Enhancing isoprenoid production through systematically assembling and modulating efflux pumps in Escherichia coli

Applied Microbiology and Biotechnology

Volumn 97, Issue 18, 2013, Pages 8057-8067

  Wang, Jian Feng ^a,b   Xiong, Zhi Qiang ^a   Li, Shi Yuan ^a   Wang, Yong ^a  

^a INSTITUTE OF PLANT PHYSIOLOGY AND ECOLOGY   (China)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Amorphadiene; Efflux pumps; Escherichia coli; Heterologous production; Isoprenoids; Kaurene

Indexed keywords

AMORPHADIENE; EFFLUX PUMPS; HETEROLOGOUS PRODUCTION; ISOPRENOIDS; KAURENE;

LIPIDS;

ESCHERICHIA COLI;

ACRA PROTEIN; ACRB PROTEIN; BACTERIAL PROTEIN; ESCHERICHIA COLI PROTEIN; ISOPRENOID; KAURENE DERIVATIVE; MEXA PROTEIN; MEXB PROTEIN; SESQUITERPENE; TOLC PROTEIN; UNCLASSIFIED DRUG;

BACTERIUM; ISOPRENOID; MICROBIAL ACTIVITY;

ARTICLE; BACTERIAL GENE; BACTERIAL SECRETION SYSTEM; BACTERIAL STRAIN; BIOSYNTHESIS; CELL GROWTH; CONTROLLED STUDY; ESCHERICHIA COLI; FERMENTATION; GENE DOSAGE; GENE OVEREXPRESSION; HETEROLOGOUS EXPRESSION; HYDROPHOBICITY; METABOLIC ENGINEERING; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PLEIOTROPY; PSEUDOMONAS AERUGINOSA;

ESCHERICHIA COLI; PSEUDOMONAS AERUGINOSA;

BIOLOGICAL TRANSPORT; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MEMBRANE PROTEINS; METABOLIC ENGINEERING; TERPENES;

EID: 84883553644     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-013-5062-z     Document Type: Article

References (28)

1. Ajikumar PK, Xiao WH, Tyo KE, Wang Y, Simeon F, Leonard E, Mucha O, Phon TH, Pfeifer B, Stephanopoulos G (2010) Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli. Science 330(6000):70-74
2. Aono R (1998) Improvement of organic solvent tolerance level of Escherichia coli by overexpression of stress-responsive genes. Extremophiles 2(3):239-248 (Pubitemid 28408005)
3. Asako H, Nakajima H, Kobayashi K, Kobayashi M, Aono R (1997) Organic solvent tolerance and antibiotic resistance increased by overexpression of marA in Escherichia coli. Appl Environ Microb 63(4):1428-1433 (Pubitemid 27174850)
4. Chang MCY, Eachus RA, Trieu W, Ro DK, Keasling JD (2007) Engineering Escherichia coli for production of functionalized terpenoids using plant P450s. Nat Chem Biol 3(5):274-277 (Pubitemid 46625834)
5. Deininger KNW, Horikawa A, Kitko RD, Tatsumi R, Rosner JL, Wachi M, Slonczewski JL (2011) A requirement of tolC and MDR efflux pumps for acid adaptation and GadAB induction in Escherichia coli. PLoS One 6(4):e18960
6. Dunlop M (2011) Engineering microbes for tolerance to next-generation biofuels. Biotechnol Biofuels 4(1):32
7. Dunlop MJ, Dossani ZY, Szmidt HL, Chu HC, Lee TS, Keasling JD, Hadi MZ, Mukhopadhyay A (2011) Engineering microbial biofuel tolerance and export using efflux pumps. Mol Syst Biol 7
8. Hasdemir U (2007) The role of cell wall organization and active efflux pump systems in multidrug resistance of bacteria. Mikrobiyol Bul 41(2):309-327
9. Keeney D, Ruzin A, McAleese F, Murphy E, Bradford PA (2008) MarA-mediated overexpression of the AcrAB efflux pump results in decreased susceptibility to tigecycline in Escherichia coli. J Antimicrob Chemother 61(1):46-53
10. Li XZ, Nikaido H (2009) Efflux-mediated drug resistance in bacteria: an update. Drugs 69(12):1555-1623
11. Nishino K, Senda Y, Hayashi-Nishino M, Yamaguchi A (2009) Role of the AraC-XylS family regulator YdeO in multi-drug resistance of Escherichia coli. J Antibiot 62(5):251-257
12. Ostash I, Rebets Y, Ostash B, Kobylyanskyy A, Myronovskyy M, Nakamura T, Walker S, Fedorenko V (2008) An ABC transporter encoding gene lndW confers resistance to landomycin E. Arch Microbiol 190(1):105-109
13. Papadopoulos CJ, Carson CF, Chang BJ, Riley TV (2008) Role of the MexAB-OprM efflux pump of Pseudomonas aeruginosa in tolerance to tea tree (Melaleuca alternifolia) oil and its monoterpene components terpinen-4-ol, 1,8-cineole, and alpha-terpineol. Appl Environ Microb 74(6):1932-1935 (Pubitemid 351400150)
14. Peralta-Yahya PP, Zhang F, Del Cardayre SB, Keasling JD (2012) Microbial engineering for the production of advanced biofuels. Nature 488(7411):320-328
15. Poole K (2005) Efflux-mediated antimicrobial resistance. J Antimicrob Chemother 56(1):20-51 (Pubitemid 41418335)
16. Qiu J, Zhuo Y, Zhu D, Zhou X, Zhang L, Bai L, Deng Z (2011) Overexpression of the ABC transporter AvtAB increases avermectin production in Streptomyces avermitilis. Appl Microbiol Biotechnol 92(2):337-345
17. Ro D-K, Paradise EM, Ouellet M, Fisher KJ, Newman KL, Ndungu JM, Ho KA, Eachus RA, Ham TS, Kirby J, Chang MCY, Withers ST, Shiba Y, Sarpong R, Keasling JD (2006) Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 440(7086):940-943
18. Sambrook JDWR (2001) Molecular cloning: a laboratory manual, 3rd edn. Cold Spring Harbor Laboratory, Cold Spring Harbor
19. Shah AA, Wang C, Chung YR, Kim JY, Choi ES, Kim SW (2013) Enhancement of geraniol resistance of Escherichia coli by MarA overexpression. J Biosci Bioeng 115(3):253-258
20. Sharff A, Fanutti C, Shi J, Calladine C, Luisi B (2001) The role of the TolC family in protein transport and multidrug efflux. Eur J Biochem 268(19):5011-5026 (Pubitemid 32955553)
21. Sulavik MC, Houseweart C, Cramer C, Jiwani N, Murgolo N, Greene J, DiDomenico B, Shaw KJ, Miller GH, Hare R, Shimer G (2001) Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes. Antimicrob Agents Chemother 45(4):1126-1136 (Pubitemid 32230993)
22. Tenover FC (2006) Mechanisms of antimicrobial resistance in bacteria. Am J Med 119(6, Suppl 1):S3-S10 (Pubitemid 43776140)
23. Tikhonova E, Yamada Y, Zgurskaya H (2011) Sequential mechanism of assembly of multidrug efflux pump AcrAB-TolC. Chem Biol 18(4):454-463
24. Tikhonova EB, Dastidar V, Rybenkov VV, Zgurskaya HI (2009) Kinetic control of TolC recruitment by multidrug efflux complexes. Proc Natl Acad Sci U S A 106(38):16416-16421
25. Tikhonova EB, Zgurskaya HI (2004) AcrA, AcrB, and TolC of Escherichia coli form a stable intermembrane multidrug efflux complex. J Biol Chem 279(31):32116-32124 (Pubitemid 39014658)
26. Touzé T, Eswaran J, Bokma E, Koronakis E, Hughes C, Koronakis V (2004) Interactions underlying assembly of the Escherichia coli AcrAB-TolC multidrug efflux system. Mol Microbiol 53(2):697-706 (Pubitemid 38998186)
27. Tsuruta H, Paddon CJ, Eng D, Lenihan JR, Horning T, Anthony LC, Regentin R, Keasling JD, Renninger NS, Newman JD (2009) High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli. PLoS One 4(2):e4489
28. Walsh C (2000) Molecular mechanisms that confer antibacterial drug resistance. Nature 406(6797):775-781