Vascular contributions to cognitive impairment and dementia including Alzheimer's disease

Alzheimer's and Dementia

Volumn 11, Issue 6, 2015, Pages 710-717

  Snyder, Heather M ^a   Corriveau, Roderick A ^b   Craft, Suzanne ^c   Faber, James E ^d   Greenberg, Steven M ^e   Knopman, David ^f   Lamb, Bruce T ^g   Montine, Thomas J ^h   Nedergaard, Maiken ⁱ   Schaffer, Chris B ^j   Schneider, Julie A ^k   Wellington, Cheryl ^l   Wilcock, Donna M ^m   Zipfel, Gregory J ⁿ   Zlokovic, Berislav ^o   Bain, Lisa J ^p   Bosetti, Francesca ^b   Galis, Zorina S ^q   Koroshetz, Walter ^b   Carrillo, Maria C ^a  

^a ALZHEIMER'S ASSOCIATION   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f MAYO CLINIC   (United States)

^g LERNER RESEARCH INSTITUTE   (United States)

^h UNIVERSITY OF WASHINGTON   (United States)

ⁱ UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^j Cornell University   (United States)

^k RUSH UNIVERSITY MEDICAL CENTER   (United States)

^l UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^m UNIVERSITY OF KENTUCKY   (United States)

ⁿ WASHINGTON UNIVERSITY   (United States)

^o UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^p NONE   (United States)

^q NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

more..

Author keywords

Alzheimer's disease; Animal models; Biomarkers; Dementia; Small vessel disease; Vascular dementia

Indexed keywords

AMYLOID; AMYLOID PRECURSOR PROTEIN; BIOLOGICAL MARKER; NITRIC OXIDE SYNTHASE;

ADAPTIVE IMMUNITY; ALZHEIMER DISEASE; ARTERIOLOSCLEROSIS; BLOOD BRAIN BARRIER; BLOOD VESSEL INJURY; BRAIN ANGIOGRAPHY; BRAIN ATHEROSCLEROSIS; BRAIN BLOOD FLOW; BRAIN CIRCULATION; BRAIN HEMORRHAGE; BRAIN INFARCTION; CARDIOVASCULAR DISEASE; CAROTID ARTERY OBSTRUCTION; CEREBROVASCULAR ACCIDENT; CEREBROVASCULAR DISEASE; CHRONIC INFLAMMATION; COGNITIVE DEFECT; COLLATERAL CIRCULATION; DEMENTIA; DEPRESSION; DIFFUSION WEIGHTED IMAGING; DISEASE MODEL; ENVIRONMENTAL FACTOR; GENETIC ASSOCIATION; GENETIC RISK; HUMAN; HYPERCHOLESTEROLEMIA; HYPERHOMOCYSTEINEMIA; HYPERTENSION; INNATE IMMUNITY; INSULIN RESISTANCE; LIPID METABOLISM; LIPOPROTEIN METABOLISM; MIDDLE CEREBRAL ARTERY OCCLUSION; MULTIINFARCT DEMENTIA; NATIONAL HEALTH ORGANIZATION; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; OCCLUSIVE CEREBROVASCULAR DISEASE; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PHYSICAL ACTIVITY; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SLEEP DISORDER; SMOKING; VASCULAR AMYLOIDOSIS; VASCULAR DISEASE; WHITE MATTER LESION; ANIMAL; BRAIN; ORGANIZATION; PATHOPHYSIOLOGY; UNITED STATES; VASCULARIZATION;

ANIMALS; BRAIN; CEREBROVASCULAR DISORDERS; COGNITION DISORDERS; CONGRESSES AS TOPIC; DEMENTIA; HUMANS; NATIONAL HEART, LUNG, AND BLOOD INSTITUTE (U.S.); NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; SOCIETIES; UNITED STATES;

EID: 84924296638     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2014.10.008     Document Type: Review

References (80)

1. P.B. Gorelick, A. Scuteri, S.E. Black, C. Decarli, S.M. Greenberg, C. Iadecola, et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke Association Stroke 42 2011 2672 2713
2. B.G. Vickrey, T.G. Brott, W.J. Koroshetz, and Stroke Research Priorities Meeting Steering C, the National Advisory Neurological D, Stroke C, et al. Research priority setting: a summary of the 2012 NINDS Stroke Planning Meeting Report Stroke 44 2013 2338 2342
3. Montine TJ, NINDS ADRD 2013 Commitee. Alzheimer's Disease-Related Dementias: Research challenges and opportunities. Conference and recommendations report to the NINDS Council. Neurology. in press
4. U.S. Department of Health and Human Services. National plan to address Alzheimer's disease: 2013 Available at: http://aspe.hhs.gov/daltcp/napa/natlplan.shtml. Accessed November 27, 2013.
5. L.J. Launer, T.M. Hughes, and L.R. White Microinfarcts, brain atrophy, and cognitive function: the Honolulu Asia Aging Study Autopsy Study Ann Neurol 70 2011 774 780
6. M. Garcia-Alloza, J. Gregory, K.V. Kuchibhotla, S. Fine, Y. Wei, C. Ayata, et al. Cerebrovascular lesions induce transient beta-amyloid deposition Brain 134 Pt 12 2011 3697 3707
7. J.A. Schneider, R.S. Wilson, J.L. Bienias, D.A. Evans, and D.A. Bennett Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathology Neurology 62 2004 1148 1155
8. J.A. Schneider, Z. Arvanitakis, S.E. Leurgans, and D.A. Bennett The neuropathology of probable Alzheimer disease and mild cognitive impairment Ann Neurol 66 2009 200 208
9. D.A. Snowdon, L.H. Greiner, J.A. Mortimer, K.P. Riley, P.A. Greiner, and W.R. Markesbery Brain infarction and the clinical expression of Alzheimer disease. The Nun Study JAMA 277 1997 813 817
10. S.M. Butler, and D.A. Snowdon Trends in mortality in older women: findings from the Nun Study J Gerontol B Psychol Sci Soc Sci 51 1996 S201 S208
11. D.A. Snowdon, S.J. Kemper, J.A. Mortimer, L.H. Greiner, D.R. Wekstein, and W.R. Markesbery Linguistic ability in early life and cognitive function and Alzheimer's disease in late life. Findings from the Nun Study JAMA 275 1996 528 532
12. F. Rincon, and C.B. Wright Current pathophysiological concepts in cerebral small vessel disease Front Aging Neurosci 6 2014 24
13. C. Iadecola Neurovascular regulation in the normal brain and in Alzheimer's disease Nat Rev Neurosci 5 2004 347 360
14. L. Park, P. Zhou, R. Pitstick, C. Capone, J. Anrather, E.H. Norris, et al. Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein Proc Natl Acad Sci U S A 105 2008 1347 1352
15. M.A. Koike, K.N. Green, M. Blurton-Jones, and F.M. Laferla Oligemic hypoperfusion differentially affects tau and amyloid-{beta} Am J Pathol 177 2010 300 310
16. M.J. Luitse, G.J. Biessels, G.E. Rutten, and L.J. Kappelle Diabetes, hyperglycaemia, and acute ischaemic stroke Lancet Neurol 11 2012 261 271
17. G. Cheng, C. Huang, H. Deng, and H. Wang Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies Intern Med J 42 2012 484 491
18. F.E. Matthews, A. Arthur, L.E. Barnes, J. Bond, C. Jagger, L. Robinson, et al. A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: results of the Cognitive Function and Ageing Study I and II Lancet 382 2013 1405 1412
19. J.A. Schneider, Z. Arvanitakis, W. Bang, and D.A. Bennett Mixed brain pathologies account for most dementia cases in community-dwelling older persons Neurology 69 2007 2197 2204
20. B.D. James, D.A. Bennett, P.A. Boyle, S. Leurgans, and J.A. Schneider Dementia from Alzheimer disease and mixed pathologies in the oldest old JAMA 307 2012 1798 1800
21. Z. Arvanitakis, S.E. Leurgans, L.L. Barnes, D.A. Bennett, and J.A. Schneider Microinfarct pathology, dementia, and cognitive systems Stroke 42 2011 722 727
22. E.E. Smith, J.A. Schneider, J.M. Wardlaw, and S.M. Greenberg Cerebral microinfarcts: the invisible lesions Lancet Neurol 11 2012 272 282
23. Group LS 2001-2011: a decade of the LADIS (Leukoaraiosis And DISability) Study: what have we learned about white matter changes and small-vessel disease? Cerebrovasc Dis 32 2011 577 588
24. S. Craft The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads converged Arch Neurol 66 2009 300 305
25. K. Richardson, B.C. Stephan, P.G. Ince, C. Brayne, F.E. Matthews, and M.M. Esiri The neuropathology of vascular disease in the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS) Curr Alzheimer Res 9 2012 687 696
26. J.C. Lambert, C.A. Ibrahim-Verbaas, D. Harold, A.C. Naj, R. Sims, C. Bellenguez, et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease Nat Genet 45 2013 1452 1458
27. R. Jin, G. Yang, and G. Li Inflammatory mechanisms in ischemic stroke: role of inflammatory cells J Leukoc Biol 87 2010 779 789
28. P.L. McGeer, and E.G. McGeer Local neuroinflammation and the progression of Alzheimer's disease J Neurovirol 8 2002 529 538
29. L.F. Lue, L. Brachova, W.H. Civin, and J. Rogers Inflammation, a beta deposition, and neurofibrillary tangle formation as correlates of Alzheimer's disease neurodegeneration J Neuropathol Exp Neurol 55 1996 1083 1088
30. R.M. Ransohoff Microglia and monocytes: 'tis plain the twain meet in the brain Nat Neurosci 14 2011 1098 1100
31. K.E. Bernstein, Y. Koronyo, B.C. Salumbides, J. Sheyn, L. Pelissier, D.H. Lopes, et al. Angiotensin-converting enzyme overexpression in myelomonocytes prevents Alzheimer's-like cognitive decline J Clin Invest 124 2014 1000 1012
32. K.M. Cullen, Z. Kocsi, and J. Stone Pericapillary haem-rich deposits: evidence for microhaemorrhages in aging human cerebral cortex J Cereb Blood Flow Metab 25 2005 1656 1667
33. A.J. Farrall, and J.M. Wardlaw Blood-brain barrier: ageing and microvascular disease - systematic review and meta-analysis Neurobiol Aging 30 2009 337 352
34. M. Fiala, Q.N. Liu, J. Sayre, V. Pop, V. Brahmandam, M.C. Graves, et al. Cyclooxygenase-2-positive macrophages infiltrate the Alzheimer's disease brain and damage the blood-brain barrier Eur J Clin Invest 32 2002 360 371
35. J.D. Goos, M.I. Kester, F. Barkhof, M. Klein, M.A. Blankenstein, P. Scheltens, et al. Patients with Alzheimer disease with multiple microbleeds: relation with cerebrospinal fluid biomarkers and cognition Stroke 40 2009 3455 3460
36. H. Hanyu, Y. Tanaka, S. Shimizu, M. Takasaki, and K. Abe Cerebral microbleeds in Alzheimer's disease J Neurol 250 2003 1496 1497
37. B.V. Zlokovic Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders Nat Rev Neurosci 12 2011 723 738
38. E.H. Corder, A.M. Saunders, W.J. Strittmatter, D.E. Schmechel, P.C. Gaskell, G.W. Small, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families Science 261 1993 921 923
39. B.V. Zlokovic Cerebrovascular effects of apolipoprotein E: implications for Alzheimer disease JAMA Neurol 70 2013 440 444
40. R.D. Bell, E.A. Winkler, I. Singh, A.P. Sagare, R. Deane, Z. Wu, et al. Apolipoprotein E controls cerebrovascular integrity via cyclophilin Nature 485 2012 512 516
41. M.R. Halliday, N. Pomara, A.P. Sagare, W.J. Mack, B. Frangione, and B.V. Zlokovic Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown JAMA Neurol 70 2013 1198 1200
42. E.A. Winkler, R.D. Bell, and B.V. Zlokovic Central nervous system pericytes in health and disease Nat Neurosci 14 2011 1398 1405
43. J.D. Fryer, K. Simmons, M. Parsadanian, K.R. Bales, S.M. Paul, P.M. Sullivan, et al. Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model J Neurosci 25 2005 2803 2810
44. V. Hirsch-Reinshagen, L.F. Maia, B.L. Burgess, J.F. Blain, K.E. Naus, S.A. McIsaac, et al. The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease J Biol Chem 280 2005 43243 43256
45. P. Xu, D. Li, X. Tang, X. Bao, J. Huang, Y. Tang, et al. LXR agonists: new potential therapeutic drug for neurodegenerative diseases Mol Neurobiol 48 2013 715 728
46. H. Vollbach, R. Heun, C.M. Morris, J.A. Edwardson, I.G. McKeith, F. Jessen, et al. APOA1 polymorphism influences risk for early-onset nonfamiliar AD Ann Neurol 58 2005 436 441
47. I. Lefterov, N.F. Fitz, A.A. Cronican, A. Fogg, P. Lefterov, R. Kodali, et al. Apolipoprotein A-I deficiency increases cerebral amyloid angiopathy and cognitive deficits in APP/PS1DeltaE9 mice J Biol Chem 285 2010 36945 36957
48. M. Riwanto, and U. Landmesser High density lipoproteins and endothelial functions: mechanistic insights and alterations in cardiovascular disease J Lipid Res 54 2013 3227 3243
49. M. Riwanto, L. Rohrer, B. Roschitzki, C. Besler, P. Mocharla, M. Mueller, et al. Altered activation of endothelial anti- and proapoptotic pathways by high-density lipoprotein from patients with coronary artery disease: role of high-density lipoprotein-proteome remodeling Circulation 127 2013 891 904
50. J.A. Shaw, A. Bobik, A. Murphy, P. Kanellakis, P. Blombery, N. Mukhamedova, et al. Infusion of reconstituted high-density lipoprotein leads to acute changes in human atherosclerotic plaque Circ Res 103 2008 1084 1091
51. S. Stukas, J. Robert, and C.L. Wellington High-density lipoproteins and cerebrovascular integrity in Alzheimer's disease Cell Metab 19 2014 574 591
52. D. Chalothorn, and J.E. Faber Formation and maturation of the native cerebral collateral circulation J Mol Cell Cardiol 49 2010 251 259
53. X. Dai, and J.E. Faber Endothelial nitric oxide synthase deficiency causes collateral vessel rarefaction and impairs activation of a cell cycle gene network during arteriogenesis Circ Res 106 2010 1870 1881
54. J.E. Faber, H. Zhang, R.M. Lassance-Soares, P. Prabhakar, A.H. Najafi, M.S. Burnett, et al. Aging causes collateral rarefaction and increased severity of ischemic injury in multiple tissues Arterioscler Thromb Vasc Biol 31 2011 1748 1756
55. R. Sealock, H. Zhang, J.L. Lucitti, S.M. Moore, and J.E. Faber Congenic fine-mapping identifies a major causal locus for variation in the native collateral circulation and ischemic injury in brain and lower extremity Circ Res 114 2014 660 671
56. M. Arbel-Ornath, E. Hudry, K. Eikermann-Haerter, S. Hou, J.L. Gregory, L. Zhao, et al. Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer's disease mouse models Acta Neuropathol 126 2013 353 364
57. J.J. Iliff, M. Wang, D.M. Zeppenfeld, A. Venkataraman, B.A. Plog, Y. Liao, et al. Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain J Neurosci 33 2013 18190 18199
58. L. Xie, H. Kang, Q. Xu, M.J. Chen, Y. Liao, M. Thiyagarajan, et al. Sleep drives metabolite clearance from the adult brain Science 342 2013 373 377
59. E.I. Most, S. Aboudan, P. Scheltens, and E.J. Van Someren Discrepancy between subjective and objective sleep disturbances in early- and moderate-stage Alzheimer disease Am J Geriatr Psychiatry 20 2012 460 467
60. J.M. Castellano, R. Deane, A.J. Gottesdiener, P.B. Verghese, F.R. Stewart, T. West, et al. Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Abeta clearance in a mouse model of beta-amyloidosis Proc Natl Acad Sci U S A 109 2012 15502 15507
61. R. Deane, Z. Wu, A. Sagare, J. Davis, S. Du Yan, K. Hamm, et al. LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms Neuron 43 2004 333 344
62. N. Nishimura, G. Otte, J. Zhou, E. Beverly, C. Slack, C. Iadecola, et al. Capillary plugging by leukocytes contributes to blood flow reduction in mouse models of Alzheimer's disease 2011 Society for Neuroscience Annual Meeting Washington, D.C.
63. D.I. Bink, K. Ritz, E. Aronica, L. van der Weerd, and M.J. Daemen Mouse models to study the effect of cardiovascular risk factors on brain structure and cognition J Cereb Blood Flow Metab 33 2013 1666 1684
64. V. Bouet, T. Freret, J. Toutain, D. Divoux, M. Boulouard, and P. Schumann-Bard Sensorimotor and cognitive deficits after transient middle cerebral artery occlusion in the mouse Exp Neurol 203 2007 555 567
65. M. Shibata, R. Ohtani, M. Ihara, and H. Tomimoto White matter lesions and glial activation in a novel mouse model of chronic cerebral hypoperfusion Stroke 35 2004 2598 2603
66. J.H. Lee, B.J. Bacskai, and C. Ayata Genetic animal models of cerebral vasculopathies Prog Mol Biol Transl Sci 105 2012 25 55
67. M.C. Herzig, D.T. Winkler, P. Burgermeister, M. Pfeifer, E. Kohler, S.D. Schmidt, et al. Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis Nat Neurosci 7 2004 954 960
68. J. Davis, M.R. Wagner, W. Zhang, F. Xu, and W.E. Van Nostrand Amyloid beta-protein stimulates the expression of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) in human cerebrovascular smooth muscle cells J Biol Chem 278 2003 19054 19061
69. F.Y. Jalal, Y. Yang, J. Thompson, A.C. Lopez, and G.A. Rosenberg Myelin loss associated with neuroinflammation in hypertensive rats Stroke 43 2012 1115 1122
70. T.L. Sudduth, D.K. Powell, C.D. Smith, A. Greenstein, and D.M. Wilcock Induction of hyperhomocysteinemia models vascular dementia by induction of cerebral microhemorrhages and neuroinflammation J Cereb Blood Flow Metab 33 2013 708 715
71. S.M. Moore, M. Waters, H. Zhang, and J.E. Faber Hypertension and other cardiovascular risk factors lead to premature rarefaction of the native collateral circulation J Vasc Surg 57 2013 79S
72. E. Auriel, M.E. Gurol, A. Ayres, A.P. Dumas, K.M. Schwab, A. Vashkevich, et al. Characteristic distributions of intracerebral hemorrhage-associated diffusion-weighted lesions Neurology 79 2012 2335 2341
73. S. Peca, C.R. McCreary, E. Donaldson, G. Kumarpillai, N. Shobha, K. Sanchez, et al. Neurovascular decoupling is associated with severity of cerebral amyloid angiopathy Neurology 81 2013 1659 1665
74. B.H. Han, M.L. Zhou, A.K. Vellimana, E. Milner, D.H. Kim, J.K. Greenberg, et al. Resorufin analogs preferentially bind cerebrovascular amyloid: potential use as imaging ligands for cerebral amyloid angiopathy Mol Neurodegener 6 2011 86
75. A.P. Sagare, R.D. Bell, Z. Zhao, Q. Ma, E.A. Winkler, A. Ramanathan, et al. Pericyte loss influences Alzheimer-like neurodegeneration in mice Nat Commun 4 2013 2932
76. J.M. Wardlaw, E.E. Smith, G.J. Biessels, C. Cordonnier, F. Fazekas, R. Frayne, et al. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration Lancet Neurol 12 2013 822 838
77. S.J. van Veluw, J.J. Zwanenburg, J. Engelen-Lee, W.G. Spliet, J. Hendrikse, P.R. Luijten, et al. In vivo detection of cerebral cortical microinfarcts with high-resolution 7T MRI J Cereb Blood Flow Metab 33 2013 322 329
78. K.A. Johnson, M. Gregas, J.A. Becker, C. Kinnecom, D.H. Salat, E.K. Moran, et al. Imaging of amyloid burden and distribution in cerebral amyloid angiopathy Ann Neurol 62 2007 229 234
79. J.V. Ly, G.A. Donnan, V.L. Villemagne, J.A. Zavala, H. Ma, G. O'Keefe, et al. 11C-PIB binding is increased in patients with cerebral amyloid angiopathy-related hemorrhage Neurology 74 2010 487 493
80. F. Rebeles, J. Fink, Y. Anzai, and K.R. Maravilla Blood-brain barrier imaging and therapeutic potentials Top Magn Reson Imaging 17 2006 107 116