Identification of bottlenecks in Escherichia coli engineered for the production of CoQ 10

Metabolic Engineering

Volumn 13, Issue 6, 2011, Pages 733-744

  Cluis, Corinne P ^a   Ekins, Andrew ^a   Narcross, Lauren ^a   Jiang, Heng ^a   Gold, Nicholas D ^a   Burja, Adam M ^b   Martin, Vincent J J ^a  

^a Gina Cody School of Engineering and Computer Science   (Canada)

^b Ocean Nutrition Canada   (Canada)

Author keywords

Coenzyme Q 10; Decaprenyl diphosphate synthase; Escherichia coli; Metabolic engineering; Ubiquinone

Indexed keywords

BIOSYNTHETIC PRECURSORS; COENZYME Q; COFACTORS; DIPHOSPHATES; E. COLI; ERYTHROBACTER; FARNESYL DIPHOSPHATE; GENES CODING; HETEROLOGOUS EXPRESSION; ISOPRENOIDS; METABOLIC ENGINEERING; MEVALONATE; OVER-EXPRESSION; RATE-LIMITING ENZYMES; SPHINGOMONAS; SYNTHASE GENE; UBIQUINONE;

BIOCHEMISTRY; BIOSYNTHESIS; ESCHERICHIA COLI; LIPIDS;

GENE EXPRESSION;

2 DECAPRENYLPHENOL; 4 AMINOBENZOIC ACID; 4 HYDROXYBENZOATE 3 MONOOXYGENASE; 4 HYDROXYBENZOIC ACID DECAPRENYLTRANSFERASE; BACTERIAL ENZYME; ESCHERICHIA COLI PROTEIN; FARNESYL DIPHOSPHATE; FOLIC ACID; ISOPRENOID; MEVALONIC ACID; OCTAPRENYLDIPHOSPHATE SYNTHASE; PHENOL; SYNTHETASE; TRANSFERASE; UBIDECARENONE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL METABOLISM; BACTERIAL STRAIN; BACTERIUM; CHEMICAL STRUCTURE; CONTROLLED STUDY; DECAPRENYLATION; ERYTHROBACTER; ESCHERICHIA COLI; GENE OVEREXPRESSION; HETEROLOGOUS EXPRESSION; METABOLIC ENGINEERING; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; OPERON; PRECURSOR; PRENYLATION; PRIORITY JOURNAL; SPHINGOMONAS; SPHINGOMONAS BAEKRYUNGENSIS; WILD TYPE;

4-AMINOBENZOIC ACID; ALKYL AND ARYL TRANSFERASES; DIMETHYLALLYLTRANSTRANSFERASE; ESCHERICHIA COLI; GENE DELETION; GENETIC ENGINEERING; MEVALONIC ACID; PARABENS; PHENOLS; POLYISOPRENYL PHOSPHATES; PROMOTER REGIONS, GENETIC; SESQUITERPENES; SPHINGOMONADACEAE; SPHINGOMONAS; TERPENES; UBIQUINONE; UP-REGULATION;

ERYTHROBACTER SP.; ESCHERICHIA COLI; SPHINGOPYXIS BAEKRYUNGENSIS;

EID: 80555122760     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2011.09.009     Document Type: Article

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