Modular pathway engineering of diterpenoid synthases and the mevalonic acid pathway for miltiradiene production

Journal of the American Chemical Society

Volumn 134, Issue 6, 2012, Pages 3234-3241

  Zhou, Yongjin J ^a,e   Gao, Wei ^b,c   Rong, Qixian ^b   Jin, Guojie ^a,e   Chu, Huiying ^a   Liu, Wujun ^a   Yang, Wei ^a   Zhu, Zhiwei ^a,e   Li, Guohui ^a   Zhu, Guofeng ^d   Huang, Luqi ^b   Zhao, Zongbao K ^a  

^a DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

^b CACMS   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

^d INSTITUTE OF PATHOGEN BIOLOGY   (China)

^e UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BIOREACTOR CULTURES; CHINESE MEDICINAL HERBS; CLOSE PROXIMITY; COMPREHENSIVE EVALUATION; DITERPENE SYNTHASES; DITERPENOIDS; FARNESYL DIPHOSPHATE SYNTHASE; GERANYLGERANYL DIPHOSPHATE; METABOLIC FLUX; MICROBIAL PRODUCTION; MULTIPLE GENES; NATURAL PLANTS; PROTEIN FUSION; SALVIA MILTIORRHIZA; SYNTHASES; TERPENOIDS; YEAST SACCHAROMYCES CEREVISIAE;

BIOCHEMISTRY; BIOSYNTHESIS; CARBOXYLIC ACIDS; GENES; OLEFINS; PLANTS (BOTANY); YEAST;

LIPIDS;

ABIETANE DERIVATIVE; DITERPENOID; MEVALONIC ACID; MILTIRADIENE; SYNTHETASE; TANSHINONE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ISOLATION; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ANALYSIS; MOLECULAR INTERACTION; NONHUMAN; SACCHAROMYCES CEREVISIAE;

AMINO ACID SEQUENCE; DITERPENES; DNA; DNA PRIMERS; DRUG DESIGN; HUMANS; MEVALONIC ACID; MODELS, CHEMICAL; PHYTOTHERAPY; PLANT EXTRACTS; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SALVIA; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84863116515     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja2114486     Document Type: Article

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