Small Molecule-Based Promotion of PKCα-Mediated β-Catenin Degradation Suppresses the Proliferation of CRT-Positive Cancer Cells

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Gwak, Jungsug ^a,b   Lee, Jee Hyun ^c   Chung, Young Hwa ^d   Song, Gyu Yong ^c   Oh, Sangtaek ^a,b  

^a Kookmin University   (South Korea)

^b Inje University   (South Korea)

^c Chungnam National University   (South Korea)

^d Pusan National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BETA CATENIN; CGK 062; CYCLIN D1; MYC PROTEIN; PROTEIN KINASE C ALPHA; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CASTRATION RESISTANT PROSTATE CANCER; CELL GROWTH; CELL PROLIFERATION; COLON CANCER; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; GENE EXPRESSION; GENE REPRESSION; GENE TARGETING; GENETIC CODE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; TUMOR GROWTH; TUMOR XENOGRAFT; WNT SIGNALING PATHWAY;

ACRYLATES; ANIMALS; ANTINEOPLASTIC AGENTS; BETA CATENIN; BETA-TRANSDUCIN REPEAT-CONTAINING PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMANS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOGEN SYNTHASE KINASE 3; HEK293 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MICE, NUDE; PHOSPHORYLATION; PROTEIN KINASE C-ALPHA; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOLYSIS; TRANSCRIPTION, GENETIC; WNT SIGNALING PATHWAY; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MUS MUSCULUS;

EID: 84867153804     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046697     Document Type: Article

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