APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction

PLoS Biology

Volumn 13, Issue 10, 2015, Pages 1-33

  Soto, Ileana ^a   Graham, Leah C ^a,b   Richter, Hannah J ^a   Simeone, Stephen N ^a   Radell, Jake E ^a   Grabowska, Weronika ^a   Funkhouser, W Keith ^a   Howell, Megan C ^a   Howell, Gareth R ^a,b  

^a JACKSON LABORATORY   (United States)

^b TUFTS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; COMPLEMENT; COMPLEMENT COMPONENT C1Q; NERVE PROTEIN;

AEROBIC EXERCISE; AGING; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; CELL ACTIVATION; CELL LOSS; COMPLEMENT ACTIVATION; CONTROLLED STUDY; HISTOPATHOLOGY; MICROGLIA; MOUSE; NERVE CELL PLASTICITY; NERVOUS SYSTEM INFLAMMATION; NEUROVASCULAR DYSFUNCTION; NONHUMAN; PERICYTE; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN STABILITY; RNA SEQUENCE; UPREGULATION; VASCULAR DISEASE; ANIMAL; BLOOD; BLOOD BRAIN BARRIER; C57BL MOUSE; CHEMISTRY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HOMOZYGOTE; IMMUNOLOGY; METABOLISM; MONOCYTE; MOTOR ACTIVITY; MUTATION; NEURODEGENERATIVE DISEASES; NEUROVASCULAR COUPLING; PATHOLOGY; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE; VASCULAR DISEASES; VASCULAR ENDOTHELIUM;

AGING; ANIMALS; APOLIPOPROTEINS E; ASTROCYTES; BLOOD-BRAIN BARRIER; COMPLEMENT ACTIVATION; COMPLEMENT C1Q; ENDOTHELIUM, VASCULAR; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMOZYGOTE; MICE, INBRED C57BL; MICROSCOPY, ELECTRON, TRANSMISSION; MONOCYTES; MOTOR ACTIVITY; MUTATION; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; NEURONAL PLASTICITY; NEUROVASCULAR COUPLING; PROTEIN STABILITY; VASCULAR DISEASES;

EID: 84946066133     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1002279     Document Type: Article

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