-
1
-
-
0020634260
-
Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters
-
Kikkawa U, Takai Y, Tanaka Y, Miyake R, Nishizuka Y. Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters. J Biol Chem 1983; 258: 11442–11445.
-
(1983)
J Biol Chem
, vol.258
, pp. 11442-11445
-
-
Kikkawa, U.1
Takai, Y.2
Tanaka, Y.3
Miyake, R.4
Nishizuka, Y.5
-
2
-
-
0003053406
-
Characterization of a specific phorbol ester aporeceptor in mouse brain cytosol
-
Leach KL, James ML, Blumberg PM. Characterization of a specific phorbol ester aporeceptor in mouse brain cytosol. Proc Natl Acad Sci USA 1983; 80: 4208–4212.
-
(1983)
Proc Natl Acad Sci USA
, vol.80
, pp. 4208-4212
-
-
Leach, K.L.1
James, M.L.2
Blumberg, P.M.3
-
3
-
-
33947603008
-
Protein kinase C and other diacylglycerol effectors in cancer
-
Griner EM, Kazanietz MG. Protein kinase C and other diacylglycerol effectors in cancer. Nat Rev Cancer 2007; 7: 281–294.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 281-294
-
-
Griner, E.M.1
Kazanietz, M.G.2
-
4
-
-
34548787911
-
Protein kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer
-
Aziz MH, Manoharan HT, Church DR, Dreckschmidt NE, Zhong W, Oberley TD et al. Protein kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer. Cancer Res 2007; 67: 8828–8838.
-
(2007)
Cancer Res
, vol.67
, pp. 8828-8838
-
-
Aziz, M.H.1
Manoharan, H.T.2
Church, D.R.3
Dreckschmidt, N.E.4
Zhong, W.5
Oberley, T.D.6
-
5
-
-
34447119557
-
Protein kinase C epsilon is overexpressed in primary human non-small cell lung cancers and functionally required for proliferation of non-small cell lung cancer cells in a p21/Cip1-dependent manner
-
Bae KM, Wang H, Jiang G, Chen MG, Lu L, Xiao L. Protein kinase C epsilon is overexpressed in primary human non-small cell lung cancers and functionally required for proliferation of non-small cell lung cancer cells in a p21/Cip1-dependent manner. Cancer Res 2007; 67: 6053–6063.
-
(2007)
Cancer Res
, vol.67
, pp. 6053-6063
-
-
Bae, K.M.1
Wang, H.2
Jiang, G.3
Chen, M.G.4
Lu, L.5
Xiao, L.6
-
6
-
-
79551571444
-
Transgenic overexpression of PKCepsilon in the mouse prostate induces preneoplastic lesions
-
Benavides F, Blando J, Perez CJ, Garg R, Conti CJ, DiGiovanni J et al. Transgenic overexpression of PKCepsilon in the mouse prostate induces preneoplastic lesions. Cell Cycle 2011; 10: 268–277.
-
(2011)
Cell Cycle
, vol.10
, pp. 268-277
-
-
Benavides, F.1
Blando, J.2
Perez, C.J.3
Garg, R.4
Conti, C.J.5
Digiovanni, J.6
-
7
-
-
24944563309
-
Protein kinase C epsilon is a predictive biomarker of aggressive breast cancer and a validated target for RNA interference anticancer therapy
-
Pan Q, Bao LW, Kleer CG, Sabel MS, Griffith KA, Teknos TN et al. Protein kinase C epsilon is a predictive biomarker of aggressive breast cancer and a validated target for RNA interference anticancer therapy. Cancer Res 2005; 65: 8366–8371.
-
(2005)
Cancer Res
, vol.65
, pp. 8366-8371
-
-
Pan, Q.1
Bao, L.W.2
Kleer, C.G.3
Sabel, M.S.4
Griffith, K.A.5
Teknos, T.N.6
-
8
-
-
84877734323
-
Protein kinase C pharmacology: Refining the toolbox
-
Wu-Zhang AX, Newton AC. Protein kinase C pharmacology: refining the toolbox. Biochem J 2013; 452: 195–209.
-
(2013)
Biochem J
, vol.452
, pp. 195-209
-
-
Wu-Zhang, A.X.1
Newton, A.C.2
-
9
-
-
4644368371
-
Genetically encoded FRET probe for PKC activity based on pleckstrin
-
Schleifenbaum A, Stier G, Gasch A, Sattler M, Schultz C. Genetically encoded FRET probe for PKC activity based on pleckstrin. J Am Chem Soc 2004; 126: 11786–11787.
-
(2004)
J am Chem Soc
, vol.126
, pp. 11786-11787
-
-
Schleifenbaum, A.1
Stier, G.2
Gasch, A.3
Sattler, M.4
Schultz, C.5
-
10
-
-
1542298996
-
Biosensors of protein kinase action: From in vitro assays to living cells
-
Chen CA, Yeh RH, Yan X, Lawrence DS. Biosensors of protein kinase action: from in vitro assays to living cells. Biochim Biophys Acta 2004; 1697: 39–51.
-
(2004)
Biochim Biophys Acta
, vol.1697
, pp. 39-51
-
-
Chen, C.A.1
Yeh, R.H.2
Yan, X.3
Lawrence, D.S.4
-
11
-
-
33750072605
-
Targeting protein kinase C activity reporter to discrete intracellular regions reveals spatiotemporal differences in agonist-dependent signaling
-
Gallegos LL, Kunkel MT, Newton AC. Targeting protein kinase C activity reporter to discrete intracellular regions reveals spatiotemporal differences in agonist-dependent signaling. J Biol Chem 2006; 281: 30947–30956.
-
(2006)
J Biol Chem
, vol.281
, pp. 30947-30956
-
-
Gallegos, L.L.1
Kunkel, M.T.2
Newton, A.C.3
-
12
-
-
80054746900
-
Genetically encoded fluorescent reporters to visualize protein kinase C activation in live cells
-
Gallegos LL, Newton AC. Genetically encoded fluorescent reporters to visualize protein kinase C activation in live cells. Methods Mol Biol 2011; 756: 295–310.
-
(2011)
Methods Mol Biol
, vol.756
, pp. 295-310
-
-
Gallegos, L.L.1
Newton, A.C.2
-
13
-
-
0037110732
-
Nuclear import of PKCdelta is required for apoptosis: Identification of a novel nuclear import sequence
-
DeVries TA, Neville MC, Reyland ME. Nuclear import of PKCdelta is required for apoptosis: identification of a novel nuclear import sequence. Embo J 2002; 21: 6050–6060.
-
(2002)
Embo J
, vol.21
, pp. 6050-6060
-
-
Devries, T.A.1
Neville, M.C.2
Reyland, M.E.3
-
14
-
-
77950872183
-
P23/Tmp21 differentially targets the Rac-GAP beta2-chimaerin and protein kinase C via their C1 domains
-
Wang H, Kazanietz MG. p23/Tmp21 differentially targets the Rac-GAP beta2-chimaerin and protein kinase C via their C1 domains. Mol Biol Cell 2010; 21: 1398–1408.
-
(2010)
Mol Biol Cell
, vol.21
, pp. 1398-1408
-
-
Wang, H.1
Kazanietz, M.G.2
-
15
-
-
0034057863
-
Protein kinase C binding partners
-
Jaken S, Parker PJ. Protein kinase C binding partners. Bioessays 2000; 22: 245–254.
-
(2000)
Bioessays
, vol.22
, pp. 245-254
-
-
Jaken, S.1
Parker, P.J.2
-
16
-
-
79955534014
-
P23/Tmp21 associates with protein kinase Cdelta (PKCdelta) and modulates its apoptotic function
-
Wang H, Xiao L, Kazanietz MG. p23/Tmp21 associates with protein kinase Cdelta (PKCdelta) and modulates its apoptotic function. J Biol Chem 2011; 286: 15821–15831.
-
(2011)
J Biol Chem
, vol.286
, pp. 15821-15831
-
-
Wang, H.1
Xiao, L.2
Kazanietz, M.G.3
-
17
-
-
83955165865
-
Synthesis by precipitation polymerization of molecularly imprinted polymer for the selective extraction of diclofenac from water samples
-
Dai CM, Zhou XF, Zhang YL, Liu SG, Zhang J. Synthesis by precipitation polymerization of molecularly imprinted polymer for the selective extraction of diclofenac from water samples. J Hazard Mater 2011; 198: 175–181.
-
(2011)
J Hazard Mater
, vol.198
, pp. 175-181
-
-
Dai, C.M.1
Zhou, X.F.2
Zhang, Y.L.3
Liu, S.G.4
Zhang, J.5
-
18
-
-
47049109143
-
PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival
-
Cameron AJ, Procyk KJ, Leitges M, Parker PJ. PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival. Int J Cancer 2008; 123: 769–779.
-
(2008)
Int J Cancer
, vol.123
, pp. 769-779
-
-
Cameron, A.J.1
Procyk, K.J.2
Leitges, M.3
Parker, P.J.4
-
19
-
-
70350728812
-
Protein kinase C alpha-dependent signaling mediates endometrial cancer cell growth and tumorigenesis
-
Haughian JM, Reno EM, Thorne AM, Bradford AP. Protein kinase C alpha-dependent signaling mediates endometrial cancer cell growth and tumorigenesis. Int J Cancer 2009; 125: 2556–2564.
-
(2009)
Int J Cancer
, vol.125
, pp. 2556-2564
-
-
Haughian, J.M.1
Reno, E.M.2
Thorne, A.M.3
Bradford, A.P.4
-
20
-
-
0242406701
-
Cell growth inhibition by all-trans retinoic acid in SKBR-3 breast cancer cells: Involvement of protein kinase Calpha and extracellular signal-regulated kinase mitogen-activated protein kinase
-
Nakagawa S, Fujii T, Yokoyama G, Kazanietz MG, Yamana H, Shirouzu K. Cell growth inhibition by all-trans retinoic acid in SKBR-3 breast cancer cells: involvement of protein kinase Calpha and extracellular signal-regulated kinase mitogen-activated protein kinase. Mol Carcinog 2003; 38: 106–116.
-
(2003)
Mol Carcinog
, vol.38
, pp. 106-116
-
-
Nakagawa, S.1
Fujii, T.2
Yokoyama, G.3
Kazanietz, M.G.4
Yamana, H.5
Shirouzu, K.6
-
21
-
-
20444476856
-
Role of protein kinase C-alpha in superficial bladder carcinoma recurrence
-
Kong C, Zhu Y, Liu D, Yu M, Li S, Li Z et al. Role of protein kinase C-alpha in superficial bladder carcinoma recurrence. Urology 2005; 65: 1228–1232.
-
(2005)
Urology
, vol.65
, pp. 1228-1232
-
-
Kong, C.1
Zhu, Y.2
Liu, D.3
Yu, M.4
Li, S.5
Li, Z.6
-
22
-
-
1442326130
-
Resveratrol antagonizes EGFR-dependent Erk1/2 activation in human androgen-independent prostate cancer cells with associated isozyme-selective PKC alpha inhibition
-
Stewart JR, O’Brian CA. Resveratrol antagonizes EGFR-dependent Erk1/2 activation in human androgen-independent prostate cancer cells with associated isozyme-selective PKC alpha inhibition. Invest New Drugs 2004; 22: 107–117.
-
(2004)
Invest New Drugs
, vol.22
, pp. 107-117
-
-
Stewart, J.R.1
O’Brian, C.A.2
-
23
-
-
0031938826
-
Down-regulation of protein kinase C-alpha detected in human colorectal cancer
-
Suga K, Sugimoto I, Ito H, Hashimoto E. Down-regulation of protein kinase C-alpha detected in human colorectal cancer. Biochem Mol Biol Int 1998; 44: 523–528.
-
(1998)
Biochem Mol Biol Int
, vol.44
, pp. 523-528
-
-
Suga, K.1
Sugimoto, I.2
Ito, H.3
Hashimoto, E.4
-
24
-
-
84860238688
-
MicroRNA 15a, inversely correlated to PKCalpha, is a potential marker to differentiate between benign and malignant renal tumors in biopsy and urine samples
-
von Brandenstein M, Pandarakalam JJ, Kroon L, Loeser H, Herden J, Braun G et al. MicroRNA 15a, inversely correlated to PKCalpha, is a potential marker to differentiate between benign and malignant renal tumors in biopsy and urine samples. Am J Pathol 2012; 180: 1787–1797.
-
(2012)
Am J Pathol
, vol.180
, pp. 1787-1797
-
-
von Brandenstein, M.1
Pandarakalam, J.J.2
Kroon, L.3
Loeser, H.4
Herden, J.5
Braun, G.6
-
25
-
-
0029064245
-
Protein kinase C isoform alpha overexpression in C6 glioma cells and its role in cell proliferation
-
Baltuch GH, Dooley NP, Rostworowski KM, Villemure JG, Yong VW. Protein kinase C isoform alpha overexpression in C6 glioma cells and its role in cell proliferation. J Neurooncol 1995; 24: 241–250.
-
(1995)
J Neurooncol
, vol.24
, pp. 241-250
-
-
Baltuch, G.H.1
Dooley, N.P.2
Rostworowski, K.M.3
Villemure, J.G.4
Yong, V.W.5
-
26
-
-
0035354188
-
Protein kinase Calpha and protein kinase Cdelta play opposite roles in the proliferation and apoptosis of glioma cells
-
Mandil R, Ashkenazi E, Blass M, Kronfeld I, Kazimirsky G, Rosenthal G et al. Protein kinase Calpha and protein kinase Cdelta play opposite roles in the proliferation and apoptosis of glioma cells. Cancer Res 2001; 61: 4612–4619.
-
(2001)
Cancer Res
, vol.61
, pp. 4612-4619
-
-
Mandil, R.1
Ashkenazi, E.2
Blass, M.3
Kronfeld, I.4
Kazimirsky, G.5
Rosenthal, G.6
-
27
-
-
0032520787
-
Differential induction of cell death in human glioma cell lines by sodium nitroprusside
-
Blackburn RV, Galoforo SS, Berns CM, Motwani NM, Corry PM, Lee YJ. Differential induction of cell death in human glioma cell lines by sodium nitroprusside. Cancer 1998; 82: 1137–1145.
-
(1998)
Cancer
, vol.82
, pp. 1137-1145
-
-
Blackburn, R.V.1
Galoforo, S.S.2
Berns, C.M.3
Motwani, N.M.4
Corry, P.M.5
Lee, Y.J.6
-
28
-
-
77956255433
-
PKC alpha phosphorylates cytosolic NF-kappaB/p65 and PKC delta delays nuclear translocation of NF-kappaB/p65 in U1242 glioblastoma cells
-
Mut M, Amos S, Hussaini IM. PKC alpha phosphorylates cytosolic NF-kappaB/p65 and PKC delta delays nuclear translocation of NF-kappaB/p65 in U1242 glioblastoma cells. Turk Neurosurg 2010; 20: 277–285.
-
(2010)
Turk Neurosurg
, vol.20
, pp. 277-285
-
-
Mut, M.1
Amos, S.2
Hussaini, I.M.3
-
29
-
-
33645453677
-
Phase III study of gemcitabine and cisplatin with or without aprinocarsen, a protein kinase C-alpha antisense oligonucleotide, in patients with advanced-stage non-small-cell lung cancer
-
Paz-Ares L, Douillard JY, Koralewski P, Manegold C, Smit EF, Reyes JM et al. Phase III study of gemcitabine and cisplatin with or without aprinocarsen, a protein kinase C-alpha antisense oligonucleotide, in patients with advanced-stage non-small-cell lung cancer. J Clin Oncol 2006; 24: 1428–1434.
-
(2006)
J Clin Oncol
, vol.24
, pp. 1428-1434
-
-
Paz-Ares, L.1
Douillard, J.Y.2
Koralewski, P.3
Manegold, C.4
Smit, E.F.5
Reyes, J.M.6
-
30
-
-
9144226837
-
A Phase II trial of aprinocarsen, an antisense oligonucleotide inhibitor of protein kinase C alpha, administered as a 21-day infusion to patients with advanced ovarian carcinoma
-
Advani R, Peethambaram P, Lum BL, Fisher GA, Hartmann L, Long HJ et al. A Phase II trial of aprinocarsen, an antisense oligonucleotide inhibitor of protein kinase C alpha, administered as a 21-day infusion to patients with advanced ovarian carcinoma. Cancer 2004; 100: 321–326.
-
(2004)
Cancer
, vol.100
, pp. 321-326
-
-
Advani, R.1
Peethambaram, P.2
Lum, B.L.3
Fisher, G.A.4
Hartmann, L.5
Long, H.J.6
-
31
-
-
14644438523
-
Efficacy and toxicity of the antisense oligonucleotide aprinocarsen directed against protein kinase C-alpha delivered as a 21-day continuous intravenous infusion in patients with recurrent high-grade astrocytomas
-
Grossman SA, Alavi JB, Supko JG, Carson KA, Priet R, Dorr FA et al. Efficacy and toxicity of the antisense oligonucleotide aprinocarsen directed against protein kinase C-alpha delivered as a 21-day continuous intravenous infusion in patients with recurrent high-grade astrocytomas. Neuro Oncol 2005; 7: 32–40.
-
(2005)
Neuro Oncol
, vol.7
, pp. 32-40
-
-
Grossman, S.A.1
Alavi, J.B.2
Supko, J.G.3
Carson, K.A.4
Priet, R.5
Dorr, F.A.6
-
32
-
-
0028306807
-
Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue
-
Seynaeve CM, Kazanietz MG, Blumberg PM, Sausville EA, Worland PJ. Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue. Mol Pharmacol 1994; 45: 1207–1214.
-
(1994)
Mol Pharmacol
, vol.45
, pp. 1207-1214
-
-
Seynaeve, C.M.1
Kazanietz, M.G.2
Blumberg, P.M.3
Sausville, E.A.4
Worland, P.J.5
-
33
-
-
2442651763
-
UCN-01-induced cell cycle arrest requires the transcriptional induction of p21(Waf1/cip1) by activation of mitogen-activated protein/extracellular signal-regulated kinase kinase/extra-cellular signal-regulated kinase pathway
-
Facchinetti MM, De Siervi A, Toskos D, Senderowicz AM. UCN-01-induced cell cycle arrest requires the transcriptional induction of p21(waf1/cip1) by activation of mitogen-activated protein/extracellular signal-regulated kinase kinase/extra-cellular signal-regulated kinase pathway. Cancer Res 2004; 64: 3629–3637.
-
(2004)
Cancer Res
, vol.64
, pp. 3629-3637
-
-
Facchinetti, M.M.1
de Siervi, A.2
Toskos, D.3
Senderowicz, A.M.4
-
34
-
-
0028903545
-
MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype
-
Ways DK, Kukoly CA, deVente J, Hooker JL, Bryant WO, Posekany KJ et al. MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype. J Clin Invest 1995; 95: 1906–1915.
-
(1995)
J Clin Invest
, vol.95
, pp. 1906-1915
-
-
Ways, D.K.1
Kukoly, C.A.2
Devente, J.3
Hooker, J.L.4
Bryant, W.O.5
Posekany, K.J.6
-
35
-
-
0033821711
-
Stable transfection of protein kinase C alpha cDNA in hormone-dependent breast cancer cell lines
-
Tonetti DA, Chisamore MJ, Grdina W, Schurz H, Jordan VC. Stable transfection of protein kinase C alpha cDNA in hormone-dependent breast cancer cell lines. Br J Cancer 2000; 83: 782–791.
-
(2000)
Br J Cancer
, vol.83
, pp. 782-791
-
-
Tonetti, D.A.1
Chisamore, M.J.2
Grdina, W.3
Schurz, H.4
Jordan, V.C.5
-
36
-
-
0034792172
-
Novel antitumor effect of estradiol in athymic mice injected with a T47D breast cancer cell line overexpressing protein kinase Calpha
-
Chisamore MJ, Ahmed Y, Bentrem DJ, Jordan VC, Tonetti DA. Novel antitumor effect of estradiol in athymic mice injected with a T47D breast cancer cell line overexpressing protein kinase Calpha. Clin Cancer Res 2001; 7: 3156–3165.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 3156-3165
-
-
Chisamore, M.J.1
Ahmed, Y.2
Bentrem, D.J.3
Jordan, V.C.4
Tonetti, D.A.5
-
37
-
-
84881405994
-
Crosstalk between PKCalpha and Notch-4 in endocrine-resistant breast cancer cells
-
Yun J, Pannuti A, Espinoza I, Zhu H, Hicks C, Zhu X et al. Crosstalk between PKCalpha and Notch-4 in endocrine-resistant breast cancer cells. Oncogenesis 2013; 2: e60.
-
(2013)
Oncogenesis
, vol.2
, pp. 60
-
-
Yun, J.1
Pannuti, A.2
Espinoza, I.3
Zhu, H.4
Hicks, C.5
Zhu, X.6
-
38
-
-
36048969501
-
Protein kinase C isoform expression as a predictor of disease outcome on endocrine therapy in breast cancer
-
Assender JW, Gee JM, Lewis I, Ellis IO, Robertson JF, Nicholson RI. Protein kinase C isoform expression as a predictor of disease outcome on endocrine therapy in breast cancer. J Clin Pathol 2007; 60: 1216–1221.
-
(2007)
J Clin Pathol
, vol.60
, pp. 1216-1221
-
-
Assender, J.W.1
Gee, J.M.2
Lewis, I.3
Ellis, I.O.4
Robertson, J.F.5
Nicholson, R.I.6
-
39
-
-
0038146847
-
Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure
-
Tonetti DA, Morrow M, Kidwai N, Gupta A, Badve S. Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure. Br J Cancer 2003; 88: 1400–1402.
-
(2003)
Br J Cancer
, vol.88
, pp. 1400-1402
-
-
Tonetti, D.A.1
Morrow, M.2
Kidwai, N.3
Gupta, A.4
Badve, S.5
-
40
-
-
77953479806
-
PKCalpha expression is a marker for breast cancer aggressiveness
-
Lonne GK, Cornmark L, Zahirovic IO, Landberg G, Jirstrom K, Larsson C. PKCalpha expression is a marker for breast cancer aggressiveness. Mol Cancer 2010; 9: 76.
-
(2010)
Mol Cancer
, vol.9
, pp. 76
-
-
Lonne, G.K.1
Cornmark, L.2
Zahirovic, I.O.3
Landberg, G.4
Jirstrom, K.5
Larsson, C.6
-
41
-
-
33744936606
-
Upregulation and activation of PKC alpha by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKC alpha and Src inhibitors
-
Tan M, Li P, Sun M, Yin G, Yu D. Upregulation and activation of PKC alpha by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKC alpha and Src inhibitors. Oncogene 2006; 25: 3286–3295.
-
(2006)
Oncogene
, vol.25
, pp. 3286-3295
-
-
Tan, M.1
Li, P.2
Sun, M.3
Yin, G.4
Yu, D.5
-
42
-
-
0027157640
-
Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976
-
Martiny-Baron G, Kazanietz MG, Mischak H, Blumberg PM, Kochs G, Hug H et al. Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976. J Biol Chem 1993; 268: 9194–9197.
-
(1993)
J Biol Chem
, vol.268
, pp. 9194-9197
-
-
Martiny-Baron, G.1
Kazanietz, M.G.2
Mischak, H.3
Blumberg, P.M.4
Kochs, G.5
Hug, H.6
-
43
-
-
0027959058
-
12(S)-HETE enhancement of prostate tumor cell invasion: Selective role of PKC alpha
-
Liu B, Maher RJ, Hannun YA, Porter AT, Honn KV. 12(S)-HETE enhancement of prostate tumor cell invasion: selective role of PKC alpha. J Natl Cancer Inst 1994; 86: 1145–1151.
-
(1994)
J Natl Cancer Inst
, vol.86
, pp. 1145-1151
-
-
Liu, B.1
Maher, R.J.2
Hannun, Y.A.3
Porter, A.T.4
Honn, K.V.5
-
44
-
-
84864619584
-
PKCalpha and ERbeta are associated with triple-negative breast cancers in African American and Caucasian patients
-
Tonetti DA, Gao W, Escarzaga D, Walters K, Szafran A, Coon JS. PKCalpha and ERbeta are associated with triple-negative breast cancers in African American and Caucasian patients. Int J Breast Cancer 2012; 2012: 740353.
-
(2012)
Int J Breast Cancer
, vol.2012
-
-
Tonetti, D.A.1
Gao, W.2
Escarzaga, D.3
Walters, K.4
Szafran, A.5
Coon, J.S.6
-
45
-
-
84883621632
-
Protein Kinase C alpha Is a central signaling node and therapeutic target for breast cancer stem cells
-
Tam WL, Lu H, Buikhuisen J, Soh BS, Lim E, Reinhardt F et al. Protein Kinase C alpha Is a central signaling node and therapeutic target for breast cancer stem cells. Cancer Cell 2013; 24: 347–364.
-
(2013)
Cancer Cell
, vol.24
, pp. 347-364
-
-
Tam, W.L.1
Lu, H.2
Buikhuisen, J.3
Soh, B.S.4
Lim, E.5
Reinhardt, F.6
-
46
-
-
41949140742
-
S-Phase-specific activation of PKC alpha induces senescence in non-small cell lung cancer cells
-
Oliva JL, Caino MC, Senderowicz AM, Kazanietz MG. S-Phase-specific activation of PKC alpha induces senescence in non-small cell lung cancer cells. J Biol Chem 2008; 283: 5466–5476.
-
(2008)
J Biol Chem
, vol.283
, pp. 5466-5476
-
-
Oliva, J.L.1
Caino, M.C.2
Senderowicz, A.M.3
Kazanietz, M.G.4
-
47
-
-
33744963882
-
Protein kinase C alpha signaling inhibits cyclin D1 translation in intestinal epithelial cells
-
Hizli AA, Black AR, Pysz MA, Black JD. Protein kinase C alpha signaling inhibits cyclin D1 translation in intestinal epithelial cells. J Biol Chem 2006; 281: 14596–14603.
-
(2006)
J Biol Chem
, vol.281
, pp. 14596-14603
-
-
Hizli, A.A.1
Black, A.R.2
Pysz, M.A.3
Black, J.D.4
-
48
-
-
0034645064
-
Protein kinase C signaling mediates a program of cell cycle withdrawal in the intestinal epithelium
-
Frey MR, Clark JA, Leontieva O, Uronis JM, Black AR, Black JD. Protein kinase C signaling mediates a program of cell cycle withdrawal in the intestinal epithelium. J Cell Biol 2000; 151: 763–778.
-
(2000)
J Cell Biol
, vol.151
, pp. 763-778
-
-
Frey, M.R.1
Clark, J.A.2
Leontieva, O.3
Uronis, J.M.4
Black, A.R.5
Black, J.D.6
-
49
-
-
34250635347
-
Protein kinase C-mediated down-regulation of cyclin D1 involves activation of the translational repressor 4E-BP1 via a phosphoinositide 3-kinase/Akt-independent, protein phosphatase 2A-dependent mechanism in intestinal epithelial cells
-
Guan L, Song K, Pysz MA, Curry KJ, Hizli AA, Danielpour D et al. Protein kinase C-mediated down-regulation of cyclin D1 involves activation of the translational repressor 4E-BP1 via a phosphoinositide 3-kinase/Akt-independent, protein phosphatase 2A-dependent mechanism in intestinal epithelial cells. J Biol Chem 2007; 282: 14213–14225.
-
(2007)
J Biol Chem
, vol.282
, pp. 14213-14225
-
-
Guan, L.1
Song, K.2
Pysz, M.A.3
Curry, K.J.4
Hizli, A.A.5
Danielpour, D.6
-
50
-
-
72949112245
-
Stimulation of protein kinase C-alpha suppresses colon cancer cell proliferation by down-regulation of beta-catenin
-
Gwak J, Jung SJ, Kang DI, Kim EY, Kim DE, Chung YH et al. Stimulation of protein kinase C-alpha suppresses colon cancer cell proliferation by down-regulation of beta-catenin. J Cell Mol Med 2009; 13: 2171–2180.
-
(2009)
J Cell Mol Med
, vol.13
, pp. 2171-2180
-
-
Gwak, J.1
Jung, S.J.2
Kang, D.I.3
Kim, E.Y.4
Kim, D.E.5
Chung, Y.H.6
-
51
-
-
74749106487
-
RORalpha attenuates Wnt/beta-catenin signaling by PKCalpha-dependent phosphorylation in colon cancer
-
Lee JM, Kim IS, Kim H, Lee JS, Kim K, Yim HY et al. RORalpha attenuates Wnt/beta-catenin signaling by PKCalpha-dependent phosphorylation in colon cancer. Mol Cell 2010; 37: 183–195.
-
(2010)
Mol Cell
, vol.37
, pp. 183-195
-
-
Lee, J.M.1
Kim, I.S.2
Kim, H.3
Lee, J.S.4
Kim, K.5
Yim, H.Y.6
-
52
-
-
84867153804
-
Small molecule-based promotion of PKCalpha-mediated beta-catenin degradation suppresses the proliferation of CRT-positive cancer cells
-
Gwak J, Lee JH, Chung YH, Song GY, Oh S. Small molecule-based promotion of PKCalpha-mediated beta-catenin degradation suppresses the proliferation of CRT-positive cancer cells. PLoS One 2012; 7: e46697.
-
(2012)
Plos One
, vol.7
-
-
Gwak, J.1
Lee, J.H.2
Chung, Y.H.3
Song, G.Y.4
Oh, S.5
-
53
-
-
69449093075
-
Anew mechanism of SOX9 action to regulate PKCalpha expression in the intestine epithelium
-
Dupasquier S, Abdel-Samad R, Glazer RI, Bastide P, Jay P, Joubert D et al. Anew mechanism of SOX9 action to regulate PKCalpha expression in the intestine epithelium. J Cell Sci 2009; 122: 2191–2196.
-
(2009)
J Cell Sci
, vol.122
, pp. 2191-2196
-
-
Dupasquier, S.1
Abdel-Samad, R.2
Glazer, R.I.3
Bastide, P.4
Jay, P.5
Joubert, D.6
-
54
-
-
33746909044
-
Protein kinase C alpha but not PKCzeta suppresses intestinal tumor formation in ApcMin/ þ mice
-
Oster H, Leitges M. Protein kinase C alpha but not PKCzeta suppresses intestinal tumor formation in ApcMin/ þ mice. Cancer Res 2006; 66: 6955–6963.
-
(2006)
Cancer Res
, vol.66
, pp. 6955-6963
-
-
Oster, H.1
Leitges, M.2
-
55
-
-
64049104386
-
PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1
-
Pysz MA, Leontieva OV, Bateman NW, Uronis JM, Curry KJ, Threadgill DW et al. PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1. Exp Cell Res 2009; 315: 1415–1428.
-
(2009)
Exp Cell Res
, vol.315
, pp. 1415-1428
-
-
Pysz, M.A.1
Leontieva, O.V.2
Bateman, N.W.3
Uronis, J.M.4
Curry, K.J.5
Threadgill, D.W.6
-
56
-
-
84865688957
-
PKCalpha suppresses 7,12-dimethylbenz[a]anthracene-induced skin tumor formation
-
Hara T, Matsumura S, Hakuno F, Takahashi S, Chida K. PKCalpha suppresses 7,12-dimethylbenz[a]anthracene-induced skin tumor formation. Anticancer Res 2012; 32: 3097–3101.
-
(2012)
Anticancer Res
, vol.32
, pp. 3097-3101
-
-
Hara, T.1
Matsumura, S.2
Hakuno, F.3
Takahashi, S.4
Chida, K.5
-
57
-
-
0141594871
-
Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway
-
Tanaka Y, Gavrielides MV, Mitsuuchi Y, Fujii T, Kazanietz MG. Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway. J Biol Chem 2003; 278: 33753–33762.
-
(2003)
J Biol Chem
, vol.278
, pp. 33753-33762
-
-
Tanaka, Y.1
Gavrielides, M.V.2
Mitsuuchi, Y.3
Fujii, T.4
Kazanietz, M.G.5
-
58
-
-
18544378008
-
Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha
-
Garcia-Bermejo ML, Leskow FC, Fujii T, Wang Q, Blumberg PM, Ohba M et al. Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha. J Biol Chem 2002; 277: 645–655.
-
(2002)
J Biol Chem
, vol.277
, pp. 645-655
-
-
Garcia-Bermejo, M.L.1
Leskow, F.C.2
Fujii, T.3
Wang, Q.4
Blumberg, P.M.5
Ohba, M.6
-
59
-
-
66149158200
-
PKCalpha activation downregulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo
-
Truman JP, Rotenberg SA, Kang JH, Lerman G, Fuks Z, Kolesnick R et al. PKCalpha activation downregulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo. Cancer Biol Ther 2009; 8: 54–63.
-
(2009)
Cancer Biol Ther
, vol.8
, pp. 54-63
-
-
Truman, J.P.1
Rotenberg, S.A.2
Kang, J.H.3
Lerman, G.4
Fuks, Z.5
Kolesnick, R.6
-
60
-
-
84899408283
-
Protein kinase Cα suppresses Kras-mediated lung tumor formation through activation of a p38 MAPK-TGFβ signaling axis
-
Hill KS, Erdogan E, Khoor A, Walsh MP, Leitges M, Murray NR et al. Protein kinase Cα suppresses Kras-mediated lung tumor formation through activation of a p38 MAPK-TGFβ signaling axis. Oncogene 2013; 33: 2134–2144.
-
(2013)
Oncogene
, vol.33
, pp. 2134-2144
-
-
Hill, K.S.1
Erdogan, E.2
Khoor, A.3
Walsh, M.P.4
Leitges, M.5
Murray, N.R.6
-
61
-
-
78650161078
-
Rb-dependent cellular senescence, multinucleation and susceptibility to oncogenic transformation through PKC scaffolding by SSeCKS/AKAP12
-
Akakura S, Nochajski P, Gao L, Sotomayor P, Matsui S, Gelman IH. Rb-dependent cellular senescence, multinucleation and susceptibility to oncogenic transformation through PKC scaffolding by SSeCKS/AKAP12. Cell Cycle 2010; 9: 4656–4665.
-
(2010)
Cell Cycle
, vol.9
, pp. 4656-4665
-
-
Akakura, S.1
Nochajski, P.2
Gao, L.3
Sotomayor, P.4
Matsui, S.5
Gelman, I.H.6
-
62
-
-
79955977887
-
Protein kinase Calpha signaling regulates inhibitor of DNA binding 1 in the intestinal epithelium
-
Hao F, Pysz MA, Curry KJ, Haas KN, Seedhouse SJ, Black AR et al. Protein kinase Calpha signaling regulates inhibitor of DNA binding 1 in the intestinal epithelium. J Biol Chem 2011; 286: 18104–18117.
-
(2011)
J Biol Chem
, vol.286
, pp. 18104-18117
-
-
Hao, F.1
Pysz, M.A.2
Curry, K.J.3
Haas, K.N.4
Seedhouse, S.J.5
Black, A.R.6
-
63
-
-
77952186587
-
Polyphenol-rich extracts from Solanum nigrum attenuated PKC alpha-mediated migration and invasion of hepatocellular carcinoma cells
-
Yang MY, Hsu LS, Peng CH, Shi YS, Wu CH, Wang CJ. Polyphenol-rich extracts from Solanum nigrum attenuated PKC alpha-mediated migration and invasion of hepatocellular carcinoma cells. J Agric Food Chem 2010; 58: 5806–5814.
-
(2010)
J Agric Food Chem
, vol.58
, pp. 5806-5814
-
-
Yang, M.Y.1
Hsu, L.S.2
Peng, C.H.3
Shi, Y.S.4
Wu, C.H.5
Wang, C.J.6
-
64
-
-
39749123870
-
Protein kinase C alpha-CARMA3 signaling axis links Ras to NF-kappa B for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells
-
Mahanivong C, Chen HM, Yee SW, Pan ZK, Dong Z, Huang S. Protein kinase C alpha-CARMA3 signaling axis links Ras to NF-kappa B for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells. Oncogene 2008; 27: 1273–1280.
-
(2008)
Oncogene
, vol.27
, pp. 1273-1280
-
-
Mahanivong, C.1
Chen, H.M.2
Yee, S.W.3
Pan, Z.K.4
Dong, Z.5
Huang, S.6
-
65
-
-
77956501267
-
12-O-tetra-decanoylphorbol-13-acetate-induced invasion/migration of glioblastoma cells through activating PKCalpha/ERK/NF-kappaB-dependent MMP-9 expression
-
Lin CW, Shen SC, Chien CC, Yang LY, Shia LT, Chen YC. 12-O-tetra-decanoylphorbol-13-acetate-induced invasion/migration of glioblastoma cells through activating PKCalpha/ERK/NF-kappaB-dependent MMP-9 expression. J Cell Physiol 2010; 225: 472–481.
-
(2010)
J Cell Physiol
, vol.225
, pp. 472-481
-
-
Lin, C.W.1
Shen, S.C.2
Chien, C.C.3
Yang, L.Y.4
Shia, L.T.5
Chen, Y.C.6
-
66
-
-
84876188680
-
Suppression of 12-O-tetra-decanoylphorbol-13-acetate-induced MCF-7 breast adenocarcinoma cells invasion/migration by alpha-tomatine through activating PKCalpha/ERK/ NF-kappaB-dependent MMP-2/MMP-9 expressions
-
Shi MD, Shih YW, Lee YS, Cheng YF, Tsai LY. Suppression of 12-O-tetra-decanoylphorbol-13-acetate-induced MCF-7 breast adenocarcinoma cells invasion/migration by alpha-tomatine through activating PKCalpha/ERK/ NF-kappaB-dependent MMP-2/MMP-9 expressions. Cell Biochem Biophys 2013; 66: 161–174.
-
(2013)
Cell Biochem Biophys
, vol.66
, pp. 161-174
-
-
Shi, M.D.1
Shih, Y.W.2
Lee, Y.S.3
Cheng, Y.F.4
Tsai, L.Y.5
-
67
-
-
77952241390
-
RNAi-mediated knockdown of protein kinase C-alpha inhibits cell migration in MM-RU human metastatic melanoma cell line
-
Byers HR, Boissel SJ, Tu C, Park HY. RNAi-mediated knockdown of protein kinase C-alpha inhibits cell migration in MM-RU human metastatic melanoma cell line. Melanoma Res 2010; 20: 171–178.
-
(2010)
Melanoma Res
, vol.20
, pp. 171-178
-
-
Byers, H.R.1
Boissel, S.J.2
Tu, C.3
Park, H.Y.4
-
68
-
-
38149132242
-
Reduction of PKC alpha decreases cell proliferation, migration, and invasion of human malignant hepatocellular carcinoma
-
Wu TT, Hsieh YH, Hsieh YS, Liu JY. Reduction of PKC alpha decreases cell proliferation, migration, and invasion of human malignant hepatocellular carcinoma. J Cell Biochem 2008; 103: 9–20.
-
(2008)
J Cell Biochem
, vol.103
, pp. 9-20
-
-
Wu, T.T.1
Hsieh, Y.H.2
Hsieh, Y.S.3
Liu, J.Y.4
-
69
-
-
84862802000
-
Berberine suppresses the TPA-induced MMP-1 and MMP-9 expressions through the inhibition of PKC-alpha in breast cancer cells
-
Kim S, Han J, Lee SK, Choi MY, Kim J, Lee J et al. Berberine suppresses the TPA-induced MMP-1 and MMP-9 expressions through the inhibition of PKC-alpha in breast cancer cells. J Surg Res 2012; 176: e21–e29.
-
(2012)
J Surg Res
, vol.176
, pp. e21-e29
-
-
Kim, S.1
Han, J.2
Lee, S.K.3
Choi, M.Y.4
Kim, J.5
Lee, J.6
-
70
-
-
5644271449
-
Protein kinase C alpha expression in breast and ovarian cancer
-
Lahn M, Kohler G, Sundell K, Su C, Li S, Paterson BM et al. Protein kinase C alpha expression in breast and ovarian cancer. Oncology 2004; 67: 1–10.
-
(2004)
Oncology
, vol.67
, pp. 1-10
-
-
Lahn, M.1
Kohler, G.2
Sundell, K.3
Su, C.4
Li, S.5
Paterson, B.M.6
-
71
-
-
78751643333
-
Sustained inhibition of PKCalpha reduces intravasation and lung seeding during mammary tumor metastasis in an in vivo mouse model
-
Kim J, Thorne SH, Sun L, Huang B, Mochly-Rosen D. Sustained inhibition of PKCalpha reduces intravasation and lung seeding during mammary tumor metastasis in an in vivo mouse model. Oncogene 2011; 30: 323–333.
-
(2011)
Oncogene
, vol.30
, pp. 323-333
-
-
Kim, J.1
Thorne, S.H.2
Sun, L.3
Huang, B.4
Mochly-Rosen, D.5
-
72
-
-
0038515329
-
Role of cycloox-ygenase 2 in protein kinase C beta II-mediated colon carcinogenesis
-
Yu W, Murray NR, Weems C, Chen L, Guo H, Ethridge R et al. Role of cycloox-ygenase 2 in protein kinase C beta II-mediated colon carcinogenesis. J Biol Chem 2003; 278: 11167–11174.
-
(2003)
J Biol Chem
, vol.278
, pp. 11167-11174
-
-
Yu, W.1
Murray, N.R.2
Weems, C.3
Chen, L.4
Guo, H.5
Ethridge, R.6
-
73
-
-
53049108851
-
Cen-trosomal PKCbetaII and pericentrin are critical for human prostate cancer growth and angiogenesis
-
Kim J, Choi YL, Vallentin A, Hunrichs BS, Hellerstein MK, Peehl DM et al. Cen-trosomal PKCbetaII and pericentrin are critical for human prostate cancer growth and angiogenesis. Cancer Res 2008; 68: 6831–6839.
-
(2008)
Cancer Res
, vol.68
, pp. 6831-6839
-
-
Kim, J.1
Choi, Y.L.2
Vallentin, A.3
Hunrichs, B.S.4
Hellerstein, M.K.5
Peehl, D.M.6
-
74
-
-
33747825439
-
Membrane PKC-beta 2 protein expression predicts for poor response to chemotherapy and survival in patients with diffuse large B-cell lymphoma
-
Espinosa I, Briones J, Bordes R, Brunet S, Martino R, Sureda A et al. Membrane PKC-beta 2 protein expression predicts for poor response to chemotherapy and survival in patients with diffuse large B-cell lymphoma. Ann Hematol 2006; 85: 597–603.
-
(2006)
Ann Hematol
, vol.85
, pp. 597-603
-
-
Espinosa, I.1
Briones, J.2
Bordes, R.3
Brunet, S.4
Martino, R.5
Sureda, A.6
-
75
-
-
0036021216
-
Antiangiogenic and antitumor effects of a protein kinase Cbeta inhibitor in human breast cancer and ovarian cancer xenografts
-
Teicher BA, Menon K, Alvarez E, Shih C, Faul MM. Antiangiogenic and antitumor effects of a protein kinase Cbeta inhibitor in human breast cancer and ovarian cancer xenografts. Invest New Drugs 2002; 20: 241–251.
-
(2002)
Invest New Drugs
, vol.20
, pp. 241-251
-
-
Teicher, B.A.1
Menon, K.2
Alvarez, E.3
Shih, C.4
Faul, M.M.5
-
76
-
-
0034899448
-
Antiangiogenic and antitumor effects of a protein kinase Cbeta inhibitor in human T98G glioblastoma multiforme xenografts
-
Teicher BA, Menon K, Alvarez E, Galbreath E, Shih C, Faul M. Antiangiogenic and antitumor effects of a protein kinase Cbeta inhibitor in human T98G glioblastoma multiforme xenografts. Clin Cancer Res 2001; 7: 634–640.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 634-640
-
-
Teicher, B.A.1
Menon, K.2
Alvarez, E.3
Galbreath, E.4
Shih, C.5
Faul, M.6
-
77
-
-
0030001021
-
Protein kinase C beta II specifically binds to and is activated by F-actin
-
Blobe GC, Stribling DS, Fabbro D, Stabel S, Hannun YA. Protein kinase C beta II specifically binds to and is activated by F-actin. J Biol Chem 1996; 271: 15823–15830.
-
(1996)
J Biol Chem
, vol.271
, pp. 15823-15830
-
-
Blobe, G.C.1
Stribling, D.S.2
Fabbro, D.3
Stabel, S.4
Hannun, Y.A.5
-
78
-
-
0032493823
-
Mapping of a molecular determinant for protein kinase C betaII isozyme function
-
Gokmen-Polar Y, Fields AP. Mapping of a molecular determinant for protein kinase C betaII isozyme function. J Biol Chem 1998; 273: 20261–20266.
-
(1998)
J Biol Chem
, vol.273
, pp. 20261-20266
-
-
Gokmen-Polar, Y.1
Fields, A.P.2
-
79
-
-
0035839578
-
Binding specificity for RACK1 resides in the V5 region of beta II protein kinase C
-
Stebbins EG, Mochly-Rosen D. Binding specificity for RACK1 resides in the V5 region of beta II protein kinase C. J Biol Chem 2001; 276: 29644–29650.
-
(2001)
J Biol Chem
, vol.276
, pp. 29644-29650
-
-
Stebbins, E.G.1
Mochly-Rosen, D.2
-
80
-
-
0026762671
-
Alterations in protein kinase C in 1,2-dimethylhy-drazine induced colonic carcinogenesis
-
Craven PA, DeRubertis FR. Alterations in protein kinase C in 1,2-dimethylhy-drazine induced colonic carcinogenesis. Cancer Res 1992; 52: 2216–2221.
-
(1992)
Cancer Res
, vol.52
, pp. 2216-2221
-
-
Craven, P.A.1
Derubertis, F.R.2
-
81
-
-
0031926179
-
Non-invasive detection of fecal protein kinase C betaII and zeta messenger RNA: Putative biomarkers for colon cancer
-
Davidson LA, Aymond CM, Jiang YH, Turner ND, Lupton JR, Chapkin RS. Non-invasive detection of fecal protein kinase C betaII and zeta messenger RNA: putative biomarkers for colon cancer. Carcinogenesis 1998; 19: 253–257.
-
(1998)
Carcinogenesis
, vol.19
, pp. 253-257
-
-
Davidson, L.A.1
Aymond, C.M.2
Jiang, Y.H.3
Turner, N.D.4
Lupton, J.R.5
Chapkin, R.S.6
-
82
-
-
0028308407
-
Unique catalytic properties dictate the enhanced function of p59fynT, the hemopoietic cell-specific isoform of the Fyn tyrosine protein kinase, in T cells
-
Davidson D, Viallet J, Veillette A. Unique catalytic properties dictate the enhanced function of p59fynT, the hemopoietic cell-specific isoform of the Fyn tyrosine protein kinase, in T cells. Mol Cell Biol 1994; 14: 4554–4564.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 4554-4564
-
-
Davidson, D.1
Viallet, J.2
Veillette, A.3
-
83
-
-
67349100957
-
Protein kinase C-beta II (PKC-beta II) expression in patients with colorectal cancer
-
Spindler KL, Lindebjerg J, Lahn M, Kjaer-Frifeldt S, Jakobsen A. Protein kinase C-beta II (PKC-beta II) expression in patients with colorectal cancer. Int J Colorectal Dis 2009; 24: 641–645.
-
(2009)
Int J Colorectal Dis
, vol.24
, pp. 641-645
-
-
Spindler, K.L.1
Lindebjerg, J.2
Lahn, M.3
Kjaer-Frifeldt, S.4
Jakobsen, A.5
-
84
-
-
10244235304
-
Protein kinase C beta 1 and protein kinase C beta 2 activate p57 mitogen-activated protein kinase and block differentiation in colon carcinoma cells
-
Sauma S, Yan Z, Ohno S, Friedman E. Protein kinase C beta 1 and protein kinase C beta 2 activate p57 mitogen-activated protein kinase and block differentiation in colon carcinoma cells. Cell Growth Differ 1996; 7: 587–594.
-
(1996)
Cell Growth Differ
, vol.7
, pp. 587-594
-
-
Sauma, S.1
Yan, Z.2
Ohno, S.3
Friedman, E.4
-
85
-
-
0027537717
-
Signal transduction through extracellular signal-regulated kinase-like pp57 blocked in differentiated cells having low protein kinase C beta activity
-
Lee H, Ghose-Dastidar J, Winawer S, Friedman E. Signal transduction through extracellular signal-regulated kinase-like pp57 blocked in differentiated cells having low protein kinase C beta activity. J Biol Chem 1993; 268: 5255–5263.
-
(1993)
J Biol Chem
, vol.268
, pp. 5255-5263
-
-
Lee, H.1
Ghose-Dastidar, J.2
Winawer, S.3
Friedman, E.4
-
86
-
-
0033577858
-
Overexpression of protein kinase C betaII induces colonic hyper-proliferation and increased sensitivity to colon carcinogenesis
-
Murray NR, Davidson LA, Chapkin RS, Clay Gustafson W, Schattenberg DG, Fields AP. Overexpression of protein kinase C betaII induces colonic hyper-proliferation and increased sensitivity to colon carcinogenesis. J Cell Biol 1999; 145: 699–711.
-
(1999)
J Cell Biol
, vol.145
, pp. 699-711
-
-
Murray, N.R.1
Davidson, L.A.2
Chapkin, R.S.3
Clay Gustafson, W.4
Schattenberg, D.G.5
Fields, A.P.6
-
87
-
-
42549127895
-
Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon
-
Calcagno SR, Li S, Colon M, Kreinest PA, Thompson EA, Fields AP et al. Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon. Int J Cancer 2008; 122: 2462–2470.
-
(2008)
Int J Cancer
, vol.122
, pp. 2462-2470
-
-
Calcagno, S.R.1
Li, S.2
Colon, M.3
Kreinest, P.A.4
Thompson, E.A.5
Fields, A.P.6
-
88
-
-
2542506202
-
Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway
-
Zhang J, Anastasiadis PZ, Liu Y, Thompson EA, Fields AP. Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway. J Biol Chem 2004; 279: 22118–22123.
-
(2004)
J Biol Chem
, vol.279
, pp. 22118-22123
-
-
Zhang, J.1
Anastasiadis, P.Z.2
Liu, Y.3
Thompson, E.A.4
Fields, A.P.5
-
89
-
-
0029065363
-
Overexpression of protein kinase C beta 1 in the SW480 colon cancer cell line causes growth suppression
-
Goldstein DR, Cacace AM, Weinstein IB. Overexpression of protein kinase C beta 1 in the SW480 colon cancer cell line causes growth suppression. Carcinogenesis 1995; 16: 1121–1126.
-
(1995)
Carcinogenesis
, vol.16
, pp. 1121-1126
-
-
Goldstein, D.R.1
Cacace, A.M.2
Weinstein, I.B.3
-
90
-
-
0035879754
-
Expression of protein kinase C beta1 confers resistance to TNFalpha-and paclitaxel-induced apoptosis in HT-29 colon carcinoma cells
-
Cesaro P, Raiteri E, Demoz M, Castino R, Baccino FM, Bonelli G et al. Expression of protein kinase C beta1 confers resistance to TNFalpha-and paclitaxel-induced apoptosis in HT-29 colon carcinoma cells. Int J Cancer 2001; 93: 179–184.
-
(2001)
Int J Cancer
, vol.93
, pp. 179-184
-
-
Cesaro, P.1
Raiteri, E.2
Demoz, M.3
Castino, R.4
Baccino, F.M.5
Bonelli, G.6
-
91
-
-
77950460256
-
Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4
-
Metzger E, Imhof A, Patel D, Kahl P, Hoffmeyer K, Friedrichs N et al. Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4. Nature 2010; 464: 792–796.
-
(2010)
Nature
, vol.464
, pp. 792-796
-
-
Metzger, E.1
Imhof, A.2
Patel, D.3
Kahl, P.4
Hoffmeyer, K.5
Friedrichs, N.6
-
92
-
-
48349117187
-
Enzastaurin inhibits tumours sensitive and resistant to anti-EGFR drugs
-
Gelardi T, Caputo R, Damiano V, Daniele G, Pepe S, Ciardiello F et al. Enzastaurin inhibits tumours sensitive and resistant to anti-EGFR drugs. Br J Cancer 2008; 99: 473–480.
-
(2008)
Br J Cancer
, vol.99
, pp. 473-480
-
-
Gelardi, T.1
Caputo, R.2
Damiano, V.3
Daniele, G.4
Pepe, S.5
Ciardiello, F.6
-
93
-
-
33845732645
-
Protein kinase C beta enhances growth and expression of cyclin D1 in human breast cancer cells
-
Li H, Weinstein IB. Protein kinase C beta enhances growth and expression of cyclin D1 in human breast cancer cells. Cancer Res 2006; 66: 11399–11408.
-
(2006)
Cancer Res
, vol.66
, pp. 11399-11408
-
-
Li, H.1
Weinstein, I.B.2
-
94
-
-
0029851475
-
Induction of a less aggressive breast cancer phenotype by protein kinase C-alpha and-beta overexpression
-
Manni A, Buckwalter E, Etindi R, Kunselman S, Rossini A, Mauger D et al. Induction of a less aggressive breast cancer phenotype by protein kinase C-alpha and-beta overexpression. Cell Growth Differ 1996; 7: 1187–1198.
-
(1996)
Cell Growth Differ
, vol.7
, pp. 1187-1198
-
-
Manni, A.1
Buckwalter, E.2
Etindi, R.3
Kunselman, S.4
Rossini, A.5
Mauger, D.6
-
95
-
-
70449553663
-
Opposite effects of protein kinase C beta1 (PKCbeta1) and PKCepsilon in the metastatic potential of a breast cancer murine model
-
Grossoni VC, Todaro LB, Kazanietz MG, de Kier Joffe ED, Urtreger AJ. Opposite effects of protein kinase C beta1 (PKCbeta1) and PKCepsilon in the metastatic potential of a breast cancer murine model. Breast Cancer Res Treat 2009; 118: 469–480.
-
(2009)
Breast Cancer Res Treat
, vol.118
, pp. 469-480
-
-
Grossoni, V.C.1
Todaro, L.B.2
Kazanietz, M.G.3
de Kier Joffe, E.D.4
Urtreger, A.J.5
-
96
-
-
34248631942
-
Antitumor activity of enzastaurin (LY317615.HCl) against human cancer cell lines and freshly explanted tumors investigated in in-vitro [corrected] soft-agar cloning experiments
-
Hanauske AR, Oberschmidt O, Hanauske-Abel H, Lahn MM, Eismann U. Antitumor activity of enzastaurin (LY317615.HCl) against human cancer cell lines and freshly explanted tumors investigated in in-vitro [corrected] soft-agar cloning experiments. Invest New Drugs 2007; 25: 205–210.
-
(2007)
Invest New Drugs
, vol.25
, pp. 205-210
-
-
Hanauske, A.R.1
Oberschmidt, O.2
Hanauske-Abel, H.3
Lahn, M.M.4
Eismann, U.5
-
97
-
-
44449102550
-
Enzastaurin renders MCF-7 breast cancer cells sensitive to radiation through reversal of radiation-induced activation of protein kinase C
-
Jasinski P, Terai K, Zwolak P, Dudek AZ. Enzastaurin renders MCF-7 breast cancer cells sensitive to radiation through reversal of radiation-induced activation of protein kinase C. Eur J Cancer 2008; 44: 1315–1322.
-
(2008)
Eur J Cancer
, vol.44
, pp. 1315-1322
-
-
Jasinski, P.1
Terai, K.2
Zwolak, P.3
Dudek, A.Z.4
-
98
-
-
78649331684
-
Differential subcellular expression of protein kinase C betaII in breast cancer: Correlation with breast cancer subtypes
-
Gokmen-Polar Y, Mehta R, Tuzmen S, Mousses S, Thorat MA, Sanders KL et al. Differential subcellular expression of protein kinase C betaII in breast cancer: correlation with breast cancer subtypes. Breast Cancer Res Treat 2010; 124: 327–335.
-
(2010)
Breast Cancer Res Treat
, vol.124
, pp. 327-335
-
-
Gokmen-Polar, Y.1
Mehta, R.2
Tuzmen, S.3
Mousses, S.4
Thorat, M.A.5
Sanders, K.L.6
-
99
-
-
0035210102
-
Antiangiogenic and antitumor effects of a protein kinase Cbeta inhibitor in murine lewis lung carcinoma and human Calu-6 non-small-cell lung carcinoma xenografts
-
Teicher BA, Menon K, Alvarez E, Galbreath E, Shih C, Faul MM. Antiangiogenic and antitumor effects of a protein kinase Cbeta inhibitor in murine lewis lung carcinoma and human Calu-6 non-small-cell lung carcinoma xenografts. Cancer Chemo Pharmacol 2001; 48: 473–480.
-
(2001)
Cancer Chemo Pharmacol
, vol.48
, pp. 473-480
-
-
Teicher, B.A.1
Menon, K.2
Alvarez, E.3
Galbreath, E.4
Shih, C.5
Faul, M.M.6
-
100
-
-
50249122093
-
Molecular pathways involved in the synergistic interaction of the PKC beta inhibitor enzastaurin with the antifolate pemetrexed in non-small cell lung cancer cells
-
Tekle C, Giovannetti E, Sigmond J, Graff JR, Smid K, Peters GJ. Molecular pathways involved in the synergistic interaction of the PKC beta inhibitor enzastaurin with the antifolate pemetrexed in non-small cell lung cancer cells. Br J Cancer 2008; 99: 750–759.
-
(2008)
Br J Cancer
, vol.99
, pp. 750-759
-
-
Tekle, C.1
Giovannetti, E.2
Sigmond, J.3
Graff, J.R.4
Smid, K.5
Peters, G.J.6
-
101
-
-
77955491136
-
Enzastaurin (LY317615), a protein kinase C beta selective inhibitor, enhances antiangiogenic effect of radiation
-
Willey CD, Xiao D, Tu T, Kim KW, Moretti L, Niermann KJ et al. Enzastaurin (LY317615), a protein kinase C beta selective inhibitor, enhances antiangiogenic effect of radiation. Int J Radiat Oncol Biol Phys 2010; 77: 1518–1526.
-
(2010)
Int J Radiat Oncol Biol Phys
, vol.77
, pp. 1518-1526
-
-
Willey, C.D.1
Xiao, D.2
Tu, T.3
Kim, K.W.4
Moretti, L.5
Niermann, K.J.6
-
102
-
-
23844521568
-
The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts
-
Graff JR, McNulty AM, Hanna KR, Konicek BW, Lynch RL, Bailey SN et al. The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. Cancer Res 2005; 65: 7462–7469.
-
(2005)
Cancer Res
, vol.65
, pp. 7462-7469
-
-
Graff, J.R.1
McNulty, A.M.2
Hanna, K.R.3
Konicek, B.W.4
Lynch, R.L.5
Bailey, S.N.6
-
103
-
-
75849133697
-
A phase I/II trial of enzastaurin in patients with recurrent high-grade gliomas
-
Kreisl TN, Kotliarova S, Butman JA, Albert PS, Kim L, Musib L et al. A phase I/II trial of enzastaurin in patients with recurrent high-grade gliomas. Neuro Oncol 2010; 12: 181–189.
-
(2010)
Neuro Oncol
, vol.12
, pp. 181-189
-
-
Kreisl, T.N.1
Kotliarova, S.2
Butman, J.A.3
Albert, P.S.4
Kim, L.5
Musib, L.6
-
104
-
-
25144466151
-
Expression of PKC-beta or cyclin D2 predicts for inferior survival in diffuse large B-cell lymphoma
-
Hans CP, Weisenburger DD, Greiner TC, Chan WC, Aoun P, Cochran GT et al. Expression of PKC-beta or cyclin D2 predicts for inferior survival in diffuse large B-cell lymphoma. Mod Pathol 2005; 18: 1377–1384.
-
(2005)
Mod Pathol
, vol.18
, pp. 1377-1384
-
-
Hans, C.P.1
Weisenburger, D.D.2
Greiner, T.C.3
Chan, W.C.4
Aoun, P.5
Cochran, G.T.6
-
105
-
-
34248151884
-
Retrospective analysis of protein kinase C-beta (PKC-beta) expression in lymphoid malignancies and its association with survival in diffuse large B-cell lymphomas
-
Li S, Phong M, Lahn M, Brail L, Sutton S, Lin BK et al. Retrospective analysis of protein kinase C-beta (PKC-beta) expression in lymphoid malignancies and its association with survival in diffuse large B-cell lymphomas. Biol Direct 2007; 2: 8.
-
(2007)
Biol Direct
, vol.2
, pp. 8
-
-
Li, S.1
Phong, M.2
Lahn, M.3
Brail, L.4
Sutton, S.5
Lin, B.K.6
-
106
-
-
33745207996
-
The selective protein kinase C beta inhibitor enzastaurin induces apoptosis in cutaneous T-cell lymphoma cell lines through the AKT pathway
-
Querfeld C, Rizvi MA, Kuzel TM, Guitart J, Rademaker A, Sabharwal SS et al. The selective protein kinase C beta inhibitor enzastaurin induces apoptosis in cutaneous T-cell lymphoma cell lines through the AKT pathway. J Invest Dermatol 2006; 126: 1641–1647.
-
(2006)
J Invest Dermatol
, vol.126
, pp. 1641-1647
-
-
Querfeld, C.1
Rizvi, M.A.2
Kuzel, T.M.3
Guitart, J.4
Rademaker, A.5
Sabharwal, S.S.6
-
107
-
-
77953212331
-
Effects of enzastaurin, alone or in combination, on signaling pathway controlling growth and survival of B-cell lymphoma cell lines
-
Civallero M, Cosenza M, Grisendi G, Marcheselli L, Todoerti K, Sacchi S. Effects of enzastaurin, alone or in combination, on signaling pathway controlling growth and survival of B-cell lymphoma cell lines. Leuk Lymphoma 2010; 51: 671–679.
-
(2010)
Leuk Lymphoma
, vol.51
, pp. 671-679
-
-
Civallero, M.1
Cosenza, M.2
Grisendi, G.3
Marcheselli, L.4
Todoerti, K.5
Sacchi, S.6
-
108
-
-
80052936028
-
Genomic profiling of enzastaurin-treated B cell lymphoma RL cells
-
Civallero M, Cosenza M, Neri A, Bari A. Genomic profiling of enzastaurin-treated B cell lymphoma RL cells. Hematol Oncol 2011; 29: 154–156.
-
(2011)
Hematol Oncol
, vol.29
, pp. 154-156
-
-
Civallero, M.1
Cosenza, M.2
Neri, A.3
Bari, A.4
-
109
-
-
79960398013
-
Multicenter phase II trial of enzastaurin in patients with relapsed or refractory advanced cutaneous T-cell lymphoma
-
Querfeld C, Kuzel TM, Kim YH, Porcu P, Duvic M, Musiek A et al. Multicenter phase II trial of enzastaurin in patients with relapsed or refractory advanced cutaneous T-cell lymphoma. Leuk Lymphoma 2011; 52: 1474–1480.
-
(2011)
Leuk Lymphoma
, vol.52
, pp. 1474-1480
-
-
Querfeld, C.1
Kuzel, T.M.2
Kim, Y.H.3
Porcu, P.4
Duvic, M.5
Musiek, A.6
-
110
-
-
84872387409
-
Protein kinase c-beta-dependent activation of NF-kappaB in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo
-
Lutzny G, Kocher T, Schmidt-Supprian M, Rudelius M, Klein-Hitpass L, Finch AJ et al. Protein kinase c-beta-dependent activation of NF-kappaB in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo. Cancer Cell 2013; 23: 77–92.
-
(2013)
Cancer Cell
, vol.23
, pp. 77-92
-
-
Lutzny, G.1
Kocher, T.2
Schmidt-Supprian, M.3
Rudelius, M.4
Klein-Hitpass, L.5
Finch, A.J.6
-
111
-
-
84860338528
-
Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase Cdelta
-
Irie K, Yanagita RC, Nakagawa Y. Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase Cdelta. Med Res Rev 2012; 32: 518–535.
-
(2012)
Med Res Rev
, vol.32
, pp. 518-535
-
-
Irie, K.1
Yanagita, R.C.2
Nakagawa, Y.3
-
113
-
-
67549115857
-
Perspectives of protein kinase C (PKC) inhibitors as anti-cancer agents
-
Gonelli A, Mischiati C, Guerrini R, Voltan R, Salvadori S, Zauli G. Perspectives of protein kinase C (PKC) inhibitors as anti-cancer agents. Mini Rev Med Chem 2009; 9: 498–509.
-
(2009)
Mini Rev Med Chem
, vol.9
, pp. 498-509
-
-
Gonelli, A.1
Mischiati, C.2
Guerrini, R.3
Voltan, R.4
Salvadori, S.5
Zauli, G.6
-
115
-
-
78650274723
-
Two faces of protein kinase Cdelta: The contrasting roles of PKCdelta in cell survival and cell death
-
Basu A, Pal D. Two faces of protein kinase Cdelta: the contrasting roles of PKCdelta in cell survival and cell death. Scientific World J 2010; 10: 2272–2284.
-
(2010)
Scientific World J
, vol.10
, pp. 2272-2284
-
-
Basu, A.1
Pal, D.2
-
116
-
-
0039765390
-
Involvement of protein kinase C delta (PKCdelta) in phorbol ester-induced apoptosis in LNCaP prostate cancer cells
-
Fujii T, Garcia-Bermejo ML, Bernabo JL, Caamano J, Ohba M, Kuroki T et al. Involvement of protein kinase C delta (PKCdelta) in phorbol ester-induced apoptosis in LNCaP prostate cancer cells. Lack of proteolytic cleavage of PKCdelta. J Biol Chem 2000; 275: 7574–7582.
-
(2000)
Lack of Proteolytic Cleavage of Pkcdelta. J Biol Chem
, vol.275
, pp. 7574-7582
-
-
Fujii, T.1
Garcia-Bermejo, M.L.2
Bernabo, J.L.3
Caamano, J.4
Ohba, M.5
Kuroki, T.6
-
117
-
-
70350389704
-
ROCK mediates phorbol ester-induced apoptosis in prostate cancer cells via p21Cip1 up-regulation and JNK
-
Xiao L, Eto M, Kazanietz MG. ROCK mediates phorbol ester-induced apoptosis in prostate cancer cells via p21Cip1 up-regulation and JNK. J Biol Chem 2009; 284: 29365–29375.
-
(2009)
J Biol Chem
, vol.284
, pp. 29365-29375
-
-
Xiao, L.1
Eto, M.2
Kazanietz, M.G.3
-
118
-
-
28244474477
-
Phorbol ester-induced apoptosis in prostate cancer cells via autocrine activation of the extrinsic apoptotic cascade: A key role for protein kinase C delta
-
Gonzalez-Guerrico AM, Kazanietz MG. Phorbol ester-induced apoptosis in prostate cancer cells via autocrine activation of the extrinsic apoptotic cascade: a key role for protein kinase C delta. J Biol Chem 2005; 280: 38982–38991.
-
(2005)
J Biol Chem
, vol.280
, pp. 38982-38991
-
-
Gonzalez-Guerrico, A.M.1
Kazanietz, M.G.2
-
119
-
-
50349085285
-
Phorbol ester-induced apoptosis and senescence in cancer cell models
-
Xiao L, Caino MC, von Burstin VA, Oliva JL, Kazanietz MG. Phorbol ester-induced apoptosis and senescence in cancer cell models. Methods Enzymol 2008; 446: 123–139.
-
(2008)
Methods Enzymol
, vol.446
, pp. 123-139
-
-
Xiao, L.1
Caino, M.C.2
von Burstin, V.A.3
Oliva, J.L.4
Kazanietz, M.G.5
-
120
-
-
62349139176
-
PKC-mediated secretion of death factors in LNCaP prostate cancer cells is regulated by androgens
-
Xiao L, Gonzalez-Guerrico A, Kazanietz MG. PKC-mediated secretion of death factors in LNCaP prostate cancer cells is regulated by androgens. Mol Carcinog 2009; 48: 187–195.
-
(2009)
Mol Carcinog
, vol.48
, pp. 187-195
-
-
Xiao, L.1
Gonzalez-Guerrico, A.2
Kazanietz, M.G.3
-
121
-
-
0027418816
-
Overexpression of protein kinase C-delta and-epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity
-
Mischak H, Goodnight JA, Kolch W, Martiny-Baron G, Schaechtle C, Kazanietz MG et al. Overexpression of protein kinase C-delta and-epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity. J Biol Chem 1993; 268: 6090–6096.
-
(1993)
J Biol Chem
, vol.268
, pp. 6090-6096
-
-
Mischak, H.1
Goodnight, J.A.2
Kolch, W.3
Martiny-Baron, G.4
Schaechtle, C.5
Kazanietz, M.G.6
-
122
-
-
3042647350
-
Protein kinase C and prostate carcinogenesis: Targeting the cell cycle and apoptotic mechanisms
-
Gavrielides MV, Frijhoff AF, Conti CJ, Kazanietz MG. Protein kinase C and prostate carcinogenesis: targeting the cell cycle and apoptotic mechanisms. Curr Drug Targets 2004; 5: 431–443.
-
(2004)
Curr Drug Targets
, vol.5
, pp. 431-443
-
-
Gavrielides, M.V.1
Frijhoff, A.F.2
Conti, C.J.3
Kazanietz, M.G.4
-
123
-
-
26644461205
-
Phorbol ester-induced G1 phase arrest selectively mediated by protein kinase Cdelta-dependent induction of p21
-
Nakagawa M, Oliva JL, Kothapalli D, Fournier A, Assoian RK, Kazanietz MG. Phorbol ester-induced G1 phase arrest selectively mediated by protein kinase Cdelta-dependent induction of p21. J Biol Chem 2005; 280: 33926–33934.
-
(2005)
J Biol Chem
, vol.280
, pp. 33926-33934
-
-
Nakagawa, M.1
Oliva, J.L.2
Kothapalli, D.3
Fournier, A.4
Assoian, R.K.5
Kazanietz, M.G.6
-
124
-
-
25444490131
-
Protein kinase C delta stimulates apoptosis by initiating G1 phase cell cycle progression and S phase arrest
-
Santiago-Walker AE, Fikaris AJ, Kao GD, Brown EJ, Kazanietz MG, Meinkoth JL. Protein kinase C delta stimulates apoptosis by initiating G1 phase cell cycle progression and S phase arrest. J Biol Chem 2005; 280: 32107–32114.
-
(2005)
J Biol Chem
, vol.280
, pp. 32107-32114
-
-
Santiago-Walker, A.E.1
Fikaris, A.J.2
Kao, G.D.3
Brown, E.J.4
Kazanietz, M.G.5
Meinkoth, J.L.6
-
125
-
-
33947607017
-
Protein kinase C delta enhances proliferation and survival of murine mammary cells
-
Grossoni VC, Falbo KB, Kazanietz MG, de Kier Joffe ED, Urtreger AJ. Protein kinase C delta enhances proliferation and survival of murine mammary cells. Mol Carcinog 2007; 46: 381–390.
-
(2007)
Mol Carcinog
, vol.46
, pp. 381-390
-
-
Grossoni, V.C.1
Falbo, K.B.2
Kazanietz, M.G.3
de Kier Joffe, E.D.4
Urtreger, A.J.5
-
126
-
-
36749065508
-
Analysis of protein kinase C delta (PKC delta) expression in endometrial tumors
-
Reno EM, Haughian JM, Dimitrova IK, Jackson TA, Shroyer KR, Bradford AP. Analysis of protein kinase C delta (PKC delta) expression in endometrial tumors. Hum Pathol 2008; 39: 21–29.
-
(2008)
Hum Pathol
, vol.39
, pp. 21-29
-
-
Reno, E.M.1
Haughian, J.M.2
Dimitrova, I.K.3
Jackson, T.A.4
Shroyer, K.R.5
Bradford, A.P.6
-
127
-
-
80053139310
-
Protein kinase Cdelta in tumorigenesis of human malignant fibrous histiocytoma
-
Fukase N, Kawamoto T, Kishimoto K, Hara H, Okada Y, Onishi Y et al. Protein kinase Cdelta in tumorigenesis of human malignant fibrous histiocytoma. Oncology Reports 2011; 26: 1221–1226.
-
(2011)
Oncology Reports
, vol.26
, pp. 1221-1226
-
-
Fukase, N.1
Kawamoto, T.2
Kishimoto, K.3
Hara, H.4
Okada, Y.5
Onishi, Y.6
-
128
-
-
77749264374
-
Loss of protein kinase C delta gene expression in human squamous cell carcinomas: A laser capture microdissection study
-
Yadav V, Yanez NC, Fenton SE, Denning MF. Loss of protein kinase C delta gene expression in human squamous cell carcinomas: a laser capture microdissection study. Am J Pathol 2010; 176: 1091–1096.
-
(2010)
Am J Pathol
, vol.176
, pp. 1091-1096
-
-
Yadav, V.1
Yanez, N.C.2
Fenton, S.E.3
Denning, M.F.4
-
129
-
-
0034695174
-
Alteration in the expression of protein kinase C isoforms in human hepatocellular carcinoma
-
Tsai JH, Hsieh YS, Kuo SJ, Chen ST, Yu SY, Huang CY et al. Alteration in the expression of protein kinase C isoforms in human hepatocellular carcinoma. Cancer Lett 2000; 161: 171–175.
-
(2000)
Cancer Lett
, vol.161
, pp. 171-175
-
-
Tsai, J.H.1
Hsieh, Y.S.2
Kuo, S.J.3
Chen, S.T.4
Yu, S.Y.5
Huang, C.Y.6
-
130
-
-
84857463679
-
Over-expression of protein kinase Cisoforms (Alpha, delta, theta and zeta) in squamous cervical cancer
-
Yu LR, Lv JQ, Jin LY, Ding SD, Ma XY, Wang JJ et al. Over-expression of protein kinase Cisoforms (alpha, delta, theta and zeta) in squamous cervical cancer. Neoplasma 2011; 58: 491–498.
-
(2011)
Neoplasma
, vol.58
, pp. 491-498
-
-
Yu, L.R.1
Lv, J.Q.2
Jin, L.Y.3
Ding, S.D.4
Ma, X.Y.5
Wang, J.J.6
-
131
-
-
33645916718
-
Protein kinase Cdelta signaling downstream of the EGF receptor mediates migration and invasiveness of prostate cancer cells
-
Kharait S, Dhir R, Lauffenburger D, Wells A. Protein kinase Cdelta signaling downstream of the EGF receptor mediates migration and invasiveness of prostate cancer cells. Biochem Biophys Res Commun 2006; 343: 848–856.
-
(2006)
Biochem Biophys Res Commun
, vol.343
, pp. 848-856
-
-
Kharait, S.1
Dhir, R.2
Lauffenburger, D.3
Wells, A.4
-
132
-
-
36348971856
-
PCPH/ ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism
-
Villar J, Arenas MI, MacCarthy CM, Blanquez MJ, Tirado OM, Notario V. PCPH/ ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism. Cancer Res 2007; 67: 10859–10868.
-
(2007)
Cancer Res
, vol.67
, pp. 10859-10868
-
-
Villar, J.1
Arenas, M.I.2
Maccarthy, C.M.3
Blanquez, M.J.4
Tirado, O.M.5
Notario, V.6
-
133
-
-
55949118472
-
Protein kinase Cdelta expression in breast cancer as measured by real-time PCR, western blotting and ELISA
-
McKiernan E, O’Brien K, Grebenchtchikov N, Geurts-Moespot A, Sieuwerts AM, Martens JW et al. Protein kinase Cdelta expression in breast cancer as measured by real-time PCR, western blotting and ELISA. Br J Cancer 2008; 99: 1644–1650.
-
(2008)
Br J Cancer
, vol.99
, pp. 1644-1650
-
-
McKiernan, E.1
O’Brien, K.2
Grebenchtchikov, N.3
Geurts-Moespot, A.4
Sieuwerts, A.M.5
Martens, J.W.6
-
134
-
-
16444380600
-
PKC theta, a novel immunohistochemical marker for gastrointestinal stromal tumors (GIST), especially useful for identifying KIT-negative tumors
-
Motegi A, Sakurai S, Nakayama H, Sano T, Oyama T, Nakajima T. PKC theta, a novel immunohistochemical marker for gastrointestinal stromal tumors (GIST), especially useful for identifying KIT-negative tumors. Pathol Int 2005; 55: 106–112.
-
(2005)
Pathol Int
, vol.55
, pp. 106-112
-
-
Motegi, A.1
Sakurai, S.2
Nakayama, H.3
Sano, T.4
Oyama, T.5
Nakajima, T.6
-
135
-
-
79957917277
-
DOG1 and PKC-theta are useful in the diagnosis of KIT-negative gastrointestinal stromal tumors
-
Kang GH, Srivastava A, Kim YE, Park HJ, Park CK, Sohn TS et al. DOG1 and PKC-theta are useful in the diagnosis of KIT-negative gastrointestinal stromal tumors. Mod Pathol 2011; 24: 866–875.
-
(2011)
Mod Pathol
, vol.24
, pp. 866-875
-
-
Kang, G.H.1
Srivastava, A.2
Kim, Y.E.3
Park, H.J.4
Park, C.K.5
Sohn, T.S.6
-
136
-
-
84863385776
-
Diagnostic relevance of overexpressions of PKC-theta and DOG-1 and KIT/PDGFRA gene mutations in extragastrointestinal stromal tumors: A Korean six-centers study of 28 cases
-
Kim KH, Nelson SD, Kim DH, Choi KU, Kim SJ, Min KW et al. Diagnostic relevance of overexpressions of PKC-theta and DOG-1 and KIT/PDGFRA gene mutations in extragastrointestinal stromal tumors: a Korean six-centers study of 28 cases. Anticancer Res 2012; 32: 923–937.
-
(2012)
Anticancer Res
, vol.32
, pp. 923-937
-
-
Kim, K.H.1
Nelson, S.D.2
Kim, D.H.3
Choi, K.U.4
Kim, S.J.5
Min, K.W.6
-
137
-
-
0033571747
-
Transgenic mice overexpressing protein kinase Cdelta in the epidermis are resistant to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate
-
Reddig PJ, Dreckschmidt NE, Ahrens H, Simsiman R, Tseng CP, Zou J et al. Transgenic mice overexpressing protein kinase Cdelta in the epidermis are resistant to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res 1999; 59: 5710–5718.
-
(1999)
Cancer Res
, vol.59
, pp. 5710-5718
-
-
Reddig, P.J.1
Dreckschmidt, N.E.2
Ahrens, H.3
Simsiman, R.4
Tseng, C.P.5
Zou, J.6
-
138
-
-
79952775543
-
Protein kinase C delta is a downstream effector of oncogenic K-ras in lung tumors
-
Symonds JM, Ohm AM, Carter CJ, Heasley LE, Boyle TA, Franklin WA et al. Protein kinase C delta is a downstream effector of oncogenic K-ras in lung tumors. Cancer Res 2011; 71: 2087–2097.
-
(2011)
Cancer Res
, vol.71
, pp. 2087-2097
-
-
Symonds, J.M.1
Ohm, A.M.2
Carter, C.J.3
Heasley, L.E.4
Boyle, T.A.5
Franklin, W.A.6
-
139
-
-
84895924663
-
Protein kinase Cdelta is required for ErbB2-driven mammary gland tumorigenesis and negatively correlates with prognosis in human breast cancer
-
Allen-Petersen BL, Carter CJ, Ohm AM, Reyland ME. Protein kinase Cdelta is required for ErbB2-driven mammary gland tumorigenesis and negatively correlates with prognosis in human breast cancer. Oncogene 2013; 33: 1306–1315.
-
(2013)
Oncogene
, vol.33
, pp. 1306-1315
-
-
Allen-Petersen, B.L.1
Carter, C.J.2
Ohm, A.M.3
Reyland, M.E.4
-
140
-
-
74049146296
-
Bal de Kier Joffe, E.D. & Puricelli, L.L. PKC Delta (PKCdelta) promotes tumoral progression of human ductal pancreatic cancer
-
Mauro LV, Grossoni VC, Urtreger AJ, Yang C, Colombo LL, Morandi A et al. Bal de Kier Joffe, E.D. & Puricelli, L.L. PKC Delta (PKCdelta) promotes tumoral progression of human ductal pancreatic cancer. Pancreas 2010; 39: e31–e41.
-
(2010)
Pancreas
, vol.39
, pp. e31-e41
-
-
Mauro, L.V.1
Grossoni, V.C.2
Urtreger, A.J.3
Yang, C.4
Colombo, L.L.5
Morandi, A.6
-
141
-
-
79955603001
-
PKCdelta activation mediates angiogenesis via NADPH oxidase activity in PC-3 prostate cancer cells
-
Kim J, Koyanagi T, Mochly-Rosen D. PKCdelta activation mediates angiogenesis via NADPH oxidase activity in PC-3 prostate cancer cells. Prostate 2011; 71: 946–954.
-
(2011)
Prostate
, vol.71
, pp. 946-954
-
-
Kim, J.1
Koyanagi, T.2
Mochly-Rosen, D.3
-
142
-
-
84884588730
-
PKCdelta-mediated phosphorylation of BAG3 at Ser187 site induces epithelial-mesenchymal transition and enhances invasiveness in thyroid cancer FRO cells
-
Li N, Du ZX, Zong ZH, Liu BQ, Li C, Zhang Q et al. PKCdelta-mediated phosphorylation of BAG3 at Ser187 site induces epithelial-mesenchymal transition and enhances invasiveness in thyroid cancer FRO cells. Oncogene 2012; 32: 4539–4548.
-
(2012)
Oncogene
, vol.32
, pp. 4539-4548
-
-
Li, N.1
Du, Z.X.2
Zong, Z.H.3
Liu, B.Q.4
Li, C.5
Zhang, Q.6
-
143
-
-
79952165882
-
VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-con-taining protein 1 to stimulate PKC{delta}-driven migration
-
Razorenova OV, Finger EC, Colavitti R, Chernikova SB, Boiko AD, Chan CK et al. VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-con-taining protein 1 to stimulate PKC{delta}-driven migration. Proc Natl Acad Sci USA 2011; 108: 1931–1936.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 1931-1936
-
-
Razorenova, O.V.1
Finger, E.C.2
Colavitti, R.3
Chernikova, S.B.4
Boiko, A.D.5
Chan, C.K.6
-
144
-
-
77953797255
-
CUB domain-containing protein 1, a prognostic factor for human pancreatic cancers, promotes cell migration and extracellular matrix degradation
-
Miyazawa Y, Uekita T, Hiraoka N, Fujii S, Kosuge T, Kanai Y et al. CUB domain-containing protein 1, a prognostic factor for human pancreatic cancers, promotes cell migration and extracellular matrix degradation. Cancer Res 2010; 70: 5136–5146.
-
(2010)
Cancer Res
, vol.70
, pp. 5136-5146
-
-
Miyazawa, Y.1
Uekita, T.2
Hiraoka, N.3
Fujii, S.4
Kosuge, T.5
Kanai, Y.6
-
145
-
-
77649209136
-
Reduction of protein kinase C delta attenuates tenascin-C stimulated glioma invasion in three-dimensional matrix
-
Sarkar S, Yong VW. Reduction of protein kinase C delta attenuates tenascin-C stimulated glioma invasion in three-dimensional matrix. Carcinogenesis 2010; 31: 311–317.
-
(2010)
Carcinogenesis
, vol.31
, pp. 311-317
-
-
Sarkar, S.1
Yong, V.W.2
-
146
-
-
18344390740
-
Suppression of cell migration by protein kinase Cdelta
-
Jackson D, Zheng Y, Lyo D, Shen Y, Nakayama K, Nakayama KI et al. Suppression of cell migration by protein kinase Cdelta. Oncogene 2005; 24: 3067–3072.
-
(2005)
Oncogene
, vol.24
, pp. 3067-3072
-
-
Jackson, D.1
Zheng, Y.2
Lyo, D.3
Shen, Y.4
Nakayama, K.5
Nakayama, K.I.6
-
147
-
-
0141542627
-
Distinct mechanisms mediate the initial and sustained phases of cell migration in epidermal growth factor receptor-overexpressing cells
-
Kruger JS, Reddy KB. Distinct mechanisms mediate the initial and sustained phases of cell migration in epidermal growth factor receptor-overexpressing cells. Mol Cancer Res 2003; 1: 801–809.
-
(2003)
Mol Cancer Res
, vol.1
, pp. 801-809
-
-
Kruger, J.S.1
Reddy, K.B.2
-
148
-
-
0033168515
-
Protein kinase C delta involvement in mammary tumor cell metastasis
-
Kiley SC, Clark KJ, Goodnough M, Welch DR, Jaken S. Protein kinase C delta involvement in mammary tumor cell metastasis. Cancer Res 1999; 59: 3230–3238.
-
(1999)
Cancer Res
, vol.59
, pp. 3230-3238
-
-
Kiley, S.C.1
Clark, K.J.2
Goodnough, M.3
Welch, D.R.4
Jaken, S.5
-
149
-
-
0034353302
-
Overexpression of nPKCdelta in BL6 murine melanoma cells enhances TGFbeta1 release into the plasma of metastasized animals
-
La Porta CA, Comolli R. Overexpression of nPKCdelta in BL6 murine melanoma cells enhances TGFbeta1 release into the plasma of metastasized animals. Melanoma Res 2000; 10: 527–534.
-
(2000)
Melanoma Res
, vol.10
, pp. 527-534
-
-
la Porta, C.A.1
Comolli, R.2
-
150
-
-
0034063189
-
Overexpression of novel protein kinase C delta in BL6 murine melanoma cells inhibits the proliferative capacity in vitro but enhances the metastatic potential in vivo
-
La Porta CA, Di Dio A, Porro D, Comolli R. Overexpression of novel protein kinase C delta in BL6 murine melanoma cells inhibits the proliferative capacity in vitro but enhances the metastatic potential in vivo. Melanoma Res 2000; 10: 93–102.
-
(2000)
Melanoma Res
, vol.10
, pp. 93-102
-
-
la Porta, C.A.1
Di Dio, A.2
Porro, D.3
Comolli, R.4
-
151
-
-
0027182090
-
The epsilon isoform of protein kinase C is an oncogene when overexpressed in rat fibroblasts
-
Cacace AM, Guadagno SN, Krauss RS, Fabbro D, Weinstein IB. The epsilon isoform of protein kinase C is an oncogene when overexpressed in rat fibroblasts. Oncogene 1993; 8: 2095–2104.
-
(1993)
Oncogene
, vol.8
, pp. 2095-2104
-
-
Cacace, A.M.1
Guadagno, S.N.2
Krauss, R.S.3
Fabbro, D.4
Weinstein, I.B.5
-
152
-
-
0030050822
-
Overexpression of protein kinase C epsilon is oncogenic in rat colonic epithelial cells
-
Perletti GP, Folini M, Lin HC, Mischak H, Piccinini F, Tashjian Jr. AH. Overexpression of protein kinase C epsilon is oncogenic in rat colonic epithelial cells. Oncogene 1996; 12: 847–854.
-
(1996)
Oncogene
, vol.12
, pp. 847-854
-
-
Perletti, G.P.1
Folini, M.2
Lin, H.C.3
Mischak, H.4
Piccinini, F.5
Tashjian, A.H.6
-
153
-
-
0031038588
-
Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase
-
Cai H, Smola U, Wixler V, Eisenmann-Tappe I, Diaz-Meco MT, Moscat J et al. Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase. Mol Cell Biol 1997; 17: 732–741.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 732-741
-
-
Cai, H.1
Smola, U.2
Wixler, V.3
Eisenmann-Tappe, I.4
Diaz-Meco, M.T.5
Moscat, J.6
-
154
-
-
0030445276
-
PKC epsilon functions as an oncogene by enhancing activation of the Raf kinase
-
Cacace AM, Ueffing M, Philipp A, Han EK, Kolch W, Weinstein IB. PKC epsilon functions as an oncogene by enhancing activation of the Raf kinase. Oncogene 1996; 13: 2517–2526.
-
(1996)
Oncogene
, vol.13
, pp. 2517-2526
-
-
Cacace, A.M.1
Ueffing, M.2
Philipp, A.3
Han, E.K.4
Kolch, W.5
Weinstein, I.B.6
-
155
-
-
0032565768
-
Protein kinase Cepsilon is oncogenic in colon epithelial cells by interaction with the ras signal transduction pathway
-
Perletti GP, Concari P, Brusaferri S, Marras E, Piccinini F, Tashjian Jr. AH. Protein kinase Cepsilon is oncogenic in colon epithelial cells by interaction with the ras signal transduction pathway. Oncogene 1998; 16: 3345–3348.
-
(1998)
Oncogene
, vol.16
, pp. 3345-3348
-
-
Perletti, G.P.1
Concari, P.2
Brusaferri, S.3
Marras, E.4
Piccinini, F.5
Tashjian, A.H.6
-
156
-
-
0035800770
-
Constitutive association of c-N-Ras with c-Raf-1 and protein kinase C epsilon in latent signaling modules
-
Hamilton M, Liao J, Cathcart MK, Wolfman A. Constitutive association of c-N-Ras with c-Raf-1 and protein kinase C epsilon in latent signaling modules. J Biol Chem 2001; 276: 29079–29090.
-
(2001)
J Biol Chem
, vol.276
, pp. 29079-29090
-
-
Hamilton, M.1
Liao, J.2
Cathcart, M.K.3
Wolfman, A.4
-
157
-
-
0031596745
-
Overexpression of PKCepsilon in R6 fibroblasts causes increased production of active TGFbeta
-
Cacace AM, Ueffing M, Han EK, Marme D, Weinstein IB. Overexpression of PKCepsilon in R6 fibroblasts causes increased production of active TGFbeta. J Cell Physiol 1998; 175: 314–322.
-
(1998)
J Cell Physiol
, vol.175
, pp. 314-322
-
-
Cacace, A.M.1
Ueffing, M.2
Han, E.K.3
Marme, D.4
Weinstein, I.B.5
-
158
-
-
0032552032
-
Oncogene-induced up-regulation of Caco-2 cell proliferation involves IGF-II gene activation through a protein kinase C-mediated pathway
-
Cadoret A, Baron-Delage S, Bertrand F, Kornprost M, Groyer A, Gespach C et al. Oncogene-induced up-regulation of Caco-2 cell proliferation involves IGF-II gene activation through a protein kinase C-mediated pathway. Oncogene 1998; 17: 877–887.
-
(1998)
Oncogene
, vol.17
, pp. 877-887
-
-
Cadoret, A.1
Baron-Delage, S.2
Bertrand, F.3
Kornprost, M.4
Groyer, A.5
Gespach, C.6
-
159
-
-
0032894014
-
Protein kinase C isoenzyme patterns characteristically modulated in early prostate cancer
-
Cornford P, Evans J, Dodson A, Parsons K, Woolfenden A, Neoptolemos J et al. Protein kinase C isoenzyme patterns characteristically modulated in early prostate cancer. Am J Pathol 1999; 154: 137–144.
-
(1999)
Am J Pathol
, vol.154
, pp. 137-144
-
-
Cornford, P.1
Evans, J.2
Dodson, A.3
Parsons, K.4
Woolfenden, A.5
Neoptolemos, J.6
-
160
-
-
0344874067
-
Protein kinase C eta is associated with progression of renal cell carcinoma (RCC)
-
Brenner W, Farber G, Herget T, Wiesner C, Hengstler JG, Thuroff JW. Protein kinase C eta is associated with progression of renal cell carcinoma (RCC). Anticancer Res 2003; 23: 4001–4006.
-
(2003)
Anticancer Res
, vol.23
, pp. 4001-4006
-
-
Brenner, W.1
Farber, G.2
Herget, T.3
Wiesner, C.4
Hengstler, J.G.5
Thuroff, J.W.6
-
161
-
-
84859962336
-
PKCeta is a novel prognostic marker in non-small cell lung cancer
-
Krasnitsky E, Baumfeld Y, Freedman J, Sion-Vardy N, Ariad S, Novack V et al. PKCeta is a novel prognostic marker in non-small cell lung cancer. Anticancer Res 2012; 32: 1507–1513.
-
(2012)
Anticancer Res
, vol.32
, pp. 1507-1513
-
-
Krasnitsky, E.1
Baumfeld, Y.2
Freedman, J.3
Sion-Vardy, N.4
Ariad, S.5
Novack, V.6
-
162
-
-
77956873470
-
Expression of protein kinase C family in human hepatocellular carcinoma
-
Lu HC, Chou FP, Yeh KT, Chang YS, Hsu NC, Chang JG. Expression of protein kinase C family in human hepatocellular carcinoma. Pathol Oncol Res 2010; 16: 385–391.
-
(2010)
Pathol Oncol Res
, vol.16
, pp. 385-391
-
-
Lu, H.C.1
Chou, F.P.2
Yeh, K.T.3
Chang, Y.S.4
Hsu, N.C.5
Chang, J.G.6
-
163
-
-
0034168037
-
Protein kinase C-mediated regulation of the cell cycle
-
Black JD. Protein kinase C-mediated regulation of the cell cycle. Front Bio 2000; 5: D406–D423.
-
(2000)
Front Bio
, vol.5
, pp. D406-D423
-
-
Black, J.D.1
-
164
-
-
61649084727
-
Protein kinase C epsilon: An oncogene and emerging tumor biomarker
-
Gorin MA, Pan Q. Protein kinase C epsilon: an oncogene and emerging tumor biomarker. Mol Cancer 2009; 8: 9.
-
(2009)
Mol Cancer
, vol.8
, pp. 9
-
-
Gorin, M.A.1
Pan, Q.2
-
165
-
-
0031984081
-
The role of protein kinase C in G1 and G2/M phases of the cell cycle (Review)
-
Fishman DD, Segal S, Livneh E. The role of protein kinase C in G1 and G2/M phases of the cell cycle (review). Int J Oncol 1998; 12: 181–186.
-
(1998)
Int J Oncol
, vol.12
, pp. 181-186
-
-
Fishman, D.D.1
Segal, S.2
Livneh, E.3
-
166
-
-
34250669166
-
Protein kinase Cepsilon makes the life and death decision
-
Basu A, Sivaprasad U. Protein kinase Cepsilon makes the life and death decision. Cell Signal 2007; 19: 1633–1642.
-
(2007)
Cell Signal
, vol.19
, pp. 1633-1642
-
-
Basu, A.1
Sivaprasad, U.2
-
167
-
-
0345549478
-
Protein kinase Cepsilon interacts with Bax and promotes survival of human prostate cancer cells
-
McJilton MA, Van Sikes C, Wescott GG, Wu D, Foreman TL, Gregory CW et al. Protein kinase Cepsilon interacts with Bax and promotes survival of human prostate cancer cells. Oncogene 2003; 22: 7958–7968.
-
(2003)
Oncogene
, vol.22
, pp. 7958-7968
-
-
McJilton, M.A.1
van Sikes, C.2
Wescott, G.G.3
Wu, D.4
Foreman, T.L.5
Gregory, C.W.6
-
168
-
-
23844474726
-
Protein kinase C-epsilon regulates the apoptosis and survival of glioma cells
-
Okhrimenko H, Lu W, Xiang C, Hamburger N, Kazimirsky G, Brodie C. Protein kinase C-epsilon regulates the apoptosis and survival of glioma cells. Cancer Res 2005; 65: 7301–7309.
-
(2005)
Cancer Res
, vol.65
, pp. 7301-7309
-
-
Okhrimenko, H.1
Lu, W.2
Xiang, C.3
Hamburger, N.4
Kazimirsky, G.5
Brodie, C.6
-
169
-
-
33747356750
-
Protein kinase Cepsilon activates protein kinase B/Akt via DNA-PK to protect against tumor necrosis factor-alpha-induced cell death
-
Lu D, Huang J, Basu A. Protein kinase Cepsilon activates protein kinase B/Akt via DNA-PK to protect against tumor necrosis factor-alpha-induced cell death. J Biol Chem 2006; 281: 22799–22807.
-
(2006)
J Biol Chem
, vol.281
, pp. 22799-22807
-
-
Lu, D.1
Huang, J.2
Basu, A.3
-
170
-
-
77956215859
-
Regulation of prostate cancer cell survival by protein kinase Cepsilon involves bad phosphorylation and modulation of the TNFalpha/JNK pathway
-
Meshki J, Caino MC, von Burstin VA, Griner E, Kazanietz MG. Regulation of prostate cancer cell survival by protein kinase Cepsilon involves bad phosphorylation and modulation of the TNFalpha/JNK pathway. J Biol Chem 2010; 285: 26033–26040.
-
(2010)
J Biol Chem
, vol.285
, pp. 26033-26040
-
-
Meshki, J.1
Caino, M.C.2
von Burstin, V.A.3
Griner, E.4
Kazanietz, M.G.5
-
171
-
-
32644431783
-
Molecular mechanisms of protein kinase C-induced apoptosis in prostate cancer cells
-
Gonzalez-Guerrico AM, Meshki J, Xiao L, Benavides F, Conti CJ, Kazanietz MG. Molecular mechanisms of protein kinase C-induced apoptosis in prostate cancer cells. J Biochem Mol Biol 2005; 38: 639–645.
-
(2005)
J Biochem Mol Biol
, vol.38
, pp. 639-645
-
-
Gonzalez-Guerrico, A.M.1
Meshki, J.2
Xiao, L.3
Benavides, F.4
Conti, C.J.5
Kazanietz, M.G.6
-
172
-
-
79955843451
-
Proteasome inhibitors sensitize glioma cells and glioma stem cells to TRAIL-induced apoptosis by PKCepsilon-dependent downregulation of AKT and XIAP expressions
-
Kahana S, Finniss S, Cazacu S, Xiang C, Lee HK, Brodie S et al. Proteasome inhibitors sensitize glioma cells and glioma stem cells to TRAIL-induced apoptosis by PKCepsilon-dependent downregulation of AKT and XIAP expressions. Cell Signal 2011; 23: 1348–1357.
-
(2011)
Cell Signal
, vol.23
, pp. 1348-1357
-
-
Kahana, S.1
Finniss, S.2
Cazacu, S.3
Xiang, C.4
Lee, H.K.5
Brodie, S.6
-
173
-
-
39649094089
-
Inhibition of novel protein kinase C-epsilon augments TRAIL-induced cell death in A549 lung cancer cells
-
Felber M, Sonnemann J, Beck JF. Inhibition of novel protein kinase C-epsilon augments TRAIL-induced cell death in A549 lung cancer cells. Pathol Oncol Res 2007; 13: 295–301.
-
(2007)
Pathol Oncol Res
, vol.13
, pp. 295-301
-
-
Felber, M.1
Sonnemann, J.2
Beck, J.F.3
-
174
-
-
34848886876
-
Protein kinase C-epsilon protects MCF-7 cells from TNF-mediated cell death by inhibiting Bax translocation
-
Lu D, Sivaprasad U, Huang J, Shankar E, Morrow S, Basu A. Protein kinase C-epsilon protects MCF-7 cells from TNF-mediated cell death by inhibiting Bax translocation. Apoptosis 2007; 12: 1893–1900.
-
(2007)
Apoptosis
, vol.12
, pp. 1893-1900
-
-
Lu, D.1
Sivaprasad, U.2
Huang, J.3
Shankar, E.4
Morrow, S.5
Basu, A.6
-
175
-
-
84861379628
-
Proteins kinase Cvarepsilon is required for non-small cell lung carcinoma growth and regulates the expression of apoptotic genes
-
Caino MC, Lopez-Haber C, Kim J, Mochly-Rosen D, Kazanietz MG. Proteins kinase Cvarepsilon is required for non-small cell lung carcinoma growth and regulates the expression of apoptotic genes. Oncogene 2012; 31: 2593–2600.
-
(2012)
Oncogene
, vol.31
, pp. 2593-2600
-
-
Caino, M.C.1
Lopez-Haber, C.2
Kim, J.3
Mochly-Rosen, D.4
Kazanietz, M.G.5
-
176
-
-
84868241317
-
Activation of Nuclear Factor kappaB (NF-kappaB) in Prostate Cancer Is Mediated by Protein Kinase C {epsilon} (PKC{epsilon})
-
Garg R, Blando J, Perez CJ, Wang H, Benavides FJ, Kazanietz MG. Activation of Nuclear Factor kappaB (NF-kappaB) in Prostate Cancer Is Mediated by Protein Kinase C {epsilon} (PKC{epsilon}). J Biol Chem 2012; 287: 37570–37582.
-
(2012)
J Biol Chem
, vol.287
, pp. 37570-37582
-
-
Garg, R.1
Blando, J.2
Perez, C.J.3
Wang, H.4
Benavides, F.J.5
Kazanietz, M.G.6
-
177
-
-
0037089018
-
Protein kinase cepsilon has the potential to advance the recurrence of human prostate cancer
-
Wu D, Foreman TL, Gregory CW, McJilton MA, Wescott GG, Ford OH et al. Protein kinase cepsilon has the potential to advance the recurrence of human prostate cancer. Cancer Res 2002; 62: 2423–2429.
-
(2002)
Cancer Res
, vol.62
, pp. 2423-2429
-
-
Wu, D.1
Foreman, T.L.2
Gregory, C.W.3
McJilton, M.A.4
Wescott, G.G.5
Ford, O.H.6
-
178
-
-
79952760132
-
Genetic ablation of PKC epsilon inhibits prostate cancer development and metastasis in transgenic mouse model of prostate adenocarcinoma
-
Hafeez BB, Zhong W, Weichert J, Dreckschmidt NE, Jamal MS, Verma AK. Genetic ablation of PKC epsilon inhibits prostate cancer development and metastasis in transgenic mouse model of prostate adenocarcinoma. Cancer Res 2011; 71: 2318–2327.
-
(2011)
Cancer Res
, vol.71
, pp. 2318-2327
-
-
Hafeez, B.B.1
Zhong, W.2
Weichert, J.3
Dreckschmidt, N.E.4
Jamal, M.S.5
Verma, A.K.6
-
179
-
-
80053370351
-
The expression and role of protein kinase C (PKC) epsilon in clear cell renal cell carcinoma
-
Huang B, Cao K, Li X, Guo S, Mao X, Wang Z et al. The expression and role of protein kinase C (PKC) epsilon in clear cell renal cell carcinoma. J Exp Clin Cancer Res 2011; 30: 88.
-
(2011)
J Exp Clin Cancer Res
, vol.30
, pp. 88
-
-
Huang, B.1
Cao, K.2
Li, X.3
Guo, S.4
Mao, X.5
Wang, Z.6
-
180
-
-
48249137015
-
Protein kinase Cepsilon: Multiple roles in the function of, and signaling mediated by, the cytoskeleton
-
Akita Y. Protein kinase Cepsilon: multiple roles in the function of, and signaling mediated by, the cytoskeleton. FEBS J 2008; 275: 3995–4004.
-
(2008)
FEBS J
, vol.275
, pp. 3995-4004
-
-
Akita, Y.1
-
181
-
-
0036956424
-
Protein kinase C-epsilon (PKC-epsilon): Its unique structure and function
-
Akita Y. Protein kinase C-epsilon (PKC-epsilon): its unique structure and function. J Biochem 2002; 132: 847–852.
-
(2002)
J Biochem
, vol.132
, pp. 847-852
-
-
Akita, Y.1
-
182
-
-
0030042104
-
Identification and localization of an actin-binding motif that is unique to the epsilon isoform of protein kinase C and participates in the regulation of synaptic function
-
Prekeris R, Mayhew MW, Cooper JB, Terrian DM. Identification and localization of an actin-binding motif that is unique to the epsilon isoform of protein kinase C and participates in the regulation of synaptic function. J Cell Biol 1996; 132: 77–90.
-
(1996)
J Cell Biol
, vol.132
, pp. 77-90
-
-
Prekeris, R.1
Mayhew, M.W.2
Cooper, J.B.3
Terrian, D.M.4
-
183
-
-
0035163505
-
Biochemical and morphogenic effects of the interaction between protein kinase C-epsilon and actin in vitro and in cultured NIH3T3 cells
-
Hernandez RM, Wescott GG, Mayhew MW, McJilton MA, Terrian DM. Biochemical and morphogenic effects of the interaction between protein kinase C-epsilon and actin in vitro and in cultured NIH3T3 cells. J Cell Biochem 2001; 83: 532–546.
-
(2001)
J Cell Biochem
, vol.83
, pp. 532-546
-
-
Hernandez, R.M.1
Wescott, G.G.2
Mayhew, M.W.3
McJilton, M.A.4
Terrian, D.M.5
-
184
-
-
0036237907
-
Regulation of tumor invasion and metastasis in protein kinase C epsilon-transformed NIH3T3 fibroblasts
-
Tachado SD, Mayhew MW, Wescott GG, Foreman TL, Goodwin CD, McJilton MA et al. Regulation of tumor invasion and metastasis in protein kinase C epsilon-transformed NIH3T3 fibroblasts. J Cell Biochem 2002; 85: 785–797.
-
(2002)
J Cell Biochem
, vol.85
, pp. 785-797
-
-
Tachado, S.D.1
Mayhew, M.W.2
Wescott, G.G.3
Foreman, T.L.4
Goodwin, C.D.5
McJilton, M.A.6
-
185
-
-
0035504758
-
Differential activation of ERKs to focal adhesions by PKC epsilon is required for PMA-induced adhesion and migration of human glioma cells
-
Besson A, Davy A, Robbins SM, Yong VW. Differential activation of ERKs to focal adhesions by PKC epsilon is required for PMA-induced adhesion and migration of human glioma cells. Oncogene 2001; 20: 7398–7407.
-
(2001)
Oncogene
, vol.20
, pp. 7398-7407
-
-
Besson, A.1
Davy, A.2
Robbins, S.M.3
Yong, V.W.4
-
186
-
-
9644259240
-
Integrin signaling links protein kinase Cepsilon to the protein kinase B/Akt survival pathway in recurrent prostate cancer cells
-
Wu D, Thakore CU, Wescott GG, McCubrey JA, Terrian DM. Integrin signaling links protein kinase Cepsilon to the protein kinase B/Akt survival pathway in recurrent prostate cancer cells. Oncogene 2004; 23: 8659–8672.
-
(2004)
Oncogene
, vol.23
, pp. 8659-8672
-
-
Wu, D.1
Thakore, C.U.2
Wescott, G.G.3
McCubrey, J.A.4
Terrian, D.M.5
-
187
-
-
33750379275
-
Targeted disruption of protein kinase C epsilon reduces cell invasion and motility through inactivation of RhoA and RhoC GTPases in head and neck squamous cell carcinoma
-
Pan Q, Bao LW, Teknos TN, Merajver SD. Targeted disruption of protein kinase C epsilon reduces cell invasion and motility through inactivation of RhoA and RhoC GTPases in head and neck squamous cell carcinoma. Cancer Res 2006; 66: 9379–9384.
-
(2006)
Cancer Res
, vol.66
, pp. 9379-9384
-
-
Pan, Q.1
Bao, L.W.2
Teknos, T.N.3
Merajver, S.D.4
-
188
-
-
84857578369
-
Non-small cell lung carcinoma cell motility, rac activation and metastatic dissemination are mediated by protein kinase C epsilon
-
Caino MC, Lopez-Haber C, Kissil JL, Kazanietz MG. Non-small cell lung carcinoma cell motility, rac activation and metastatic dissemination are mediated by protein kinase C epsilon. PLoS One 2012; 7: e31714.
-
(2012)
Plos One
, vol.7
-
-
Caino, M.C.1
Lopez-Haber, C.2
Kissil, J.L.3
Kazanietz, M.G.4
-
189
-
-
0035110896
-
Protein kinase C-epsilon transgenic mice: A unique model for metastatic squamous cell carcinoma
-
Jansen AP, Verwiebe EG, Dreckschmidt NE, Wheeler DL, Oberley TD, Verma AK. Protein kinase C-epsilon transgenic mice: a unique model for metastatic squamous cell carcinoma. Cancer Res 2001; 61: 808–812.
-
(2001)
Cancer Res
, vol.61
, pp. 808-812
-
-
Jansen, A.P.1
Verwiebe, E.G.2
Dreckschmidt, N.E.3
Wheeler, D.L.4
Oberley, T.D.5
Verma, A.K.6
-
190
-
-
7444232271
-
Protein kinase C epsilon is an endogenous photosensitizer that enhances ultraviolet radiation-induced cutaneous damage and development of squamous cell carcinomas
-
Wheeler DL, Martin KE, Ness KJ, Li Y, Dreckschmidt NE, Wartman M et al. Protein kinase C epsilon is an endogenous photosensitizer that enhances ultraviolet radiation-induced cutaneous damage and development of squamous cell carcinomas. Cancer Res 2004; 64: 7756–7765.
-
(2004)
Cancer Res
, vol.64
, pp. 7756-7765
-
-
Wheeler, D.L.1
Martin, K.E.2
Ness, K.J.3
Li, Y.4
Dreckschmidt, N.E.5
Wartman, M.6
-
191
-
-
72049119612
-
PKCepsilon overexpression, irrespective of genetic background, sensitizes skin to UVR-induced development of squamous-cell carcinomas
-
Sand JM, Aziz MH, Dreckschmidt NE, Havighurst TC, Kim K, Oberley TD et al. PKCepsilon overexpression, irrespective of genetic background, sensitizes skin to UVR-induced development of squamous-cell carcinomas. J Invest Dermatol 2010; 130: 270–277.
-
(2010)
J Invest Dermatol
, vol.130
, pp. 270-277
-
-
Sand, J.M.1
Aziz, M.H.2
Dreckschmidt, N.E.3
Havighurst, T.C.4
Kim, K.5
Oberley, T.D.6
-
192
-
-
11144231707
-
Overexpression of protein kinase C-{epsilon} in the mouse epidermis leads to a spontaneous myeloproliferative-like disease
-
Wheeler DL, Reddig PJ, Ness KJ, Leith CP, Oberley TD, Verma AK. Overexpression of protein kinase C-{epsilon} in the mouse epidermis leads to a spontaneous myeloproliferative-like disease. Am J Pathol 2005; 166: 117–126.
-
(2005)
Am J Pathol
, vol.166
, pp. 117-126
-
-
Wheeler, D.L.1
Reddig, P.J.2
Ness, K.J.3
Leith, C.P.4
Oberley, T.D.5
Verma, A.K.6
-
193
-
-
67651004942
-
Preclinical development of a bifunctional cancer cell homing, PKCepsilon inhibitory peptide for the treatment of head and neck cancer
-
Bao L, Gorin MA, Zhang M, Ventura AC, Pomerantz WC, Merajver SD et al. Preclinical development of a bifunctional cancer cell homing, PKCepsilon inhibitory peptide for the treatment of head and neck cancer. Cancer Res 2009; 69: 5829–5834.
-
(2009)
Cancer Res
, vol.69
, pp. 5829-5834
-
-
Bao, L.1
Gorin, M.A.2
Zhang, M.3
Ventura, A.C.4
Pomerantz, W.C.5
Merajver, S.D.6
-
194
-
-
84896395145
-
P120 catenin is a key effector of a Ras-PKCvarepsilon oncogenic signaling axis
-
Dann SG, Golas J, Miranda M, Shi C, Wu J, Jin G et al. p120 catenin is a key effector of a Ras-PKCvarepsilon oncogenic signaling axis. Oncogene 2013; 33: 1385–1394.
-
(2013)
Oncogene
, vol.33
, pp. 1385-1394
-
-
Dann, S.G.1
Golas, J.2
Miranda, M.3
Shi, C.4
Wu, J.5
Jin, G.6
-
195
-
-
0027431089
-
Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells
-
Selbie LA, Schmitz-Peiffer C, Sheng Y, Biden TJ. Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells. J Biol Chem 1993; 268: 24296–24302.
-
(1993)
J Biol Chem
, vol.268
, pp. 24296-24302
-
-
Selbie, L.A.1
Schmitz-Peiffer, C.2
Sheng, Y.3
Biden, T.J.4
-
196
-
-
0001613219
-
Protein kinase C zeta subspecies from rat brain: Its structure, expression, and properties
-
Ono Y, Fujii T, Ogita K, Kikkawa U, Igarashi K, Nishizuka Y. Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties. Proc Natl Acad Sci USA 1989; 86: 3099–3103.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 3099-3103
-
-
Ono, Y.1
Fujii, T.2
Ogita, K.3
Kikkawa, U.4
Igarashi, K.5
Nishizuka, Y.6
-
197
-
-
34249072202
-
Molecular concepts analysis links tumors, pathways, mechanisms, and drugs
-
Rhodes DR, Kalyana-Sundaram S, Tomlins SA, Mahavisno V, Kasper N, Varambally R et al. Molecular concepts analysis links tumors, pathways, mechanisms, and drugs. Neoplasia 2007; 9: 443–454.
-
(2007)
Neoplasia
, vol.9
, pp. 443-454
-
-
Rhodes, D.R.1
Kalyana-Sundaram, S.2
Tomlins, S.A.3
Mahavisno, V.4
Kasper, N.5
Varambally, R.6
-
198
-
-
19944432807
-
Molecular profiling of human prostate tissues: Insights into gene expression patterns of prostate development during puberty
-
Dhanasekaran SM, Dash A, Yu J, Maine IP, Laxman B, Tomlins SA et al. Molecular profiling of human prostate tissues: insights into gene expression patterns of prostate development during puberty. FASEB J 2005; 19: 243–245.
-
(2005)
FASEB J
, vol.19
, pp. 243-245
-
-
Dhanasekaran, S.M.1
Dash, A.2
Yu, J.3
Maine, I.P.4
Laxman, B.5
Tomlins, S.A.6
-
199
-
-
2542565666
-
Gene expression in the urinary bladder: A common carcinoma in situ gene expression signature exists disregarding histopathological classification
-
Dyrskjot L, Kruhoffer M, Thykjaer T, Marcussen N, Jensen JL, Moller K et al. Gene expression in the urinary bladder: a common carcinoma in situ gene expression signature exists disregarding histopathological classification. Cancer Res 2004; 64: 4040–4048.
-
(2004)
Cancer Res
, vol.64
, pp. 4040-4048
-
-
Dyrskjot, L.1
Kruhoffer, M.2
Thykjaer, T.3
Marcussen, N.4
Jensen, J.L.5
Moller, K.6
-
200
-
-
33644867290
-
Defining molecular profiles of poor outcome in patients with invasive bladder cancer using oligonucleotide microarrays
-
Sanchez-Carbayo M, Socci ND, Lozano J, Saint F, Cordon-Cardo C. Defining molecular profiles of poor outcome in patients with invasive bladder cancer using oligonucleotide microarrays. J Clin Oncol 2006; 24: 778–789.
-
(2006)
J Clin Oncol
, vol.24
, pp. 778-789
-
-
Sanchez-Carbayo, M.1
Socci, N.D.2
Lozano, J.3
Saint, F.4
Cordon-Cardo, C.5
-
201
-
-
16844376909
-
Reverse engineering of regulatory networks in human B cells
-
Basso K, Margolin AA, Stolovitzky G, Klein U, Dalla-Favera R, Califano A. Reverse engineering of regulatory networks in human B cells. Nat Genet 2005; 37: 382–390.
-
(2005)
Nat Genet
, vol.37
, pp. 382-390
-
-
Basso, K.1
Margolin, A.A.2
Stolovitzky, G.3
Klein, U.4
Dalla-Favera, R.5
Califano, A.6
-
202
-
-
33645279862
-
Molecular diagnosis of Burkitt’s lymphoma
-
Dave SS, Fu K, Wright GW, Lam LT, Kluin P, Boerma EJ et al. Molecular diagnosis of Burkitt’s lymphoma. N Engl J Med 2006; 354: 2431–2442.
-
(2006)
N Engl J Med
, vol.354
, pp. 2431-2442
-
-
Dave, S.S.1
Fu, K.2
Wright, G.W.3
Lam, L.T.4
Kluin, P.5
Boerma, E.J.6
-
203
-
-
33645772227
-
Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain
-
Sun L, Hui AM, Su Q, Vortmeyer A, Kotliarov Y, Pastorino S et al. Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain. Cancer Cell 2006; 9: 287–300.
-
(2006)
Cancer Cell
, vol.9
, pp. 287-300
-
-
Sun, L.1
Hui, A.M.2
Su, Q.3
Vortmeyer, A.4
Kotliarov, Y.5
Pastorino, S.6
-
204
-
-
29244472476
-
Gene expression profiles associated with treatment response in oligodendrogliomas
-
French PJ, Swagemakers SM, Nagel JH, Kouwenhoven MC, Brouwer E, van der Spek P et al. Gene expression profiles associated with treatment response in oligodendrogliomas. Cancer Res 2005; 65: 11335–11344.
-
(2005)
Cancer Res
, vol.65
, pp. 11335-11344
-
-
French, P.J.1
Swagemakers, S.M.2
Nagel, J.H.3
Kouwenhoven, M.C.4
Brouwer, E.5
van der Spek, P.6
-
205
-
-
0035884608
-
Distinctive molecular profiles of high-grade and low-grade gliomas based on oligonucleotide microarray analysis
-
Rickman DS, Bobek MP, Misek DE, Kuick R, Blaivas M, Kurnit DM et al. Distinctive molecular profiles of high-grade and low-grade gliomas based on oligonucleotide microarray analysis. Cancer Res 2001; 61: 6885–6891.
-
(2001)
Cancer Res
, vol.61
, pp. 6885-6891
-
-
Rickman, D.S.1
Bobek, M.P.2
Misek, D.E.3
Kuick, R.4
Blaivas, M.5
Kurnit, D.M.6
-
206
-
-
25444448993
-
Functional network analysis reveals extended gliomagenesis pathway maps and three novel MYC-interacting genes in human gliomas
-
Bredel M, Bredel C, Juric D, Harsh GR, Vogel H, Recht LD et al. Functional network analysis reveals extended gliomagenesis pathway maps and three novel MYC-interacting genes in human gliomas. Cancer Res 2005; 65: 8679–8689.
-
(2005)
Cancer Res
, vol.65
, pp. 8679-8689
-
-
Bredel, M.1
Bredel, C.2
Juric, D.3
Harsh, G.R.4
Vogel, H.5
Recht, L.D.6
-
207
-
-
0035923521
-
Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses
-
Bhattacharjee A, Richards WG, Staunton J, Li C, Monti S, Vasa P et al. Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc Natl Acad Sci USA 2001; 98: 13790–13795.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 13790-13795
-
-
Bhattacharjee, A.1
Richards, W.G.2
Staunton, J.3
Li, C.4
Monti, S.5
Vasa, P.6
-
208
-
-
28244499333
-
Analysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcinogen-induced murine model
-
Stearman RS, Dwyer-Nield L, Zerbe L, Blaine SA, Chan Z, Bunn Jr PA et al. Analysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcinogen-induced murine model. Am J Pathol 2005; 167: 1763–1775.
-
(2005)
Am J Pathol
, vol.167
, pp. 1763-1775
-
-
Stearman, R.S.1
Dwyer-Nield, L.2
Zerbe, L.3
Blaine, S.A.4
Chan, Z.5
Bunn, P.A.6
-
209
-
-
58149473474
-
Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo
-
Galvez AS, Duran A, Linares JF, Pathrose P, Castilla EA, Abu-Baker S et al. Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo. Mol Cell Biol 2009; 29: 104–115.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 104-115
-
-
Galvez, A.S.1
Duran, A.2
Linares, J.F.3
Pathrose, P.4
Castilla, E.A.5
Abu-Baker, S.6
-
210
-
-
3042752912
-
Previously unidentified changes in renal cell carcinoma gene expression identified by parametric analysis of microarray data
-
Lenburg ME, Liou LS, Gerry NP, Frampton GM, Cohen HT, Christman MF. Previously unidentified changes in renal cell carcinoma gene expression identified by parametric analysis of microarray data. BMC Cancer 2003; 3: 31.
-
(2003)
BMC Cancer
, vol.3
, pp. 31
-
-
Lenburg, M.E.1
Liou, L.S.2
Gerry, N.P.3
Frampton, G.M.4
Cohen, H.T.5
Christman, M.F.6
-
211
-
-
27144537768
-
Novel genes associated with malignant melanoma but not benign melanocytic lesions
-
Talantov D, Mazumder A, Yu JX, Briggs T, Jiang Y, Backus J et al. Novel genes associated with malignant melanoma but not benign melanocytic lesions. Clin Cancer Res 2005; 11: 7234–7242.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 7234-7242
-
-
Talantov, D.1
Mazumder, A.2
Yu, J.X.3
Briggs, T.4
Jiang, Y.5
Backus, J.6
-
212
-
-
27144454969
-
Transcriptome analysis of microdissected pancreatic intraepithelial neoplastic lesions
-
Buchholz M, Braun M, Heidenblut A, Kestler HA, Kloppel G, Schmiegel W et al. Transcriptome analysis of microdissected pancreatic intraepithelial neoplastic lesions. Oncogene 2005; 24: 6626–6636.
-
(2005)
Oncogene
, vol.24
, pp. 6626-6636
-
-
Buchholz, M.1
Braun, M.2
Heidenblut, A.3
Kestler, H.A.4
Kloppel, G.5
Schmiegel, W.6
-
213
-
-
33749328492
-
Protein kinase-zeta inhibits collagen I-dependent and anchorage-independent growth and enhances apoptosis of human Caco-2 cells
-
Mustafi R, Cerda S, Chumsangsri A, Fichera A, Bissonnette M. Protein kinase-zeta inhibits collagen I-dependent and anchorage-independent growth and enhances apoptosis of human Caco-2 cells. Mol Cancer Res 2006; 4: 683–694.
-
(2006)
Mol Cancer Res
, vol.4
, pp. 683-694
-
-
Mustafi, R.1
Cerda, S.2
Chumsangsri, A.3
Fichera, A.4
Bissonnette, M.5
-
214
-
-
77953790111
-
Atypical protein kinase C zeta exhibits a proapoptotic function in ovarian cancer
-
Nazarenko I, Jenny M, Keil J, Gieseler C, Weisshaupt K, Sehouli J et al. Atypical protein kinase C zeta exhibits a proapoptotic function in ovarian cancer. Mol Cancer Res 2010; 8: 919–934.
-
(2010)
Mol Cancer Res
, vol.8
, pp. 919-934
-
-
Nazarenko, I.1
Jenny, M.2
Keil, J.3
Gieseler, C.4
Weisshaupt, K.5
Sehouli, J.6
-
215
-
-
0036569943
-
RhoA-dependent murine prostate cancer cell proliferation and apoptosis: Role of protein kinase Czeta
-
Ghosh PM, Bedolla R, Mikhailova M, Kreisberg JI. RhoA-dependent murine prostate cancer cell proliferation and apoptosis: role of protein kinase Czeta. Cancer Res 2002; 62: 2630–2636.
-
(2002)
Cancer Res
, vol.62
, pp. 2630-2636
-
-
Ghosh, P.M.1
Bedolla, R.2
Mikhailova, M.3
Kreisberg, J.I.4
-
216
-
-
0037086155
-
Atypical protein kinase C zeta as a target for chemosensitization of tumor cells
-
Filomenko R, Poirson-Bichat F, Billerey C, Belon JP, Garrido C, Solary E et al. Atypical protein kinase C zeta as a target for chemosensitization of tumor cells. Cancer Res 2002; 62: 1815–1821.
-
(2002)
Cancer Res
, vol.62
, pp. 1815-1821
-
-
Filomenko, R.1
Poirson-Bichat, F.2
Billerey, C.3
Belon, J.P.4
Garrido, C.5
Solary, E.6
-
217
-
-
0036893717
-
Overexpression of protein kinase Czeta confers protection against antileukemic drugs by inhibiting the redox-dependent sphingomyelinase activation
-
Bezombes C, de Thonel A, Apostolou A, Louat T, Jaffrezou JP, Laurent G et al. Overexpression of protein kinase Czeta confers protection against antileukemic drugs by inhibiting the redox-dependent sphingomyelinase activation. Mol Pharmacol 2002; 62: 1446–1455.
-
(2002)
Mol Pharmacol
, vol.62
, pp. 1446-1455
-
-
Bezombes, C.1
de Thonel, A.2
Apostolou, A.3
Louat, T.4
Jaffrezou, J.P.5
Laurent, G.6
-
218
-
-
0037215683
-
Protein kinase C zeta nuclear translocation mediates the occurrence of radioresistance in friend erythroleukemia cells
-
Cataldi A, Centurione L, Di Pietro R, Rapino M, Bosco D, Grifone G et al. Protein kinase C zeta nuclear translocation mediates the occurrence of radioresistance in friend erythroleukemia cells. J Cell Biochem 2003; 88: 144–151.
-
(2003)
J Cell Biochem
, vol.88
, pp. 144-151
-
-
Cataldi, A.1
Centurione, L.2
Di Pietro, R.3
Rapino, M.4
Bosco, D.5
Grifone, G.6
-
219
-
-
34547101741
-
Protein kinase Czeta abrogates the proapoptotic function of Bax through phosphorylation
-
Xin M, Gao F, May WS, Flagg T, Deng X. Protein kinase Czeta abrogates the proapoptotic function of Bax through phosphorylation. J Biol Chem 2007; 282: 21268–21277.
-
(2007)
J Biol Chem
, vol.282
, pp. 21268-21277
-
-
Xin, M.1
Gao, F.2
May, W.S.3
Flagg, T.4
Deng, X.5
-
220
-
-
84857946886
-
The selective inhibition of nuclear PKCzeta restores the effectiveness of chemotherapeutic agents in chemoresistant cells
-
Rimessi A, Zecchini E, Siviero R, Giorgi C, Leo S, Rizzuto R et al. The selective inhibition of nuclear PKCzeta restores the effectiveness of chemotherapeutic agents in chemoresistant cells. Cell cycle 2012; 11: 1040–1048.
-
(2012)
Cell Cycle
, vol.11
, pp. 1040-1048
-
-
Rimessi, A.1
Zecchini, E.2
Siviero, R.3
Giorgi, C.4
Leo, S.5
Rizzuto, R.6
-
221
-
-
84876213030
-
C-Myc phosphorylation by PKCzeta represses prostate tumorigenesis
-
Kim JY, Valencia T, Abu-Baker S, Linares J, Lee SJ, Yajima T et al. c-Myc phosphorylation by PKCzeta represses prostate tumorigenesis. Proc Natl Acad Sci USA 2013; 110: 6418–6423.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 6418-6423
-
-
Kim, J.Y.1
Valencia, T.2
Abu-Baker, S.3
Linares, J.4
Lee, S.J.5
Yajima, T.6
-
222
-
-
84873318679
-
Control of nutrient stress-induced metabolic reprogramming by PKCzeta in tumorigenesis
-
Ma L, Tao Y, Duran A, Llado V, Galvez A, Barger JF et al. Control of nutrient stress-induced metabolic reprogramming by PKCzeta in tumorigenesis. Cell 2013; 152: 599–611.
-
(2013)
Cell
, vol.152
, pp. 599-611
-
-
Ma, L.1
Tao, Y.2
Duran, A.3
Llado, V.4
Galvez, A.5
Barger, J.F.6
-
223
-
-
33646418390
-
Integrative genomic analysis of protein kinase C (PKC) family identifies PKCiota as a biomarker and potential oncogene in ovarian carcinoma
-
Zhang L, Huang J, Yang N, Liang S, Barchetti A, Giannakakis A et al. Integrative genomic analysis of protein kinase C (PKC) family identifies PKCiota as a biomarker and potential oncogene in ovarian carcinoma. Cancer Res 2006; 66: 4627–4635.
-
(2006)
Cancer Res
, vol.66
, pp. 4627-4635
-
-
Zhang, L.1
Huang, J.2
Yang, N.3
Liang, S.4
Barchetti, A.5
Giannakakis, A.6
-
224
-
-
24644490121
-
Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer
-
Eder AM, Sui X, Rosen DG, Nolden LK, Cheng KW, Lahad JP et al. Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer. Proc Natl Acad Sci USA 2005; 102: 12519–12524.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 12519-12524
-
-
Eder, A.M.1
Sui, X.2
Rosen, D.G.3
Nolden, L.K.4
Cheng, K.W.5
Lahad, J.P.6
-
225
-
-
34248219165
-
Amplification of MDS1/EVI1 and EVI1, located in the 3q26.2 amplicon, is associated with favorable patient prognosis in ovarian cancer
-
Nanjundan M, Nakayama Y, Cheng KW, Lahad J, Liu J, Lu K et al. Amplification of MDS1/EVI1 and EVI1, located in the 3q26.2 amplicon, is associated with favorable patient prognosis in ovarian cancer. Cancer Res 2007; 67: 3074–3084.
-
(2007)
Cancer Res
, vol.67
, pp. 3074-3084
-
-
Nanjundan, M.1
Nakayama, Y.2
Cheng, K.W.3
Lahad, J.4
Liu, J.5
Lu, K.6
-
226
-
-
1542334781
-
Bcr-Abl regulates protein kinase Ciota (PKCiota) transcription via an Elk1 site in the PKCiota promoter
-
Gustafson WC, Ray S, Jamieson L, Thompson EA, Brasier AR, Fields AP. Bcr-Abl regulates protein kinase Ciota (PKCiota) transcription via an Elk1 site in the PKCiota promoter. J Biol Chem 2004; 279: 9400–9408.
-
(2004)
J Biol Chem
, vol.279
, pp. 9400-9408
-
-
Gustafson, W.C.1
Ray, S.2
Jamieson, L.3
Thompson, E.A.4
Brasier, A.R.5
Fields, A.P.6
-
227
-
-
4444221607
-
Protein kinase Ciota is required for Ras transformation and colon carcinogenesis in vivo
-
Murray NR, Jamieson L, Yu W, Zhang J, Gokmen-Polar Y, Sier D et al. Protein kinase Ciota is required for Ras transformation and colon carcinogenesis in vivo. J Cell Biol 2004; 164: 797–802.
-
(2004)
J Cell Biol
, vol.164
, pp. 797-802
-
-
Murray, N.R.1
Jamieson, L.2
Yu, W.3
Zhang, J.4
Gokmen-Polar, Y.5
Sier, D.6
-
228
-
-
77950250455
-
Protein kinase Ciota is required for pancreatic cancer cell transformed growth and tumorigenesis
-
Scotti ML, Bamlet WR, Smyrk TC, Fields AP, Murray NR. Protein kinase Ciota is required for pancreatic cancer cell transformed growth and tumorigenesis. Cancer Res 2010; 70: 2064–2074.
-
(2010)
Cancer Res
, vol.70
, pp. 2064-2074
-
-
Scotti, M.L.1
Bamlet, W.R.2
Smyrk, T.C.3
Fields, A.P.4
Murray, N.R.5
-
229
-
-
79251508328
-
Protein kinase Ciota expression and oncogenic signaling mechanisms in cancer
-
Murray NR, Kalari KR, Fields AP. Protein kinase Ciota expression and oncogenic signaling mechanisms in cancer. J Cell Physiol 2011; 226: 879–887.
-
(2011)
J Cell Physiol
, vol.226
, pp. 879-887
-
-
Murray, N.R.1
Kalari, K.R.2
Fields, A.P.3
-
230
-
-
49649126819
-
Matrix metalloproteinase-10 is a critical effector of protein kinase Ciota-Par6alpha-mediated lung cancer
-
Frederick LA, Matthews JA, Jamieson L, Justilien V, Thompson EA, Radisky DC et al. Matrix metalloproteinase-10 is a critical effector of protein kinase Ciota-Par6alpha-mediated lung cancer. Oncogene 2008; 27: 4841–4853.
-
(2008)
Oncogene
, vol.27
, pp. 4841-4853
-
-
Frederick, L.A.1
Matthews, J.A.2
Jamieson, L.3
Justilien, V.4
Thompson, E.A.5
Radisky, D.C.6
-
231
-
-
70350236536
-
Atypical protein kinase C{iota} is required for bronchioalveolar stem cell expansion and lung tumorigenesis
-
Regala RP, Davis RK, Kunz A, Khoor A, Leitges M, Fields AP. Atypical protein kinase C{iota} is required for bronchioalveolar stem cell expansion and lung tumorigenesis. Cancer Res 2009; 69: 7603–7611.
-
(2009)
Cancer Res
, vol.69
, pp. 7603-7611
-
-
Regala, R.P.1
Davis, R.K.2
Kunz, A.3
Khoor, A.4
Leitges, M.5
Fields, A.P.6
-
232
-
-
24744469442
-
Atypical protein kinase Ciota plays a critical role in human lung cancer cell growth and tumorigenicity
-
Regala RP, Weems C, Jamieson L, Copland JA, Thompson EA, Fields AP. Atypical protein kinase Ciota plays a critical role in human lung cancer cell growth and tumorigenicity. J Biol Chem 2005; 280: 31109–31115.
-
(2005)
J Biol Chem
, vol.280
, pp. 31109-31115
-
-
Regala, R.P.1
Weems, C.2
Jamieson, L.3
Copland, J.A.4
Thompson, E.A.5
Fields, A.P.6
-
233
-
-
25444531988
-
Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer
-
Regala RP, Weems C, Jamieson L, Khoor A, Edell ES, Lohse CM et al. Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer. Cancer Res 2005; 65: 8905–8911.
-
(2005)
Cancer Res
, vol.65
, pp. 8905-8911
-
-
Regala, R.P.1
Weems, C.2
Jamieson, L.3
Khoor, A.4
Edell, E.S.5
Lohse, C.M.6
-
234
-
-
79953154962
-
Oncogenic activity of Ect2 is regulated through protein kinase C iota-mediated phosphorylation
-
Justilien V, Jameison L, Der CJ, Rossman KL, Fields AP. Oncogenic activity of Ect2 is regulated through protein kinase C iota-mediated phosphorylation. J Biol Chem 2011; 286: 8149–8157.
-
(2011)
J Biol Chem
, vol.286
, pp. 8149-8157
-
-
Justilien, V.1
Jameison, L.2
Der, C.J.3
Rossman, K.L.4
Fields, A.P.5
-
235
-
-
48649092328
-
Atypical protein kinase C iota expression and aurothiomalate sensitivity in human lung cancer cells
-
Regala RP, Thompson EA, Fields AP. Atypical protein kinase C iota expression and aurothiomalate sensitivity in human lung cancer cells. Cancer Res 2008; 68: 5888–5895.
-
(2008)
Cancer Res
, vol.68
, pp. 5888-5895
-
-
Regala, R.P.1
Thompson, E.A.2
Fields, A.P.3
-
236
-
-
79959968305
-
Atypical protein kinase C (APKCzeta and aPKClambda) is dispensable for mammalian hematopoietic stem cell activity and blood formation
-
Sengupta A, Duran A, Ishikawa E, Florian MC, Dunn SK, Ficker AM et al. Atypical protein kinase C (aPKCzeta and aPKClambda) is dispensable for mammalian hematopoietic stem cell activity and blood formation. Proc Natl Acad Sci USA 2011; 108: 9957–9962.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 9957-9962
-
-
Sengupta, A.1
Duran, A.2
Ishikawa, E.3
Florian, M.C.4
Dunn, S.K.5
Ficker, A.M.6
-
237
-
-
84874359079
-
GLI activation by atypical protein kinase C iota/lambda regulates the growth of basal cell carcinomas
-
Atwood SX, Li M, Lee A, Tang JY, Oro AE. GLI activation by atypical protein kinase C iota/lambda regulates the growth of basal cell carcinomas. Nature 2013; 494: 484–488.
-
(2013)
Nature
, vol.494
, pp. 484-488
-
-
Atwood, S.X.1
Li, M.2
Lee, A.3
Tang, J.Y.4
Oro, A.E.5
-
238
-
-
44449112209
-
Regulation of glioblastoma cell invasion by PKC iota and RhoB
-
Baldwin RM, Parolin DA, Lorimer IA. Regulation of glioblastoma cell invasion by PKC iota and RhoB. Oncogene 2008; 27: 3587–3595.
-
(2008)
Oncogene
, vol.27
, pp. 3587-3595
-
-
Baldwin, R.M.1
Parolin, D.A.2
Lorimer, I.A.3
-
239
-
-
52149112088
-
Atypical protein kinase C phosphorylates IKKal-phabeta in transformed non-malignant and malignant prostate cell survival
-
Win HY, Acevedo-Duncan M. Atypical protein kinase C phosphorylates IKKal-phabeta in transformed non-malignant and malignant prostate cell survival. Cancer Lett 2008; 270: 302–311.
-
(2008)
Cancer Lett
, vol.270
, pp. 302-311
-
-
Win, H.Y.1
Acevedo-Duncan, M.2
-
240
-
-
70349485623
-
APKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6
-
Ishiguro H, Akimoto K, Nagashima Y, Kojima Y, Sasaki T, Ishiguro-Imagawa Y et al. aPKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6. Proc Natl Acad Sci USA 2009; 106: 16369–16374.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 16369-16374
-
-
Ishiguro, H.1
Akimoto, K.2
Nagashima, Y.3
Kojima, Y.4
Sasaki, T.5
Ishiguro-Imagawa, Y.6
-
241
-
-
79954567234
-
Atypical protein kinase Ciota (PKCiota) promotes metastasis of esophageal squamous cell carcinoma by enhancing resistance to Anoikis via PKCiota-SKP2-AKT pathway
-
Liu SG, Wang BS, Jiang YY, Zhang TT, Shi ZZ, Yang Y et al. Atypical protein kinase Ciota (PKCiota) promotes metastasis of esophageal squamous cell carcinoma by enhancing resistance to Anoikis via PKCiota-SKP2-AKT pathway. Mol Cancer Res 2011; 9: 390–402.
-
(2011)
Mol Cancer Res
, vol.9
, pp. 390-402
-
-
Liu, S.G.1
Wang, B.S.2
Jiang, Y.Y.3
Zhang, T.T.4
Shi, Z.Z.5
Yang, Y.6
-
243
-
-
0034776809
-
Protein kinase C isozymes, novel phorbol ester receptors and cancer chemotherapy
-
Barry OP, Kazanietz MG. Protein kinase C isozymes, novel phorbol ester receptors and cancer chemotherapy. Curr Pharm Des 2001; 7: 1725–1744.
-
(2001)
Curr Pharm Des
, vol.7
, pp. 1725-1744
-
-
Barry, O.P.1
Kazanietz, M.G.2
-
244
-
-
0028167842
-
Binding of [26-3H]bryostatin 1 and analogs to calcium-dependent and calcium-independent protein kinase C isozymes
-
Kazanietz MG, Lewin NE, Gao F, Pettit GR, Blumberg PM. Binding of [26-3H]bryostatin 1 and analogs to calcium-dependent and calcium-independent protein kinase C isozymes. Mol Pharmacol 1994; 46: 374–379.
-
(1994)
Mol Pharmacol
, vol.46
, pp. 374-379
-
-
Kazanietz, M.G.1
Lewin, N.E.2
Gao, F.3
Pettit, G.R.4
Blumberg, P.M.5
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