-
1
-
-
79955563790
-
Organic synthesis toward small-molecule probes and drugs
-
Schreiber, S.L.; Halpern, J. Organic synthesis toward small-molecule probes and drugs. Proc. Natl. Acad. Sci. USA 2011, 108, 6699–6702. [CrossRef] [PubMed]
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 6699-6702
-
-
Schreiber, S.L.1
Halpern, J.2
-
2
-
-
79851507787
-
Genomics-inspired discovery of natural products
-
Winter, J.M.; Behnken, S.; Hertweck, C. Genomics-inspired discovery of natural products. Curr. Opin. Chem. Biol. 2011, 15, 22–31. [CrossRef] [PubMed]
-
(2011)
Curr. Opin. Chem. Biol.
, vol.15
, pp. 22-31
-
-
Winter, J.M.1
Behnken, S.2
Hertweck, C.3
-
3
-
-
42949160050
-
Natural products as leads to potential drugs: An old process or the new hope for drug discovery?
-
Newman, D.J. Natural products as leads to potential drugs: An old process or the new hope for drug discovery? J. Med. Chem. 2008, 51, 2589–2599. [CrossRef] [PubMed]
-
(2008)
J. Med. Chem.
, vol.51
, pp. 2589-2599
-
-
Newman, D.J.1
-
4
-
-
34447524208
-
Expression of biosynthetic gene clusters in heterologous hosts for natural product production and combinatorial biosynthesis
-
Galm, U.; Shen, B. Expression of biosynthetic gene clusters in heterologous hosts for natural product production and combinatorial biosynthesis. Expert Opin. Drug Discov. 2006, 1, 409–437. [CrossRef] [PubMed]
-
(2006)
Expert Opin. Drug Discov.
, vol.1
, pp. 409-437
-
-
Galm, U.1
Shen, B.2
-
5
-
-
84937459775
-
Engineered biosynthesis of natural products in heterologous hosts
-
Luo, Y.; Li, B.-Z.; Liu, D.; Zhang, L.; Chen, Y.; Jia, B.; Zeng, B.-X.; Zhao, H.; Yuan, Y.-J. Engineered biosynthesis of natural products in heterologous hosts. Chem. Soc. Rev. 2015, 44, 5265–5290. [CrossRef] [PubMed]
-
(2015)
Chem. Soc. Rev.
, vol.44
, pp. 5265-5290
-
-
Luo, Y.1
Li, B.-Z.2
Liu, D.3
Zhang, L.4
Chen, Y.5
Jia, B.6
Zeng, B.-X.7
Zhao, H.8
Yuan, Y.-J.9
-
6
-
-
84865515585
-
Synthetic biological approaches to natural product biosynthesis
-
Winter, J.M.; Tang, Y. Synthetic biological approaches to natural product biosynthesis. Curr. Opin. Biotechnol. 2012, 23, 736–743. [CrossRef] [PubMed]
-
(2012)
Curr. Opin. Biotechnol.
, vol.23
, pp. 736-743
-
-
Winter, J.M.1
Tang, Y.2
-
7
-
-
84873086193
-
Perspectives in metabolic engineering: Understanding cellular regulation towards the control of metabolic routes
-
Zadran, S.; Levine, R.D. Perspectives in metabolic engineering: Understanding cellular regulation towards the control of metabolic routes. Appl. Biochem. Biotechnol. 2013, 169, 55–65. [CrossRef] [PubMed]
-
(2013)
Appl. Biochem. Biotechnol.
, vol.169
, pp. 55-65
-
-
Zadran, S.1
Levine, R.D.2
-
8
-
-
33645870422
-
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
-
Ho, K.A.; Keasling, J.D.; Kirby, J.; Shiba, Y.; Paradise, E.M.; Fisher, K.J.; Ro, D.-K.; Ndungu, J.M.; Chang, M.C.Y.; Newman, K.L.; et al. Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 2006, 440, 940–943.
-
(2006)
Nature
, vol.440
, pp. 940-943
-
-
Ho, K.A.1
Keasling, J.D.2
Kirby, J.3
Shiba, Y.4
Paradise, E.M.5
Fisher, K.J.6
Ro, D.-K.7
Ndungu, J.M.8
Chang, M.C.Y.9
Newman, K.L.10
-
9
-
-
84922067763
-
A microbial biomanufacturing platform for natural and semisynthetic opioids
-
Thodey, K.; Galanie, S.; Smolke, C.D. A microbial biomanufacturing platform for natural and semisynthetic opioids. Nat. Chem. Biol. 2014, 10, 837–844. [CrossRef] [PubMed]
-
(2014)
Nat. Chem. Biol.
, vol.10
, pp. 837-844
-
-
Thodey, K.1
Galanie, S.2
Smolke, C.D.3
-
10
-
-
77957329119
-
Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli
-
Ajikumar, P.K.; Xiao, W.-H.; Keith, E.J.T.; Wang, Y.; Simeon, F.; Leonard, E.; Mucha, O.; Phon, T.H.; Pfeifer, B.; Stephanopoulos, G. Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli. Science 2010, 330, 70–74. [CrossRef] [PubMed]
-
(2010)
Science
, vol.330
, pp. 70-74
-
-
Ajikumar, P.K.1
Xiao, W.-H.2
Keith, E.J.T.3
Wang, Y.4
Simeon, F.5
Leonard, E.6
Mucha, O.7
Phon, T.H.8
Pfeifer, B.9
Stephanopoulos, G.10
-
11
-
-
84860784197
-
Direct cloning of large genomic sequences
-
Cobb, R.E.; Zhao, H.M. Direct cloning of large genomic sequences. Nat. Biotechnol. 2012, 30, 405–406. [CrossRef] [PubMed]
-
(2012)
Nat. Biotechnol.
, vol.30
, pp. 405-406
-
-
Cobb, R.E.1
Zhao, H.M.2
-
12
-
-
84861303184
-
The early stages of taxol biosynthesis: An interim report on the synthesis and identification of early pathway metabolites
-
Guerra-Bubb, J.; Croteau, R.; Williams, R.M. The early stages of taxol biosynthesis: An interim report on the synthesis and identification of early pathway metabolites. Nat. Prod. Rep. 2012, 29, 683–696. [CrossRef] [PubMed]
-
(2012)
Nat. Prod. Rep.
, vol.29
, pp. 683-696
-
-
Guerra-Bubb, J.1
Croteau, R.2
Williams, R.M.3
-
13
-
-
34447642166
-
Comparative genomics reveals novel biochemical pathways
-
Piškur, J.; Schnackerz, K.D.; Andersen, G.; Björnberg, O. Comparative genomics reveals novel biochemical pathways. Trends Genet. 2007, 23, 369–372. [CrossRef] [PubMed]
-
(2007)
Trends Genet
, vol.23
, pp. 369-372
-
-
Piškur, J.1
Schnackerz, K.D.2
Andersen, G.3
Björnberg, O.4
-
14
-
-
84890325085
-
Discovery of a metabolic alternative to the classical mevalonate pathway
-
Dellas, N.; Thomas, S.T.; Manning, G.; Noel, J.P. Discovery of a metabolic alternative to the classical mevalonate pathway. ELIFE 2013, 2, e00672. [CrossRef] [PubMed]
-
(2013)
ELIFE
, vol.2
-
-
Dellas, N.1
Thomas, S.T.2
Manning, G.3
Noel, J.P.4
-
15
-
-
33846466959
-
Teasing apart the Taxol pathway
-
Alexander, R.W. Teasing apart the Taxol pathway. Trends Biochem. Sci. 2001, 26, 152–153. [CrossRef]
-
(2001)
Trends Biochem. Sci.
, vol.26
, pp. 152-153
-
-
Alexander, R.W.1
-
16
-
-
84924417048
-
Elucidation of the shanorellin biosynthetic pathway and functional analysis of associated enzymes
-
Sato, M.; Yamada, H.; Hotta, K.; Watanabe, K. Elucidation of the shanorellin biosynthetic pathway and functional analysis of associated enzymes. Medchemcomm 2015, 6, 425–430. [CrossRef]
-
(2015)
Medchemcomm
, vol.6
, pp. 425-430
-
-
Sato, M.1
Yamada, H.2
Hotta, K.3
Watanabe, K.4
-
17
-
-
65549087156
-
Advances in analysis of microbial metabolic fluxes via (13)C isotopic labeling
-
Tang, Y.J.; Martin, H.G.; Myers, S.; Rodriguez, S.; Baidoo, E.E.; Keasling, J.D. Advances in analysis of microbial metabolic fluxes via (13)C isotopic labeling. Mass Spectrom. Rev. 2009, 28, 362–375. [CrossRef] [PubMed]
-
(2009)
Mass Spectrom. Rev.
, vol.28
, pp. 362-375
-
-
Tang, Y.J.1
Martin, H.G.2
Myers, S.3
Rodriguez, S.4
Baidoo, E.E.5
Keasling, J.D.6
-
18
-
-
33344456009
-
Elucidation of the biosynthetic pathway leading to the complex nonadride phomoidride B
-
Sulikowski, G.A.; Pongdee, R. Elucidation of the Biosynthetic Pathway Leading to the Complex Nonadride Phomoidride B. Synlett 2006, 2006, 354–363. [CrossRef]
-
(2006)
Synlett
, vol.2006
, pp. 354-363
-
-
Sulikowski, G.A.1
Pongdee, R.2
-
19
-
-
0037318402
-
A genomics-guided approach for discovering and expressing cryptic metabolic pathways
-
Nonaka, K.; Ahlert, J.; Thorson, J.S.; Bachmann, B.O.; Zazopoulos, E.; Shen, B.; Huang, K.; Staffa, A.; Liu, W.; Farnet, C.M. A genomics-guided approach for discovering and expressing cryptic metabolic pathways. Nat. Biotechnol. 2003, 21, 187–190.
-
(2003)
Nat. Biotechnol.
, vol.21
, pp. 187-190
-
-
Nonaka, K.1
Ahlert, J.2
Thorson, J.S.3
Bachmann, B.O.4
Zazopoulos, E.5
Shen, B.6
Huang, K.7
Staffa, A.8
Liu, W.9
Farnet, C.M.10
-
20
-
-
77049112083
-
Isolation and purification of a new kalimantacin/batumin-related polyketide antibiotic and elucidation of its biosynthesis gene cluster
-
Mattheus, W.; Gao, L.-J.; Herdewijn, P.; Landuyt, B.; Verhaegen, J.; Masschelein, J.; Volckaert, G.; Lavigne, R. Isolation and Purification of a New Kalimantacin/Batumin-Related Polyketide Antibiotic and Elucidation of Its Biosynthesis Gene Cluster. Chem. Biol. 2010, 17, 149–159. [CrossRef] [PubMed]
-
(2010)
Chem. Biol.
, vol.17
, pp. 149-159
-
-
Mattheus, W.1
Gao, L.-J.2
Herdewijn, P.3
Landuyt, B.4
Verhaegen, J.5
Masschelein, J.6
Volckaert, G.7
Lavigne, R.8
-
21
-
-
33846294440
-
The genomisotopic approach: A systematic method to isolate products of orphan biosynthetic gene clusters
-
Gross, H.; Stockwell, V.O.; Henkels, M.D.; Nowak-Thompson, B.; Loper, J.E.; Gerwick, W.H. The Genomisotopic Approach: A Systematic Method to Isolate Products of Orphan Biosynthetic Gene Clusters. Chem. Biol. 2007, 14, 53–63. [CrossRef] [PubMed]
-
(2007)
Chem. Biol.
, vol.14
, pp. 53-63
-
-
Gross, H.1
Stockwell, V.O.2
Henkels, M.D.3
Nowak-Thompson, B.4
Loper, J.E.5
Gerwick, W.H.6
-
22
-
-
84892688705
-
Genome sequencing and analysis of the paclitaxel-producing endophytic fungus Penicillium aurantiogriseum NRRL 62431
-
Yang, Y.F.; Zhao, H.N.; Barrero, R.A.; Zhang, B.H.; Sun, G.L.; Wilson, I.W.; Xie, F.L.; Walker, K.D.; Parks, J.W.; Bruce, R.; et al. Genome sequencing and analysis of the paclitaxel-producing endophytic fungus Penicillium aurantiogriseum NRRL 62431. BMC Genom. 2014, 15, 69. [CrossRef] [PubMed]
-
(2014)
BMC Genom
, vol.15
, pp. 69
-
-
Yang, Y.F.1
Zhao, H.N.2
Barrero, R.A.3
Zhang, B.H.4
Sun, G.L.5
Wilson, I.W.6
Xie, F.L.7
Walker, K.D.8
Parks, J.W.9
Bruce, R.10
-
23
-
-
77957601090
-
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism
-
Zhao, W.; Zhong, Y.; Yuan, H.; Wang, J.; Zheng, H.; Wang, Y.; Cen, X.; Xu, F.; Bai, J.; Han, X.; et al. Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism. Cell Res. 2010, 20, 1096–1108. [CrossRef] [PubMed]
-
(2010)
Cell Res
, vol.20
, pp. 1096-1108
-
-
Zhao, W.1
Zhong, Y.2
Yuan, H.3
Wang, J.4
Zheng, H.5
Wang, Y.6
Cen, X.7
Xu, F.8
Bai, J.9
Han, X.10
-
24
-
-
77949847651
-
Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy
-
Hagel, J.M.; Facchini, P.J. Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy. Nat. Chem. Biol. 2010, 6, 273–275. [CrossRef] [PubMed]
-
(2010)
Nat. Chem. Biol.
, vol.6
, pp. 273-275
-
-
Hagel, J.M.1
Facchini, P.J.2
-
25
-
-
79959472680
-
The first insight into the tissue specific taxus transcriptome via illumina second generation sequencing
-
Hao, D.C.; Ge, G.B.; Xiao, P.G.; Zhang, Y.Y.; Yang, L. The First Insight into the Tissue Specific Taxus Transcriptome via Illumina Second Generation Sequencing. PLoS ONE 2011, 6, e21220. [CrossRef] [PubMed]
-
(2011)
PLoS ONE
, vol.6
-
-
Hao, D.C.1
Ge, G.B.2
Xiao, P.G.3
Zhang, Y.Y.4
Yang, L.5
-
26
-
-
54749115137
-
Ribosomal synthesis of tricyclic depsipeptides in bloom-forming cyanobacteria
-
Ziemert, N.; Ishida, K.; Liaimer, A.; Hertweck, C.; Dittmann, E. Ribosomal synthesis of tricyclic depsipeptides in bloom-forming cyanobacteria. Angew. Chem. 2008, 47, 7756–7759. [CrossRef] [PubMed]
-
(2008)
Angew. Chem.
, vol.47
, pp. 7756-7759
-
-
Ziemert, N.1
Ishida, K.2
Liaimer, A.3
Hertweck, C.4
Dittmann, E.5
-
27
-
-
84893456760
-
Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A
-
Yamanaka, K.; Reynolds, K.A.; Kersten, R.D.; Ryan, K.S.; Gonzalez, D.J.; Nizet, V.; Dorrestein, P.C.; Moore, B.S. Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A. Proc. Natl. Acad. Sci. 2014, 111, 1957–1962. [CrossRef] [PubMed]
-
(2014)
Proc. Natl. Acad. Sci.
, vol.111
, pp. 1957-1962
-
-
Yamanaka, K.1
Reynolds, K.A.2
Kersten, R.D.3
Ryan, K.S.4
Gonzalez, D.J.5
Nizet, V.6
Dorrestein, P.C.7
Moore, B.S.8
-
28
-
-
29544433799
-
Directed evolution of metabolic pathways
-
Chatterjee, R.; Yuan, L. Directed evolution of metabolic pathways. Trends Biotechnol. 2006, 24, 28–38. [CrossRef] [PubMed]
-
(2006)
Trends Biotechnol
, vol.24
, pp. 28-38
-
-
Chatterjee, R.1
Yuan, L.2
-
29
-
-
42949144998
-
Activation of fungal silent gene clusters: A new avenue to drug discovery
-
Brakhage, A.A.; Schuemann, J.; Bergmann, S.; Scherlach, K.; Schroeckh, V.; Hertweck, C. Activation of fungal silent gene clusters: A new avenue to drug discovery. Prog. Res. Fortschr. Arzneim. Prog. Rech. Pharm. 2008, 66, 1–12.
-
(2008)
Prog. Res. Fortschr. Arzneim. Prog. Rech. Pharm.
, vol.66
, pp. 1-12
-
-
Brakhage, A.A.1
Schuemann, J.2
Bergmann, S.3
Scherlach, K.4
Schroeckh, V.5
Hertweck, C.6
-
30
-
-
84895107216
-
Recent advances in genome mining of secondary metabolite biosynthetic gene clusters and the development of heterologous expression systems in Aspergillus nidulans
-
Yaegashi, J.; Oakley, B.R.; Wang, C.C.C. Recent advances in genome mining of secondary metabolite biosynthetic gene clusters and the development of heterologous expression systems in Aspergillus nidulans. J. Ind. Microbiol. Biotechnol. 2014, 41, 433–442. [CrossRef] [PubMed]
-
(2014)
J. Ind. Microbiol. Biotechnol.
, vol.41
, pp. 433-442
-
-
Yaegashi, J.1
Oakley, B.R.2
Wang, C.C.C.3
-
31
-
-
68049088909
-
A Gene Cluster Containing Two Fungal Polyketide Synthases Encodes the Biosynthetic Pathway for a Polyketide, Asperfuranone, in Aspergillus nidulans
-
Chiang, Y.M.; Szewczyk, E.; Davidson, A.D.; Keller, N.; Oakley, B.R.; Wang, C.C.C. A Gene Cluster Containing Two Fungal Polyketide Synthases Encodes the Biosynthetic Pathway for a Polyketide, Asperfuranone, in Aspergillus nidulans. J. Am. Chem. Soc. 2009, 131, 2965–2970. [CrossRef] [PubMed]
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 2965-2970
-
-
Chiang, Y.M.1
Szewczyk, E.2
Davidson, A.D.3
Keller, N.4
Oakley, B.R.5
Wang, C.C.C.6
-
32
-
-
67650321573
-
Chromatin-level regulation of biosynthetic gene clusters
-
Chiang, Y.-M.; Lo, H.-C.; Strauss, J.; Wang, C.C.C.; Davidson, A.D.; Oakley, B.R.; Reyes-Dominguez, Y.; Watanabe, K.; Szewczyk, E.; Sanchez, J.F.; et al. Chromatin-level regulation of biosynthetic gene clusters. Nat. Chem. Biol. 2009, 5, 462–464.
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 462-464
-
-
Chiang, Y.-M.1
Lo, H.-C.2
Strauss, J.3
Wang, C.C.C.4
Davidson, A.D.5
Oakley, B.R.6
Reyes-Dominguez, Y.7
Watanabe, K.8
Szewczyk, E.9
Sanchez, J.F.10
-
33
-
-
84903314895
-
Microbial co-culture: Harnessing intermicrobial signaling for the production of novel antimicrobials
-
Moody, S.C. Microbial co-culture: Harnessing intermicrobial signaling for the production of novel antimicrobials. Fut. Microbiol. 2014, 9, 575–578. [CrossRef] [PubMed]
-
(2014)
Fut. Microbiol.
, vol.9
, pp. 575-578
-
-
Moody, S.C.1
-
34
-
-
84942125055
-
Acyclic sesquiterpenes released by Candida albicans inhibit growth of dermatophytes
-
Brasch, J.; Horter, F.; Fritsch, D.; Beck-Jendroschek, V.; Tröger, A.; Francke, W. Acyclic sesquiterpenes released by Candida albicans inhibit growth of dermatophytes. Med. Mycol. 2014, 52, 46–55. [PubMed]
-
(2014)
Med. Mycol.
, vol.52
, pp. 46-55
-
-
Brasch, J.1
Horter, F.2
Fritsch, D.3
Beck-Jendroschek, V.4
Tröger, A.5
Francke, W.6
-
35
-
-
84901407853
-
Production of induced secondary metabolites by a co-culture of sponge-associated actinomycetes, Actinokineospora sp. Eg49 and Nocardiopsis sp. Rv163
-
Dashti, Y.; Grkovic, T.; Abdelmohsen, U.R.; Hentschel, U.; Quinn, R.J. Production of Induced Secondary Metabolites by a Co-Culture of Sponge-Associated Actinomycetes, Actinokineospora sp. EG49 and Nocardiopsis sp. RV163. Mar. Drugs 2014, 12, 3046–3059. [CrossRef] [PubMed]
-
(2014)
Mar. Drugs
, vol.12
, pp. 3046-3059
-
-
Dashti, Y.1
Grkovic, T.2
Abdelmohsen, U.R.3
Hentschel, U.4
Quinn, R.J.5
-
36
-
-
84890086658
-
Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster
-
Luo, Y.; Huang, H.; Liang, J.; Wang, M.; Lu, L.; Shao, Z.; Cobb, R.E.; Zhao, H. Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster. Nat. Commun. 2013, 4, 2894. [CrossRef] [PubMed]
-
(2013)
Nat. Commun.
, vol.4
, pp. 2894
-
-
Luo, Y.1
Huang, H.2
Liang, J.3
Wang, M.4
Lu, L.5
Shao, Z.6
Cobb, R.E.7
Zhao, H.8
-
37
-
-
84859870038
-
Modification of natural products for drug discovery
-
Guo, Z.-R. Modification of natural products for drug discovery. Acta Pharm. Sin. 2012, 47, 144–157.
-
(2012)
Acta Pharm. Sin.
, vol.47
, pp. 144-157
-
-
Guo, Z.-R.1
-
38
-
-
84928801703
-
Insights into drug discovery from natural products through structural modification
-
Chen, J.C.; Li, W.L.; Yao, H.Q.; Xu, J.Y. Insights into drug discovery from natural products through structural modification. Fitoterapia 2015, 103, 231–241. [CrossRef] [PubMed]
-
(2015)
Fitoterapia
, vol.103
, pp. 231-241
-
-
Chen, J.C.1
Li, W.L.2
Yao, H.Q.3
Xu, J.Y.4
-
39
-
-
84867419830
-
Overcoming tumor multidrug resistance using drugs able to evade P-glycoprotein or to exploit its expression
-
Nobili, S.; Landini, I.; Mazzei, T.; Mini, E. Overcoming tumor multidrug resistance using drugs able to evade P-glycoprotein or to exploit its expression. Med. Res. Rev. 2012, 32, 1220–1262. [CrossRef] [PubMed]
-
(2012)
Med. Res. Rev.
, vol.32
, pp. 1220-1262
-
-
Nobili, S.1
Landini, I.2
Mazzei, T.3
Mini, E.4
-
40
-
-
48649094535
-
Synthesis and biological evaluation of novel 1-O- and 14-O-derivatives of oridonin as potential anticancer drug candidates
-
Xu, J.; Yang, J.; Ran, Q.; Wang, L.; Wang, Z.; Liu, J.; Wu, X.; Hua, W.; Yuan, S.; Zhang, L.; et al. Synthesis and biological evaluation of novel 1-O- and 14-O-derivatives of oridonin as potential anticancer drug candidates. Bioorg. Med. Chem. Lett. 2008, 18, 4741–4744. [CrossRef] [PubMed]
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 4741-4744
-
-
Xu, J.1
Yang, J.2
Ran, Q.3
Wang, L.4
Wang, Z.5
Liu, J.6
Wu, X.7
Hua, W.8
Yuan, S.9
Zhang, L.10
-
41
-
-
39049097281
-
An improved manufacturing process for the antimalaria drug coartem. Part I
-
Boehm, M.; Fuenfschilling, P.C.; Krieger, M.; Kuesters, E.; Struber, F. An improved manufacturing process for the antimalaria drug coartem. Part I. Org. Process Res. Dev. 2007, 11, 336–340. [CrossRef]
-
(2007)
Org. Process Res. Dev.
, vol.11
, pp. 336-340
-
-
Boehm, M.1
Fuenfschilling, P.C.2
Krieger, M.3
Kuesters, E.4
Struber, F.5
-
42
-
-
84856389651
-
Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin
-
Westfall, P.J.; Pitera, D.J.; Lenihan, J.R.; Eng, D.; Woolard, F.X.; Regentin, R.; Horning, T.; Tsuruta, H.; Melis, D.J.; Owens, A.; et al. Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin. Proc. Natl. Acad. Sci. USA 2012, 109, E111–E118. [CrossRef] [PubMed]
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. E111-E118
-
-
Westfall, P.J.1
Pitera, D.J.2
Lenihan, J.R.3
Eng, D.4
Woolard, F.X.5
Regentin, R.6
Horning, T.7
Tsuruta, H.8
Melis, D.J.9
Owens, A.10
-
43
-
-
84899654025
-
Semi-synthesis of neomangiferin from mangiferin
-
Wei, X.; Liang, D.; Ning, M.; Wang, Q.; Meng, X.; Li, Z. Semi-synthesis of neomangiferin from mangiferin. Tetrahedron Lett. 2014, 55, 3083–3086. [CrossRef]
-
(2014)
Tetrahedron Lett
, vol.55
, pp. 3083-3086
-
-
Wei, X.1
Liang, D.2
Ning, M.3
Wang, Q.4
Meng, X.5
Li, Z.6
-
44
-
-
84877705890
-
Artemisinic acid: A promising molecule potentially suitable for the semi-synthesis of artemisinin
-
Kong, J.; Yang, Y.; Wang, W.; Cheng, K.; Zhu, P. Artemisinic acid: A promising molecule potentially suitable for the semi-synthesis of artemisinin. RSC Adv. 2013, 3, 7622–7641. [CrossRef]
-
(2013)
RSC Adv
, vol.3
, pp. 7622-7641
-
-
Kong, J.1
Yang, Y.2
Wang, W.3
Cheng, K.4
Zhu, P.5
-
45
-
-
84880848134
-
Computational tools for guided discovery and engineering of metabolic pathways
-
Moura, M.; Broadbelt, L.; Tyo, K. Computational tools for guided discovery and engineering of metabolic pathways. Methods Mol. Biol. 2013, 985, 123–147. [PubMed]
-
(2013)
Methods Mol. Biol.
, vol.985
, pp. 123-147
-
-
Moura, M.1
Broadbelt, L.2
Tyo, K.3
-
46
-
-
83555163791
-
Integrating computational methods to retrofit enzymes to synthetic pathways
-
Brunk, E.; Neri, M.; Tavernelli, I.; Hatzimanikatis, V.; Rothlisberger, U. Integrating computational methods to retrofit enzymes to synthetic pathways. Biotechnol. Bioeng. 2012, 109, 572–582. [CrossRef] [PubMed]
-
(2012)
Biotechnol. Bioeng.
, vol.109
, pp. 572-582
-
-
Brunk, E.1
Neri, M.2
Tavernelli, I.3
Hatzimanikatis, V.4
Rothlisberger, U.5
-
47
-
-
80053393229
-
Protein design in metabolic engineering and synthetic biology
-
Pleiss, J. Protein design in metabolic engineering and synthetic biology. Curr. Opin. Biotechnol. 2011, 22, 611–617. [CrossRef] [PubMed]
-
(2011)
Curr. Opin. Biotechnol.
, vol.22
, pp. 611-617
-
-
Pleiss, J.1
-
48
-
-
84867512666
-
Minimally invasive mutagenesis gives rise to a biosynthetic polyketide library
-
Kushnir, S.; Sundermann, U.; Yahiaoui, S.; Brockmeyer, A.; Janning, P.; Schulz, F. Minimally Invasive Mutagenesis Gives Rise to a Biosynthetic Polyketide Library. Angew. Chem. Int. Ed. 2012, 51, 10664–10669. [CrossRef] [PubMed]
-
(2012)
Angew. Chem. Int. Ed.
, vol.51
, pp. 10664-10669
-
-
Kushnir, S.1
Sundermann, U.2
Yahiaoui, S.3
Brockmeyer, A.4
Janning, P.5
Schulz, F.6
-
49
-
-
77954797329
-
Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture
-
Savile, C.K.; Janey, J.M.; Mundorff, E.C.; Moore, J.C.; Tam, S.; Jarvis, W.R.; Colbeck, J.C.; Krebber, A.; Fleitz, F.J.; Brands, J.; et al. Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture. Science 2010, 329, 305–309. [CrossRef] [PubMed]
-
(2010)
Science
, vol.329
, pp. 305-309
-
-
Savile, C.K.1
Janey, J.M.2
Mundorff, E.C.3
Moore, J.C.4
Tam, S.5
Jarvis, W.R.6
Colbeck, J.C.7
Krebber, A.8
Fleitz, F.J.9
Brands, J.10
-
50
-
-
79957450871
-
Directed evolution of the nonribosomal peptide synthetase ADMK generates new andrimid derivatives in vivo
-
Evans, B.S.; Chen, Y.; Metcalf, W.W.; Zhao, H.; Kelleher, N.L. Directed Evolution of the Nonribosomal Peptide Synthetase AdmK Generates New Andrimid Derivatives In Vivo. Chem. Biol. 2011, 18, 601–607. [CrossRef] [PubMed]
-
(2011)
Chem. Biol.
, vol.18
, pp. 601-607
-
-
Evans, B.S.1
Chen, Y.2
Metcalf, W.W.3
Zhao, H.4
Kelleher, N.L.5
-
51
-
-
84923072157
-
Recent advances in combinatorial biosynthesis for drug discovery
-
Sun, H.; Liu, Z.; Zhao, H.; El, A. Recent advances in combinatorial biosynthesis for drug discovery. Drug Des. Dev Ther. 2015, 2015, 823–833.
-
(2015)
Drug Des. Dev Ther.
, vol.2015
, pp. 823-833
-
-
Sun, H.1
Liu, Z.2
Zhao, H.3
El, A.4
-
52
-
-
80052078373
-
Engineering of an “Unnatural” Natural Product by Swapping Polyketide Synthase Domains in Aspergillus nidulans
-
Liu, T.; Chiang, Y.M.; Somoza, A.D.; Oakley, B.R.; Wang, C.C.C. Engineering of an “Unnatural” Natural Product by Swapping Polyketide Synthase Domains in Aspergillus nidulans. J. Am. Chem. Soc. 2011, 133, 13314–13316. [CrossRef] [PubMed]
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 13314-13316
-
-
Liu, T.1
Chiang, Y.M.2
Somoza, A.D.3
Oakley, B.R.4
Wang, C.C.C.5
-
53
-
-
84941346066
-
Complete biosynthesis of opioids in yeast
-
Galanie, S.; Thodey, K.; Trenchard, I.J.; Interrante, M.F.; Smolke, C.D. Complete biosynthesis of opioids in yeast. Science 2015, 349, 1095–1100. [CrossRef] [PubMed]
-
(2015)
Science
, vol.349
, pp. 1095-1100
-
-
Galanie, S.1
Thodey, K.2
Trenchard, I.J.3
Interrante, M.F.4
Smolke, C.D.5
-
54
-
-
84926646130
-
Distributing a metabolic pathway among a microbial consortium enhances production of natural products
-
Zhou, K.; Qiao, K.; Edgar, S.; Stephanopoulos, G. Distributing a metabolic pathway among a microbial consortium enhances production of natural products. Nat. Biotechnol. 2015, 33, 377–383. [CrossRef] [PubMed]
-
(2015)
Nat. Biotechnol.
, vol.33
, pp. 377-383
-
-
Zhou, K.1
Qiao, K.2
Edgar, S.3
Stephanopoulos, G.4
-
55
-
-
84880075289
-
Phage P1-derived artificial chromosomes facilitate heterologous expression of the FK506 gene cluster
-
Jones, A.C.; Gust, B.; Kulik, A.; Heide, L.; Buttner, M.J.; Bibb, M.J. Phage P1-Derived Artificial Chromosomes Facilitate Heterologous Expression of the FK506 Gene Cluster. PLoS ONE 2013, 8, e69319. [CrossRef] [PubMed]
-
(2013)
PLoS ONE
, vol.8
-
-
Jones, A.C.1
Gust, B.2
Kulik, A.3
Heide, L.4
Buttner, M.J.5
Bibb, M.J.6
-
56
-
-
0034723333
-
Cloning and heterologous expression of the epothilone gene cluster
-
Tang, L.; Shah, S.; Chung, L.; Carney, J.; Katz, L.; Khosla, C.; Julien, B. Cloning and Heterologous Expression of the Epothilone Gene Cluster. Science 2000, 287, 640–642. [CrossRef] [PubMed]
-
(2000)
Science
, vol.287
, pp. 640-642
-
-
Tang, L.1
Shah, S.2
Chung, L.3
Carney, J.4
Katz, L.5
Khosla, C.6
Julien, B.7
-
57
-
-
65849183178
-
Golden gate shuffling: A one-pot DNA shuffling method based on type IIS restriction enzymes
-
Engler, C.; Gruetzner, R.; Kandzia, R.; Marillonnet, S. Golden Gate Shuffling: A One-Pot DNA Shuffling Method Based on Type IIs Restriction Enzymes. PLoS ONE 2009, 4, e5553. [CrossRef] [PubMed]
-
(2009)
PLoS ONE
, vol.4
-
-
Engler, C.1
Gruetzner, R.2
Kandzia, R.3
Marillonnet, S.4
-
58
-
-
84889985095
-
High-level diterpene production by transient expression in Nicotiana benthamiana
-
Bruckner, K.; Tissier, A. High-level diterpene production by transient expression in Nicotiana benthamiana. Plant Methods 2013, 9, 46. [CrossRef] [PubMed]
-
(2013)
Plant Methods
, vol.9
, pp. 46
-
-
Bruckner, K.1
Tissier, A.2
-
59
-
-
59649108349
-
DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways
-
Shao, Z.; Zhao, H. DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways. Nucleic Acids Res. 2009, 37, e16. [CrossRef] [PubMed]
-
(2009)
Nucleic Acids Res
, vol.37
-
-
Shao, Z.1
Zhao, H.2
-
60
-
-
84928393363
-
Synthesis of Morphinan Alkaloids in Saccharomyces cerevisiae
-
Fossati, E.; Narcross, L.; Ekins, A.; Falgueyret, J.P.; Martin, V.J.J. Synthesis of Morphinan Alkaloids in Saccharomyces cerevisiae. PLoS ONE 2015, 10, e0124459. [CrossRef] [PubMed]
-
(2015)
PLoS ONE
, vol.10
-
-
Fossati, E.1
Narcross, L.2
Ekins, A.3
Falgueyret, J.P.4
Martin, V.J.J.5
-
61
-
-
15744370033
-
Heterologous expression of a myxobacterial natural products assembly line in pseudomonads via Red/ET recombineering
-
Wenzel, S.C.; Gross, F.; Zhang, Y.; Fu, J.; Stewart, A.F.; Müller, R. Heterologous Expression of a Myxobacterial Natural Products Assembly Line in Pseudomonads via Red/ET Recombineering. Chem. Biol. 2005, 12, 349–356. [CrossRef] [PubMed]
-
(2005)
Chem. Biol.
, vol.12
, pp. 349-356
-
-
Wenzel, S.C.1
Gross, F.2
Zhang, Y.3
Fu, J.4
Stewart, A.F.5
Müller, R.6
-
62
-
-
84893493312
-
DNA assembly techniques for next-generation combinatorial biosynthesis of natural products
-
Cobb, R.E.; Ning, J.C.; Zhao, H. DNA assembly techniques for next-generation combinatorial biosynthesis of natural products. J. Ind. Microbiol. Biotechnol. 2014, 41, 469–477. [CrossRef] [PubMed]
-
(2014)
J. Ind. Microbiol. Biotechnol.
, vol.41
, pp. 469-477
-
-
Cobb, R.E.1
Ning, J.C.2
Zhao, H.3
-
63
-
-
84864534856
-
Multiple Post-translational Modifications Affect Heterologous Protein Synthesis
-
Tokmakov, A.A.; Kurotani, A.; Takagi, T.; Toyama, M.; Shirouzu, M.; Fukami, Y.; Yokoyama, S. Multiple Post-translational Modifications Affect Heterologous Protein Synthesis. J. Biol. Chem. 2012, 287, 27106–27116. [CrossRef] [PubMed]
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 27106-27116
-
-
Tokmakov, A.A.1
Kurotani, A.2
Takagi, T.3
Toyama, M.4
Shirouzu, M.5
Fukami, Y.6
Yokoyama, S.7
-
64
-
-
3042782585
-
Codon bias and heterologous protein expression
-
Gustafsson, C.; Govindarajan, S.; Minshull, J. Codon bias and heterologous protein expression. Trends Biotechnol. 2004, 22, 346–353. [CrossRef] [PubMed]
-
(2004)
Trends Biotechnol
, vol.22
, pp. 346-353
-
-
Gustafsson, C.1
Govindarajan, S.2
Minshull, J.3
-
65
-
-
83755163795
-
Heterologous expression of membrane proteins: Choosing the appropriate host
-
Bernaudat, F.; Frelet-Barrand, A.; Pochon, N.; Dementin, S.; Hivin, P.; Boutigny, S.; Rioux, J.B.; Salvi, D.; Seigneurin-Berny, D.; Richaud, P.; et al. Heterologous Expression of Membrane Proteins: Choosing the Appropriate Host. PLoS ONE 2011, 6, e29191. [CrossRef] [PubMed]
-
(2011)
PLoS ONE
, vol.6
-
-
Bernaudat, F.1
Frelet-Barrand, A.2
Pochon, N.3
Dementin, S.4
Hivin, P.5
Boutigny, S.6
Rioux, J.B.7
Salvi, D.8
Seigneurin-Berny, D.9
Richaud, P.10
-
66
-
-
84941778233
-
A Streptomyces coelicolor host for the heterologous expression of Type III polyketide synthase genes
-
Thanapipatsiri, A.; Claesen, J.; Gomez-Escribano, J.P.; Bibb, M.; Thamchaipenet, A. A Streptomyces coelicolor host for the heterologous expression of Type III polyketide synthase genes. Microb. Cell Factories 2015, 14, 145. [CrossRef] [PubMed]
-
(2015)
Microb. Cell Factories
, vol.14
, pp. 145
-
-
Thanapipatsiri, A.1
Claesen, J.2
Gomez-Escribano, J.P.3
Bibb, M.4
Thamchaipenet, A.5
-
67
-
-
84865487193
-
Efficient codon optimization with motif engineering
-
Condon, A.; Thachuk, C. Efficient codon optimization with motif engineering. J. Discret. Algorithms 2012, 16, 104. [CrossRef]
-
(2012)
J. Discret. Algorithms
, vol.16
, pp. 104
-
-
Condon, A.1
Thachuk, C.2
-
68
-
-
78649775828
-
Codon preference optimization increases heterologous PEDF expression
-
Gvritishvili, A.G.; Leung, K.W.; Tombran-Tink, J. Codon Preference Optimization Increases Heterologous PEDF Expression. PLoS ONE 2010, 5, e15056. [CrossRef] [PubMed]
-
(2010)
PLoS ONE
, vol.5
-
-
Gvritishvili, A.G.1
Leung, K.W.2
Tombran-Tink, J.3
-
69
-
-
84941192024
-
Heterologous expression of tyrosinase (MelC2) from Streptomyces avermitilis MA4680 in E. Coli and its application for ortho-hydroxylation of resveratrol to produce piceatannol
-
Lee, N.; Lee, S.-H.; Baek, K.; Kim, B.-G. Heterologous expression of tyrosinase (MelC2) from Streptomyces avermitilis MA4680 in E. coli and its application for ortho-hydroxylation of resveratrol to produce piceatannol. Appl. Microbiol. Biotechnol. 2015, 99, 7915–7924. [CrossRef] [PubMed]
-
(2015)
Appl. Microbiol. Biotechnol.
, vol.99
, pp. 7915-7924
-
-
Lee, N.1
Lee, S.-H.2
Baek, K.3
Kim, B.-G.4
-
70
-
-
80052092565
-
Nine Post-translational Modifications during the Biosynthesis of Cinnamycin
-
Okesli, A.; Cooper, L.E.; Fogle, E.J.; van der Donk, W.A. Nine Post-translational Modifications during the Biosynthesis of Cinnamycin. J. Am. Chem. Soc. 2011, 133, 13753–13760. [CrossRef] [PubMed]
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 13753-13760
-
-
Okesli, A.1
Cooper, L.E.2
Fogle, E.J.3
Van Der Donk, W.A.4
-
71
-
-
0035793858
-
Biosynthesis of complex polyketides in a metabolically engineered strain of E. Coli
-
Pfeifer, B.A.; Admiraal, S.J.; Gramajo, H.; Cane, D.E.; Khosla, C. Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli. Science 2001, 291, 1790–1792. [CrossRef] [PubMed]
-
(2001)
Science
, vol.291
, pp. 1790-1792
-
-
Pfeifer, B.A.1
Admiraal, S.J.2
Gramajo, H.3
Cane, D.E.4
Khosla, C.5
-
72
-
-
84931573824
-
An enzyme-coupled biosensor enables (S)-reticuline production in yeast from glucose
-
DeLoache, W.C.; Russ, Z.N.; Narcross, L.; Gonzales, A.M.; Martin, V.J.; Dueber, J.E. An enzyme-coupled biosensor enables (S)-reticuline production in yeast from glucose. Nat. Chem. Biol. 2015, 11, 465–471. [CrossRef] [PubMed]
-
(2015)
Nat. Chem. Biol.
, vol.11
, pp. 465-471
-
-
DeLoache, W.C.1
Russ, Z.N.2
Narcross, L.3
Gonzales, A.M.4
Martin, V.J.5
Dueber, J.E.6
-
73
-
-
84893746107
-
Precursor engineering and cell physiological regulation for high level rapamycin production by Streptomyces hygroscopicus
-
Zou, X.; Li, J. Precursor engineering and cell physiological regulation for high level rapamycin production by Streptomyces hygroscopicus. Ann. Microbiol. 2013, 63, 1371–1378. [CrossRef]
-
(2013)
Ann. Microbiol.
, vol.63
, pp. 1371-1378
-
-
Zou, X.1
Li, J.2
-
74
-
-
33750969392
-
Engineering of primary carbohydrate metabolism for increased production of actinorhodin in Streptomyces coelicolor
-
Ryu, Y.G.; Butler, M.J.; Chater, K.F.; Lee, K.J. Engineering of primary carbohydrate metabolism for increased production of actinorhodin in Streptomyces coelicolor. Appl. Environ. Microbiol. 2006, 72, 7132–7139. [CrossRef] [PubMed]
-
(2006)
Appl. Environ. Microbiol.
, vol.72
, pp. 7132-7139
-
-
Ryu, Y.G.1
Butler, M.J.2
Chater, K.F.3
Lee, K.J.4
-
75
-
-
84884353163
-
Enhancement of FK506 production by engineering secondary pathways of Streptomyces tsukubaensis and exogenous feeding strategies
-
Huang, D.; Xia, M.; Li, S.; Wen, J.; Jia, X. Enhancement of FK506 production by engineering secondary pathways of Streptomyces tsukubaensis and exogenous feeding strategies. J. Ind. Microbiol. Biotechnol. 2013, 40, 1023–1037. [CrossRef] [PubMed]
-
(2013)
J. Ind. Microbiol. Biotechnol.
, vol.40
, pp. 1023-1037
-
-
Huang, D.1
Xia, M.2
Li, S.3
Wen, J.4
Jia, X.5
-
76
-
-
84922782676
-
13 C-metabolic flux analysis of a xylose-consuming Saccharomyces cerevisiae strain expressing xylose isomerase
-
13 C-metabolic flux analysis of a xylose-consuming Saccharomyces cerevisiae strain expressing xylose isomerase. Biotechnol. Bioeng. 2015, 112, 470–483. [CrossRef] [PubMed]
-
(2015)
Biotechnol. Bioeng.
, vol.112
, pp. 470-483
-
-
Wasylenko, T.M.1
Stephanopoulos, G.2
-
79
-
-
79952204848
-
Bridging the gap between fluxomics and industrial biotechnology
-
Feng, X.; Page, L.; Rubens, J.; Chircus, L.; Colletti, P.; Pakrasi, H.B.; Tang, Y.J. Bridging the gap between fluxomics and industrial biotechnology. J. Biomed. Biotechnol. 2010, 2010, 460717. [CrossRef] [PubMed]
-
(2010)
J. Biomed. Biotechnol.
, vol.2010
, pp. 460717
-
-
Feng, X.1
Page, L.2
Rubens, J.3
Chircus, L.4
Colletti, P.5
Pakrasi, H.B.6
Tang, Y.J.7
-
80
-
-
81955167921
-
Metabolic Flux Analysis and Principal Nodes Identification for Daptomycin Production Improvement by Streptomyces roseosporus
-
Huang, D.; Jia, X.; Wen, J.; Wang, G.; Yu, G.; Caiyin, Q.; Chen, Y. Metabolic Flux Analysis and Principal Nodes Identification for Daptomycin Production Improvement by Streptomyces roseosporus. Appl. Biochem. Biotechnol. 2011, 165, 1725–1739. [CrossRef] [PubMed]
-
(2011)
Appl. Biochem. Biotechnol.
, vol.165
, pp. 1725-1739
-
-
Huang, D.1
Jia, X.2
Wen, J.3
Wang, G.4
Yu, G.5
Caiyin, Q.6
Chen, Y.7
-
81
-
-
0037195078
-
Bottlenecks for metabolic engineering of isoflavone glycoconjugates in Arabidopsis
-
Liu, C.-J.; Blount, J.W.; Steele, C.L.; Dixon, R.A. Bottlenecks for Metabolic Engineering of Isoflavone Glycoconjugates in Arabidopsis. Proc. Natl. Acad. Sci. USA 2002, 99, 14578–14583. [CrossRef] [PubMed]
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 14578-14583
-
-
Liu, C.-J.1
Blount, J.W.2
Steele, C.L.3
Dixon, R.A.4
-
82
-
-
80555122760
-
Identification of bottlenecks in Escherichia coli engineered for the production of CoQ(10)
-
Cluis, C.P.; Ekins, A.; Narcross, L.; Jiang, H.; Gold, N.D.; Burja, A.M.; Martin, V.J.J. Identification of bottlenecks in Escherichia coli engineered for the production of CoQ(10). Metabol. Eng. 2011, 13, 733–744. [CrossRef] [PubMed]
-
(2011)
Metabol. Eng.
, vol.13
, pp. 733-744
-
-
Cluis, C.P.1
Ekins, A.2
Narcross, L.3
Jiang, H.4
Gold, N.D.5
Burja, A.M.6
Martin, V.J.J.7
-
83
-
-
84923923224
-
Systems metabolic engineering of Escherichia coli for gram scale production of the antitumor drug deoxyviolacein from glycerol
-
Rodrigues, A.L.; Becker, J.; de Souza Lima, A.O.; Porto, L.M.; Wittmann, C. Systems metabolic engineering of Escherichia coli for gram scale production of the antitumor drug deoxyviolacein from glycerol. Biotechnol. Bioeng. 2014, 111, 2280–2289. [CrossRef] [PubMed]
-
(2014)
Biotechnol. Bioeng.
, vol.111
, pp. 2280-2289
-
-
Rodrigues, A.L.1
Becker, J.2
De Souza Lima, A.O.3
Porto, L.M.4
Wittmann, C.5
-
84
-
-
75649122638
-
The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis
-
Guo, J.; Zhao, J.; Li, L.; Chen, Z.; Wen, Y.; Li, J. The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis. Mol. Genet. Genom. 2010, 283, 123–133. [CrossRef] [PubMed]
-
(2010)
Mol. Genet. Genom.
, vol.283
, pp. 123-133
-
-
Guo, J.1
Zhao, J.2
Li, L.3
Chen, Z.4
Wen, Y.5
Li, J.6
-
85
-
-
84921479351
-
Engineering metabolism through dynamic control
-
Venayak, N.; Anesiadis, N.; Cluett, W.R.; Mahadevan, R. Engineering metabolism through dynamic control. Curr. Opin. Biotechnol. 2015, 34, 142–152. [CrossRef] [PubMed]
-
(2015)
Curr. Opin. Biotechnol.
, vol.34
, pp. 142-152
-
-
Venayak, N.1
Anesiadis, N.2
Cluett, W.R.3
Mahadevan, R.4
-
86
-
-
24644515752
-
Tuning genetic control through promoter engineering
-
Alper, H.; Fischer, C.; Nevoigt, E.; Stephanopoulos, G.; Langer, R. Tuning Genetic Control through Promoter Engineering. Proc. Natl. Acad. Sci. USA 2005, 102, 12678–12683. [CrossRef] [PubMed]
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 12678-12683
-
-
Alper, H.1
Fischer, C.2
Nevoigt, E.3
Stephanopoulos, G.4
Langer, R.5
-
87
-
-
84859633048
-
Design of a dynamic sensor-regulator system for production of chemicals and fuels derived from fatty acids
-
Zhang, F.Z.; Carothers, J.M.; Keasling, J.D. Design of a dynamic sensor-regulator system for production of chemicals and fuels derived from fatty acids. Nat. Biotechnol. 2012, 30, 354–359. [CrossRef] [PubMed]
-
(2012)
Nat. Biotechnol.
, vol.30
, pp. 354-359
-
-
Zhang, F.Z.1
Carothers, J.M.2
Keasling, J.D.3
-
88
-
-
84925639589
-
Quorum-sensing linked RNA interference for dynamic metabolic pathway control in Saccharomyces cerevisiae
-
Williams, T.C.; Averesch, N.J.H.; Winter, G.; Plan, M.R.; Vickers, C.E.; Nielsen, L.K.; Krömer, J.O. Quorum-sensing linked RNA interference for dynamic metabolic pathway control in Saccharomyces cerevisiae. Metab. Eng. 2015, 29, 124–134. [CrossRef] [PubMed]
-
(2015)
Metab. Eng.
, vol.29
, pp. 124-134
-
-
Williams, T.C.1
Averesch, N.J.H.2
Winter, G.3
Plan, M.R.4
Vickers, C.E.5
Nielsen, L.K.6
Krömer, J.O.7
-
89
-
-
84887422015
-
Engineering dynamic pathway regulation using stress-response promoters
-
Dahl, R.H.; Zhang, F.; Alonso-Gutierrez, J.; Baidoo, E.; Batth, T.S.; Redding-Johanson, A.M.; Petzold, C.J.; Mukhopadhyay, A.; Lee, T.S.; Adams, P.D.; et al. Engineering dynamic pathway regulation using stress-response promoters. Nat. Biotechnol. 2013, 31, 1039–1046. [CrossRef] [PubMed]
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 1039-1046
-
-
Dahl, R.H.1
Zhang, F.2
Alonso-Gutierrez, J.3
Baidoo, E.4
Batth, T.S.5
Redding-Johanson, A.M.6
Petzold, C.J.7
Mukhopadhyay, A.8
Lee, T.S.9
Adams, P.D.10
-
90
-
-
84923913705
-
Programmed evolution for optimization of orthogonal metabolic output in bacteria
-
Eckdahl, T.T.; Campbell, A.M.; Heyer, L.J.; Poet, J.L.; Blauch, D.N.; Snyder, N.L.; Atchley, D.T.; Baker, E.J.; Brown, M.; Brunner, E.C.; et al. Programmed Evolution for Optimization of Orthogonal Metabolic Output in Bacteria. PLoS ONE 2015, 10, e0118322. [CrossRef] [PubMed]
-
(2015)
PLoS ONE
, vol.10
-
-
Eckdahl, T.T.1
Campbell, A.M.2
Heyer, L.J.3
Poet, J.L.4
Blauch, D.N.5
Snyder, N.L.6
Atchley, D.T.7
Baker, E.J.8
Brown, M.9
Brunner, E.C.10
-
91
-
-
84902181907
-
Combinatorial approaches for inverse metabolic engineering applications
-
Skretas, G.; Kolisis, F.N. Combinatorial approaches for inverse metabolic engineering applications. Comput. Struct. Biotechnol. J. 2012, 3, e201210021. [CrossRef] [PubMed]
-
(2012)
Comput. Struct. Biotechnol. J.
, vol.3
-
-
Skretas, G.1
Kolisis, F.N.2
-
92
-
-
84921496822
-
Cell-free metabolic engineering: Biomanufacturing beyond the cell
-
Dudley, Q.M.; Karim, A.S.; Jewett, M.C. Cell-free metabolic engineering: Biomanufacturing beyond the cell. Biotechnol. J. 2015, 10, 69–82. [CrossRef] [PubMed]
-
(2015)
Biotechnol. J.
, vol.10
, pp. 69-82
-
-
Dudley, Q.M.1
Karim, A.S.2
Jewett, M.C.3
-
93
-
-
49349085256
-
Redox compartmentalization in eukaryotic cells
-
Go, Y.-M.; Jones, D.P. Redox compartmentalization in eukaryotic cells. BBA Gen. Subj. 2008, 1780, 1273–1290. [CrossRef] [PubMed]
-
(2008)
BBA Gen. Subj.
, vol.1780
, pp. 1273-1290
-
-
Go, Y.-M.1
Jones, D.P.2
-
94
-
-
84869875863
-
Designing biological compartmentalization
-
Chen, A.H.; Silver, P.A. Designing biological compartmentalization. Trends Cell Biol. 2012, 22, 662–670. [CrossRef] [PubMed]
-
(2012)
Trends Cell Biol
, vol.22
, pp. 662-670
-
-
Chen, A.H.1
Silver, P.A.2
-
95
-
-
84896040096
-
Metabolic engineering of chloroplasts for artemisinic acid biosynthesis and impact on plant growth
-
Saxena, B.; Subramaniyan, M.; Malhotra, K.; Bhavesh, N.S.; Potlakayala, S.D.; Kumar, S. Metabolic engineering of chloroplasts for artemisinic acid biosynthesis and impact on plant growth. J. Biosci. 2014, 39, 33–41. [CrossRef] [PubMed]
-
(2014)
J. Biosci.
, vol.39
, pp. 33-41
-
-
Saxena, B.1
Subramaniyan, M.2
Malhotra, K.3
Bhavesh, N.S.4
Potlakayala, S.D.5
Kumar, S.6
-
96
-
-
84905443683
-
Improvement of Aspergillus nidulans penicillin production by targeting AcvA to peroxisomes
-
Herr, A.; Fischer, R. Improvement of Aspergillus nidulans penicillin production by targeting AcvA to peroxisomes. Metab. Eng. 2014, 25, 131–139. [CrossRef] [PubMed]
-
(2014)
Metab. Eng.
, vol.25
, pp. 131-139
-
-
Herr, A.1
Fischer, R.2
-
97
-
-
80052030821
-
Harnessing yeast subcellular compartments for the production of plant terpenoids
-
Farhi, M.; Marhevka, E.; Masci, T.; Marcos, E.; Eyal, Y.; Ovadis, M.; Abeliovich, H.; Vainstein, A. Harnessing yeast subcellular compartments for the production of plant terpenoids. Metab. Eng. 2011, 13, 474–481. [CrossRef] [PubMed]
-
(2011)
Metab. Eng.
, vol.13
, pp. 474-481
-
-
Farhi, M.1
Marhevka, E.2
Masci, T.3
Marcos, E.4
Eyal, Y.5
Ovadis, M.6
Abeliovich, H.7
Vainstein, A.8
-
98
-
-
84858009996
-
Engineered protein nano-compartments for targeted enzyme localization
-
Choudhary, S.; Quin, M.B.; Sanders, M.A.; Johnson, E.T.; Schmidt-Dannert, C. Engineered protein nano-compartments for targeted enzyme localization. PLoS ONE 2012, 7, e33342. [CrossRef] [PubMed]
-
(2012)
PLoS ONE
, vol.7
-
-
Choudhary, S.1
Quin, M.B.2
Sanders, M.A.3
Johnson, E.T.4
Schmidt-Dannert, C.5
-
99
-
-
68449088806
-
Synthetic protein scaffolds provide modular control over metabolic flux
-
Wu, G.C.; Prather, K.L.J.; Malmirchegini, G.R.; Petzold, C.J.; Ullal, A.V.; Dueber, J.E.; Moon, T.S.; Keasling, J.D. Synthetic protein scaffolds provide modular control over metabolic flux. Nat. Biotechnol. 2009, 27, 753–759.
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 753-759
-
-
Wu, G.C.1
Prather, K.L.J.2
Malmirchegini, G.R.3
Petzold, C.J.4
Ullal, A.V.5
Dueber, J.E.6
Moon, T.S.7
Keasling, J.D.8
-
100
-
-
84863116515
-
Modular pathway engineering of diterpenoid synthases and the mevalonic acid pathway for miltiradiene production
-
Zhou, Y.J.; Gao, W.; Rong, Q.X.; Jin, G.J.; Chu, H.Y.; Liu, W.J.; Yang, W.; Zhu, Z.W.; Li, G.H.; Zhu, G.F.; et al. Modular Pathway Engineering of Diterpenoid Synthases and the Mevalonic Acid Pathway for Miltiradiene Production. J. Am. Chem. Soc. 2012, 134, 3234–3241. [CrossRef] [PubMed]
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 3234-3241
-
-
Zhou, Y.J.1
Gao, W.2
Rong, Q.X.3
Jin, G.J.4
Chu, H.Y.5
Liu, W.J.6
Yang, W.7
Zhu, Z.W.8
Li, G.H.9
Zhu, G.F.10
-
101
-
-
84883553644
-
Enhancing isoprenoid production through systematically assembling and modulating efflux pumps in Escherichia coli
-
Wang, J.-F.; Xiong, Z.-Q.; Li, S.-Y.; Wang, Y. Enhancing isoprenoid production through systematically assembling and modulating efflux pumps in Escherichia coli. Appl. Microbiol. Biotechnol. 2013, 97, 8057–8067. [CrossRef] [PubMed]
-
(2013)
Appl. Microbiol. Biotechnol.
, vol.97
, pp. 8057-8067
-
-
Wang, J.-F.1
Xiong, Z.-Q.2
Li, S.-Y.3
Wang, Y.4
-
102
-
-
84902257693
-
A multivariate approach to the integration of multi-omics datasets
-
Meng, C.; Kuster, B.; Culhane, A.C.; Gholami, A.M. A multivariate approach to the integration of multi-omics datasets. BMC Bioinform. 2014, 15, 162. [CrossRef] [PubMed]
-
(2014)
BMC Bioinform
, vol.15
, pp. 162
-
-
Meng, C.1
Kuster, B.2
Culhane, A.C.3
Gholami, A.M.4
-
103
-
-
84873729095
-
Multiplex genome engineering using CRISPR/Cas systems
-
Cong, L.; Ran, F.A.; Cox, D.; Lin, S.; Barretto, R.; Habib, N.; Hsu, P.D.; Wu, X.; Jiang, W.; Marraffini, L.A.; et al. Multiplex Genome Engineering Using CRISPR/Cas Systems. Science 2013, 339, 819–823. [CrossRef] [PubMed]
-
(2013)
Science
, vol.339
, pp. 819-823
-
-
Cong, L.1
Ran, F.A.2
Cox, D.3
Lin, S.4
Barretto, R.5
Habib, N.6
Hsu, P.D.7
Wu, X.8
Jiang, W.9
Marraffini, L.A.10
-
104
-
-
84859776222
-
The future of metabolic engineering and synthetic biology: Towards a systematic practice
-
Yadav, V.G.; de Mey, M.; Lim, C.G.; Ajikumar, P.K.; Stephanopoulos, G. The future of metabolic engineering and synthetic biology: Towards a systematic practice. Metab. Eng. 2012, 14, 233–241. [CrossRef] [PubMed]
-
(2012)
Metab. Eng.
, vol.14
, pp. 233-241
-
-
Yadav, V.G.1
De Mey, M.2
Lim, C.G.3
Ajikumar, P.K.4
Stephanopoulos, G.5
-
105
-
-
84920992414
-
Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds
-
Zalatan, J.G.; Lee, M.E.; Almeida, R.; Gilbert, L.A.; Whitehead, E.H.; La Russa, M.; Tsai, J.C.; Weissman, J.S.; Dueber, J.E.; Qi, L.S.; et al. Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds. Cell 2015, 160, 339–350. [CrossRef] [PubMed]
-
(2015)
Cell
, vol.160
, pp. 339-350
-
-
Zalatan, J.G.1
Lee, M.E.2
Almeida, R.3
Gilbert, L.A.4
Whitehead, E.H.5
La Russa, M.6
Tsai, J.C.7
Weissman, J.S.8
Dueber, J.E.9
Qi, L.S.10
-
106
-
-
84905668376
-
Improving fatty acids production by engineering dynamic pathway regulation and metabolic control
-
Xu, P.; Li, L.; Zhang, F.; Stephanopoulos, G.; Koffas, M. Improving fatty acids production by engineering dynamic pathway regulation and metabolic control. Proc. Natl. Acad. Sci. USA 2014, 111, 11299–11304. [CrossRef] [PubMed]
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 11299-11304
-
-
Xu, P.1
Li, L.2
Zhang, F.3
Stephanopoulos, G.4
Koffas, M.5
-
107
-
-
84921420837
-
Kinetic folding design of aptazyme-regulated expression devices as riboswitches for metabolic engineering
-
Sparkman-Yager, D.; Correa-Rojas, R.A.; Carothers, J.M. Kinetic folding design of aptazyme-regulated expression devices as riboswitches for metabolic engineering. Methods Enzymol. 2015, 550, 321. [PubMed]
-
(2015)
Methods Enzymol
, vol.550
, pp. 321
-
-
Sparkman-Yager, D.1
Correa-Rojas, R.A.2
Carothers, J.M.3
|