Metabolic engineering of chloroplasts for artemisinic acid biosynthesis and impact on plant growth

Journal of Biosciences

Volumn 39, Issue 1, 2014, Pages 33-41

  Saxena, Bhawna ^a   Subramaniyan, Mayavan ^a   Malhotra, Karan ^a   Bhavesh, Neel Sarovar ^a   Potlakayala, Shobha Devi ^b   Kumar, Shashi ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Antimalarial drug; artemisinin; gene pyramiding; isopentenyl diphosphate isopentenyl pyrophosphate (IPP); metabolic flux; mevalonate (MEV) pathway; plastome; transplastomics

Indexed keywords

AMORPHA 4,11 DIENE C 12 OXIDASE; AMORPHA 4,11 DIENE SYNTHASE; ARTEMISINIC ACID; CELL ENZYME; CYTOCHROME P450 REDUCTASE; ISOPENTENYL DIPHOSPHATE DELTA ISOMERASE; MEVALONIC ACID; OXIDOREDUCTASE; SYNTHETASE; UNCLASSIFIED DRUG;

ACID; CHLOROPLAST; DRUG; GROWTH RATE; ISOPRENOID; MASS SPECTROMETRY; METABOLISM; TOBACCO; TRANSGENIC PLANT;

ARTEMISIA ANNUA; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL TRANSFORMATION; CHLOROPLAST; CHLOROPLAST GENOME; CONTROLLED STUDY; CYTOCHROME P450 REDUCTASE GENE; DRUG DETERMINATION; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; GENE EXPRESSION; GENOME ANALYSIS; METABOLIC ENGINEERING; MOLECULAR DYNAMICS; NONHUMAN; PHENOTYPE; PLANT GENE; PLANT GROWTH; PLANTLET; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TOBACCO; TRANSGENE;

NICOTIANA TABACUM;

ARTEMISININS; BIOSYNTHETIC PATHWAYS; CARBON ISOTOPES; CHLOROPLASTS; HEMITERPENES; HOMOLOGOUS RECOMBINATION; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; METABOLIC ENGINEERING; ORGANOPHOSPHORUS COMPOUNDS; TOBACCO; TRANSGENES;

EID: 84896040096     PISSN: 02505991     EISSN: 09737138     Source Type: Journal    
DOI: 10.1007/s12038-013-9402-z     Document Type: Article

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