CA, Sullivan PM, Hands S, Weller RO, Nicoll JAR, Carare RO. Disruption of arterial perivascular drainage of amyloid-β from the brains of mice expressing the human APOE e4 allele. PLoS One 2012; 7: e41636
    • (2012) PLoS One , vol.7 , pp. e41636
    • Hawkes, C.A.1    Sullivan, P.M.2    Hands, S.3    Weller, R.O.4    Nicoll, J.A.R.5    Carare, R.O.6
  • 91
    • 67349118757 scopus 로고    scopus 로고
    • Microvasculature changes and cerebral amyloid angiopathy in Alzheimer's disease and their potential impact on therapy
    • Weller RO, Boche D, Nicoll JAR. Microvasculature changes and cerebral amyloid angiopathy in Alzheimer's disease and their potential impact on therapy. Acta Neuropathol (Berl) 2009; 118: 87-102
    • (2009) Acta Neuropathol (Berl , vol.118 , pp. 87-102
    • Weller, R.O.1    Boche, D.2    Nicoll, J.A.R.3
  • 92
    • 84906931766 scopus 로고    scopus 로고
    • Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: Interplay with cerebral blood flow
    • Li H, Guo Q, Inoue T, Polito VA, Tabuchi K, Hammer RE, et al. Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow. Mol Neurodegener 2014; 9: 28
    • (2014) Mol Neurodegener , vol.9 , pp. 28
    • Li, H.1    Guo, Q.2    Inoue, T.3    Polito, V.A.4    Tabuchi, K.5    Hammer, R.E.6
  • 93
    • 84903627137 scopus 로고    scopus 로고
    • Alzheimer's disease genetics: From the bench to the clinic
    • Karch CM, Cruchaga C, Goate AM. Alzheimer's disease genetics: from the bench to the clinic. Neuron 2014; 83: 11-26
    • (2014) Neuron , vol.83 , pp. 11-26
    • Karch, C.M.1    Cruchaga, C.2    Goate, A.M.3
  • 94
    • 33749042749 scopus 로고    scopus 로고
    • Sorting through the cell biology of Alzheimer's disease: Intracellular pathways to pathogenesis
    • Small SA, Gandy S. Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis. Neuron 2006; 52: 15-31
    • (2006) Neuron , vol.52 , pp. 15-31
    • Small, S.A.1    Gandy, S.2
  • 95
    • 38549131905 scopus 로고    scopus 로고
    • Small cerebral vessel disease in familial amyloid and non-Amyloid angiopathies: Fad-ps-1 (p117l) mutation and cadasil immunohistochemical and ultrastructural studies
    • Szpak GM, Lewandowska E, Wierzba-Bobrowicz T, Bertrand E, Pasennik E, Mendel T, et al. Small cerebral vessel disease in familial amyloid and non-Amyloid angiopathies: FAD-PS-1 (P117L) mutation and CADASIL. Immunohistochemical and ultrastructural studies. Folia Neuropathol 2007; 45: 192-204
    • (2007) Folia Neuropathol , vol.45 , pp. 192-204
    • Szpak, G.M.1    Lewandowska, E.2    Wierzba-Bobrowicz, T.3    Bertrand, E.4    Pasennik, E.5    Mendel, T.6
  • 96
    • 62249133805 scopus 로고    scopus 로고
    • Spatial correlations between beta-Amyloid (abeta) deposits and blood vessels in familial Alzheimer's disease
    • Armstrong RA. Spatial correlations between beta-Amyloid (Abeta) deposits and blood vessels in familial Alzheimer's disease. Folia Neuropathol 2008; 46: 241-248
    • (2008) Folia Neuropathol , vol.46 , pp. 241-248
    • Armstrong, R.A.1
  • 97
    • 42249102801 scopus 로고    scopus 로고
    • Clinical and neuropathological features of the arctic app gene mutation causing early-onset Alzheimer disease
    • Basum H, Bogdanovic N, Ingelsson M, Almkvist O, Naslund J, Axelman K, et al. Clinical and neuropathological features of the arctic APP gene mutation causing early-onset Alzheimer disease. Arch Neurol 2008; 65: 499-505
    • (2008) Arch Neurol , vol.65 , pp. 499-505
    • Basum, H.1    Bogdanovic, N.2    Ingelsson, M.3    Almkvist, O.4    Naslund, J.5    Axelman, K.6
  • 98
    • 84875803331 scopus 로고    scopus 로고
    • Clinical and neuropathological findings in a patient with familial Alzheimer disease showing a mutation in the psen1 gene: Familial Alzheimer disease with psen1
    • Niwa A, Matsuo K, Shindo A, Yata K, Shiraishi T, Tomimoto H. Clinical and neuropathological findings in a patient with familial Alzheimer disease showing a mutation in the PSEN1 gene: familial Alzheimer disease with PSEN1. Neuropathology 2013; 33: 199-203
    • (2013) Neuropathology , vol.33 , pp. 199-203
    • Niwa, A.1    Matsuo, K.2    Shindo, A.3    Yata, K.4    Shiraishi, T.5    Tomimoto, H.6
  • 99
    • 84922681924 scopus 로고    scopus 로고
    • Restoration of cerebral and systemic microvascular architecture in app/ps1 transgenic mice following treatment with liraglutide(tm
    • Kelly P, McClean P, Ackermann M, Konerding MA, Hölscher C, Mitchell CA. Restoration of cerebral and systemic microvascular architecture in APP/PS1 transgenic mice following treatment with Liraglutide(TM). Microcirculation 2014; 22: 133-145
    • (2014) Microcirculation , vol.22 , pp. 133-145
    • Kelly, P.1    McClean, P.2    Ackermann, M.3    Konerding, M.A.4    Hölscher, C.5    Mitchell, C.A.6
  • 100
    • 73949119034 scopus 로고    scopus 로고
    • Age-related vascular pathology in transgenic mice expressing presenilin 1-Associated familial Alzheimer's disease mutations
    • Gama Sosa MA, Gasperi RD, Rocher AB, Wang AC-J, Janssen WGM, Flores T, et al. Age-related vascular pathology in transgenic mice expressing presenilin 1-Associated familial Alzheimer's disease mutations. Am J Pathol 2010; 176: 353-368
    • (2010) Am J Pathol , vol.176 , pp. 353-368
    • Gama Sosa, M.A.1    Gasperi, R.D.2    Rocher, A.B.3    Wang, A.C.-J.4    Janssen, W.G.M.5    Flores, T.6
  • 102
    • 57449084208 scopus 로고    scopus 로고
    • Apoe isoform-specific disruption of amyloid beta peptide clearance from mouse brain
    • Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, et al. apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J Clin Invest 2008; 118: 4002-4013
    • (2008) J Clin Invest , vol.118 , pp. 4002-4013
    • Deane, R.1    Sagare, A.2    Hamm, K.3    Parisi, M.4    Lane, S.5    Finn, M.B.6
  • 103
    • 84883796045 scopus 로고    scopus 로고
    • Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown
    • Halliday MR, Pomara N, Sagare AP, Mack WJ, Frangione B, Zlokovic BV. Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown. JAMA Neurol 2013; 70: 1198-1200
    • (2013) JAMA Neurol , vol.70 , pp. 1198-1200
    • Halliday, M.R.1    Pomara, N.2    Sagare, A.P.3    MacK, W.J.4    Frangione, B.5    Zlokovic, B.V.6
  • 104
    • 84951568640 scopus 로고    scopus 로고
    • Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein e4 carriers with Alzheimer's disease
    • Halliday MR, Rege SV, Ma Q, Zhao Z, Miller CA, Winkler EA, et al. Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease. J Cereb Blood Flow Metab 2015. doi: 10.1038/jcbfm.2015.44
    • (2015) J Cereb Blood Flow Metab
    • Halliday, M.R.1    Rege, S.V.2    Ma, Q.3    Zhao, Z.4    Miller, C.A.5    Winkler, E.A.6
  • 105
    • 84905440886 scopus 로고    scopus 로고
    • Clinical predictors of severe cerebral amyloid angiopathy and influence of apoe genotype in persons with pathologically verified Alzheimer disease
    • Ringman JM, Sachs MC, Zhou Y, Monsell SE, Saver JL, Vinters HV. Clinical predictors of severe cerebral amyloid angiopathy and influence of APOE genotype in persons with pathologically verified Alzheimer disease. JAMA Neurol 2014; 71: 878-883
    • (2014) JAMA Neurol , vol.71 , pp. 878-883
    • Ringman, J.M.1    Sachs, M.C.2    Zhou, Y.3    Monsell, S.E.4    Saver, J.L.5    Vinters, H.V.6
  • 107
    • 84920686030 scopus 로고    scopus 로고
    • Human apolipoprotein e e4 expression impairs cerebral vascularization and blood-brain barrier function in mice
    • Alata W, Ye Y, St-Amour I, Vandal M, Calon F. Human apolipoprotein E e4 expression impairs cerebral vascularization and blood-brain barrier function in mice. J Cereb Blood Flow Metab 2015; 35: 86-94
    • (2015) J Cereb Blood Flow Metab , vol.35 , pp. 86-94
    • Alata, W.1    Ye, Y.2    St-Amour, I.3    Vandal, M.4    Calon, F.5
  • 108
    • 70349558522 scopus 로고    scopus 로고
    • Genome-wide association study identifies variants at clu and picalm associated with Alzheimer's disease
    • Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet 2009; 41: 1088-1093
    • (2009) Nat Genet , vol.41 , pp. 1088-1093
    • Harold, D.1    Abraham, R.2    Hollingworth, P.3    Sims, R.4    Gerrish, A.5    Hamshere, M.L.6
  • 109
    • 79955484414 scopus 로고    scopus 로고
    • Common variants at abca7, ms4a6a/ms4a4e, epha1, cd33 and cd2ap are associated with Alzheimer's disease
    • Hollingworth P, Harold D, Sims R, Gerrish A, Lambert J-C, Carrasquillo MM, et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet 2011; 43: 429-435
    • (2011) Nat Genet , vol.43 , pp. 429-435
    • Hollingworth, P.1    Harold, D.2    Sims, R.3    Gerrish, A.4    Lambert, J.-C.5    Carrasquillo, M.M.6
  • 110
    • 84888317489 scopus 로고    scopus 로고
    • Meta-Analysis of 74, 046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
    • Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, et al. Meta-Analysis of 74, 046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet 2013; 45: 1452-1458
    • (2013) Nat Genet , vol.45 , pp. 1452-1458
    • Lambert, J.C.1    Ibrahim-Verbaas, C.A.2    Harold, D.3    Naj, A.C.4    Sims, R.5    Bellenguez, C.6
  • 111
    • 34247506244 scopus 로고    scopus 로고
    • Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins e and j in the mouse central nervous system
    • Bell RD, Sagare AP, Friedman AE, Bedi GS, Holtzman DM, Deane R, et al. Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system. J Cereb Blood Flow Metab 2007; 27: 909-918
    • (2007) J Cereb Blood Flow Metab , vol.27 , pp. 909-918
    • Bell, R.D.1    Sagare, A.P.2    Friedman, A.E.3    Bedi, G.S.4    Holtzman, D.M.5    Deane, R.6
  • 112
    • 84885704987 scopus 로고    scopus 로고
    • Adam10 missense mutations potentiate β-Amyloid accumulation by impairing prodomain chaperone function
    • Suh J, Choi SH, Romano DM, Gannon MA, Lesinski AN, Kim DY, et al. ADAM10 missense mutations potentiate β-Amyloid accumulation by impairing prodomain chaperone function. Neuron 2013; 80: 385-401
    • (2013) Neuron , vol.80 , pp. 385-401
    • Suh, J.1    Choi, S.H.2    Romano, D.M.3    Gannon, M.A.4    Lesinski, A.N.5    Kim, D.Y.6
  • 113
    • 84867608942 scopus 로고    scopus 로고
    • The genetics of Alzheimer disease
    • a006296
    • Tanzi RE. The genetics of Alzheimer disease. Cold Spring Harb Perspect Med 2012; 2: pii: a006296
    • (2012) Cold Spring Harb Perspect Med , vol.2
    • Tanzi, R.E.1
  • 114
    • 84889817038 scopus 로고    scopus 로고
    • New insights into the dementia epidemic
    • Larson EB, Yaffe K, Langa KM. New insights into the dementia epidemic. N Engl J Med 2013; 369: 2275-2277
    • (2013) N Engl J Med , vol.369 , pp. 2275-2277
    • Larson, E.B.1    Yaffe, K.2    Langa, K.M.3
  • 115
  • 116
    • 84876937682 scopus 로고    scopus 로고
    • Dha supplementation improved both memory and reaction time in healthy young adults: A randomized controlled trial
    • Stonehouse W, Conlon CA, Podd J, Hill SR, Minihane AM, Haskell C, et al. DHA supplementation improved both memory and reaction time in healthy young adults: a randomized controlled trial. Am J Clin Nutr 2013; 97: 1134-1143
    • (2013) Am J Clin Nutr , vol.97 , pp. 1134-1143
    • Stonehouse, W.1    Conlon, C.A.2    Podd, J.3    Hill, S.R.4    Minihane, A.M.5    Haskell, C.6
  • 117
    • 84903538383 scopus 로고    scopus 로고
    • Human cerebrospinal fluid fatty acid levels differ between supernatant fluid and brain-derived nanoparticle fractions, and are altered in Alzheimer's disease
    • Fonteh AN, Cipolla M, Chiang J, Arakaki X, Harrington MG. Human cerebrospinal fluid fatty acid levels differ between supernatant fluid and brain-derived nanoparticle fractions, and are altered in Alzheimer's disease. PLoS One 2014; 9: e100519
    • (2014) PLoS One , vol.9 , pp. e100519
    • Fonteh, A.N.1    Cipolla, M.2    Chiang, J.3    Arakaki, X.4    Harrington, M.G.5
  • 118
    • 84901260638 scopus 로고    scopus 로고
    • Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid
    • Nguyen LN, Ma D, Shui G, Wong P, Cazenave-Gassiot A, Zhang X, et al. Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. Nature 2014; 509: 503-506
    • (2014) Nature , vol.509 , pp. 503-506
    • Nguyen, L.N.1    Ma, D.2    Shui, G.3    Wong, P.4    Cazenave-Gassiot, A.5    Zhang, X.6
  • 119
    • 84901269974 scopus 로고    scopus 로고
    • Mfsd2a is critical for the formation and function of the blood-brain barrier
    • Ben-Zvi A, Lacoste B, Kur E, Andreone BJ, Mayshar Y, Yan H, et al. Mfsd2a is critical for the formation and function of the blood-brain barrier. Nature 2014; 509: 507-511
    • (2014) Nature , vol.509 , pp. 507-511
    • Ben-Zvi, A.1    Lacoste, B.2    Kur, E.3    Andreone, B.J.4    Mayshar, Y.5    Yan, H.6
  • 120
    • 84901777562 scopus 로고    scopus 로고
    • Blood-brain barrier: A dual life of mfsd2a
    • Zhao Z, Zlokovic BV. Blood-brain barrier: a dual life of MFSD2A? Neuron 2014; 82: 728-730
    • (2014) Neuron , vol.82 , pp. 728-730
    • Zhao, Z.1    Zlokovic, B.V.2
  • 121
    • 84899462816 scopus 로고    scopus 로고
    • Reduction in dha transport to the brain of mice expressing human apoe4 compared to apoe2
    • Vandal M, Alata W, Tremblay C, Rioux-Perreault C, Salem N, Calon F, et al. Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2. J Neurochem 2014; 129: 516-526
    • (2014) J Neurochem , vol.129 , pp. 516-526
    • Vandal, M.1    Alata, W.2    Tremblay, C.3    Rioux-Perreault, C.4    Salem, N.5    Calon, F.6
  • 123
    • 84982085564 scopus 로고    scopus 로고
    • Vascular plasticity and cognition during normal aging and dementia
    • Montagne A, Pa J, Zlokovic BV. Vascular plasticity and cognition during normal aging and dementia. JAMA Neurol 2015. doi: 10.1001/jamaneurol. 2014.4636
    • (2015) JAMA Neurol
    • Montagne, A.1    Pa, J.2    Zlokovic, B.V.3
  • 124
    • 84873330831 scopus 로고    scopus 로고
    • The association between midlife cardiorespiratory fitness levels and later-life dementia: A cohort study
    • Defina LF, Willis BL, Radford NB, Gao A, Leonard D, Haskell WL, et al. The association between midlife cardiorespiratory fitness levels and later-life dementia: a cohort study. Ann Intern Med 2013; 158: 162-168
    • (2013) Ann Intern Med , vol.158 , pp. 162-168
    • Defina, L.F.1    Willis, B.L.2    Radford, N.B.3    Gao, A.4    Leonard, D.5    Haskell, W.L.6
  • 125
    • 20044377403 scopus 로고    scopus 로고
    • Environmental enrichment reduces abeta levels and amyloid deposition in transgenic mice
    • Lazarov O, Robinson J, Tang Y-P, Hairston IS, Korade-Mirnics Z, Lee VM-Y, et al. Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice. Cell 2005; 120: 701-713
    • (2005) Cell , vol.120 , pp. 701-713
    • Lazarov, O.1    Robinson, J.2    Tang, Y.-P.3    Hairston, I.S.4    Korade-Mirnics, Z.5    Lee, V.M.-Y.6
  • 126
    • 33746633882 scopus 로고    scopus 로고
    • Reduction of amyloid angiopathy and abeta plaque burden after enriched housing in tgcrnd8 mice: Involvement of multiple pathways
    • Ambrée O, Leimer U, Herring A, Görtz N, Sachser N, Heneka MT, et al. Reduction of amyloid angiopathy and Abeta plaque burden after enriched housing in TgCRND8 mice: involvement of multiple pathways. Am J Pathol 2006; 169: 544-552
    • (2006) Am J Pathol , vol.169 , pp. 544-552
    • Ambrée, O.1    Leimer, U.2    Herring, A.3    Görtz, N.4    Sachser, N.5    Heneka, M.T.6
  • 127
    • 38349147618 scopus 로고    scopus 로고
    • Environmental enrichment counteracts Alzheimer's neurovascular dysfunction in tgcrnd8 mice
    • Herring A, Yasin H, Ambrée O, Sachser N, Paulus W, Keyvani K. Environmental enrichment counteracts Alzheimer's neurovascular dysfunction in TgCRND8 mice. Brain Pathol 2008; 18: 32-39
    • (2008) Brain Pathol , vol.18 , pp. 32-39
    • Herring, A.1    Yasin, H.2    Ambrée, O.3    Sachser, N.4    Paulus, W.5    Keyvani, K.6
  • 128
    • 84869037441 scopus 로고    scopus 로고
    • Lrp1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β
    • Kanekiyo T, Liu C-C, Shinohara M, Li J, Bu G. LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β. J Neurosci 2012; 32: 16458-16465
    • (2012) J Neurosci , vol.32 , pp. 16458-16465
    • Kanekiyo, T.1    Liu, C.-C.2    Shinohara, M.3    Li, J.4    Bu, G.5
  • 129
    • 84859723641 scopus 로고    scopus 로고
    • A multimodal ragespecific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease
    • Deane R, Singh I, Sagare AP, Bell RD, Ross NT, LaRue B, et al. A multimodal RAGEspecific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. J Clin Invest 2012; 122: 1377-1392
    • (2012) J Clin Invest , vol.122 , pp. 1377-1392
    • Deane, R.1    Singh, I.2    Sagare, A.P.3    Bell, R.D.4    Ross, N.T.5    Larue, B.6
  • 131
    • 70350061949 scopus 로고    scopus 로고
    • Multimodal techniques for diagnosis and prognosis of Alzheimer's disease
    • Perrin RJ, Fagan AM, Holtzman DM. Multimodal techniques for diagnosis and prognosis of Alzheimer's disease. Nature 2009; 461: 916-922
    • (2009) Nature , vol.461 , pp. 916-922
    • Perrin, R.J.1    Fagan, A.M.2    Holtzman, D.M.3
  • 132
    • 77949423619 scopus 로고    scopus 로고
    • Cerebrospinal fluid and plasma biomarkers in Alzheimer disease
    • Blennow K, Hampel H, Weiner M, Zetterberg H. Cerebrospinal fluid and plasma biomarkers in Alzheimer disease. Nat Rev Neurol 2010; 6: 131-144
    • (2010) Nat Rev Neurol , vol.6 , pp. 131-144
    • Blennow, K.1    Hampel, H.2    Weiner, M.3    Zetterberg, H.4
  • 134
    • 84879122146 scopus 로고    scopus 로고
    • Amyloid imaging and csf biomarkers in predicting cognitive impairment up to 7.5 years later
    • Roe CM, Fagan AM, Grant EA, Hassenstab J, Moulder KL, Maue Dreyfus D, et al. Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later. Neurology 2013; 80: 1784-1791
    • (2013) Neurology , vol.80 , pp. 1784-1791
    • Roe, C.M.1    Fagan, A.M.2    Grant, E.A.3    Hassenstab, J.4    Moulder, K.L.5    Maue Dreyfus, D.6
  • 135
    • 84896332591 scopus 로고    scopus 로고
    • Alzheimer's disease: New data highlight nonneuronal cell types and the necessity for presymptomatic prevention strategies
    • Gandy S. Alzheimer's disease: new data highlight nonneuronal cell types and the necessity for presymptomatic prevention strategies. Biol Psychiatry 2014; 75: 553-557
    • (2014) Biol Psychiatry , vol.75 , pp. 553-557
    • Gandy, S.1
  • 136
    • 44349096287 scopus 로고    scopus 로고
    • Hypertension and cerebrovascular dysfunction
    • Iadecola C, Davisson RL. Hypertension and cerebrovascular dysfunction. Cell Metab 2008; 7: 476-484
    • (2008) Cell Metab , vol.7 , pp. 476-484
    • Iadecola, C.1    Davisson, R.L.2
  • 138
    • 0025978236 scopus 로고
    • White-matter lesions on ct in Alzheimer patients: Relation to clinical symptomatology and vascular factors
    • Blennow K, Wallin A, Uhlemann C, Gottfries CG. White-matter lesions on CT in Alzheimer patients: relation to clinical symptomatology and vascular factors. Acta Neurol Scand 1991; 83: 187-193
    • (1991) Acta Neurol Scand , vol.83 , pp. 187-193
    • Blennow, K.1    Wallin, A.2    Uhlemann, C.3    Gottfries, C.G.4
  • 139
    • 0033202419 scopus 로고    scopus 로고
    • Cerebrospinal fluid markers of pathogenetic processes in vascular dementia, with special reference to the subcortical subtype
    • Wallin A, Blennow K, Rosengren L. Cerebrospinal fluid markers of pathogenetic processes in vascular dementia, with special reference to the subcortical subtype. Alzheimer Dis Assoc Disord 1999; 13 Suppl 3: S102-S105
    • (1999) Alzheimer Dis Assoc Disord , vol.13 , pp. S102-S105
    • Wallin, A.1    Blennow, K.2    Rosengren, L.3
  • 140
    • 0031922362 scopus 로고    scopus 로고
    • A population study on blood-brain barrier function in 85-year-olds: Relation to Alzheimer's disease and vascular dementia
    • Skoog I, Wallin A, Fredman P, Hesse C, Aevarsson O, Karlsson I, et al. A population study on blood-brain barrier function in 85-year-olds: relation to Alzheimer's disease and vascular dementia. Neurology 1998; 50: 966-971
    • (1998) Neurology , vol.50 , pp. 966-971
    • Skoog, I.1    Wallin, A.2    Fredman, P.3    Hesse, C.4    Aevarsson, O.5    Karlsson, I.6
  • 141
    • 79955431733 scopus 로고    scopus 로고
    • Multiplexed immunoassay panel identifies novel csf biomarkers for Alzheimer's disease diagnosis and prognosis
    • Craig-Schapiro R, Kuhn M, Xiong C, Pickering EH, Liu J, Misko TP, et al. Multiplexed immunoassay panel identifies novel CSF biomarkers for Alzheimer's disease diagnosis and prognosis. PLoS One 2011; 6: e18850
    • (2011) PLoS One , vol.6 , pp. e18850
    • Craig-Schapiro, R.1    Kuhn, M.2    Xiong, C.3    Pickering, E.H.4    Liu, J.5    Misko, T.P.6
  • 144
    • 84901928902 scopus 로고    scopus 로고
    • Analysis of matrix metallo-proteases and the plasminogen system in mild cognitive impairment and Alzheimer's disease cerebrospinal fluid
    • Hanzel CE, Iulita MF, Eyjolfsdottir H, Hjorth E, Schultzberg M, Eriksdotter M, et al. Analysis of matrix metallo-proteases and the plasminogen system in mild cognitive impairment and Alzheimer's disease cerebrospinal fluid. J Alzheimers Dis 2014; 40: 667-678
    • (2014) J Alzheimers Dis , vol.40 , pp. 667-678
    • Hanzel, C.E.1    Iulita, M.F.2    Eyjolfsdottir, H.3    Hjorth, E.4    Schultzberg, M.5    Eriksdotter, M.6
  • 145
    • 80055014830 scopus 로고    scopus 로고
    • Central nervous system pericytes in health and disease
    • Winkler EA, Bell RD, Zlokovic BV. Central nervous system pericytes in health and disease. Nat Neurosci 2011; 14: 1398-1405
    • (2011) Nat Neurosci , vol.14 , pp. 1398-1405
    • Winkler, E.A.1    Bell, R.D.2    Zlokovic, B.V.3
  • 149
    • 79960167261 scopus 로고    scopus 로고
    • Markedly elevated soluble intercellular adhesion molecule 1, soluble vascular cell adhesion molecule 1 levels, and blood-brain barrier breakdown in neuromyelitis optica
    • Uzawa A, Mori M, Masuda S, Kuwabara S. Markedly elevated soluble intercellular adhesion molecule 1, soluble vascular cell adhesion molecule 1 levels, and blood-brain barrier breakdown in neuromyelitis optica. Arch Neurol 2011; 68: 913-917
    • (2011) Arch Neurol , vol.68 , pp. 913-917
    • Uzawa, A.1    Mori, M.2    Masuda, S.3    Kuwabara, S.4
  • 150
    • 0032761967 scopus 로고    scopus 로고
    • Evidence of blood-brain barrier alteration and activation in HIV-1 gp120 transgenic mice
    • Toneatto S, Finco O, van der Putten H, Abrignani S, Annunziata P. Evidence of blood-brain barrier alteration and activation in HIV-1 gp120 transgenic mice. AIDS 1999; 13: 2343-2348
    • (1999) AIDS , vol.13 , pp. 2343-2348
    • Toneatto, S.1    Finco, O.2    Van Der Putten, H.3    Abrignani, S.4    Annunziata, P.5
  • 151
    • 33947205974 scopus 로고    scopus 로고
    • Soluble adhesion molecules and angiotensin-converting enzyme in dementia
    • Nielsen HM, Londos E, Minthon L, Janciauskiene SM. Soluble adhesion molecules and angiotensin-converting enzyme in dementia. Neurobiol Dis 2007; 26: 27-35
    • (2007) Neurobiol Dis , vol.26 , pp. 27-35
    • Nielsen, H.M.1    Londos, E.2    Minthon, L.3    Janciauskiene, S.M.4
  • 152
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet P. Angiogenesis in health and disease. Nat Med 2003; 9: 653-660
    • (2003) Nat Med , vol.9 , pp. 653-660
    • Carmeliet, P.1
  • 154
    • 33749385489 scopus 로고    scopus 로고
    • Vascular endothelial growth factor in amyotrophic lateral sclerosis and other neurodegenerative diseases
    • Bogaert E, Van Damme P, Van Den Bosch L, Robberecht W. Vascular endothelial growth factor in amyotrophic lateral sclerosis and other neurodegenerative diseases. Muscle Nerve 2006; 34: 391-405
    • (2006) Muscle Nerve , vol.34 , pp. 391-405
    • Bogaert, E.1    Van Damme, P.2    Van Den Bosch, L.3    Robberecht, W.4
  • 155
    • 0036167595 scopus 로고    scopus 로고
    • Increased intrathecal levels of the angiogenic factors vegf and tgf-beta in Alzheimer's disease and vascular dementia
    • Tarkowski E, Issa R, Sjögren M, Wallin A, Blennow K, Tarkowski A, et al. Increased intrathecal levels of the angiogenic factors VEGF and TGF-beta in Alzheimer's disease and vascular dementia. Neurobiol Aging 2002; 23: 237-243
    • (2002) Neurobiol Aging , vol.23 , pp. 237-243
    • Tarkowski, E.1    Issa, R.2    Sjögren, M.3    Wallin, A.4    Blennow, K.5    Tarkowski, A.6
  • 156
    • 24744457932 scopus 로고    scopus 로고
    • Role of the meox2 homeobox gene in neurovascular dysfunction in Alzheimer disease
    • Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R, et al. Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. Nat Med 2005; 11: 959-965
    • (2005) Nat Med , vol.11 , pp. 959-965
    • Wu, Z.1    Guo, H.2    Chow, N.3    Sallstrom, J.4    Bell, R.D.5    Deane, R.6
  • 158
    • 84886641249 scopus 로고    scopus 로고
    • Glial influence on the blood brain barrier
    • Alvarez JI, Katayama T, Prat A. Glial influence on the blood brain barrier. Glia 2013; 61: 1939-1958
    • (2013) Glia , vol.61 , pp. 1939-1958
    • Alvarez, J.I.1    Katayama, T.2    Prat, A.3
  • 159
    • 0035696282 scopus 로고    scopus 로고
    • The role of activated astrocytes and of the neurotrophic cytokine s100b in the pathogenesis of Alzheimer's disease
    • Mrak RE, Griffinbc WS. The role of activated astrocytes and of the neurotrophic cytokine S100B in the pathogenesis of Alzheimer's disease. Neurobiol Aging 2001; 22: 915-922
    • (2001) Neurobiol Aging , vol.22 , pp. 915-922
    • Mrak, R.E.1    Griffinbc, W.S.2
  • 160
    • 75849133906 scopus 로고    scopus 로고
    • Overexpression of human s100b exacerbates cerebral amyloidosis and gliosis in the tg2576 mouse model of Alzheimer's disease
    • Mori T, Koyama N, Arendash GW, Horikoshi-Sakuraba Y, Tan J, Town T. Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease. Glia 2010; 58: 300-314
    • (2010) Glia , vol.58 , pp. 300-314
    • Mori, T.1    Koyama, N.2    Arendash, G.W.3    Horikoshi-Sakuraba, Y.4    Tan, J.5    Town, T.6
  • 163
    • 0033621568 scopus 로고    scopus 로고
    • S100beta induction of the proinflammatory cytokine interleukin-6 in neurons
    • Li Y, Barger SW, Liu L, Mrak RE, Griffin WS. S100beta induction of the proinflammatory cytokine interleukin-6 in neurons. J Neurochem 2000; 74: 143-150
    • (2000) J Neurochem , vol.74 , pp. 143-150
    • Li, Y.1    Barger, S.W.2    Liu, L.3    Mrak, R.E.4    Griffin, W.S.5
  • 165
    • 84911006075 scopus 로고    scopus 로고
    • Body fluid cytokine levels in mild cognitive impairment and Alzheimer's disease: A comparative overview
    • Brosseron F, Krauthausen M, Kummer M, Heneka MT. Body fluid cytokine levels in mild cognitive impairment and Alzheimer's disease: a comparative overview. Mol Neurobiol 2014; 50: 534-544
    • (2014) Mol Neurobiol , vol.50 , pp. 534-544
    • Brosseron, F.1    Krauthausen, M.2    Kummer, M.3    Heneka, M.T.4
  • 168
    • 20344393856 scopus 로고    scopus 로고
    • Cerebrospinal fluid tau abeta1-42 and inflammatory cytokines in patients with Alzheimer's disease and vascular dementia
    • Jia JP, Meng R, Sun YX, Sun WJ, Ji XM, Jia LF. Cerebrospinal fluid tau, Abeta1-42 and inflammatory cytokines in patients with Alzheimer's disease and vascular dementia. Neurosci Lett 2005; 383: 12-16
    • (2005) Neurosci Lett , vol.383 , pp. 12-16
    • Jia, J.P.1    Meng, R.2    Sun, Y.X.3    Sun, W.J.4    Ji, X.M.5    Jia, L.F.6
  • 169
    • 0032981238 scopus 로고    scopus 로고
    • Unchanged levels of interleukins, neopterin, interferon-gamma and tumor necrosis factor-Alpha in cerebrospinal fluid of patients with dementia of the Alzheimer type
    • Engelborghs S, De Brabander M, De Crée J, D'Hooge R, Geerts H, Verhaegen H, et al. Unchanged levels of interleukins, neopterin, interferon-gamma and tumor necrosis factor-Alpha in cerebrospinal fluid of patients with dementia of the Alzheimer type. Neurochem Int 1999; 34: 523-530
    • (1999) Neurochem Int , vol.34 , pp. 523-530
    • Engelborghs, S.1    De Brabander, M.2    De Crée, J.3    D'hooge, R.4    Geerts, H.5    Verhaegen, H.6
  • 170
    • 0028938729 scopus 로고
    • Decreased interleukin-6 level in the cerebrospinal fluid of patients with Alzheimer-Type dementia
    • Yamada K, Kono K, Umegaki H, Yamada K, Iguchi A, Fukatsu T, et al. Decreased interleukin-6 level in the cerebrospinal fluid of patients with Alzheimer-Type dementia. Neurosci Lett 1995; 186: 219-221
    • (1995) Neurosci Lett , vol.186 , pp. 219-221
    • Yamada, K.1    Kono, K.2    Umegaki, H.3    Yamada, K.4    Iguchi, A.5    Fukatsu, T.6
  • 171
    • 0029417080 scopus 로고
    • Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients
    • Blum-Degen D, Müller T, Kuhn W, Gerlach M, Przuntek H, Riederer P. Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients. Neurosci Lett 1995; 202: 17-20
    • (1995) Neurosci Lett , vol.202 , pp. 17-20
    • Blum-Degen, D.1    Müller, T.2    Kuhn, W.3    Gerlach, M.4    Przuntek, H.5    Riederer, P.6
  • 173
    • 0033608824 scopus 로고    scopus 로고
    • Discriminant power of combined cerebrospinal fluid tau protein and of the soluble interleukin-6 receptor complex in the diagnosis of Alzheimer's disease
    • Hampel H, Teipel SJ, Padberg F, Haslinger A, Riemenschneider M, Schwarz MJ, et al. Discriminant power of combined cerebrospinal fluid tau protein and of the soluble interleukin-6 receptor complex in the diagnosis of Alzheimer's disease. Brain Res 1999; 823: 104-112
    • (1999) Brain Res , vol.823 , pp. 104-112
    • Hampel, H.1    Teipel, S.J.2    Padberg, F.3    Haslinger, A.4    Riemenschneider, M.5    Schwarz, M.J.6
  • 174
    • 84906794973 scopus 로고    scopus 로고
    • Diffusion tensor imaging of white matter degeneration in Alzheimer's disease and mild cognitive impairment
    • Amlien IK, Fjell AM. Diffusion tensor imaging of white matter degeneration in Alzheimer's disease and mild cognitive impairment. Neuroscience 2014; 276C: 206-215
    • (2014) Neuroscience , vol.276 C , pp. 206-215
    • Amlien, I.K.1    Fjell, A.M.2
  • 175
  • 176
    • 84882395407 scopus 로고    scopus 로고
    • Dissociable effects of Alzheimer disease and white matter hyperintensities on brain metabolism
    • Haight TJ, Landau SM, Carmichael O, Schwarz C, DeCarli C, Jagust WJ, et al. Dissociable effects of Alzheimer disease and white matter hyperintensities on brain metabolism. JAMA Neurol 2013; 70: 1039-1045
    • (2013) JAMA Neurol , vol.70 , pp. 1039-1045
    • Haight, T.J.1    Landau, S.M.2    Carmichael, O.3    Schwarz, C.4    Decarli, C.5    Jagust, W.J.6
  • 177
    • 33845946376 scopus 로고    scopus 로고
    • Extent and distribution of white matter hyperintensities in normal aging mci, and ad
    • Yoshita M, Fletcher E, Harvey D, Ortega M, Martinez O, Mungas DM, et al. Extent and distribution of white matter hyperintensities in normal aging, MCI, and AD. Neurology 2006; 67: 2192-2198
    • (2006) Neurology , vol.67 , pp. 2192-2198
    • Yoshita, M.1    Fletcher, E.2    Harvey, D.3    Ortega, M.4    Martinez, O.5    Mungas, D.M.6
  • 179
    • 0022366560 scopus 로고
    • A derivative of myelin-Associated glycoprotein in cerebrospinal fluid of normal subjects and patients with neurological disease
    • Yanagisawa K, Quarles RH, Johnson D, Brady RO, Whitaker JN. A derivative of myelin-Associated glycoprotein in cerebrospinal fluid of normal subjects and patients with neurological disease. Ann Neurol 1985; 18: 464-469
    • (1985) Ann Neurol , vol.18 , pp. 464-469
    • Yanagisawa, K.1    Quarles, R.H.2    Johnson, D.3    Brady, R.O.4    Whitaker, J.N.5
  • 182
    • 3142743789 scopus 로고    scopus 로고
    • Value of csf beta-Amyloid1-42 and tau as predictors of Alzheimer's disease in patients with mild cognitive impairment
    • Hampel H, Teipel SJ, Fuchsberger T, Andreasen N, Wiltfang J, Otto M, et al. Value of CSF beta-Amyloid1-42 and tau as predictors of Alzheimer's disease in patients with mild cognitive impairment. Mol Psychiatry 2004; 9: 705-710
    • (2004) Mol Psychiatry , vol.9 , pp. 705-710
    • Hampel, H.1    Teipel, S.J.2    Fuchsberger, T.3    Andreasen, N.4    Wiltfang, J.5    Otto, M.6
  • 184
    • 84901921220 scopus 로고    scopus 로고
    • Biomarkers for predicting cognitive decline in those with normal cognition
    • Steenland K, Zhao L, Goldstein F, Cellar J, Lah J. Biomarkers for predicting cognitive decline in those with normal cognition. J Alzheimers Dis 2014; 40: 587-594
    • (2014) J Alzheimers Dis , vol.40 , pp. 587-594
    • Steenland, K.1    Zhao, L.2    Goldstein, F.3    Cellar, J.4    Lah, J.5
  • 185
    • 84907978955 scopus 로고    scopus 로고
    • Accuracy of brain amyloid detection in clinical practice using cerebrospinal fluid β-Amyloid 42: A cross-validation study against amyloid positron emission tomography
    • Palmqvist S, Zetterberg H, Blennow K, Vestberg S, Andreasson U, Brooks DJ, et al. Accuracy of brain amyloid detection in clinical practice using cerebrospinal fluid β-Amyloid 42: a cross-validation study against amyloid positron emission tomography. JAMA Neurol 2014; 71: 1282-1289
    • (2014) JAMA Neurol , vol.71 , pp. 1282-1289
    • Palmqvist, S.1    Zetterberg, H.2    Blennow, K.3    Vestberg, S.4    Andreasson, U.5    Brooks, D.J.6
  • 186
    • 27844561678 scopus 로고    scopus 로고
    • Increased levels of csf phosphorylated tau in apolipoprotein e epsilon4 carriers with mild cognitive impairment
    • Buerger K, Teipel SJ, Zinkowski R, Sunderland T, Andreasen N, Blennow K, et al. Increased levels of CSF phosphorylated tau in apolipoprotein E epsilon4 carriers with mild cognitive impairment. Neurosci Lett 2005; 391: 48-50
    • (2005) Neurosci Lett , vol.391 , pp. 48-50
    • Buerger, K.1    Teipel, S.J.2    Zinkowski, R.3    Sunderland, T.4    Andreasen, N.5    Blennow, K.6
  • 187
    • 0037183481 scopus 로고    scopus 로고
    • Csf tau protein phosphorylated at threonine 231 correlates with cognitive decline in mci subjects
    • Buerger K, Teipel SJ, Zinkowski R, Blennow K, Arai H, Engel R, et al. CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects. Neurology 2002; 59: 627-629
    • (2002) Neurology , vol.59 , pp. 627-629
    • Buerger, K.1    Teipel, S.J.2    Zinkowski, R.3    Blennow, K.4    Arai, H.5    Engel, R.6
  • 188
    • 7444271086 scopus 로고    scopus 로고
    • Cerebrospinal fluid beta-Amyloid1-42 and tau in control subjects at risk for Alzheimer's disease: The effect of apoe epsilon4 allele
    • Sunderland T, Mirza N, Putnam KT, Linker G, Bhupali D, Durham R, et al. Cerebrospinal fluid beta-Amyloid1-42 and tau in control subjects at risk for Alzheimer's disease: the effect of APOE epsilon4 allele. Biol Psychiatry 2004; 56: 670-676
    • (2004) Biol Psychiatry , vol.56 , pp. 670-676
    • Sunderland, T.1    Mirza, N.2    Putnam, K.T.3    Linker, G.4    Bhupali, D.5    Durham, R.6
  • 190
    • 0037040525 scopus 로고    scopus 로고
    • Elevated levels of phosphorylated neurofilament proteins in cerebrospinal fluid of Alzheimer disease patients
    • Hu Y-Y, He S-S, Wang X-C, Duan Q-H, Khatoon S, Iqbal K, et al. Elevated levels of phosphorylated neurofilament proteins in cerebrospinal fluid of Alzheimer disease patients. Neurosci Lett 2002; 320: 156-160
    • (2002) Neurosci Lett , vol.320 , pp. 156-160
    • Hu, Y.-Y.1    He, S.-S.2    Wang, X.-C.3    Duan, Q.-H.4    Khatoon, S.5    Iqbal, K.6
  • 192
    • 50849136540 scopus 로고    scopus 로고
    • Cerebrospinal fluid neuron-specific enolase: A further marker of Alzheimer's disease
    • Palumbo B, Siepi D, Sabalich I, Tranfaglia C, Parnetti L. Cerebrospinal fluid neuron-specific enolase: a further marker of Alzheimer's disease? Funct Neurol 2008; 23: 93-96
    • (2008) Funct Neurol , vol.23 , pp. 93-96
    • Palumbo, B.1    Siepi, D.2    Sabalich, I.3    Tranfaglia, C.4    Parnetti, L.5
  • 193
    • 84899698364 scopus 로고    scopus 로고
    • Elevated levels of cerebrospinal fluid neuron-specific enolase (nse) in Alzheimer's disease
    • Schmidt FM, Mergl R, Stach B, Jahn I, Gertz H-J, Schönknecht P. Elevated levels of cerebrospinal fluid neuron-specific enolase (NSE) in Alzheimer's disease. Neurosci Lett 2014; 570: 81-85
    • (2014) Neurosci Lett , vol.570 , pp. 81-85
    • Schmidt, F.M.1    Mergl, R.2    Stach, B.3    Jahn, I.4    Gertz, H.-J.5    Schönknecht, P.6
  • 195
    • 79955675470 scopus 로고    scopus 로고
    • Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-β is an early biomarker for mild cognitive impairment preceding Alzheimer's disease
    • Sagare AP, Deane R, Zetterberg H, Wallin A, Blennow K, Zlokovic BV. Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-β is an early biomarker for mild cognitive impairment preceding Alzheimer's disease. J Alzheimers Dis 2011; 24: 25-34
    • (2011) J Alzheimers Dis , vol.24 , pp. 25-34
    • Sagare, A.P.1    Deane, R.2    Zetterberg, H.3    Wallin, A.4    Blennow, K.5    Zlokovic, B.V.6
  • 197
    • 84907546402 scopus 로고    scopus 로고
    • Effects of a disrupted blood-brain barrier on cholesterol homeostasis in the brain
    • Saeed AA, Genové G, Li T, Lütjohann D, Olin M, Mast N, et al. Effects of a disrupted blood-brain barrier on cholesterol homeostasis in the brain. J Biol Chem 2014; 289: 23712-23722
    • (2014) J Biol Chem , vol.289 , pp. 23712-23722
    • Saeed, A.A.1    Genové, G.2    Li, T.3    Lütjohann, D.4    Olin, M.5    Mast, N.6
  • 198
    • 84867091169 scopus 로고    scopus 로고
    • Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease
    • Popp J, Lewczuk P, Kölsch H, Meichsner S, Maier W, Kornhuber J, et al. Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease. J Neurochem 2012; 123: 310-316
    • (2012) J Neurochem , vol.123 , pp. 310-316
    • Popp, J.1    Lewczuk, P.2    Kölsch, H.3    Meichsner, S.4    Maier, W.5    Kornhuber, J.6
  • 201
    • 84892377153 scopus 로고    scopus 로고
    • Pulse pressure is associated with Alzheimer biomarkers in cognitively normal older adults
    • Nation DA, Edland SD, Bondi MW, Salmon DP, Delano-Wood L, Peskind ER, et al. Pulse pressure is associated with Alzheimer biomarkers in cognitively normal older adults. Neurology 2013; 81: 2024-2027
    • (2013) Neurology , vol.81 , pp. 2024-2027
    • Nation, D.A.1    Edland, S.D.2    Bondi, M.W.3    Salmon, D.P.4    Delano-Wood, L.5    Peskind, E.R.6
  • 202
    • 84885175046 scopus 로고    scopus 로고
    • Blood pressure decrease correlates with tau pathology and memory decline in hypertensive elderly
    • Glodzik L, Rusinek H, Pirraglia E, McHugh P, Tsui W, Williams S, et al. Blood pressure decrease correlates with tau pathology and memory decline in hypertensive elderly. Neurobiol Aging 2014; 35: 64-71
    • (2014) Neurobiol Aging , vol.35 , pp. 64-71
    • Glodzik, L.1    Rusinek, H.2    Pirraglia, E.3    McHugh, P.4    Tsui, W.5    Williams, S.6
  • 205
    • 84889664846 scopus 로고    scopus 로고
    • Candidate blood proteome markers of Alzheimer's disease onset and progression: A systematic review and replication study
    • Kiddle SJ, Sattlecker M, Proitsi P, Simmons A, Westman E, Bazenet C, et al. Candidate blood proteome markers of Alzheimer's disease onset and progression: a systematic review and replication study. J Alzheimers Dis 2014; 38: 515-531
    • (2014) J Alzheimers Dis , vol.38 , pp. 515-531
    • Kiddle, S.J.1    Sattlecker, M.2    Proitsi, P.3    Simmons, A.4    Westman, E.5    Bazenet, C.6
  • 206
    • 84881298420 scopus 로고    scopus 로고
    • Progress towards a consensus on biomarkers for Alzheimer's disease: A review of peripheral analytes
    • Rembach A, Ryan TM, Roberts BR, Doecke JD, Wilson WJ, Watt AD, et al. Progress towards a consensus on biomarkers for Alzheimer's disease: a review of peripheral analytes. Biomark Med 2013; 7: 641-662
    • (2013) Biomark Med , vol.7 , pp. 641-662
    • Rembach, A.1    Ryan, T.M.2    Roberts, B.R.3    Doecke, J.D.4    Wilson, W.J.5    Watt, A.D.6
  • 207
    • 84856008210 scopus 로고    scopus 로고
    • Standardization of preanalytical aspects of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: A consensus paper from the Alzheimer's biomarkers standardization initiative
    • Vanderstichele H, Bibl M, Engelborghs S, Le Bastard N, Lewczuk P, Molinuevo JL, et al. Standardization of preanalytical aspects of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: a consensus paper from the Alzheimer's Biomarkers Standardization Initiative. Alzheimers Dement 2012; 8: 65-73
    • (2012) Alzheimers Dement , vol.8 , pp. 65-73
    • Vanderstichele, H.1    Bibl, M.2    Engelborghs, S.3    Le Bastard, N.4    Lewczuk, P.5    Molinuevo, J.L.6
  • 208
    • 84921743474 scopus 로고    scopus 로고
    • Guidelines for uniform reporting of body fluid biomarker studies in neurologic disorders
    • Gnanapavan S, Hegen H, Khalil M, Hemmer B, Franciotta D, Hughes S, et al. Guidelines for uniform reporting of body fluid biomarker studies in neurologic disorders. Neurology 2014; 83: 1210-1216
    • (2014) Neurology , vol.83 , pp. 1210-1216
    • Gnanapavan, S.1    Hegen, H.2    Khalil, M.3    Hemmer, B.4    Franciotta, D.5    Hughes, S.6
  • 209
    • 84927178751 scopus 로고    scopus 로고
    • The clinical use of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: A consensus paper from the Alzheimer's biomarkers standardization initiative
    • Molinuevo JL, Blennow K, Dubois B, Engelborghs S, Lewczuk P, Perret-Liaudet A, et al. The clinical use of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: a consensus paper from the Alzheimer's Biomarkers Standardization Initiative. Alzheimers Dement 2014; 10: 808-817
    • (2014) Alzheimers Dement , vol.10 , pp. 808-817
    • Molinuevo, J.L.1    Blennow, K.2    Dubois, B.3    Engelborghs, S.4    Lewczuk, P.5    Perret-Liaudet, A.6
  • 210
    • 84896520534 scopus 로고    scopus 로고
    • Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in alsmodel mice
    • Winkler EA, Sengillo JD, Sagare AP, Zhao Z, Ma Q, Zuniga E, et al. Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALSmodel mice. Proc Natl Acad Sci USA 2014; 111: E1035-E1042
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. E1035-E1042
    • Winkler, E.A.1    Sengillo, J.D.2    Sagare, A.P.3    Zhao, Z.4    Ma, Q.5    Zuniga, E.6
  • 211
    • 0038115229 scopus 로고    scopus 로고
    • Activated protein c alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein c receptor and activation of protease activated receptor-1
    • Dömötör E, Benzakour O, Griffin JH, Yule D, Fukudome K, Zlokovic BV. Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. Blood 2003; 101: 4797-4801
    • (2003) Blood , vol.101 , pp. 4797-4801
    • Dömötör, E.1    Benzakour, O.2    Griffin, J.H.3    Yule, D.4    Fukudome, K.5    Zlokovic, B.V.6
  • 212
    • 0035992710 scopus 로고    scopus 로고
    • Activated protein c: Potential therapy for severe sepsis, thrombosis, and stroke
    • Griffin JH, Zlokovic B, Fernández JA. Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke. Semin Hematol 2002; 39: 197-205
    • (2002) Semin Hematol , vol.39 , pp. 197-205
    • Griffin, J.H.1    Zlokovic, B.2    Fernández, J.A.3
  • 213
    • 67349235964 scopus 로고    scopus 로고
    • Cyclophilin a enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms
    • Satoh K, Nigro P, Matoba T, O'Dell MR, Cui Z, Shi X, et al. Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms. Nat Med 2009; 15: 649-656
    • (2009) Nat Med , vol.15 , pp. 649-656
    • Satoh, K.1    Nigro, P.2    Matoba, T.3    O'dell, M.R.4    Cui, Z.5    Shi, X.6
  • 215
    • 84901801735 scopus 로고    scopus 로고
    • A novel aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer's disease mice
    • Ahn HJ, Glickman JF, Poon KL, Zamolodchikov D, Jno-Charles OC, Norris EH, et al. A novel Aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer's disease mice. J Exp Med 2014; 211: 1049-1062
    • (2014) J Exp Med , vol.211 , pp. 1049-1062
    • Ahn, H.J.1    Glickman, J.F.2    Poon, K.L.3    Zamolodchikov, D.4    Jno-Charles, O.C.5    Norris, E.H.6
  • 216
    • 84920889270 scopus 로고    scopus 로고
    • Neuropsychiatric disease relevance of circulating anti-nmda receptor autoantibodies depends on blood-brain barrier integrity
    • Hammer C, Stepniak B, Schneider A, Papiol S, Tantra M, Begemann M, et al. Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity. Mol Psychiatry 2013; 19: 1143-1149
    • (2013) Mol Psychiatry , vol.19 , pp. 1143-1149
    • Hammer, C.1    Stepniak, B.2    Schneider, A.3    Papiol, S.4    Tantra, M.5    Begemann, M.6
  • 217
    • 65649105035 scopus 로고    scopus 로고
    • Clearance of amyloid-beta peptide across the blood-brain barrier: Implication for therapies in Alzheimer's disease
    • Deane R, Bell RD, Sagare A, Zlokovic BV. Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease. CNS Neurol Disord Drug Targets 2009; 8: 16-30
    • (2009) CNS Neurol Disord Drug Targets , vol.8 , pp. 16-30
    • Deane, R.1    Bell, R.D.2    Sagare, A.3    Zlokovic, B.V.4
  • 218
    • 84866305795 scopus 로고    scopus 로고
    • Pinocembrin protects against β-Amyloid-induced toxicity in neurons through inhibiting receptor for advanced glycation end products (rage)-independent signaling pathways and regulating mitochondrion-mediated apoptosis
    • Liu R, Wu C-X, Zhou D, Yang F, Tian S, Zhang L, et al. Pinocembrin protects against β-Amyloid-induced toxicity in neurons through inhibiting receptor for advanced glycation end products (RAGE)-independent signaling pathways and regulating mitochondrion-mediated apoptosis. BMC Med 2012; 10: 105
    • (2012) BMC Med , vol.10 , pp. 105
    • Liu, R.1    Wu, C.-X.2    Zhou, D.3    Yang, F.4    Tian, S.5    Zhang, L.6
  • 219
    • 79955575449 scopus 로고    scopus 로고
    • Pinocembrin attenuates bloodbrain barrier injury induced by global cerebral ischemia-reperfusion in rats
    • Meng F, Liu R, Gao M, Wang Y, Yu X, Xuan Z, et al. Pinocembrin attenuates bloodbrain barrier injury induced by global cerebral ischemia-reperfusion in rats. Brain Res 2011; 1391: 93-101
    • (2011) Brain Res , vol.1391 , pp. 93-101
    • Meng, F.1    Liu, R.2    Gao, M.3    Wang, Y.4    Yu, X.5    Xuan, Z.6
  • 221
    • 84921752467 scopus 로고    scopus 로고
    • Biomarkers for neurology: Guides and lines
    • Fleming JO, Carlsson CM. Biomarkers for neurology: guides and lines. Neurology 2014; 83: 1130-1131
    • (2014) Neurology , vol.83 , pp. 1130-1131
    • Fleming, J.O.1    Carlsson, C.M.2
  • 222
    • 84866456583 scopus 로고    scopus 로고
    • Preventing Alzheimer's disease
    • Selkoe DJ. Preventing Alzheimer's disease. Science 2012; 337: 1488-1492
    • (2012) Science , vol.337 , pp. 1488-1492
    • Selkoe, D.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.