Spatial correlations between β-amyloid (Aβ) deposits and blood vessels in familial Alzheimer's disease

Folia Neuropathologica

Volumn 46, Issue 4, 2008, Pages 241-248

  Armstrong, Richard A ^a  

^a ASTON UNIVERSITY   (United Kingdom)

Author keywords

Blood vessels; Clustering; Diffusion; Frontal cortex; Perivascular clearance; Spatial correlation

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ANTIBODY; APOLIPOPROTEIN E; APOLIPOPROTEIN E4; COLLAGEN TYPE 4; PRESENILIN;

ADULT; AGED; ALZHEIMER DISEASE; ANTIBODY LABELING; ARTICLE; BLOOD FLOW; BRAIN CORTEX; BRAIN FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; FAMILIAL DISEASE; FEMALE; FRONTAL CORTEX; GENE CLUSTER; GENE EXPRESSION; GENE FREQUENCY; GENE MUTATION; GENOTYPE; HUMAN; HUMAN TISSUE; MALE; NEUROPATHOLOGY; PROTEIN LOCALIZATION; SPATIAL AUTOCORRELATION ANALYSIS; SPORADIC ALZHEIMER DISEASE; BRAIN; BRAIN CIRCULATION; METABOLISM; MIDDLE AGED; PATHOLOGY; VASCULARIZATION;

ADULT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; BRAIN; CEREBROVASCULAR CIRCULATION; FEMALE; HUMANS; MALE; MIDDLE AGED;

EID: 62249133805     PISSN: 16414640     EISSN: 1509572X     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Armstrong RA. The usefulness of spatial pattern analysis in understanding the pathogenesis of neurodegenerative disorders, with particular reference to plaque formation in Alzheimer's disease. Neurodegen 1993; 2: 73-80.
2. Armstrong RA. β-amyloid plaques: stages in life history or independent origin? Dement Geriatr Cogn Disord 1998; 9: 227-238.
3. Armstrong RA. Quantifying the pathology of neurodegenerative disorders: quantitative measurements, sampling strategies and data analysis. Histopathol 2003; 42: 521-529.
4. Armstrong RA. Measuring the degree of spatial correlation between histological features in thin sections of brain tissue. Neuropathol 2003; 23: 245-253.
5. Armstrong RA. Classic β-amyloid deposits cluster around large diameter blood vessels rather than capillaries in sporadic Alzheimer's disease. Curr Neurovasc Res 2006; 3: 289-294.
6. Armstrong RA. Methods of studying the planar distribution of objects in histological sections of brain tissue. J Microsc 2006; 221: 153-158.
7. Armstrong RA, Myers D, Smith CU. The spatial patterns of β/A4 deposit subtypes in Alzheimer's disease. Acta Neuropathol 1993; 86: 36-41.
8. Armstrong RA, Myers D, Smith CU. The ratio of diffuse to mature beta/A4 deposits in Alzheimer's disease varies in cases with and without pronounced congophilic angiopathy. Dementia 1993; 4: 251-255.
9. Armstrong RA, Cairns NJ, Lantos PL. Spatial distribution of diffuse, primitive, and classic amyloid-β deposits and blood vessels in the upper laminae of the frontal cortex in Alzheimer's disease. Alz Dis Assoc Disord 1998; 2: 378-383.
10. Attems J. Sporadic cerebral amyloid angiopathy: pathology, clinical implications and possible pathomechanisms. Acta Neuropathol 2005; 110: 345-359.
11. Attems J, Lintner F, Jellinger K. Amyloid beta peptide 1-42 highly correlates with capillary cerebral amyloid angiopathy and Alzheimer disease pathology. Acta Neuropathol 2004; 107: 283-291.
12. Bell M, Ball M. Neuritic plaques and vessels of visual cortex in ageing and Alzheimer's dementia. Neurobiol Ageing 1990; 11: 359-370.
13. Chalmers K, Wilcock GK, Love S. Apolipoprotein E epsilon 4 influences the pathological phenotype of Alzheimer's disease by favouring cerebrovascular over parenchymal accumulation of Aβ protein. Neuropathol Appl Neurobiol 2003; 29: 231-238.
14. Chartier-Harlin M, Crawford F, Houlden H, Warren A, Hughes D, Fidani L, Goate A, Rossor M, Rocques P, Hardy J, Mullan M. Early onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene. Nature 1991; 353: 844-846.
15. Cras P, van Harskamp F, Hendricks L, Centerick C, van Duyn CM, Stefanko SZ, Hofman A, Kris JM, van Broekhoven C, Martin JJ. Presenile Alzheimer's dementia characterized by amyloid angiopathy and large amyloid type senile plaques in the APP692 Ala→Gly mutation. Acta Neuropathol 1998; 96: 253-260.
16. Cullen, K, Kocsi, Z, Stone, J. Pericapillary haem-rich deposits: evidence for microhaemorrhages in aging human cerebral cortex. J Cer Blood Flow Met 2005; 25: 1656-1667.
17. Delaere P, Duyckaerts C, He Y, Piette F, Hauw J. Subtypes and differential laminar distributions of β/A4 deposits in Alzheimer's disease: relationship with the intellectual status of 26 cases. Acta Neuropathol 1991; 81: 328-335.
18. Dermant B, Kumar-Singh S, De Jonghe C, Cruts M, Lofgren A, Lubke U, Cras P, Dom R, De Deyn PP, Martin JJ, van Broeckhoven C. Capillary amyloid angiopathy is a pathogenic lesion in Alzheimer's disease due to a novel PS1 mutation. Brain 2001; 124: 2383-2392.
19. Fryer JD, Taylor JW, DeMattos RB, Bates KR, Paul SM, Parsadamian M, Holtzman DM. Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic mice. J Neurosci 2003; 23: 7889-7896.
20. Goate R, Chartier-Harlin M, Mullan M, Brown J, Crawford F, Fidani L, Giuffra L, Haynes A, Irving N, James L, Mant R, Newton P, Rooke K, Roques P, Talbot C, Pericak-Vance M, Roses A, Williamson R, Rossor M, Owen M, Hardy J. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991; 349: 704-706.
21. Kawai, M, Kalaria, R, Harik, S, Perry, G. The relationship of amyloid plaques to cerebral capillaries in Alzheimer's disease. Am J Pathol 1990; 137: 1435-1446.
22. Kumar-Singh S. Cerebral amyloid angiopathy: pathogenic mechanism and link to dense amyloid plaques. Genes, Brain & Behaviour 2008; 7: 67-82.
23. Levy-Lahad E, Wasco W, Poorkaj P, Romano D, Oshima J, Pettingell W, Yu C, Jondro P, Schmidt S, Wang K, Crowley A, Fu Y, Guenette S, Galas D, Nemens E, Wijsman E, Bird T, Schellenberg G, Tanzi R. Candidate gene for chromosome 1 familial Alzheimer's disease locus. Science 1995; 269: 973-977.
24. Luthert P, Williams J. A quantitative study of the coincidence of blood vessels and A4 protein deposits in Alzheimer's disease. Neurosci Lett 1991; 126: 110-112.
25. Mirra S, Heyman A, McKeel D, Sumi S, Crain B, Brownlee L, Vogel F, Hughes J, van Belle G, Berg L. The consortium to establish a registry for Alzheimer's disease (CERAD). II. Standardisation of the neuropathological assessment of Alzheimer's disease. Neurol 1991; 41: 479-486.
26. Roks G, Van Harskamp F, De Koning I, Cruts M, de Jonghe C, Kumar-Singh S, Tibben A, Tanghe H, Niermeijer MF, Hofman A, Van Swieten JC, Van Broeckhoven C, Van Duijn CM. Presentation of amyloidosis in carriers of the codon 692 mutation in the amyloid precursor protein gene (APP692). Brain 2000; 123: 2130-2140.
27. Saunders A, Strittmatter W, Schmechel D, St George-Hyslop P, Pericak-Vance M, Joo S, Rose B, Gasella J, Crapper-MacLachan D, Albersts M, Hulette C, Crain B, Goldgaber D, Roses A. Association of apolipoprotein E allele e4 with late-onset familial and sporadic Alzheimer's disease. Neurology 1993; 43: 1467-1472.
28. Sherrington R, Rogaev E, Liang Y, Rogaeva E, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, Tsuda T, Mar L, Foncin J, Bruni A, Moulese M, Sorbi S, Rainero I, Pinessi L, Nee L, Chumakov I, Pollen D, Brookes A, Sauseau P, Polinski R, Wasco R, Dasilva H, Haines J, Pericak-Vance M, Tanzi R, Roses A, Fraser P, Rommens J, St George-Hyslop P. Cloning of a gene bearing missense mutations in early onset familial Alzheimer's disease. Nature 1993; 375: 754-760.
29. Shin Y, Cho HS, Fukumoto H, Shimizu T, Shirasawa T, Greenberg SM, Rebeck GW A beta species, including IsoAsp23 Abeta, in Iowa-type familial cerebral amyloid angiopathy. Acta Neuropathol 2003; 105: 252-258.
30. Spargo E, Luthert P, Anderton B, Bruce M, Smith D, Lantos P. Antibodies raised against different proteins of the A4 protein identify a subset of plaques in Down's syndrome. Neurosci Lett 1990; 115: 345-350.
31. Steiner H, Rivesz T, Neumann M, Romig H, Grim MG, Pesold B, Kretzschmar HA, hardy J, Hotton JL, Baumeister R, Houlden H, Haass C. A pathogenic preseneilin-1 deletion causes abberant Aβ42 production in the absence of congophilic amyloid plaques. J Biol Chem 2001; 276: 7233-7239.
32. Strittmatter W, Wiesgraber K, Huang D, Dong L, Salvesan G, Pericak-Vance M, Schmachel D, Saunders A, Goldgaber D, Roses A. Binding of human apolipoprotein E to synthetic amyloid-β peptide: isoform specific effects and implications for lateonset Alzheimer's disease. Proc Natl Acad Sci USA 1993; 90: 8098-8102.
33. Su GC, Arendash GW, Kalaria RN, Bjugstad KB, Mullan M Intravascular infusions of soluble beta-amyloid compromise the blood brain barrier, activate central nervous system glial cells and induce peripheral hemorrhage. Brain Research 1999; 818: 105-117.
34. Tierney M, Fisher R, Lewis A, Zorzitto M, Snow W, Reid D, Nieuwstraten P. The NINCDS-ADRDA work group criteria for the clinical diagnosis of probable Alzheimer's disease. Neurol 1988; 38: 359-364.
35. Weller R, Nicoll J. Cerebral amyloid angiopathy; Pathogenesis and effects on the ageing and Alzheimer brain. Neurol Res 2003; 25: 611-616.
36. Weller RO, Yow HY, Preston SD, Majanti I, Nicoll JAR. Cerebrovascular disease is a major factor in the failure of elimination of Ab from the aging human brain: Implications for therapy of Alzheimer's disease. Alzheimer's disease: Vascular Etiology and pathology Annals NY Acad Sci 2002; 977: 162-168.
37. Yurchenco P, Schittny J. Molecular architexture of basement membranes. FASEB J 1990; 4: 1577-1590.