Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 17, 2017, Pages 4531-4536

  Yanagida, Keisuke ^a,b,c   Liu, Catherine H ^c   Faraco, Giuseppe ^d   Galvani, Sylvain ^a,b   Smith, Helen K ^c   Burg, Nathalie ^c   Anrather, Josef ^d   Sanchez, Teresa ^c   Iadecola, Costantino ^d   Hla, Timothy ^a,b,c  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d FEIL FAMILY BRAIN AND MIND RESEARCH INSTITUTE   (United States)

Author keywords

Blood brain barrier; Drug delivery; Endothelium; Sphingosine 1 phosphate; Tight junction

Indexed keywords

FINGOLIMOD; SPHINGOSINE 1 PHOSPHATE RECEPTOR; TIGHT JUNCTION PROTEIN; TRACER; LYSOPHOSPHOLIPID; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; CELLULAR DISTRIBUTION; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG MECHANISM; DRUG TARGETING; GENE EXPRESSION; IN VIVO STUDY; MALE; MICROVASCULATURE; MOLECULAR WEIGHT; MOUSE; NEWBORN; NONHUMAN; NOVEL OBJECT RECOGNITION TEST; PERIPHERAL VASCULAR SYSTEM; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; ANALOGS AND DERIVATIVES; ANIMAL; BRAIN; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; TIGHT JUNCTION; TRANSPORT AT THE CELLULAR LEVEL; VASCULAR ENDOTHELIUM; VASCULARIZATION;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; LYSOPHOSPHOLIPIDS; MICE; MICE, KNOCKOUT; RECEPTORS, LYSOSPHINGOLIPID; SPHINGOSINE; TIGHT JUNCTIONS;

EID: 85018848227     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1618659114     Document Type: Article

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