Synthesis and biological evaluation of novel 1-O- and 14-O-derivatives of oridonin as potential anticancer drug candidates

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 16, 2008, Pages 4741-4744

  Xu, Jinyi ^a   Yang, JingYi ^a   Ran, Qian ^a   Wang, Lei ^a   Liu, Jie ^a   Wang, Zhixuan ^a   Wu, Xiaoming ^a   Hua, Weiyi ^a   Yuan, Shengtao ^a   Zhang, Luyong ^a   Shen, Mingqin ^b   Ding, Yongfang ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b KEY LABORATORY OF NEW DRUG DELIVERY SYSTEM OF CHINESE MATERIA MEDICA   (China)

Author keywords

Anticancer; Cytotoxicity; Derivatives; Oridonin; Structure activity relationships

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLOPHOSPHAMIDE; ORIDONIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGY; CANCER CELL CULTURE; CELL STRAIN HL 60; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; DITERPENES, KAURANE; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; FLUOROURACIL; HL-60 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MODELS, CHEMICAL; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLIUM SALTS; THIAZOLES;

EID: 48649094535     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.06.097     Document Type: Article

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