Blood-brain barrier leakage in patients with early Alzheimer disease

Radiology

Volumn 281, Issue 2, 2016, Pages 527-535

  Van De Haar, Harm J ^a,b   Burgmans, Saartje ^a,b   Jansen, Jacobus F A ^a,b   Van Osch, Matthias J P ^c   Van Buchem, Mark A ^c   Muller, Majon ^c   Hofman, Paul A M ^a,b   Verhey, Frans R J ^a,b   Backes, Walter H ^a,b  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BLOOD BRAIN BARRIER LEAKAGE; BRAIN CORTEX; CENTRAL NERVOUS SYSTEM DISEASE; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; DYNAMIC CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING; FEMALE; GRAY MATTER; HUMAN; MALE; MINI MENTAL STATE EXAMINATION; PILOT STUDY; PLASMA VOLUME; PRIORITY JOURNAL; PROSPECTIVE STUDY; WHITE MATTER; BLOOD BRAIN BARRIER; BLOOD VOLUME; CASE CONTROL STUDY; DIAGNOSTIC IMAGING; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PROCEDURES; VERY ELDERLY;

CONTRAST MEDIUM;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BLOOD VOLUME; BLOOD-BRAIN BARRIER; CASE-CONTROL STUDIES; CONTRAST MEDIA; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PILOT PROJECTS;

EID: 84992111543     PISSN: 00338419     EISSN: 15271315     Source Type: Journal    
DOI: 10.1148/radiol.2016152244     Document Type: Article

References (33)

1. Iadecola C. The pathobiology of vascular dementia. Neuron 2013;80(4):844-866.
2. Srinivasa RN, Rossetti HC, Gupta MK, et al. Cardiovascular risk factors associated with smaller brain volumes in regions identified as early predictors of cognitive decline. Radiology 2016;278(1):198-204.
3. Benarroch EE. Neurovascular unit dysfunction: a vascular component of Alzheimer disease? Neurology 2007;68(20):1730-1732. [Published correction appears in Neurology 2008;70(20):1941.]
4. Zlokovic BV. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 2008;57(2):178-201.
5. Burgmans S, van de Haar HJ, Verhey FR, Backes WH. Amyloid-b interacts with blood-brain barrier function in dementia: a systematic review. J Alzheimers Dis 2013;35(4):859-873.
6. Wardlaw JM, Doubal FN, Valdes-Hernandez M, et al. Blood-brain barrier permeability and long-term clinical and imaging outcomes in cerebral small vessel disease. Stroke 2013;44(2):525-527.
7. Erickson MA, Banks WA. Blood-brain barrier dysfunction as a cause and consequence of Alzheimer's disease. J Cereb Blood Flow Metab 2013;33(10):1500-1513.
8. Oostendorp M, Post MJ, Backes WH. Vessel growth and function: depiction with contrast-enhanced MR imaging. Radiology 2009;251(2):317-335.
9. Taheri S, Gasparovic C, Shah NJ, Rosenberg GA. Quantitative measurement of blood-brain barrier permeability in human using dynamic contrast-enhanced MRI with fast T1 mapping. Magn Reson Med 2011;65(4):1036-1042.
10. Taheri S, Gasparovic C, Huisa BN, et al. Blood-brain barrier permeability abnormalities in vascular cognitive impairment. Stroke 2011;42(8):2158-2163.
11. Montagne A, Barnes SR, Sweeney MD, et al. Blood-brain barrier breakdown in the aging human hippocampus. Neuron 2015;85(2):296-302.
12. van de Haar HJ, Burgmans S, Hofman PA, Verhey FR, Jansen JF, Backes WH. Bloodbrain barrier impairment in dementia: current and future in vivo assessments. Neurosci Biobehav Rev 2015;49:71-81.
13. Jelescu IO, Leppert IR, Narayanan S, Araújo D, Arnold DL, Pike GB. Dual-temporal resolution dynamic contrast-enhanced MRI protocol for blood-brain barrier permeability measurement in enhancing multiple sclerosis lesions. J Magn Reson Imaging 2011;33(6):1291-1300.
14. Dubois B, Feldman HH, Jacova C, et al. Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDSADRDA criteria. Lancet Neurol 2007;6(8): 734-746.
15. McKhann GM, Knopman DS, Chertkow H, et al. The diagnosis of dementia due to Al zheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011;7(3):263-269.
16. Morris JC. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 1993;43(11):2412-2414.
17. Folstein MF, Folstein SE, McHugh PR. "Minimental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12(3):189-198.
18. Butman J, Gupta S. Automated computation of the vascular input function for dynamic contrast-enhanced MRI of the brain [abstr]. In: Proceedings of the Fourteenth Meeting of the International Society for Magnetic Resonance in Medicine. Berkeley, Calif: International Society for Magnetic Resonance in Medicine, 2006; 1535.
19. Li KL, Zhu XP, Waterton J, Jackson A. Improved 3D quantitative mapping of blood volume and endothelial permeability in brain tumors. J Magn Reson Imaging 2000; 12(2):347-357.
20. Lavini C, Verhoeff JJC. Reproducibility of the gadolinium concentration measurements and of the fitting parameters of the vascular input function in the superior sagittal sinus in a patient population. Magn Reson Imaging 2010;28(10):1420-1430.
21. Patlak CS, Blasberg RG, Fenstermacher JD. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 1983;3(1):1-7.
22. Barnes SR, Ng TS, Montagne A, Law M, Zlokovic BV, Jacobs RE. Optimal acquisition and modeling parameters for accurate assessment of low Ktrans bloodbrain barrier permeability using dynamic contrast-enhanced MRI. Magn Reson Med 2016;75(5):1967-1977.
23. Cramer SP, Larsson HB. Accurate determination of blood-brain barrier permeability using dynamic contrast-enhanced T1-weighted MRI: a simulation and in vivo study on healthy subjects and multiple sclerosis patients. J Cereb Blood Flow Metab 2014;34(10):1655-1665.
24. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Series B Stat Methodol 1995;57(1):289-300.
25. Starr JM, Farrall AJ, Armitage P, McGurn B, Wardlaw J. Blood-brain barrier permeability in Alzheimer's disease: a case-control MRI study. Psychiatry Res 2009;171(3):232-241.
26. Wang H, Golob EJ, Su MY. Vascular volume and blood-brain barrier permeability measured by dynamic contrast enhanced MRI in hippocampus and cerebellum of patients with MCI and normal controls. J Magn Reson Imaging 2006;24(3):695-700.
27. Hanyu H, Asano T, Tanaka Y, Iwamoto T, Takasaki M, Abe K. Increased blood-brain barrier permeability in white matter lesions of Binswanger's disease evaluated by contrast-enhanced MRI. Dement Geriatr Cogn Disord 2002;14(1):1-6.
28. Nitta T, Hata M, Gotoh S, et al. Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol 2003;161(3):653-660.
29. Abbott NJ, Rönnbäck L, Hansson E. Astrocyte-endothelial interactions at the bloodbrain barrier. Nat Rev Neurosci 2006;7(1): 41-53.
30. Wierenga CE, Hays CC, Zlatar ZZ. Cerebral blood flow measured by arterial spin labeling MRI as a preclinical marker of Alzheimer's disease. J Alzheimers Dis 2014;42(Suppl 4): S411-S419.
31. Wardlaw JM, Smith C, Dichgans M. Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging. Lancet Neurol 2013;12(5):483-497.
32. Jack CR Jr, Knopman DS, Jagust WJ, et al. Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol 2010;9(1):119-128.
33. Van Assema DM, Lubberink M, Bauer M, et al. Blood-brain barrier P-glycoprotein function in Alzheimer's disease. Brain 2012;135 (Pt 1):181-189.