Polyphenol-rich extracts from solanum nigrum attenuated PKC α-mediated migration and invasion of hepatocellular carcinoma cells

Journal of Agricultural and Food Chemistry

Volumn 58, Issue 9, 2010, Pages 5806-5814

  Yang, Mon Yuan ^a   Hsu, Li Sung ^a   Peng, Chiung Huei ^b   Shi, Yuan Shong ^a,c   Wu, Cheng Hsun ^a,d   Wang, Chau Jong ^a,e  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b HUNGKUANG UNIVERSITY   (Taiwan)

^c Changhua County Public Health Bureau   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Heptocellular carcinoma cells; Migration; PKC R; Solanum nigrum

Indexed keywords

FLAVONOID; PHENOL DERIVATIVE; PHORBOL 13 ACETATE 12 MYRISTATE; PLANT EXTRACT; POLYPHENOLS; PROTEIN KINASE C ALPHA;

ARTICLE; CHEMISTRY; ENZYMOLOGY; HUMAN; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SOLANUM NIGRUM; TUMOR CELL LINE;

CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; FLAVONOIDS; HUMANS; LIVER NEOPLASMS; PHENOLS; PHOSPHORYLATION; PLANT EXTRACTS; PROTEIN KINASE C-ALPHA; SOLANUM NIGRUM; TETRADECANOYLPHORBOL ACETATE;

SOLANUM NIGRUM;

EID: 77952186587     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf100718b     Document Type: Article

References (30)

1. Zakaria, Z. A.; Gopalan, H. K.; Zainal, H.; Mohd Poian, N. H.; Morsid, N. A.; Aris, A.; Sulaiman, M. R. Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum chloroform extract in animal models Yakugaku Zasshi 2006, 126, 1171-1178
2. Lin, H. M.; Tseng, H. C.; Wang, C. J.; Lin, J. J.; Lo, C. W.; Chou, F. P. Hepatoprotective effects of Solanum nigrum Linn extract against CCl(4)-induced oxidative damage in rats Chem.-Biol. Interact. 2008, 171, 283-293
3. Jainu, M.; Devi, C. S. Antiulcerogenic and ulcer healing effects of Solanum nigrum (L.) on experimental ulcer models: possible mechanism for the inhibition of acid formation J. Ethnopharmacol. 2006, 104, 156-163
4. Son, Y. O.; Kim, J.; Lim, J. C.; Chung, Y.; Chung, G. H.; Lee, J. C. Ripe fruit of Solanum nigrum L. inhibits cell growth and induces apoptosis in MCF-7 cells Food Chem. Toxicol. 2003, 41, 1421-1428
5. Lim, K. T. Glycoprotein isolated from Solanum nigrum L. kills HT-29 cells through apoptosis J. Med. Food 2005, 8, 215-226
6. Oh, P. S.; Lim, K. T. HeLa cells treated with phytoglycoprotein (150 kDa) were killed by activation of caspase 3 via inhibitory activities of NF-kappaB and AP-1 J. Biomed. Sci. 2007, 14, 223-232
7. Li, J.; Li, Q.; Feng, T.; Zhang, T.; Li, K.; Zhao, R.; Han, Z.; Gao, D. Antitumor activity of crude polysaccharides isolated from Solanum nigrum Linne on U14 cervical carcinoma bearing mice Phytother. Res. 2007, 21, 832-840
8. Li, J.; Li, Q. W.; Gao, D. W.; Han, Z. S.; Li, K. Antitumor effects of total alkaloids isolated from Solanum nigrum in vitro and in vivo Pharmazie 2008, 63, 534-538
9. Lin, H. M.; Tseng, H. C.; Wang, C. J.; Chyau, C. C.; Liao, K. K.; Peng, P. L.; Chou, F. P. Induction of autophagy and apoptosis by the extract of Solanum nigrum Linn in HepG2 cells J. Agric. Food Chem. 2007, 55, 3620-3628
10. Coleman, W. B. Mechanisms of human hepatocarcinogenesis Curr. Mol. Med. 2003, 3, 573-588
11. Blobe, G. C.; Obeid, L. M.; Hannun, Y. A. Regulation of protein kinase C and role in cancer biology Cancer Metastasis Rev. 1994, 13, 411-431
12. Perletti, G. P.; Smeraldi, C.; Porro, D.; Piccinini, F. Involvement of the alpha isoenzyme of protein kinase C in the growth inhibition induced by phorbol esters in MH1C1 hepatoma cells Biochem. Biophys. Res. Commun. 1994, 205, 1589-1594
13. Schmitt, M.; Horbach, A.; Kubitz, R.; Frilling, A.; Haussinger, D. Disruption of hepatocellular tight junctions by vascular endothelial growth factor (VEGF): a novel mechanism for tumor invasion J. Hepatol. 2004, 41, 274-283
14. Wu, W. S.; Tsai, R. K.; Chang, C. H.; Wang, S.; Wu, J. R.; Chang, Y. X. Reactive oxygen species mediated sustained activation of protein kinase C alpha and extracellular signal-regulated kinase for migration of human hepatoma cell Hepg2 Mol Cancer Res. 2006, 4, 747-58
15. Wu, T. T.; Hsieh, Y. H.; Wu, C. C.; Hsieh, Y. S.; Huang, C. Y.; Liu, J. Y. Overexpression of protein kinase C alpha mRNA in human hepatocellular carcinoma: a potential marker of disease prognosis Clin. Chim. Acta 2007, 382, 54-8
16. Hsieh, Y. H.; Wu, T. T.; Huang, C. Y.; Hsieh, Y. S.; Hwang, J. M.; Liu, J. Y. p38 mitogen-activated protein kinase pathway is involved in protein kinase C alpha-regulated invasion in human hepatocellular carcinoma cells Cancer Res. 2007, 67, 4320-4327
17. Wu, T. T.; Hsieh, Y. H.; Hsieh, Y. S.; Liu, J. Y. Reduction of PKC alpha decreases cell proliferation, migration, and invasion of human malignant hepatocellular carcinoma J. Cell Biochem. 2008, 103, 9-20
18. Hsu, J. D.; Kao, S. H.; Tu, C. C.; Li, Y. J.; Wang, C. J. Solanum nigrum L. extract inhibits 2-acetylaminofluorene-induced hepatocarcinogenesis through overexpression of glutathione S-transferase and antioxidant enzymes J. Agric. Food Chem. 2009, 56, 8628-8634
19. Guo, K.; Liu, Y.; Zhou, H.; Dai, Z.; Zhang, J.; Sun, R.; Chen, J.; Sun, Q.; Lu, W.; Kang, X.; Chen, P. Involvement of protein kinase C beta-extracellular signal-regulating kinase 1/2/p38 mitogen-activated protein kinase-heat shock protein 27 activation in hepatocellular carcinoma cell motility and invasion Cancer Sci. 2008, 99, 486-496
20. Tan, M.; Li, P.; Sun, M.; Yin, G.; Yu, D. Upregulation and activation of PKC alpha by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKC alpha and Src inhibitors Oncogene 2006, 25, 3286-3295
21. Zhang, J.; Anastasiadis, P. Z.; Liu, Y.; Thompson, E. A.; Fields, A. P. Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway J. Biol. Chem. 2004, 279, 22118-22123
22. Harrington, E. O.; Loffler, J.; Nelson, P. R.; Kent, K. C.; Simons, M.; Ware, J. A. Enhancement of migration by protein kinase C alpha and inhibition of proliferation and cell cycle progression by protein kinase C delta in capillary endothelial cells J. Biol. Chem. 1997, 272, 7390-7397
23. Lee, W. J.; Chen, W. K.; Wang, C. J.; Lin, W. L.; Tseng, T. H. Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and beta 4 integrin function in MDA-MB-231 breast cancer cells Toxicol. Appl. Pharmacol. 2008, 226, 178-191
24. Labbe, D.; Provencal, M.; Lamy, S.; Boivin, D.; Gingras, D.; Beliveau, R. The flavonols quercetin, kaempferol, and myricetin inhibit hepatocyte growth factor-induced medulloblastoma cell migration J. Nutr. 2009, 139, 646-652
25. Zhang, X.; Xu, Q.; Saiki, I. Quercetin inhibits the invasion and mobility of murine melanoma B16-BL6 cells through inducing apoptosis via decreasing Bcl-2 expression Clin. Exp. Metastasis 2000, 18, 415-421
26. Zhang, X. M.; Chen, J.; Xia, Y. G.; Xu, Q. Apoptosis of murine melanoma B16-BL6 cells induced by quercetin targeting mitochondria, inhibiting expression of PKC-alpha and translocating PKC-delta Cancer Chemother. Pharmacol. 2005, 55, 251-262
27. Nakajima, K.; Tohyama, Y.; Kohsaka, S.; Kurihara, T. Protein kinase C alpha requirement in the activation of p38 mitogen-activated protein kinase, which is linked to the induction of tumor necrosis factor alpha in lipopolysaccharide-stimulated microglia Neurochem. Int. 2004, 44, 205-14
28. Matsuoka, H; Tsubaki, M; Yamazoe, Y; Ogaki, M; Satou, T; Itoh, T; Kusunoki, T; Nishida, S. Tamoxifen inhibits tumor cell invasion and metastasis in mouse melanoma through suppression of PKC/MEK/ERK and PKC/PI3K/Akt pathways Exp. Cell Res. 2009, 315, 2022-2032
29. Nam, T. W.; Yoo, C. I.; Kim, H. T.; Kwon, C. H.; Park, J. Y.; Kim, Y. K. The flavonoid quercetin induces apoptosis and inhibits migration through a MAPK-dependent mechanism in osteoblasts J. Bone Miner. Metab. 2008, 26, 551-560
30. Hwang, M. K.; Song, N. R.; Kang, N. J.; Lee, K. W.; Lee, H. J. Activation of phosphatidylinositol 3-kinase is required for tumor necrosis factor-alpha-induced upregulation of matrix metalloproteinase-9: its direct inhibition by quercetin Int. J. Biochem. Cell Biol. 2009, 41, 1592-1600