-
1
-
-
11144311139
-
Lessons from natural molecules
-
Clardy J, Walsh C (2004) Lessons from natural molecules. Nature 432: 829-837
-
(2004)
Nature
, vol.432
, pp. 829-837
-
-
Clardy, J.1
Walsh, C.2
-
2
-
-
4244059507
-
Harnessing the biosynthetic potential of modular polyketide synthases
-
Khosla C (1997) Harnessing the biosynthetic potential of modular polyketide synthases. Chem Rev 97: 2577-2590
-
(1997)
Chem Rev
, vol.97
, pp. 2577-2590
-
-
Khosla, C.1
-
3
-
-
14844362054
-
Molecular mechanisms underlying nonribosomal peptide synthesis: Approaches to new antibiotics
-
Sieber SA, Marahiel MA (2005) Molecular mechanisms underlying nonribosomal peptide synthesis: approaches to new antibiotics. Chem Rev 105: 715-738
-
(2005)
Chem Rev
, vol.105
, pp. 715-738
-
-
Sieber, S.A.1
Marahiel, M.A.2
-
4
-
-
33947256914
-
Genome-wide high-throughput mining of natural-product biosynthetic gene clusters by phage display
-
Yin J, Straight PD, Hrvatin S, Dorrestein PC, Bumpus SB, Jao C, Kelleher NL, Kolter R, Walsh CT (2007) Genome-wide high-throughput mining of natural-product biosynthetic gene clusters by phage display. Chem Biol 14: 303-312
-
(2007)
Chem Biol
, vol.14
, pp. 303-312
-
-
Yin, J.1
Straight, P.D.2
Hrvatin, S.3
Dorrestein, P.C.4
Bumpus, S.B.5
Jao, C.6
Kelleher, N.L.7
Kolter, R.8
Walsh, C.T.9
-
5
-
-
17844407663
-
Microbial genomics as a guide to drug discovery, structural elucidation: ECO-02301, a novel antifungal agent, as an example
-
McAlpine JB, Bachmann BO, Piraee M, Tremblay S, Alarco AM, Zazopoulos E, Farnet CM (2005) Microbial genomics as a guide to drug discovery, structural elucidation: ECO-02301, a novel antifungal agent, as an example. J Nat Prod 68: 493-496
-
(2005)
J Nat Prod
, vol.68
, pp. 493-496
-
-
McAlpine, J.B.1
Bachmann, B.O.2
Piraee, M.3
Tremblay, S.4
Alarco, A.M.5
Zazopoulos, E.6
Farnet, C.M.7
-
6
-
-
1642453829
-
Mining the microbial metabolome: A new frontier for natural product lead discovery
-
Peric-Concha N, Long PF (2003) Mining the microbial metabolome: a new frontier for natural product lead discovery. Drug Discov Today 8: 1078-1084
-
(2003)
Drug Discov Today
, vol.8
, pp. 1078-1084
-
-
Peric-Concha, N.1
Long, P.F.2
-
7
-
-
0036902202
-
Big effects from small changes: Possible ways to explore nature's chemical diversity
-
Bode HB, Bethe B, Hofs R, Zeeck A (2002) Big effects from small changes: possible ways to explore nature's chemical diversity. Chembiochem 3: 619-627
-
(2002)
Chembiochem
, vol.3
, pp. 619-627
-
-
Bode, H.B.1
Bethe, B.2
Hofs, R.3
Zeeck, A.4
-
8
-
-
0035478654
-
Tailoring enzymes that modify nonribosomal peptides during and after chain elongation on NRPS assembly lines
-
Walsh CT, Chen H, Keating TA, Hubbard BK, Losey HC, Luo L, Marshall CG, Miller DA, Patel HM (2001) Tailoring enzymes that modify nonribosomal peptides during and after chain elongation on NRPS assembly lines. Curr Opin Chem Biol 5: 525-534
-
(2001)
Curr Opin Chem Biol
, vol.5
, pp. 525-534
-
-
Walsh, C.T.1
Chen, H.2
Keating, T.A.3
Hubbard, B.K.4
Losey, H.C.5
Luo, L.6
Marshall, C.G.7
Miller, D.A.8
Patel, H.M.9
-
9
-
-
0000153104
-
Introduction: Polyketide and nonribosomal polypeptide biosynthesis. From collie to coli
-
Cane DE (1997) Introduction: Polyketide and nonribosomal polypeptide biosynthesis. From collie to coli. Chem Rev 97: 2463-2464
-
(1997)
Chem Rev
, vol.97
, pp. 2463-2464
-
-
Cane, D.E.1
-
10
-
-
0033485280
-
The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases
-
Cane DE, Walsh CT (1999) The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases. Chem Biol 6: R319-325
-
(1999)
Chem Biol
, vol.6
-
-
Cane, D.E.1
Walsh, C.T.2
-
11
-
-
0033582596
-
The first gene in the biosynthesis of the polyketide antibiotic TA of Myxococcus xanthus codes for a unique PKS module coupled to a peptide synthetase
-
Paitan Y, Alon G, Orr E, Ron EZ, Rosenberg E (1999) The first gene in the biosynthesis of the polyketide antibiotic TA of Myxococcus xanthus codes for a unique PKS module coupled to a peptide synthetase. J Mol Biol 286: 465-474
-
(1999)
J Mol Biol
, vol.286
, pp. 465-474
-
-
Paitan, Y.1
Alon, G.2
Orr, E.3
Ron, E.Z.4
Rosenberg, E.5
-
12
-
-
0033601178
-
New lessons for combinatorial biosynthesis from myxobacteria. The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca DW4/3-1
-
Silakowski B, Schairer HU, Ehret H, Kunze B, Weinig S, Nordsiek G, Brandt P, Blocker H, Hofle G, Beyer S et al (1999) New lessons for combinatorial biosynthesis from myxobacteria. The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca DW4/3-1. J Biol Chem 274: 37391-37399
-
(1999)
J Biol Chem
, vol.274
, pp. 37391-37399
-
-
Silakowski, B.1
Schairer, H.U.2
Ehret, H.3
Kunze, B.4
Weinig, S.5
Nordsiek, G.6
Brandt, P.7
Blocker, H.8
Hofle, G.9
Beyer, S.10
-
13
-
-
15744396410
-
Structure and biosynthesis of myxochromides S1-3 in Stigmatella aurantiaca: Evidence for an iterative bacterial type I polyketide synthase and for module skipping in nonribosomal peptide biosynthesis
-
Wenzel SC, Kunze B, Hofle G, Silakowski B, Scharfe M, Blocker H, Muller R (2005) Structure and biosynthesis of myxochromides S1-3 in Stigmatella aurantiaca: evidence for an iterative bacterial type I polyketide synthase and for module skipping in nonribosomal peptide biosynthesis. Chembiochem 6: 375-385
-
(2005)
Chembiochem
, vol.6
, pp. 375-385
-
-
Wenzel, S.C.1
Kunze, B.2
Hofle, G.3
Silakowski, B.4
Scharfe, M.5
Blocker, H.6
Muller, R.7
-
14
-
-
0038561132
-
Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis
-
Ikeda H, Ishikawa J, Hanamoto A, Shinose M, Kikuchi H, Shiba T, Sakaki Y, Hattori M, Omura S (2003) Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. Nat Biotechnol 21: 526-531
-
(2003)
Nat Biotechnol
, vol.21
, pp. 526-531
-
-
Ikeda, H.1
Ishikawa, J.2
Hanamoto, A.3
Shinose, M.4
Kikuchi, H.5
Shiba, T.6
Sakaki, Y.7
Hattori, M.8
Omura, S.9
-
15
-
-
0347721776
-
Biosynthesis of the enediyne antitumor antibiotic C-1027
-
Liu W, Christenson SD, Standage S, Shen B (2002) Biosynthesis of the enediyne antitumor antibiotic C-1027. Science 297: 1170-1173
-
(2002)
Science
, vol.297
, pp. 1170-1173
-
-
Liu, W.1
Christenson, S.D.2
Standage, S.3
Shen, B.4
-
16
-
-
27144509740
-
Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes
-
Menzella HG, Reid R, Carney JR, Chandran SS, Reisinger SJ, Patel KG, Hopwood DA, Santi DV (2005) Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes. Nat Biotechnol 23: 1171-1176
-
(2005)
Nat Biotechnol
, vol.23
, pp. 1171-1176
-
-
Menzella, H.G.1
Reid, R.2
Carney, J.R.3
Chandran, S.S.4
Reisinger, S.J.5
Patel, K.G.6
Hopwood, D.A.7
Santi, D.V.8
-
17
-
-
27544477567
-
Discovery of a new peptide natural product by Streptomyces coelicolor genome mining
-
Lautru S, Deeth RJ, Bailey LM, Challis GL (2005) Discovery of a new peptide natural product by Streptomyces coelicolor genome mining. Nat Chem Biol 1: 265-269
-
(2005)
Nat Chem Biol
, vol.1
, pp. 265-269
-
-
Lautru, S.1
Deeth, R.J.2
Bailey, L.M.3
Challis, G.L.4
-
18
-
-
0037318402
-
A genomics-guided approach for discovering and expressing cryptic metabolic pathways
-
Zazopoulos E, Huang K, Staffa A, Liu W, Bachmann BO, Nonaka K, Ahlert J, Thorson JS, Shen B, Farnet CM (2003) A genomics-guided approach for discovering and expressing cryptic metabolic pathways. Nat Biotechnol 21: 187-190
-
(2003)
Nat Biotechnol
, vol.21
, pp. 187-190
-
-
Zazopoulos, E.1
Huang, K.2
Staffa, A.3
Liu, W.4
Bachmann, B.O.5
Nonaka, K.6
Ahlert, J.7
Thorson, J.S.8
Shen, B.9
Farnet, C.M.10
-
19
-
-
27544456830
-
The impact of bacterial genomics on natural product research
-
Bode HB, Muller R (2005) The impact of bacterial genomics on natural product research. Angew Chem Int Ed Engl 44: 6828-6846
-
(2005)
Angew Chem Int Ed Engl
, vol.44
, pp. 6828-6846
-
-
Bode, H.B.1
Muller, R.2
-
20
-
-
34547471696
-
A cryptic PKS-NRPS gene locus in the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of an antimitotic rhizoxin complex
-
Brendel N, Partida-Martinez LP, Scherlach K, Hertweck C (2007) A cryptic PKS-NRPS gene locus in the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of an antimitotic rhizoxin complex. Org Biomol Chem 5: 2211-2213
-
(2007)
Org Biomol Chem
, vol.5
, pp. 2211-2213
-
-
Brendel, N.1
Partida-Martinez, L.P.2
Scherlach, K.3
Hertweck, C.4
-
21
-
-
34548782637
-
A widely distributed bacterial pathway for siderophore biosynthesis independent of nonribosomal peptide synthetases
-
Challis GL (2007) A widely distributed bacterial pathway for siderophore biosynthesis independent of nonribosomal peptide synthetases. Chembiochem 8: 1477
-
(2007)
Chembiochem
, vol.8
, pp. 1477
-
-
Challis, G.L.1
-
22
-
-
33846294440
-
The genomisotopic approach: A systematic method to isolate products of orphan biosynthetic gene clusters
-
Gross H, Stockwell VO, Henkels MD, Nowak-Thompson B, Loper JE, Gerwick WH (2007) The genomisotopic approach: a systematic method to isolate products of orphan biosynthetic gene clusters. Chem Biol 14: 53-63
-
(2007)
Chem Biol
, vol.14
, pp. 53-63
-
-
Gross, H.1
Stockwell, V.O.2
Henkels, M.D.3
Nowak-Thompson, B.4
Loper, J.E.5
Gerwick, W.H.6
-
23
-
-
28844461287
-
Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae
-
Galagan JE, Calvo SE, Cuomo C, Ma LJ, Wortman JR, Batzoglou S, Lee SI, Basturkmen M, Spevak CC, Clutterbuck J et al (2005) Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae. Nature 438: 1105-1115
-
(2005)
Nature
, vol.438
, pp. 1105-1115
-
-
Galagan, J.E.1
Calvo, S.E.2
Cuomo, C.3
Ma, L.J.4
Wortman, J.R.5
Batzoglou, S.6
Lee, S.I.7
Basturkmen, M.8
Spevak, C.C.9
Clutterbuck, J.10
-
24
-
-
29244442741
-
Genome sequencing and analysis of Aspergillus oryzae
-
Machida M, Asai K, Sano M, Tanaka T, Kumagai T, Terai G, Kusumoto K, Arima T, Akita O, Kashiwagi Y et al (2005) Genome sequencing and analysis of Aspergillus oryzae. Nature 438: 1157-1161
-
(2005)
Nature
, vol.438
, pp. 1157-1161
-
-
Machida, M.1
Asai, K.2
Sano, M.3
Tanaka, T.4
Kumagai, T.5
Terai, G.6
Kusumoto, K.7
Arima, T.8
Akita, O.9
Kashiwagi, Y.10
-
25
-
-
28644434509
-
Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
-
Nierman WC, Pain A, Anderson MJ, Wortman JR, Kim HS, Arroyo J, Berriman M, Abe K, Archer DB, Bermejo C et al (2005) Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature 438: 1151-1156
-
(2005)
Nature
, vol.438
, pp. 1151-1156
-
-
Nierman, W.C.1
Pain, A.2
Anderson, M.J.3
Wortman, J.R.4
Kim, H.S.5
Arroyo, J.6
Berriman, M.7
Abe, K.8
Archer, D.B.9
Bermejo, C.10
-
26
-
-
33750083918
-
Phylogenomic analysis of non-ribosomal peptide synthetases in the genus Aspergillus
-
Cramer RA Jr, Stajich JE, Yamanaka Y, Dietrich FS, Steinbach WJ, Perfect JR (2006) Phylogenomic analysis of non-ribosomal peptide synthetases in the genus Aspergillus. Gene 383: 24-32
-
(2006)
Gene
, vol.383
, pp. 24-32
-
-
Cramer Jr, R.A.1
Stajich, J.E.2
Yamanaka, Y.3
Dietrich, F.S.4
Steinbach, W.J.5
Perfect, J.R.6
-
27
-
-
30744456748
-
Genomic ruining for Aspergillus natural products
-
Bok JW, Hoffmeister D, Maggio-Hall LA, Murillo R, Glasner JD, Keller NP (2006) Genomic ruining for Aspergillus natural products. Chem Biol 13: 31-37
-
(2006)
Chem Biol
, vol.13
, pp. 31-37
-
-
Bok, J.W.1
Hoffmeister, D.2
Maggio-Hall, L.A.3
Murillo, R.4
Glasner, J.D.5
Keller, N.P.6
-
28
-
-
33748254906
-
Discovery of aspoquinolones A-D, prenylated quinoline-2-one alkaloids from Aspergillus nidulans, motivated by genome mining
-
Scherlach K, Hertweck C (2006) Discovery of aspoquinolones A-D, prenylated quinoline-2-one alkaloids from Aspergillus nidulans, motivated by genome mining. Org Biomol Chem 4: 3517-3520
-
(2006)
Org Biomol Chem
, vol.4
, pp. 3517-3520
-
-
Scherlach, K.1
Hertweck, C.2
-
30
-
-
85055172812
-
Secondary metabolite gene clusters
-
Z An ed, Marcel Dekker, New York
-
Zhang Y-Q, Wilkinson H, Keller NP, Tsitsigiannis DI (2004) Secondary metabolite gene clusters. In: Z An (ed): Handbook of Industrial Microbiology. Marcel Dekker, New York, 355-386
-
(2004)
Handbook of Industrial Microbiology
, pp. 355-386
-
-
Zhang, Y.-Q.1
Wilkinson, H.2
Keller, N.P.3
Tsitsigiannis, D.I.4
-
31
-
-
33947308882
-
Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans
-
Bergmann S, Schuemann J, Scherlach K, Lange C, Brakhage AA, Hertweck C (2007) Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans. Nat Chem Biol 3: 213-217
-
(2007)
Nat Chem Biol
, vol.3
, pp. 213-217
-
-
Bergmann, S.1
Schuemann, J.2
Scherlach, K.3
Lange, C.4
Brakhage, A.A.5
Hertweck, C.6
-
33
-
-
4644244128
-
Fusarin C biosynthesis in Fusarium moniliforme and Fusarium venenatum
-
Song Z, Cox RJ, Lazarus CM, Simpson TT (2004) Fusarin C biosynthesis in Fusarium moniliforme and Fusarium venenatum. Chembiochem 5: 1196-1203
-
(2004)
Chembiochem
, vol.5
, pp. 1196-1203
-
-
Song, Z.1
Cox, R.J.2
Lazarus, C.M.3
Simpson, T.T.4
-
34
-
-
0029995755
-
delta-(L-alpha-aminoadipyl)-L-cysteinyl-D- valine synthetase is a rate limiting enzyme for penicillin production in Aspergillus nidulans
-
Kennedy J, Turner G (1996) delta-(L-alpha-aminoadipyl)-L-cysteinyl-D- valine synthetase is a rate limiting enzyme for penicillin production in Aspergillus nidulans. Mol Gen Genet 253: 189-197
-
(1996)
Mol Gen Genet
, vol.253
, pp. 189-197
-
-
Kennedy, J.1
Turner, G.2
-
35
-
-
0024390791
-
Characterization of an inducible expression system in Aspergillus nidulans using alcA and tubulin-coding genes
-
Waring RB, May GS, Morris NR (1989) Characterization of an inducible expression system in Aspergillus nidulans using alcA and tubulin-coding genes. Gene 79: 119-130
-
(1989)
Gene
, vol.79
, pp. 119-130
-
-
Waring, R.B.1
May, G.S.2
Morris, N.R.3
-
36
-
-
33947328945
-
Biosynthesis of the 2-pyridone tenellin in the insect pathogenic fungus Beauveria bassiana
-
Eley KL, Halo LM, Song Z, Powles H, Cox RJ, Bailey AM, Lazarus CM, Simpson TJ (2007) Biosynthesis of the 2-pyridone tenellin in the insect pathogenic fungus Beauveria bassiana. Chembiochem 8: 289-297
-
(2007)
Chembiochem
, vol.8
, pp. 289-297
-
-
Eley, K.L.1
Halo, L.M.2
Song, Z.3
Powles, H.4
Cox, R.J.5
Bailey, A.M.6
Lazarus, C.M.7
Simpson, T.J.8
-
37
-
-
0037350776
-
Novel tetramic acids and pyridone alkaloids, militarinones B, C and D, from the insect pathogenic fungus Paecilomyces militaris
-
Schmidt K, Riese U, Li Z, Hamburger M (2003) Novel tetramic acids and pyridone alkaloids, militarinones B, C and D, from the insect pathogenic fungus Paecilomyces militaris. J Nat Prod 66: 378-383
-
(2003)
J Nat Prod
, vol.66
, pp. 378-383
-
-
Schmidt, K.1
Riese, U.2
Li, Z.3
Hamburger, M.4
|