Enhancement of FK506 production by engineering secondary pathways of Streptomyces tsukubaensis and exogenous feeding strategies

Journal of Industrial Microbiology and Biotechnology

Volumn 40, Issue 9, 2013, Pages 1023-1037

  Huang, Di ^a,c   Xia, Menglei ^a   Li, Shanshan ^a   Wen, Jianping ^a,b   Jia, Xiaoqiang ^a,b  

^a TIANJIN UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c NANKAI UNIVERSITY   (China)

Author keywords

Combinatorial overexpression; Exogenous feeding strategies; FK506; Metabolic engineering; Streptomyces tsukubaensis

Indexed keywords

CHORISMIC ACID; ISOLEUCINE; LACTIC ACID; LYSINE; PIPECOLIC ACID; SHIKIMIC ACID; SOYBEAN OIL; SUCCINIC ACID; TACROLIMUS; VALINE;

ARTICLE; BACTERIAL STRAIN; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FED BATCH CULTURE; FEEDING; FERMENTATION; GENE OVEREXPRESSION; GENETIC ENGINEERING; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; STREPTOMYCES TSUKUBAENSIS;

GLYCINE MAX; STREPTOMYCES TSUKUBAENSIS;

BACTERIAL PROTEINS; BIOTECHNOLOGY; CHORISMIC ACID; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; IMMUNOSUPPRESSIVE AGENTS; METABOLIC ENGINEERING; PIPECOLIC ACIDS; POLYKETIDE SYNTHASES; SECONDARY METABOLISM; STREPTOMYCES; TACROLIMUS;

EID: 84884353163     PISSN: 13675435     EISSN: 14765535     Source Type: Journal    
DOI: 10.1007/s10295-013-1301-7     Document Type: Article

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