Pericytes are involved in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

Annals of Neurology

Volumn 78, Issue 6, 2015, Pages 887-900

  Ghosh, Mitrajit ^a,b,c   Balbi, Matilde ^a,d   Hellal, Farida ^a,c   Dichgans, Martin ^a,c   Lindauer, Ute ^b,c,e   Plesnila, Nikolaus ^a,c  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c Munich Cluster for Systems Neurology ^*  (Germany)

^d UNIVERSITY OF MUNICH   (Germany)

^e RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

NOTCH RECEPTOR; NOTCH3 PROTEIN, MOUSE;

AGE; ANIMAL; BLOOD BRAIN BARRIER; BRAIN CORTEX; CADASIL; CAPILLARY; DISEASE MODEL; GENETICS; METABOLISM; MOUSE; MUTATION; PATHOLOGY; PERICYTE; RANDOMIZATION; SINGLE BLIND PROCEDURE; TRANSGENIC MOUSE; VASCULARIZATION;

AGE FACTORS; ANIMALS; BLOOD-BRAIN BARRIER; CADASIL; CAPILLARIES; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; MICE; MICE, TRANSGENIC; MUTATION; PERICYTES; RANDOM ALLOCATION; RECEPTORS, NOTCH; SINGLE-BLIND METHOD;

EID: 84955186682     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.24512     Document Type: Article

References (36)

1. Chabriat H, Bousser MG, Pappata S,. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: a positron emission tomography study in two affected family members. Stroke 1995; 26: 1729-1730.
2. Dichgans M, Mayer M, Uttner I, et al., The phenotypic spectrum of CADASIL: clinical findings in 102 cases. Ann Neurol 1998; 44: 731-739.
3. Chabriat H, Joutel A, Dichgans M, et al., Cadasil. Lancet Neurol 2009; 8: 643-653.
4. Joutel A, Corpechot C, Ducros A, et al., Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. Nature 1996; 383: 707-710.
5. Joutel A, Monet-Lepretre M, Gosele C, et al., Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease. J Clin Invest 2010; 120: 433-445.
6. Viswanathan A, Gray F, Bousser MG, et al., Cortical neuronal apoptosis in CADASIL. Stroke 2006; 37: 2690-2695.
7. Jouvent E, Mangin JF, Duchesnay E, et al., Longitudinal changes of cortical morphology in CADASIL. Neurobiol Aging 2012; 33: 1002.e29-1002.e36.
8. Duering M, Righart R, Csanadi E, et al., Incident subcortical infarcts induce focal thinning in connected cortical regions. Neurology 2012; 79: 2025-2028.
9. Bell RD, Winkler EA, Sagare AP, et al., Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron 2010; 68: 409-427.
10. Winkler EA, Bell RD, Zlokovic BV,. Central nervous system pericytes in health and disease. Nat Neurosci 2011; 14: 1398-1405.
11. Sengillo JD, Winkler EA, Walker CT, et al., Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's disease. Brain Pathol 2013; 23: 303-310.
12. Armulik A, Genove G, Mae M, et al., Pericytes regulate the blood-brain barrier. Nature 2010; 468: 557-561.
13. Armulik A, Genove G, Betsholtz C,. Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. Dev Cell 2011; 21: 193-215.
14. Fernandez-Klett F, Offenhauser N, Dirnagl U, et al., Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain. Proc Natl Acad Sci U S A 2010; 107: 22290-22295.
15. Hall CN, Reynell C, Gesslein B, et al., Capillary pericytes regulate cerebral blood flow in health and disease. Nature 2014; 508: 55-60.
16. Zlokovic BV,. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 2008; 57: 178-201.
17. Dziewulska D, Lewandowska E,. Pericytes as a new target for pathological processes in CADASIL. Neuropathology 2012; 32: 515-521.
18. Gu X, Liu XY, Fagan A, et al., Ultrastructural changes in cerebral capillary pericytes in aged Notch3 mutant transgenic mice. Ultrastruct Pathol 2012; 36: 48-55.
19. Schwarzmaier SM, Kim SW, Trabold R, Plesnila N,. Temporal profile of thrombogenesis in the cerebral microcirculation after traumatic brain injury in mice. J Neurotrauma 2010; 27: 121-130.
20. Thal SC, Plesnila N,. Non-invasive intraoperative monitoring of blood pressure and arterial pCO2 during surgical anesthesia in mice. J Neurosci Methods 2007; 159: 261-267.
21. Schwarzmaier SM, Zimmermann R, McGarry NB, et al., In vivo temporal and spatial profile of leukocyte adhesion and migration after experimental traumatic brain injury in mice. J Neuroinflammation 2013; 10: 32.
22. Diaz-Flores L, Gutierrez R, Madrid JF, et al., Pericytes. Morphofunction, interactions and pathology in a quiescent and activated mesenchymal cell niche. Histol Histopathol 2009; 24: 909-969.
23. Quaegebeur A, Segura I, Carmeliet P,. Pericytes: blood-brain barrier safeguards against neurodegeneration? Neuron 2010; 68: 321-323.
24. Iadecola C,. The pathobiology of vascular dementia. Neuron 2013; 80: 844-866.
25. Abbott NJ, Ronnback L, Hansson E,. Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 2006; 7: 41-53.
26. Ballabh P, Braun A, Nedergaard M,. The blood-brain barrier: an overview: structure, regulation, and clinical implications. Neurobiol Dis 2004; 16: 1-13.
27. El-Khoury N, Braun A, Hu F, et al., Astrocyte end-feet in germinal matrix, cerebral cortex, and white matter in developing infants. Pediatr Res 2006; 59: 673-679.
28. Sohl G, Maxeiner S, Willecke K,. Expression and functions of neuronal gap junctions. Nat Rev Neurosci 2005; 6: 191-200.
29. Yamamoto T, Ochalski A, Hertzberg EL, Nagy JI,. LM and EM immunolocalization of the gap junctional protein connexin 43 in rat brain. Brain Res 1990; 508: 313-319.
30. Oguro K, Jover T, Tanaka H, et al., Global ischemia-induced increases in the gap junctional proteins connexin 32 (Cx32) and Cx36 in hippocampus and enhanced vulnerability of Cx32 knock-out mice. J Neurosci 2001; 21: 7534-7542.
31. Hossain MZ, Peeling J, Sutherland GR, et al., Ischemia-induced cellular redistribution of the astrocytic gap junctional protein connexin43 in rat brain. Brain Res 1994; 652: 311-322.
32. Alonso A, Reinz E, Jenne JW, et al., Reorganization of gap junctions after focused ultrasound blood-brain barrier opening in the rat brain. J Cereb Blood Flow Metab 2010; 30: 1394-1402.
33. Quaegebeur A, Carmeliet P,. Oxygen sensing: a common crossroad in cancer and neurodegeneration. Curr Top Microbiol Immunol 2010; 345: 71-103.
34. Wardlaw JM, Smith C, Dichgans M,. Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging. Lancet Neurol 2013; 12: 483-497.
35. Tucsek Z, Toth P, Tarantini S, et al., Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice. J Gerontol A Biol Sci Med Sci 2014; 69: 1339-1352.
36. Cognat E, Cleophax S, Domenga-Denier V, Joutel A,. Early white matter changes in CADASIL: evidence of segmental intramyelinic oedema in a pre-clinical mouse model. Acta Neuropathol Commun 2014; 2: 49.