Apolipoprotein E protects against neuropathology induced by a high-fat diet and maintains the integrity of the blood-brain barrier during aging

Laboratory Investigation

Volumn 81, Issue 7, 2001, Pages 953-960

  Mulder, Monique ^a   Blokland, Arjan ^b   Van Den Berg, Dirk Jan ^b   Schulten, Henny ^a   Bakker, Arjen H F ^b   Terwel, Dick ^a   Honig, Wiel ^a   De Kloet, E Ronald ^c   Havekes, Louis M ^d   Steinbusch, Harry W M ^a   De Lange, Elizabeth C M ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

^c LEIDEN UNIVERSITY   (Netherlands)

^d TNO   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL; IMMUNOGLOBULIN;

AGING; ALZHEIMER DISEASE; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; BLOOD BRAIN BARRIER; CHOLESTEROL DIET; CONTROLLED STUDY; DEGENERATIVE DISEASE; KNOCKOUT MOUSE; LIPID DIET; MOUSE; NEUROPATHY; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

EID: 0034936960     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1038/labinvest.3780307     Document Type: Article

References (37)

1. Behavioural, physiological and morphological analysis of a line of apolipoprotein E knockout mouse
2. Motor and cognitive deficits in apolipoprotein E deficient mice after closed head injury
3. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
4. Inflammatory pathogenesis in Alzheimer's disease: Biological mechanisms and cognitive sequeli
5. Progression and regression of atheroslcerosis in APOE3-Leiden transgenic mice: An immunohistochemical study
6. Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice
7. Apolipoprotein E ε4 and cerebral hemorrhage associated with amyloid angiopathy
8. Altered synaptic plasticity in hippocampal CA1 area of apolipoprotein E deficient mice
9. Cholinergic systems and long-term potentiation in memory-impaired apolipoprotein E-deficient mice
10. Increased blood-brain barrier permeability in LP-BM5 infected mice is mediated by neuroexcitatory mechanisms
11. Altered immune responses in apolipoprotein E-deficient mice
12. Apolipoprotein E-deficient mice have increased susceptibility to focal cerebral ischemia
13. Apolipoprotein E deficiency effects on learning in mice are dependent upon the background strain
14. Neurodegeneration in the central nervous system of apoE-deficient mice
15. Regional difference of lipid distribution in brain of apolipoprotein E deficient mice
16. Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides
17. Increased cerebral cortical lipid peroxidation and abnormal phospholipids in aged homozygous apoE-deficient C57BL/6J mice
18. Possible link between lipid metabolism and cerebral amyloid angiopathy in Alzheimer's disease: A role for high-density lipoproteins?
19. Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro
20. Apolipoprotein E epsilon 4 allele is associated with deposition of amyloid beta-protein following head injury
21. Severe learning deficits in apolipoprotein E-knockout mice in a water maze task
22. Cloning of monoclonal autoantibodies to epitopes of oxidized lipoproteins from apolipoprotein E-deficient mice: Demonstration of epitopes of oxidized low density lipoprotein in human plasma
23. Advances in cell biology of blood-brain barrier transport
24. Lipoproteins and their receptors in the central nervous system: Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B, E(LDL) receptors in the brain
25. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
26. Brains of aged apolipoprotein E-deficient mice have increased levels of F2-isoprostanes, in vivo markers of lipid peroxidation
27. Apolipoprotein E-ε4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer's disease
28. Association of apolipoprotein E allele E4 with late-onset familial and sporadic Alzheimer's disease
29. Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease
30. A one-step immunohistochemical method for detection of blood-brain barrier disturbances for immunoglobulins in lesioned rat brain with special reference to false-positive staining in immunohistochemistry
31. The effect of APOE on dementia is not through atherosclerosis: The Rotterdam Study
32. Apolipoprotein E ε4 and the risk of dementia with stroke: A population-based investigation
33. Reduction of isoprostanes and regression of advanced atherosclerosis by apolipoprotein E
34. Transgenic mice carrying the apolipoprotein E3-Leiden gene exhibit hyperlipoproteinemia
35. Atypical xanthomatosis in apolipoprotein E-deficient mice after cholesterol feeding
36. Synaptic alterations in apolipoprotein E knockout mice
37. Cerebral lipid deposition in aged apolipoprotein E-deficient mice