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Volumn 2, Issue 1, 2016, Pages

Metabolic engineering for production of small molecule drugs: Challenges and solutions

Author keywords

Metabolic engineering; Pathway assembly; Pathway discovery; Pathway optimization

Indexed keywords


EID: 85032587201     PISSN: None     EISSN: 23115637     Source Type: Journal    
DOI: 10.3390/fermentation2010004     Document Type: Review
Times cited : (6)

References (107)
  • 1
    • 79955563790 scopus 로고    scopus 로고
    • Organic synthesis toward small-molecule probes and drugs
    • Schreiber, S.L.; Halpern, J. Organic synthesis toward small-molecule probes and drugs. Proc. Natl. Acad. Sci. USA 2011, 108, 6699–6702. [CrossRef] [PubMed]
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 6699-6702
    • Schreiber, S.L.1    Halpern, J.2
  • 2
    • 79851507787 scopus 로고    scopus 로고
    • Genomics-inspired discovery of natural products
    • Winter, J.M.; Behnken, S.; Hertweck, C. Genomics-inspired discovery of natural products. Curr. Opin. Chem. Biol. 2011, 15, 22–31. [CrossRef] [PubMed]
    • (2011) Curr. Opin. Chem. Biol. , vol.15 , pp. 22-31
    • Winter, J.M.1    Behnken, S.2    Hertweck, C.3
  • 3
    • 42949160050 scopus 로고    scopus 로고
    • Natural products as leads to potential drugs: An old process or the new hope for drug discovery?
    • Newman, D.J. Natural products as leads to potential drugs: An old process or the new hope for drug discovery? J. Med. Chem. 2008, 51, 2589–2599. [CrossRef] [PubMed]
    • (2008) J. Med. Chem. , vol.51 , pp. 2589-2599
    • Newman, D.J.1
  • 4
    • 34447524208 scopus 로고    scopus 로고
    • Expression of biosynthetic gene clusters in heterologous hosts for natural product production and combinatorial biosynthesis
    • Galm, U.; Shen, B. Expression of biosynthetic gene clusters in heterologous hosts for natural product production and combinatorial biosynthesis. Expert Opin. Drug Discov. 2006, 1, 409–437. [CrossRef] [PubMed]
    • (2006) Expert Opin. Drug Discov. , vol.1 , pp. 409-437
    • Galm, U.1    Shen, B.2
  • 6
    • 84865515585 scopus 로고    scopus 로고
    • Synthetic biological approaches to natural product biosynthesis
    • Winter, J.M.; Tang, Y. Synthetic biological approaches to natural product biosynthesis. Curr. Opin. Biotechnol. 2012, 23, 736–743. [CrossRef] [PubMed]
    • (2012) Curr. Opin. Biotechnol. , vol.23 , pp. 736-743
    • Winter, J.M.1    Tang, Y.2
  • 7
    • 84873086193 scopus 로고    scopus 로고
    • Perspectives in metabolic engineering: Understanding cellular regulation towards the control of metabolic routes
    • Zadran, S.; Levine, R.D. Perspectives in metabolic engineering: Understanding cellular regulation towards the control of metabolic routes. Appl. Biochem. Biotechnol. 2013, 169, 55–65. [CrossRef] [PubMed]
    • (2013) Appl. Biochem. Biotechnol. , vol.169 , pp. 55-65
    • Zadran, S.1    Levine, R.D.2
  • 9
    • 84922067763 scopus 로고    scopus 로고
    • A microbial biomanufacturing platform for natural and semisynthetic opioids
    • Thodey, K.; Galanie, S.; Smolke, C.D. A microbial biomanufacturing platform for natural and semisynthetic opioids. Nat. Chem. Biol. 2014, 10, 837–844. [CrossRef] [PubMed]
    • (2014) Nat. Chem. Biol. , vol.10 , pp. 837-844
    • Thodey, K.1    Galanie, S.2    Smolke, C.D.3
  • 11
    • 84860784197 scopus 로고    scopus 로고
    • Direct cloning of large genomic sequences
    • Cobb, R.E.; Zhao, H.M. Direct cloning of large genomic sequences. Nat. Biotechnol. 2012, 30, 405–406. [CrossRef] [PubMed]
    • (2012) Nat. Biotechnol. , vol.30 , pp. 405-406
    • Cobb, R.E.1    Zhao, H.M.2
  • 12
    • 84861303184 scopus 로고    scopus 로고
    • The early stages of taxol biosynthesis: An interim report on the synthesis and identification of early pathway metabolites
    • Guerra-Bubb, J.; Croteau, R.; Williams, R.M. The early stages of taxol biosynthesis: An interim report on the synthesis and identification of early pathway metabolites. Nat. Prod. Rep. 2012, 29, 683–696. [CrossRef] [PubMed]
    • (2012) Nat. Prod. Rep. , vol.29 , pp. 683-696
    • Guerra-Bubb, J.1    Croteau, R.2    Williams, R.M.3
  • 13
    • 34447642166 scopus 로고    scopus 로고
    • Comparative genomics reveals novel biochemical pathways
    • Piškur, J.; Schnackerz, K.D.; Andersen, G.; Björnberg, O. Comparative genomics reveals novel biochemical pathways. Trends Genet. 2007, 23, 369–372. [CrossRef] [PubMed]
    • (2007) Trends Genet , vol.23 , pp. 369-372
    • Piškur, J.1    Schnackerz, K.D.2    Andersen, G.3    Björnberg, O.4
  • 14
    • 84890325085 scopus 로고    scopus 로고
    • Discovery of a metabolic alternative to the classical mevalonate pathway
    • Dellas, N.; Thomas, S.T.; Manning, G.; Noel, J.P. Discovery of a metabolic alternative to the classical mevalonate pathway. ELIFE 2013, 2, e00672. [CrossRef] [PubMed]
    • (2013) ELIFE , vol.2
    • Dellas, N.1    Thomas, S.T.2    Manning, G.3    Noel, J.P.4
  • 15
    • 33846466959 scopus 로고    scopus 로고
    • Teasing apart the Taxol pathway
    • Alexander, R.W. Teasing apart the Taxol pathway. Trends Biochem. Sci. 2001, 26, 152–153. [CrossRef]
    • (2001) Trends Biochem. Sci. , vol.26 , pp. 152-153
    • Alexander, R.W.1
  • 16
    • 84924417048 scopus 로고    scopus 로고
    • Elucidation of the shanorellin biosynthetic pathway and functional analysis of associated enzymes
    • Sato, M.; Yamada, H.; Hotta, K.; Watanabe, K. Elucidation of the shanorellin biosynthetic pathway and functional analysis of associated enzymes. Medchemcomm 2015, 6, 425–430. [CrossRef]
    • (2015) Medchemcomm , vol.6 , pp. 425-430
    • Sato, M.1    Yamada, H.2    Hotta, K.3    Watanabe, K.4
  • 18
    • 33344456009 scopus 로고    scopus 로고
    • Elucidation of the biosynthetic pathway leading to the complex nonadride phomoidride B
    • Sulikowski, G.A.; Pongdee, R. Elucidation of the Biosynthetic Pathway Leading to the Complex Nonadride Phomoidride B. Synlett 2006, 2006, 354–363. [CrossRef]
    • (2006) Synlett , vol.2006 , pp. 354-363
    • Sulikowski, G.A.1    Pongdee, R.2
  • 20
    • 77049112083 scopus 로고    scopus 로고
    • Isolation and purification of a new kalimantacin/batumin-related polyketide antibiotic and elucidation of its biosynthesis gene cluster
    • Mattheus, W.; Gao, L.-J.; Herdewijn, P.; Landuyt, B.; Verhaegen, J.; Masschelein, J.; Volckaert, G.; Lavigne, R. Isolation and Purification of a New Kalimantacin/Batumin-Related Polyketide Antibiotic and Elucidation of Its Biosynthesis Gene Cluster. Chem. Biol. 2010, 17, 149–159. [CrossRef] [PubMed]
    • (2010) Chem. Biol. , vol.17 , pp. 149-159
    • Mattheus, W.1    Gao, L.-J.2    Herdewijn, P.3    Landuyt, B.4    Verhaegen, J.5    Masschelein, J.6    Volckaert, G.7    Lavigne, R.8
  • 21
    • 33846294440 scopus 로고    scopus 로고
    • The genomisotopic approach: A systematic method to isolate products of orphan biosynthetic gene clusters
    • Gross, H.; Stockwell, V.O.; Henkels, M.D.; Nowak-Thompson, B.; Loper, J.E.; Gerwick, W.H. The Genomisotopic Approach: A Systematic Method to Isolate Products of Orphan Biosynthetic Gene Clusters. Chem. Biol. 2007, 14, 53–63. [CrossRef] [PubMed]
    • (2007) Chem. Biol. , vol.14 , pp. 53-63
    • Gross, H.1    Stockwell, V.O.2    Henkels, M.D.3    Nowak-Thompson, B.4    Loper, J.E.5    Gerwick, W.H.6
  • 22
  • 23
    • 77957601090 scopus 로고    scopus 로고
    • Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism
    • Zhao, W.; Zhong, Y.; Yuan, H.; Wang, J.; Zheng, H.; Wang, Y.; Cen, X.; Xu, F.; Bai, J.; Han, X.; et al. Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism. Cell Res. 2010, 20, 1096–1108. [CrossRef] [PubMed]
    • (2010) Cell Res , vol.20 , pp. 1096-1108
    • Zhao, W.1    Zhong, Y.2    Yuan, H.3    Wang, J.4    Zheng, H.5    Wang, Y.6    Cen, X.7    Xu, F.8    Bai, J.9    Han, X.10
  • 24
    • 77949847651 scopus 로고    scopus 로고
    • Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy
    • Hagel, J.M.; Facchini, P.J. Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy. Nat. Chem. Biol. 2010, 6, 273–275. [CrossRef] [PubMed]
    • (2010) Nat. Chem. Biol. , vol.6 , pp. 273-275
    • Hagel, J.M.1    Facchini, P.J.2
  • 25
    • 79959472680 scopus 로고    scopus 로고
    • The first insight into the tissue specific taxus transcriptome via illumina second generation sequencing
    • Hao, D.C.; Ge, G.B.; Xiao, P.G.; Zhang, Y.Y.; Yang, L. The First Insight into the Tissue Specific Taxus Transcriptome via Illumina Second Generation Sequencing. PLoS ONE 2011, 6, e21220. [CrossRef] [PubMed]
    • (2011) PLoS ONE , vol.6
    • Hao, D.C.1    Ge, G.B.2    Xiao, P.G.3    Zhang, Y.Y.4    Yang, L.5
  • 26
    • 54749115137 scopus 로고    scopus 로고
    • Ribosomal synthesis of tricyclic depsipeptides in bloom-forming cyanobacteria
    • Ziemert, N.; Ishida, K.; Liaimer, A.; Hertweck, C.; Dittmann, E. Ribosomal synthesis of tricyclic depsipeptides in bloom-forming cyanobacteria. Angew. Chem. 2008, 47, 7756–7759. [CrossRef] [PubMed]
    • (2008) Angew. Chem. , vol.47 , pp. 7756-7759
    • Ziemert, N.1    Ishida, K.2    Liaimer, A.3    Hertweck, C.4    Dittmann, E.5
  • 28
    • 29544433799 scopus 로고    scopus 로고
    • Directed evolution of metabolic pathways
    • Chatterjee, R.; Yuan, L. Directed evolution of metabolic pathways. Trends Biotechnol. 2006, 24, 28–38. [CrossRef] [PubMed]
    • (2006) Trends Biotechnol , vol.24 , pp. 28-38
    • Chatterjee, R.1    Yuan, L.2
  • 30
    • 84895107216 scopus 로고    scopus 로고
    • Recent advances in genome mining of secondary metabolite biosynthetic gene clusters and the development of heterologous expression systems in Aspergillus nidulans
    • Yaegashi, J.; Oakley, B.R.; Wang, C.C.C. Recent advances in genome mining of secondary metabolite biosynthetic gene clusters and the development of heterologous expression systems in Aspergillus nidulans. J. Ind. Microbiol. Biotechnol. 2014, 41, 433–442. [CrossRef] [PubMed]
    • (2014) J. Ind. Microbiol. Biotechnol. , vol.41 , pp. 433-442
    • Yaegashi, J.1    Oakley, B.R.2    Wang, C.C.C.3
  • 31
    • 68049088909 scopus 로고    scopus 로고
    • A Gene Cluster Containing Two Fungal Polyketide Synthases Encodes the Biosynthetic Pathway for a Polyketide, Asperfuranone, in Aspergillus nidulans
    • Chiang, Y.M.; Szewczyk, E.; Davidson, A.D.; Keller, N.; Oakley, B.R.; Wang, C.C.C. A Gene Cluster Containing Two Fungal Polyketide Synthases Encodes the Biosynthetic Pathway for a Polyketide, Asperfuranone, in Aspergillus nidulans. J. Am. Chem. Soc. 2009, 131, 2965–2970. [CrossRef] [PubMed]
    • (2009) J. Am. Chem. Soc. , vol.131 , pp. 2965-2970
    • Chiang, Y.M.1    Szewczyk, E.2    Davidson, A.D.3    Keller, N.4    Oakley, B.R.5    Wang, C.C.C.6
  • 33
    • 84903314895 scopus 로고    scopus 로고
    • Microbial co-culture: Harnessing intermicrobial signaling for the production of novel antimicrobials
    • Moody, S.C. Microbial co-culture: Harnessing intermicrobial signaling for the production of novel antimicrobials. Fut. Microbiol. 2014, 9, 575–578. [CrossRef] [PubMed]
    • (2014) Fut. Microbiol. , vol.9 , pp. 575-578
    • Moody, S.C.1
  • 34
    • 84942125055 scopus 로고    scopus 로고
    • Acyclic sesquiterpenes released by Candida albicans inhibit growth of dermatophytes
    • Brasch, J.; Horter, F.; Fritsch, D.; Beck-Jendroschek, V.; Tröger, A.; Francke, W. Acyclic sesquiterpenes released by Candida albicans inhibit growth of dermatophytes. Med. Mycol. 2014, 52, 46–55. [PubMed]
    • (2014) Med. Mycol. , vol.52 , pp. 46-55
    • Brasch, J.1    Horter, F.2    Fritsch, D.3    Beck-Jendroschek, V.4    Tröger, A.5    Francke, W.6
  • 35
    • 84901407853 scopus 로고    scopus 로고
    • Production of induced secondary metabolites by a co-culture of sponge-associated actinomycetes, Actinokineospora sp. Eg49 and Nocardiopsis sp. Rv163
    • Dashti, Y.; Grkovic, T.; Abdelmohsen, U.R.; Hentschel, U.; Quinn, R.J. Production of Induced Secondary Metabolites by a Co-Culture of Sponge-Associated Actinomycetes, Actinokineospora sp. EG49 and Nocardiopsis sp. RV163. Mar. Drugs 2014, 12, 3046–3059. [CrossRef] [PubMed]
    • (2014) Mar. Drugs , vol.12 , pp. 3046-3059
    • Dashti, Y.1    Grkovic, T.2    Abdelmohsen, U.R.3    Hentschel, U.4    Quinn, R.J.5
  • 36
    • 84890086658 scopus 로고    scopus 로고
    • Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster
    • Luo, Y.; Huang, H.; Liang, J.; Wang, M.; Lu, L.; Shao, Z.; Cobb, R.E.; Zhao, H. Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster. Nat. Commun. 2013, 4, 2894. [CrossRef] [PubMed]
    • (2013) Nat. Commun. , vol.4 , pp. 2894
    • Luo, Y.1    Huang, H.2    Liang, J.3    Wang, M.4    Lu, L.5    Shao, Z.6    Cobb, R.E.7    Zhao, H.8
  • 37
    • 84859870038 scopus 로고    scopus 로고
    • Modification of natural products for drug discovery
    • Guo, Z.-R. Modification of natural products for drug discovery. Acta Pharm. Sin. 2012, 47, 144–157.
    • (2012) Acta Pharm. Sin. , vol.47 , pp. 144-157
    • Guo, Z.-R.1
  • 38
    • 84928801703 scopus 로고    scopus 로고
    • Insights into drug discovery from natural products through structural modification
    • Chen, J.C.; Li, W.L.; Yao, H.Q.; Xu, J.Y. Insights into drug discovery from natural products through structural modification. Fitoterapia 2015, 103, 231–241. [CrossRef] [PubMed]
    • (2015) Fitoterapia , vol.103 , pp. 231-241
    • Chen, J.C.1    Li, W.L.2    Yao, H.Q.3    Xu, J.Y.4
  • 39
    • 84867419830 scopus 로고    scopus 로고
    • Overcoming tumor multidrug resistance using drugs able to evade P-glycoprotein or to exploit its expression
    • Nobili, S.; Landini, I.; Mazzei, T.; Mini, E. Overcoming tumor multidrug resistance using drugs able to evade P-glycoprotein or to exploit its expression. Med. Res. Rev. 2012, 32, 1220–1262. [CrossRef] [PubMed]
    • (2012) Med. Res. Rev. , vol.32 , pp. 1220-1262
    • Nobili, S.1    Landini, I.2    Mazzei, T.3    Mini, E.4
  • 40
    • 48649094535 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of novel 1-O- and 14-O-derivatives of oridonin as potential anticancer drug candidates
    • Xu, J.; Yang, J.; Ran, Q.; Wang, L.; Wang, Z.; Liu, J.; Wu, X.; Hua, W.; Yuan, S.; Zhang, L.; et al. Synthesis and biological evaluation of novel 1-O- and 14-O-derivatives of oridonin as potential anticancer drug candidates. Bioorg. Med. Chem. Lett. 2008, 18, 4741–4744. [CrossRef] [PubMed]
    • (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 4741-4744
    • Xu, J.1    Yang, J.2    Ran, Q.3    Wang, L.4    Wang, Z.5    Liu, J.6    Wu, X.7    Hua, W.8    Yuan, S.9    Zhang, L.10
  • 43
    • 84899654025 scopus 로고    scopus 로고
    • Semi-synthesis of neomangiferin from mangiferin
    • Wei, X.; Liang, D.; Ning, M.; Wang, Q.; Meng, X.; Li, Z. Semi-synthesis of neomangiferin from mangiferin. Tetrahedron Lett. 2014, 55, 3083–3086. [CrossRef]
    • (2014) Tetrahedron Lett , vol.55 , pp. 3083-3086
    • Wei, X.1    Liang, D.2    Ning, M.3    Wang, Q.4    Meng, X.5    Li, Z.6
  • 44
    • 84877705890 scopus 로고    scopus 로고
    • Artemisinic acid: A promising molecule potentially suitable for the semi-synthesis of artemisinin
    • Kong, J.; Yang, Y.; Wang, W.; Cheng, K.; Zhu, P. Artemisinic acid: A promising molecule potentially suitable for the semi-synthesis of artemisinin. RSC Adv. 2013, 3, 7622–7641. [CrossRef]
    • (2013) RSC Adv , vol.3 , pp. 7622-7641
    • Kong, J.1    Yang, Y.2    Wang, W.3    Cheng, K.4    Zhu, P.5
  • 45
    • 84880848134 scopus 로고    scopus 로고
    • Computational tools for guided discovery and engineering of metabolic pathways
    • Moura, M.; Broadbelt, L.; Tyo, K. Computational tools for guided discovery and engineering of metabolic pathways. Methods Mol. Biol. 2013, 985, 123–147. [PubMed]
    • (2013) Methods Mol. Biol. , vol.985 , pp. 123-147
    • Moura, M.1    Broadbelt, L.2    Tyo, K.3
  • 47
    • 80053393229 scopus 로고    scopus 로고
    • Protein design in metabolic engineering and synthetic biology
    • Pleiss, J. Protein design in metabolic engineering and synthetic biology. Curr. Opin. Biotechnol. 2011, 22, 611–617. [CrossRef] [PubMed]
    • (2011) Curr. Opin. Biotechnol. , vol.22 , pp. 611-617
    • Pleiss, J.1
  • 50
    • 79957450871 scopus 로고    scopus 로고
    • Directed evolution of the nonribosomal peptide synthetase ADMK generates new andrimid derivatives in vivo
    • Evans, B.S.; Chen, Y.; Metcalf, W.W.; Zhao, H.; Kelleher, N.L. Directed Evolution of the Nonribosomal Peptide Synthetase AdmK Generates New Andrimid Derivatives In Vivo. Chem. Biol. 2011, 18, 601–607. [CrossRef] [PubMed]
    • (2011) Chem. Biol. , vol.18 , pp. 601-607
    • Evans, B.S.1    Chen, Y.2    Metcalf, W.W.3    Zhao, H.4    Kelleher, N.L.5
  • 51
    • 84923072157 scopus 로고    scopus 로고
    • Recent advances in combinatorial biosynthesis for drug discovery
    • Sun, H.; Liu, Z.; Zhao, H.; El, A. Recent advances in combinatorial biosynthesis for drug discovery. Drug Des. Dev Ther. 2015, 2015, 823–833.
    • (2015) Drug Des. Dev Ther. , vol.2015 , pp. 823-833
    • Sun, H.1    Liu, Z.2    Zhao, H.3    El, A.4
  • 52
    • 80052078373 scopus 로고    scopus 로고
    • Engineering of an “Unnatural” Natural Product by Swapping Polyketide Synthase Domains in Aspergillus nidulans
    • Liu, T.; Chiang, Y.M.; Somoza, A.D.; Oakley, B.R.; Wang, C.C.C. Engineering of an “Unnatural” Natural Product by Swapping Polyketide Synthase Domains in Aspergillus nidulans. J. Am. Chem. Soc. 2011, 133, 13314–13316. [CrossRef] [PubMed]
    • (2011) J. Am. Chem. Soc. , vol.133 , pp. 13314-13316
    • Liu, T.1    Chiang, Y.M.2    Somoza, A.D.3    Oakley, B.R.4    Wang, C.C.C.5
  • 54
    • 84926646130 scopus 로고    scopus 로고
    • Distributing a metabolic pathway among a microbial consortium enhances production of natural products
    • Zhou, K.; Qiao, K.; Edgar, S.; Stephanopoulos, G. Distributing a metabolic pathway among a microbial consortium enhances production of natural products. Nat. Biotechnol. 2015, 33, 377–383. [CrossRef] [PubMed]
    • (2015) Nat. Biotechnol. , vol.33 , pp. 377-383
    • Zhou, K.1    Qiao, K.2    Edgar, S.3    Stephanopoulos, G.4
  • 55
    • 84880075289 scopus 로고    scopus 로고
    • Phage P1-derived artificial chromosomes facilitate heterologous expression of the FK506 gene cluster
    • Jones, A.C.; Gust, B.; Kulik, A.; Heide, L.; Buttner, M.J.; Bibb, M.J. Phage P1-Derived Artificial Chromosomes Facilitate Heterologous Expression of the FK506 Gene Cluster. PLoS ONE 2013, 8, e69319. [CrossRef] [PubMed]
    • (2013) PLoS ONE , vol.8
    • Jones, A.C.1    Gust, B.2    Kulik, A.3    Heide, L.4    Buttner, M.J.5    Bibb, M.J.6
  • 56
    • 0034723333 scopus 로고    scopus 로고
    • Cloning and heterologous expression of the epothilone gene cluster
    • Tang, L.; Shah, S.; Chung, L.; Carney, J.; Katz, L.; Khosla, C.; Julien, B. Cloning and Heterologous Expression of the Epothilone Gene Cluster. Science 2000, 287, 640–642. [CrossRef] [PubMed]
    • (2000) Science , vol.287 , pp. 640-642
    • Tang, L.1    Shah, S.2    Chung, L.3    Carney, J.4    Katz, L.5    Khosla, C.6    Julien, B.7
  • 57
    • 65849183178 scopus 로고    scopus 로고
    • Golden gate shuffling: A one-pot DNA shuffling method based on type IIS restriction enzymes
    • Engler, C.; Gruetzner, R.; Kandzia, R.; Marillonnet, S. Golden Gate Shuffling: A One-Pot DNA Shuffling Method Based on Type IIs Restriction Enzymes. PLoS ONE 2009, 4, e5553. [CrossRef] [PubMed]
    • (2009) PLoS ONE , vol.4
    • Engler, C.1    Gruetzner, R.2    Kandzia, R.3    Marillonnet, S.4
  • 58
    • 84889985095 scopus 로고    scopus 로고
    • High-level diterpene production by transient expression in Nicotiana benthamiana
    • Bruckner, K.; Tissier, A. High-level diterpene production by transient expression in Nicotiana benthamiana. Plant Methods 2013, 9, 46. [CrossRef] [PubMed]
    • (2013) Plant Methods , vol.9 , pp. 46
    • Bruckner, K.1    Tissier, A.2
  • 59
    • 59649108349 scopus 로고    scopus 로고
    • DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways
    • Shao, Z.; Zhao, H. DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways. Nucleic Acids Res. 2009, 37, e16. [CrossRef] [PubMed]
    • (2009) Nucleic Acids Res , vol.37
    • Shao, Z.1    Zhao, H.2
  • 61
    • 15744370033 scopus 로고    scopus 로고
    • Heterologous expression of a myxobacterial natural products assembly line in pseudomonads via Red/ET recombineering
    • Wenzel, S.C.; Gross, F.; Zhang, Y.; Fu, J.; Stewart, A.F.; Müller, R. Heterologous Expression of a Myxobacterial Natural Products Assembly Line in Pseudomonads via Red/ET Recombineering. Chem. Biol. 2005, 12, 349–356. [CrossRef] [PubMed]
    • (2005) Chem. Biol. , vol.12 , pp. 349-356
    • Wenzel, S.C.1    Gross, F.2    Zhang, Y.3    Fu, J.4    Stewart, A.F.5    Müller, R.6
  • 62
    • 84893493312 scopus 로고    scopus 로고
    • DNA assembly techniques for next-generation combinatorial biosynthesis of natural products
    • Cobb, R.E.; Ning, J.C.; Zhao, H. DNA assembly techniques for next-generation combinatorial biosynthesis of natural products. J. Ind. Microbiol. Biotechnol. 2014, 41, 469–477. [CrossRef] [PubMed]
    • (2014) J. Ind. Microbiol. Biotechnol. , vol.41 , pp. 469-477
    • Cobb, R.E.1    Ning, J.C.2    Zhao, H.3
  • 64
    • 3042782585 scopus 로고    scopus 로고
    • Codon bias and heterologous protein expression
    • Gustafsson, C.; Govindarajan, S.; Minshull, J. Codon bias and heterologous protein expression. Trends Biotechnol. 2004, 22, 346–353. [CrossRef] [PubMed]
    • (2004) Trends Biotechnol , vol.22 , pp. 346-353
    • Gustafsson, C.1    Govindarajan, S.2    Minshull, J.3
  • 66
  • 67
    • 84865487193 scopus 로고    scopus 로고
    • Efficient codon optimization with motif engineering
    • Condon, A.; Thachuk, C. Efficient codon optimization with motif engineering. J. Discret. Algorithms 2012, 16, 104. [CrossRef]
    • (2012) J. Discret. Algorithms , vol.16 , pp. 104
    • Condon, A.1    Thachuk, C.2
  • 68
    • 78649775828 scopus 로고    scopus 로고
    • Codon preference optimization increases heterologous PEDF expression
    • Gvritishvili, A.G.; Leung, K.W.; Tombran-Tink, J. Codon Preference Optimization Increases Heterologous PEDF Expression. PLoS ONE 2010, 5, e15056. [CrossRef] [PubMed]
    • (2010) PLoS ONE , vol.5
    • Gvritishvili, A.G.1    Leung, K.W.2    Tombran-Tink, J.3
  • 69
    • 84941192024 scopus 로고    scopus 로고
    • Heterologous expression of tyrosinase (MelC2) from Streptomyces avermitilis MA4680 in E. Coli and its application for ortho-hydroxylation of resveratrol to produce piceatannol
    • Lee, N.; Lee, S.-H.; Baek, K.; Kim, B.-G. Heterologous expression of tyrosinase (MelC2) from Streptomyces avermitilis MA4680 in E. coli and its application for ortho-hydroxylation of resveratrol to produce piceatannol. Appl. Microbiol. Biotechnol. 2015, 99, 7915–7924. [CrossRef] [PubMed]
    • (2015) Appl. Microbiol. Biotechnol. , vol.99 , pp. 7915-7924
    • Lee, N.1    Lee, S.-H.2    Baek, K.3    Kim, B.-G.4
  • 70
    • 80052092565 scopus 로고    scopus 로고
    • Nine Post-translational Modifications during the Biosynthesis of Cinnamycin
    • Okesli, A.; Cooper, L.E.; Fogle, E.J.; van der Donk, W.A. Nine Post-translational Modifications during the Biosynthesis of Cinnamycin. J. Am. Chem. Soc. 2011, 133, 13753–13760. [CrossRef] [PubMed]
    • (2011) J. Am. Chem. Soc. , vol.133 , pp. 13753-13760
    • Okesli, A.1    Cooper, L.E.2    Fogle, E.J.3    Van Der Donk, W.A.4
  • 71
    • 0035793858 scopus 로고    scopus 로고
    • Biosynthesis of complex polyketides in a metabolically engineered strain of E. Coli
    • Pfeifer, B.A.; Admiraal, S.J.; Gramajo, H.; Cane, D.E.; Khosla, C. Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli. Science 2001, 291, 1790–1792. [CrossRef] [PubMed]
    • (2001) Science , vol.291 , pp. 1790-1792
    • Pfeifer, B.A.1    Admiraal, S.J.2    Gramajo, H.3    Cane, D.E.4    Khosla, C.5
  • 72
  • 73
    • 84893746107 scopus 로고    scopus 로고
    • Precursor engineering and cell physiological regulation for high level rapamycin production by Streptomyces hygroscopicus
    • Zou, X.; Li, J. Precursor engineering and cell physiological regulation for high level rapamycin production by Streptomyces hygroscopicus. Ann. Microbiol. 2013, 63, 1371–1378. [CrossRef]
    • (2013) Ann. Microbiol. , vol.63 , pp. 1371-1378
    • Zou, X.1    Li, J.2
  • 74
    • 33750969392 scopus 로고    scopus 로고
    • Engineering of primary carbohydrate metabolism for increased production of actinorhodin in Streptomyces coelicolor
    • Ryu, Y.G.; Butler, M.J.; Chater, K.F.; Lee, K.J. Engineering of primary carbohydrate metabolism for increased production of actinorhodin in Streptomyces coelicolor. Appl. Environ. Microbiol. 2006, 72, 7132–7139. [CrossRef] [PubMed]
    • (2006) Appl. Environ. Microbiol. , vol.72 , pp. 7132-7139
    • Ryu, Y.G.1    Butler, M.J.2    Chater, K.F.3    Lee, K.J.4
  • 75
    • 84884353163 scopus 로고    scopus 로고
    • Enhancement of FK506 production by engineering secondary pathways of Streptomyces tsukubaensis and exogenous feeding strategies
    • Huang, D.; Xia, M.; Li, S.; Wen, J.; Jia, X. Enhancement of FK506 production by engineering secondary pathways of Streptomyces tsukubaensis and exogenous feeding strategies. J. Ind. Microbiol. Biotechnol. 2013, 40, 1023–1037. [CrossRef] [PubMed]
    • (2013) J. Ind. Microbiol. Biotechnol. , vol.40 , pp. 1023-1037
    • Huang, D.1    Xia, M.2    Li, S.3    Wen, J.4    Jia, X.5
  • 76
    • 84922782676 scopus 로고    scopus 로고
    • 13 C-metabolic flux analysis of a xylose-consuming Saccharomyces cerevisiae strain expressing xylose isomerase
    • 13 C-metabolic flux analysis of a xylose-consuming Saccharomyces cerevisiae strain expressing xylose isomerase. Biotechnol. Bioeng. 2015, 112, 470–483. [CrossRef] [PubMed]
    • (2015) Biotechnol. Bioeng. , vol.112 , pp. 470-483
    • Wasylenko, T.M.1    Stephanopoulos, G.2
  • 80
    • 81955167921 scopus 로고    scopus 로고
    • Metabolic Flux Analysis and Principal Nodes Identification for Daptomycin Production Improvement by Streptomyces roseosporus
    • Huang, D.; Jia, X.; Wen, J.; Wang, G.; Yu, G.; Caiyin, Q.; Chen, Y. Metabolic Flux Analysis and Principal Nodes Identification for Daptomycin Production Improvement by Streptomyces roseosporus. Appl. Biochem. Biotechnol. 2011, 165, 1725–1739. [CrossRef] [PubMed]
    • (2011) Appl. Biochem. Biotechnol. , vol.165 , pp. 1725-1739
    • Huang, D.1    Jia, X.2    Wen, J.3    Wang, G.4    Yu, G.5    Caiyin, Q.6    Chen, Y.7
  • 81
    • 0037195078 scopus 로고    scopus 로고
    • Bottlenecks for metabolic engineering of isoflavone glycoconjugates in Arabidopsis
    • Liu, C.-J.; Blount, J.W.; Steele, C.L.; Dixon, R.A. Bottlenecks for Metabolic Engineering of Isoflavone Glycoconjugates in Arabidopsis. Proc. Natl. Acad. Sci. USA 2002, 99, 14578–14583. [CrossRef] [PubMed]
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 14578-14583
    • Liu, C.-J.1    Blount, J.W.2    Steele, C.L.3    Dixon, R.A.4
  • 82
    • 80555122760 scopus 로고    scopus 로고
    • Identification of bottlenecks in Escherichia coli engineered for the production of CoQ(10)
    • Cluis, C.P.; Ekins, A.; Narcross, L.; Jiang, H.; Gold, N.D.; Burja, A.M.; Martin, V.J.J. Identification of bottlenecks in Escherichia coli engineered for the production of CoQ(10). Metabol. Eng. 2011, 13, 733–744. [CrossRef] [PubMed]
    • (2011) Metabol. Eng. , vol.13 , pp. 733-744
    • Cluis, C.P.1    Ekins, A.2    Narcross, L.3    Jiang, H.4    Gold, N.D.5    Burja, A.M.6    Martin, V.J.J.7
  • 83
    • 84923923224 scopus 로고    scopus 로고
    • Systems metabolic engineering of Escherichia coli for gram scale production of the antitumor drug deoxyviolacein from glycerol
    • Rodrigues, A.L.; Becker, J.; de Souza Lima, A.O.; Porto, L.M.; Wittmann, C. Systems metabolic engineering of Escherichia coli for gram scale production of the antitumor drug deoxyviolacein from glycerol. Biotechnol. Bioeng. 2014, 111, 2280–2289. [CrossRef] [PubMed]
    • (2014) Biotechnol. Bioeng. , vol.111 , pp. 2280-2289
    • Rodrigues, A.L.1    Becker, J.2    De Souza Lima, A.O.3    Porto, L.M.4    Wittmann, C.5
  • 84
    • 75649122638 scopus 로고    scopus 로고
    • The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis
    • Guo, J.; Zhao, J.; Li, L.; Chen, Z.; Wen, Y.; Li, J. The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis. Mol. Genet. Genom. 2010, 283, 123–133. [CrossRef] [PubMed]
    • (2010) Mol. Genet. Genom. , vol.283 , pp. 123-133
    • Guo, J.1    Zhao, J.2    Li, L.3    Chen, Z.4    Wen, Y.5    Li, J.6
  • 87
    • 84859633048 scopus 로고    scopus 로고
    • Design of a dynamic sensor-regulator system for production of chemicals and fuels derived from fatty acids
    • Zhang, F.Z.; Carothers, J.M.; Keasling, J.D. Design of a dynamic sensor-regulator system for production of chemicals and fuels derived from fatty acids. Nat. Biotechnol. 2012, 30, 354–359. [CrossRef] [PubMed]
    • (2012) Nat. Biotechnol. , vol.30 , pp. 354-359
    • Zhang, F.Z.1    Carothers, J.M.2    Keasling, J.D.3
  • 88
    • 84925639589 scopus 로고    scopus 로고
    • Quorum-sensing linked RNA interference for dynamic metabolic pathway control in Saccharomyces cerevisiae
    • Williams, T.C.; Averesch, N.J.H.; Winter, G.; Plan, M.R.; Vickers, C.E.; Nielsen, L.K.; Krömer, J.O. Quorum-sensing linked RNA interference for dynamic metabolic pathway control in Saccharomyces cerevisiae. Metab. Eng. 2015, 29, 124–134. [CrossRef] [PubMed]
    • (2015) Metab. Eng. , vol.29 , pp. 124-134
    • Williams, T.C.1    Averesch, N.J.H.2    Winter, G.3    Plan, M.R.4    Vickers, C.E.5    Nielsen, L.K.6    Krömer, J.O.7
  • 91
    • 84902181907 scopus 로고    scopus 로고
    • Combinatorial approaches for inverse metabolic engineering applications
    • Skretas, G.; Kolisis, F.N. Combinatorial approaches for inverse metabolic engineering applications. Comput. Struct. Biotechnol. J. 2012, 3, e201210021. [CrossRef] [PubMed]
    • (2012) Comput. Struct. Biotechnol. J. , vol.3
    • Skretas, G.1    Kolisis, F.N.2
  • 92
    • 84921496822 scopus 로고    scopus 로고
    • Cell-free metabolic engineering: Biomanufacturing beyond the cell
    • Dudley, Q.M.; Karim, A.S.; Jewett, M.C. Cell-free metabolic engineering: Biomanufacturing beyond the cell. Biotechnol. J. 2015, 10, 69–82. [CrossRef] [PubMed]
    • (2015) Biotechnol. J. , vol.10 , pp. 69-82
    • Dudley, Q.M.1    Karim, A.S.2    Jewett, M.C.3
  • 93
    • 49349085256 scopus 로고    scopus 로고
    • Redox compartmentalization in eukaryotic cells
    • Go, Y.-M.; Jones, D.P. Redox compartmentalization in eukaryotic cells. BBA Gen. Subj. 2008, 1780, 1273–1290. [CrossRef] [PubMed]
    • (2008) BBA Gen. Subj. , vol.1780 , pp. 1273-1290
    • Go, Y.-M.1    Jones, D.P.2
  • 94
    • 84869875863 scopus 로고    scopus 로고
    • Designing biological compartmentalization
    • Chen, A.H.; Silver, P.A. Designing biological compartmentalization. Trends Cell Biol. 2012, 22, 662–670. [CrossRef] [PubMed]
    • (2012) Trends Cell Biol , vol.22 , pp. 662-670
    • Chen, A.H.1    Silver, P.A.2
  • 95
    • 84896040096 scopus 로고    scopus 로고
    • Metabolic engineering of chloroplasts for artemisinic acid biosynthesis and impact on plant growth
    • Saxena, B.; Subramaniyan, M.; Malhotra, K.; Bhavesh, N.S.; Potlakayala, S.D.; Kumar, S. Metabolic engineering of chloroplasts for artemisinic acid biosynthesis and impact on plant growth. J. Biosci. 2014, 39, 33–41. [CrossRef] [PubMed]
    • (2014) J. Biosci. , vol.39 , pp. 33-41
    • Saxena, B.1    Subramaniyan, M.2    Malhotra, K.3    Bhavesh, N.S.4    Potlakayala, S.D.5    Kumar, S.6
  • 96
    • 84905443683 scopus 로고    scopus 로고
    • Improvement of Aspergillus nidulans penicillin production by targeting AcvA to peroxisomes
    • Herr, A.; Fischer, R. Improvement of Aspergillus nidulans penicillin production by targeting AcvA to peroxisomes. Metab. Eng. 2014, 25, 131–139. [CrossRef] [PubMed]
    • (2014) Metab. Eng. , vol.25 , pp. 131-139
    • Herr, A.1    Fischer, R.2
  • 100
    • 84863116515 scopus 로고    scopus 로고
    • Modular pathway engineering of diterpenoid synthases and the mevalonic acid pathway for miltiradiene production
    • Zhou, Y.J.; Gao, W.; Rong, Q.X.; Jin, G.J.; Chu, H.Y.; Liu, W.J.; Yang, W.; Zhu, Z.W.; Li, G.H.; Zhu, G.F.; et al. Modular Pathway Engineering of Diterpenoid Synthases and the Mevalonic Acid Pathway for Miltiradiene Production. J. Am. Chem. Soc. 2012, 134, 3234–3241. [CrossRef] [PubMed]
    • (2012) J. Am. Chem. Soc. , vol.134 , pp. 3234-3241
    • Zhou, Y.J.1    Gao, W.2    Rong, Q.X.3    Jin, G.J.4    Chu, H.Y.5    Liu, W.J.6    Yang, W.7    Zhu, Z.W.8    Li, G.H.9    Zhu, G.F.10
  • 101
    • 84883553644 scopus 로고    scopus 로고
    • Enhancing isoprenoid production through systematically assembling and modulating efflux pumps in Escherichia coli
    • Wang, J.-F.; Xiong, Z.-Q.; Li, S.-Y.; Wang, Y. Enhancing isoprenoid production through systematically assembling and modulating efflux pumps in Escherichia coli. Appl. Microbiol. Biotechnol. 2013, 97, 8057–8067. [CrossRef] [PubMed]
    • (2013) Appl. Microbiol. Biotechnol. , vol.97 , pp. 8057-8067
    • Wang, J.-F.1    Xiong, Z.-Q.2    Li, S.-Y.3    Wang, Y.4
  • 102
    • 84902257693 scopus 로고    scopus 로고
    • A multivariate approach to the integration of multi-omics datasets
    • Meng, C.; Kuster, B.; Culhane, A.C.; Gholami, A.M. A multivariate approach to the integration of multi-omics datasets. BMC Bioinform. 2014, 15, 162. [CrossRef] [PubMed]
    • (2014) BMC Bioinform , vol.15 , pp. 162
    • Meng, C.1    Kuster, B.2    Culhane, A.C.3    Gholami, A.M.4
  • 104
    • 84859776222 scopus 로고    scopus 로고
    • The future of metabolic engineering and synthetic biology: Towards a systematic practice
    • Yadav, V.G.; de Mey, M.; Lim, C.G.; Ajikumar, P.K.; Stephanopoulos, G. The future of metabolic engineering and synthetic biology: Towards a systematic practice. Metab. Eng. 2012, 14, 233–241. [CrossRef] [PubMed]
    • (2012) Metab. Eng. , vol.14 , pp. 233-241
    • Yadav, V.G.1    De Mey, M.2    Lim, C.G.3    Ajikumar, P.K.4    Stephanopoulos, G.5
  • 106
    • 84905668376 scopus 로고    scopus 로고
    • Improving fatty acids production by engineering dynamic pathway regulation and metabolic control
    • Xu, P.; Li, L.; Zhang, F.; Stephanopoulos, G.; Koffas, M. Improving fatty acids production by engineering dynamic pathway regulation and metabolic control. Proc. Natl. Acad. Sci. USA 2014, 111, 11299–11304. [CrossRef] [PubMed]
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 11299-11304
    • Xu, P.1    Li, L.2    Zhang, F.3    Stephanopoulos, G.4    Koffas, M.5
  • 107
    • 84921420837 scopus 로고    scopus 로고
    • Kinetic folding design of aptazyme-regulated expression devices as riboswitches for metabolic engineering
    • Sparkman-Yager, D.; Correa-Rojas, R.A.; Carothers, J.M. Kinetic folding design of aptazyme-regulated expression devices as riboswitches for metabolic engineering. Methods Enzymol. 2015, 550, 321. [PubMed]
    • (2015) Methods Enzymol , vol.550 , pp. 321
    • Sparkman-Yager, D.1    Correa-Rojas, R.A.2    Carothers, J.M.3


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