The selective inhibition of nuclear PKCζ restores the effectiveness of chemotherapeutic agents in chemoresistant cells

Cell Cycle

Volumn 11, Issue 5, 2012, Pages 1040-1048

  Rimessi, Alessandro ^a   Zecchini, Erika ^a   Siviero, Roberta ^a   Giorgi, Carlotta ^a   Leo, Sara ^a   Rizzuto, Rosario ^b   Pinton, Paolo ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

Apoptosis; Chemoresistance; Nuclear translocation; Oxidative stress; Protein kinase C

Indexed keywords

DOXORUBICIN; PROTEIN KINASE C ZETA; RECOMBINANT PROTEIN;

APOPTOSIS; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; DRUG EFFICACY; ENZYME INHIBITION; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; OXIDATIVE STRESS;

EID: 84857946886     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.11.5.19520     Document Type: Article

References (34)

1. Mellor H, Parker PJ. The extended protein kinase C superfamily. Biochem J 1998; 332:281-92; PMID:9601053.
2. Hug H, Sarre TF. Protein kinase C isoenzymes: divergence in signal transduction? Biochem J 1993; 291:329-43; PMID:8484714.
3. Pascale A, Govoni S, Battaini F. Age-related alteration of PKC, a key enzyme in memory processes: physiological and pathological examples. Mol Neurobiol 1998; 16:49-62; PMID:9554701; http://dx.doi.org/10.1007/BF02740602.
4. O'Brian CA, Ward NE. Biology of the protein kinase C family. Cancer Metastasis Rev 1989; 8:199-214; PMID:2697470; http://dx.doi.org/10.1007/ BF00047337.
5. Nishino N, Kitamura N, Nakai T, Hashimoto T, Tanaka C. Phorbol ester binding sites in human brain: characterization, regional distribution, age-correlation and alterations in Parkinson's disease. J Mol Neurosci 1989; 1:19-26; PMID:2642064; http://dx.doi.org/10.1007/BF02896852.
6. Giorgi C, Agnoletto C, Baldini C, Bononi A, Bonora M, Marchi S, et al. Redox control of protein kinase C: cell- and disease-specific aspects. Antioxid Redox Signal 2010; 13:1051-85; PMID:20136499; http://dx.doi.org/10.1089/ars. 2009.2825.
7. Gopalakrishna R, Jaken S. Protein kinase C signaling and oxidative stress. Free Radic Biol Med 2000; 28:1349-61; PMID:10924854; http://dx.doi.org/10.1016/S0891-5849(00)00221-5.
8. Cross CE, Halliwell B, Borish ET, Pryor WA, Ames BN, Saul RL, et al. Oxygen radicals and human disease. Ann Intern Med 1987; 107:526-45; PMID:3307585.
9. Berra E, Diaz-Meco MT, Dominguez I, Municio MM, Sanz L, Lozano J, et al. Protein kinase Czeta isoform is critical for mitogenic signal transduction. Cell 1993; 74:555-63; PMID:7688666; http://dx.doi.org/10.1016/0092-8674(93)80056-K.
10. Cohen EE, Lingen MW, Zhu B, Zhu H, Straza MW, Pierce C, et al. Protein kinase Czeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase. Cancer Res 2006; 66:6296-303; PMID:16778206; http://dx.doi.org/10.1158/0008-5472.CAN-05-3139.
11. Kampfer S, Windegger M, Hochholdinger F, Schwaiger W, Pestell RG, Baier G, et al. Protein kinase C isoforms involved in the transcriptional activation of cyclin D1 by transforming Ha-Ras. J Biol Chem 2001; 276:42834-42; PMID:11551901; http://dx.doi.org/10.1074/jbc.M102047200.
12. Leroy I, de Thonel A, Laurent G, Quillet-Mary A. Protein kinase Czeta associates with death inducing signaling complex and regulates Fas ligand-induced apoptosis. Cell Signal 2005; 17:1149-57; PMID:15993755; http://dx.doi.org/10.1016/j.cellsig.2004.12.013.
13. Moscat J, Rennert P, Diaz-Meco MT. PKCzeta at the crossroad of NFkappaB and Jak1/Stat6 signaling pathways. Cell Death Differ 2006; 13:702-11; PMID:16322752; http://dx.doi.org/10.1038/sj.cdd.4401823.
14. Bezombes C, de Thonel A, Apostolou A, Louat T, Jaffrézou JP, Laurent G, et al. Overexpression of protein kinase Czeta confers protection against antileukemic drugs by inhibiting the redox-dependent sphingomyelinase activation. Mol Pharmacol 2002; 62:1446-55; PMID:12435813; http://dx.doi.org/10. 1124/mol.62.6.1446.
15. Filomenko R, Poirson-Bichat F, Billerey C, Belon JP, Garrido C, Solary E, et al. Atypical protein kinase Czeta as a target for chemosensitization of tumor cells. Cancer Res 2002; 62:1815-21; PMID:11912160.
16. Rimessi A, Rizzuto R, Pinton P. Differential recruitment of PKC isoforms in HeLa cells during redox stress. Cell Stress Chaperones 2007; 12:291-8; PMID:18229448; http://dx.doi.org/10.1379/CSC-211.1.
17. Pinton P, Ferrari D, Rapizzi E, Di Virgilio F, Pozzan T, Rizzuto R. The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramideinduced apoptosis: significance for the molecular mechanism of Bcl-2 action. EMBO J 2001; 20:2690-701; PMID:11387204; http://dx.doi.org/10.1093/ emboj/20.11.2690.
18. Kudo N, Matsumori N, Taoka H, Fujiwara D, Schreiner EP, Wolff B, et al. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region. Proc Natl Acad Sci USA 1999; 96:9112-7; PMID:10430904; http://dx.doi.org/10.1073/pnas.96.16.9112.
19. Laudanna C, Mochly-Rosen D, Liron T, Constantin G, Butcher EC. Evidence of zeta protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis. J Biol Chem 1998; 273:30306-15; PMID:9804792; http://dx.doi.org/10.1074/jbc.273.46.30306.
20. phox and participates in formyl peptide-mediated neutrophil respiratory burst. J Immunol 2001; 166:1206-13; PMID:11145703.
21. Czarnecka AM, Kukwa W, Krawczyk T, Scinska A, Kukwa A, Cappello F. Mitochondrial DNA mutations in cancer-from bench to bedside. Front Biosci 2010; 15:437-60; PMID:20036829; http://dx.doi.org/10.2741/3629.
22. Trachootham D, Lu W, Ogasawara MA, Nilsa RD, Huang P. Redox regulation of cell survival. Antioxid Redox Signal 2008; 10:1343-74; PMID:18522489; http://dx.doi.org/10.1089/ars.2007.1957.
23. Kaiser J. Combining targeted drugs to stop resistant tumors. Science 2011; 331:1542-5; PMID:21436437; http://dx.doi.org/10.1126/science.331.6024. 1542.
24. Sokolosky ML, Stadelman KM, Chappell WH, Abrams SL, Martelli AM, Stivala F, et al. Involvement of Akt-1 and mTOR in sensitivity of breast cancer to targeted therapy. Oncotarget 2011; 2:538-50.
25. Abrams SL, Steelman LS, Shelton JG, Chappell W, Bäsecke J, Stivala F, et al. Enhancing therapeutic efficacy by targeting non-oncogene addicted cells with combinations of signal transduction inhibitors and chemotherapy. Cell Cycle 2010; 9:1839-46; PMID:20436269; http://dx.doi.org/10.4161/cc.9.9.11544.
26. Martinez-Outschoorn UE, Lin Z, Ko YH, Goldberg AF, Flomenberg N, Wang C, et al. Understanding the metabolic basis of drug resistance: therapeutic induction of the Warburg effect kills cancer cells. Cell Cycle 2011; 10:2521-8; PMID:21768775; http://dx.doi.org/10.4161/cc.10.15.16584.
27. Pinton P, Rimessi A, Marchi S, Orsini F, Migliaccio E, Giorgio M, et al. Protein kinase Cbeta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc. Science 2007; 315:659-63; PMID:17272725; http://dx.doi.org/10.1126/science.1135380.
28. O'Brian CA, Liskamp RM, Solomon DH, Weinstein IB. Inhibition of protein kinase C by tamoxifen. Cancer Res 1985; 45:2462-5; PMID:3157445.
29. Benavides F, Blando J, Perez CJ, Garg R, Conti CJ, DiGiovanni J, et al. Transgenic overexpression of PKCεin the mouse prostate induces preneoplastic lesions. Cell Cycle 2011; 10:268-77; PMID:21224724; http://dx.doi.org/10.4161/cc.10.2.14469.
30. Schwartz GK, Jiang J, Kelsen D, Albino AP. Protein kinase C: a novel target for inhibiting gastric cancer cell invasion. J Natl Cancer Inst 1993; 85:402-7; PMID:8433394; http://dx.doi.org/10.1093/jnci/85.5.402.
31. Malisan F, Testi R. Lipid signaling in CD95-mediated apoptosis. FEBS Lett 1999; 452:100-3; PMID:10376687; http://dx.doi.org/10.1016/S0014-5793(99)00543- 8.
32. Bourbon NA, Yun J, Kester M. Ceramide directly activates protein kinase Czeta to regulate a stress-activated protein kinase signaling complex. J Biol Chem 2000; 275:35617-23; PMID:10962008; http://dx.doi.org/10.1074/jbc. M007346200.
33. Brady SC, Allan LA, Clarke PR. Regulation of caspase 9 through phosphorylation by protein kinase Czeta in response to hyperosmotic stress. Mol Cell Biol 2005; 25:10543-55; PMID:16287866; http://dx.doi.org/10.1128/MCB.25.23. 10543-55.2005.
34. Pinton P, Rimessi A, Romagnoli A, Prandini A, Rizzuto R. Biosensors for the detection of calcium and pH. Methods Cell Biol 2007; 80:297-325; PMID:17445701; http://dx.doi.org/10.1016/S0091-679X(06)80015-4.