Depletion of coagulation factor XII ameliorates brain pathology and cognitive impairment in Alzheimer disease mice

Blood

Volumn 129, Issue 18, 2017, Pages 2547-2556

  Chen, Zu Lin ^a   Revenko, Alexey S ^b   Singh, Pradeep ^a   MacLeod, A Robert ^b   Norris, Erin H ^a   Strickland, Sidney ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; BLOOD CLOTTING FACTOR 12; FIBRINOGEN; HIGH MOLECULAR WEIGHT KININOGEN; MESSENGER RNA;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN TISSUE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; FIBRIN DEPOSITION; MOUSE; NERVE CELL DEGENERATION; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; ANIMAL; BLOOD; BRAIN; GENETICS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; TRANSGENIC MOUSE; VASCULAR DISEASE; VASCULARIZATION;

ALZHEIMER DISEASE; ANIMALS; BRAIN; COGNITIVE DYSFUNCTION; FACTOR XII; KININOGEN, HIGH-MOLECULAR-WEIGHT; MICE; MICE, TRANSGENIC; VASCULAR DISEASES;

EID: 85018927792     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2016-11-753202     Document Type: Article

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