PKC-mediated secretion of death factors in LNCaP prostate cancer cells is regulated by androgens

Molecular Carcinogenesis

Volumn 48, Issue 3, 2009, Pages 187-195

  Xiao, Liqing ^a   Gonzalez Guerrico, Anatilde ^a   Kazanietz, Marcelo G ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Androgens; Apoptosis; JNK; p38 MAPK; PKC; PMA

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; DEATH RECEPTOR; MESSENGER RNA; METRIBOLONE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C DELTA; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; AR PROTEIN, HUMAN; RNA; SMALL INTERFERING RNA; TNFSF10 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; CELL STRAIN LNCAP; CONTROLLED STUDY; DOWN REGULATION; HORMONE ACTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RNA INTERFERENCE; SENSITIVITY ANALYSIS; CULTURE MEDIUM; DRUG ANTAGONISM; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; MALE; METABOLISM; PATHOLOGY; PROSTATE TUMOR; SIGNAL TRANSDUCTION; TUMOR CELL LINE; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; CULTURE MEDIA, CONDITIONED; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; METRIBOLONE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROSTATIC NEOPLASMS; PROTEIN KINASE C-DELTA; RECEPTORS, ANDROGEN; RNA, NEOPLASM; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR-ALPHA;

EID: 62349139176     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20476     Document Type: Article

References (46)

1. Cross TG, Scheel-Toellner D, Henriquez NV, et al. Serine/threonine protein kinases and apoptosis. Exp Cell Res 2000;256:34-41.
2. Okada H, Mak TW. Pathways of apoptotic and non-apoptotic death in tumour cells. Nat Rev Cancer 2004;4:592-603.
3. Johnson GL, Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 2002;6:1911-1912.
4. Brodie C, Blumberg PM. Regulation of cell apoptosis by protein kinase c delta. Apoptosis 2003;8:19-27.
5. Gavrielides MV, Frijhoff AF, Conti CJ, Kazanietz MG. Protein kinase C and prostate carcinogenesis: Targeting the cell cycle and apoptotic mechanisms. Curr Drug Targets 2004;5:431-443.
6. Reyland ME. Protein kinase C delta and apoptosis. Biochem Soc Trans 2007;35:1001-1004.
7. Basu A, Sivaprasad U. Protein kinase C epsilon makes the life and death decision. Cell Signal 2007;19:1633-1642.
8. Griner EM, Kazanietz MG. Protein kinase C and other diacylglycerol effectors in cancer. Nat Rev Cancer 2007;7:281-294.
9. Powell CT, Brittis NJ, Stec D, Hug H, Heston WD, Fair WR. Persistent membrane translocation of protein kinase C alpha during 12-0- tetradecanoylphorbol-13-acetate-induced apoptosis of LNCaP human prostate cancer cells. Cell Growth Differ 1996;7:419-428.
10. Zhao X, Gschwend JE, Powell CT, Foster RG, Day KC, Day ML. Retinoblastoma protein-dependent growth signal conflict and caspase activity are required for protein kinase C-signaled apoptosis of prostate epithelial cells. J Biol Chem 1997;272:22751-22757.
11. Garzotto M, White-Jones M, Jiang Y, et al. 12-O-tetradecanoylphorbol-13- acetate-induced apoptosis in LNCaP cells is mediated through ceramide synthase. Cancer Res 1998;58:2260-2264.
12. Fujii T, García-Bermejo ML, Bernabó JL, et al. Involvement of protein kinase C delta (PKCdelta) in phorbol ester-induced apoptosis in LNCaP prostate cancer cells. Lack of proteolytic cleavage of PKCdelta. J Biol Chem 2000;275:7574-7582.
13. Truman JP, Gueven N, Lavin M, et al. Down-regulation of ATM protein sensitizes human prostate cancer cells to radiation-induced apoptosis. J Biol Chem 2005;280:23262-23272.
14. Tanaka Y, Gavrielides MV, Mitsuuchi Y, Fujii T, Kazanietz MG. Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway. J Biol Chem 2003;278:33753-33762.
15. McJilton MA, Van Sikes C, Wescott GG, et al. Protein kinase Cepsilon interacts with Bax and promotes survival of human prostate cancer cells. Oncogene 2003;22:7958-7968.
16. Ikezoe T, Yang Y, Taguchi H, Koeffler HP. JNK interacting protein 1 (JIP-1) protects LNCaP prostate cancer cells from growth arrest and apoptosis mediated by 12-0-tetradecanoylphorbol-13-acetate (TPA). Br J Cancer 2004;90:2017-2024.
17. Aggarwal BB. Signalling pathways of the TNF superfamily: A double-edged sword. Nat Rev Immunol 2003;3:745-756.
18. Gonzalez-Guerrico AM, Kazanietz MG. Phorbol esterinduced apoptosis in prostate cancer cells via autocrine activation of the extrinsic apoptotic cascade: A key role for protein kinase C delta. J Biol Chem 2005;280:38982- 38991.
19. Gavrielides MV, Gonzalez-Guerrico AM, Riobo NA, Kazanietz MG. Androgens regulate protein kinase Cdelta transcription and modulate its apoptotic function in prostate cancer cells. Cancer Res 2006;66:11792-11801.
20. Cacace AM, Ueffing M, Han EK, Marmè D, Weinstein IB. Overexpression of PKCepsilon in R6 fibroblasts causes increased production of active TGFbeta. J Cell Physiol 1998;175:314-322.
21. Chattopadhyay N, Tfelt-Hansen J, Brown EM. PKC, p42/44 MAPK and p38 MAPK regulate hepatocyte growth factor secretion from human astrocytoma cells. Brain Res Mol Brain Res 2002;102:73-82.
22. Wheeler DL, Ness KJ, Oberley TD, Verma AK. Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice. Cancer Res 2003;63:6547-6555.
23. Jariwala U, Prescott J, Jia L, et al. Identification of novel androgen receptor target genes in prostate cancer. Mol Cancer 2007;6:39.
24. Bowles DK, Maddali KK, Dhulipala VC, Korzick DH. PKCdelta mediates anti-proliferative, pro-apoptic effects of testosterone on coronary smooth muscle. Am J Physiol Cell Physiol 2007;293:805-813.
25. Peters CA, Cutler RE, Maizels ET, et al. Regulation of PKC delta expression by estrogen and rat placental lactogen-1 in luteinized rat ovarian granulosa cells. Mol Cell Endocrinol 2000;162:181-191.
26. Berry DM, Antochi R, Bhatia M, Meckling-Gill KA. 1,25-Dihydroxyvitamin D3 stimulates expression and translocation of protein kinase Calpha and Cdelta via a nongenomic mechanism and rapidly induces phosphorylation of a 33-kDa protein in acute promyelocytic NB4 cells. J Biol Chem 1996;271:16090-16096.
27. Geng WD, Boskovic G, Fultz ME, et al. Regulation of expression and activity of four PKC isozymes in confluent and mechanically stimulated UMR-108 osteoblastic cells. J Cell Physiol 2001;189:216-228.
28. Shanmugam M, Krett NL, Maizels ET, et al. Regulation of protein kinase Cdelta by estrogen in the MCF-7 human breast cancer cell line. Mol Cell Endocrinol 1999;148:109-118.
29. Rothermund CA, Gopalakrishnan VK, Eudy JD, Vishwanatha JK. Casodex treatment induces hypoxia-related gene expression in the LNCaP prostate cancer progression model. BMC Urol 2005;5:5.
30. Bozdogan O, Atasoy P, Bozdogan N, et al. BAG-1 expression in hyperplastic and neoplastic prostate tissue: Is there any relationship with BCL-related proteins and androgen receptor status? Tumori 2005;91:539-545.
31. Jia Y, Hikim AP, Lue YH, et al. Signaling pathways for germ cell death in adult cynomolgus monkeys (Macaca fascicularis) induced by mild testicular hyperthermia and exogenous testosterone treatment. Biol Reprod 2007;77:83-92.
32. Jin Z, El-Deiry WS. Overview of cell death signaling pathways. Cancer Biol Ther 2005;4:139-163.
33. Guseva NV, Taghiyev AF, Rokhlin OW, Cohen MB. Death receptor-induced cell death in prostate cancer. J Cell Biochem 2004;91:70-99.
34. Shankar S, Chen X, Srivastava RK. Effects of sequential treatments with chemotherapeutic drugs followed by TRAIL on prostate cancer in vitro and in vivo. Prostate 2005;62:165-186.
35. O'Kane HF, Watson CJ, Johnston SR, Petak I, Watson RW, Williamson KE. Targeting death receptors in bladder, prostate and renal cancer. J Urol 2006;175:432-438.
36. Shankar S, Singh TR, Srivastava RK. Ionizing radiation enhances the therapeutic potential of TRAIL in prostate cancer in vitro and in vivo: Intracellular mechanisms. Prostate 2004;61:35-49.
37. Hu H, Jiang C, Schuster T, Li GX, Daniel PT, Lü J. Inorganic selenium sensitizes prostate cancer cells to TRAIL-induced apoptosis through superoxide/p53/Bax-mediated activation of mitochondrial pathway. Mol Cancer Ther 2006;5:1873-1882.
38. An J, Sun YP, Adams J, Fisher M, Belldegrun A, Rettig MB. Drug interactions between the proteasome inhibitor bortezomib and cytotoxic chemotherapy, tumor necrosis factor (TNF) alpha, and TNF-related apoptosis-inducing ligand in prostate cancer. Clin Cancer Res 2003;9:4537-4545.
39. Kilpatrick LE, Sun S, Mackie D, Baik F, Li H, Korchak HM. Regulation of TNF mediated antiapoptotic signaling in human neutrophils: Role of delta-PKC and ERK1/2. J Leukoc Biol 2006;80:1512-1521.
40. Sumitomo M, Ohba M, Asakuma J, et al. Protein kinase Cdelta amplifies ceramide formation via mitochondrial signaling in prostate cancer cells. J Clin Invest 2002;109:827-836.
41. Mitsutake N, Namba H, Shklyaev SS, et al. PKC delta mediates ionizing radiation-induced activation of c-Jun NH(2)-terminal kinase through MKK7 in human thyroid cells. Oncogene 2001;20:989-996.
42. Michie AM, Nakagawa R. Elucidating the role of protein kinase C in chronic lymphocytic leukaemia. Hematol Oncol 2006;24:134-138.
43. Mackay HJ, Twelves CJ. Targeting the protein kinase C family: Are we there yet? Nat Rev Cancer 2007;7:554-562.
44. Fang B, Song Y, Han Z, et al. Synergistic interactions between 12-0-tetradecanoylphorbol-13-acetate (TPA) and imatinib in patients with chronic myeloid leukemia in blastic phase that is resistant to standard-dose imatinib. Leuk Res 2007;31:1441-1444.
45. Zheng X, Chang RL, Cui XX, et al. Effects of 12-O-tetradecanoylphorbol- 13-acetate (TPA) in combination with paclitaxel (Taxol) on prostate Cancer LNCaP cells cultured in vitro or grown as xenograft tumors in immunodeficient mice. Clin Cancer Res 2006;12:3444-3451.
46. Garzotto M, Haimovitz-Friedman A, Liao WC, et al. Reversal of radiation resistance in LNCaP cells by targeting apoptosis through ceramide synthase. Cancer Res 1999;59:5194-5201.