PKCα activation downregulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo

Cancer Biology and Therapy

Volumn 8, Issue 1, 2009, Pages 54-63

  Truman, Jean Philip ^a   Rotenberg, Susan A ^b   Kang, Ji Hye ^c   Lerman, Gabriel ^a   Fuks, Zvi ^a   Kolesnick, Richard ^a   Marquez, Victor E ^c   Haimovitz Friedman, Adriana ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Apoptosis; ATM; Ionizing radiation; PKC ; Prostate

Indexed keywords

ANDROGEN; ATM PROTEIN; CERAMIDE; DIACYLGLYCEROL DERIVATIVE; DIACYLGLYCEROL LACTONE; HK 654; JH131A 109; JH131E 153; LACTONE DERIVATIVE; MUTANT PROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C ALPHA; PROTEIN KINASE C GAMMA; SPHINGOSINE ACYLTRANSFERASE; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG; (1 (HYDROXYMETHYL) 4 (4 METHYL 3 (METHYLETHYL)PENTYLIDENE) 3 OXO 2 OXOLANYL)METHYL 4 METHYL 3 (METHYLETHYL)PENTANOATE; (1-(HYDROXYMETHYL)-4-(4-METHYL-3-(METHYLETHYL)PENTYLIDENE)-3-OXO-2-OXOLANYL)METHYL 4-METHYL-3-(METHYLETHYL)PENTANOATE; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; DRUG DERIVATIVE; GAMMA BUTYROLACTONE; PROTEIN SERINE THREONINE KINASE; TUMOR SUPPRESSOR PROTEIN; VALERIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER MODEL; CELL STRAIN LNCAP; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PROSTATE CANCER; PROTEIN EXPRESSION; RADIATION DOSE FRACTIONATION; RADIOSENSITIZATION; TUMOR GROWTH; CELL DIVISION; DRUG EFFECT; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM; PATHOLOGY; PROSTATE TUMOR; RADIATION EXPOSURE; TUMOR CELL LINE;

4-BUTYROLACTONE; ANDROGENS; APOPTOSIS; CELL CYCLE PROTEINS; CELL DIVISION; CELL LINE, TUMOR; DNA-BINDING PROTEINS; DOWN-REGULATION; ENZYME ACTIVATION; HUMANS; KINETICS; MALE; PROSTATIC NEOPLASMS; PROTEIN KINASE C-ALPHA; PROTEIN-SERINE-THREONINE KINASES; TETRADECANOYLPHORBOL ACETATE; TUMOR SUPPRESSOR PROTEINS; VALERATES;

EID: 66149158200     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.8.1.7119     Document Type: Article

References (36)

1. Truman JP, Gueven N, Lavin M, Leibel S, Kolesnick R, Fuks Z, Haimovitz-Friedman A. Downregulation of ATM protein sensitizes human prostate cancer cells to radiation-induced apoptosis. The Journal of biological chemistry 2005; 280:23262-23272 (Pubitemid 40853238)
2. Garcia-Bermejo ML, Leekow FC, Fujii T, Wang Q, Blumberg PM, Ohba M, Kuroki J, Han K-C, Lee J, Marquez VE, Kazanietz MG. Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCα. The Journal of biological chemistry 2002; 277:645-655
3. Newton AC. Protein kinase C: Structure, function and regulation. The Journal of biological chemistry 1995; 270:28495-28498
4. Dekker L, Parker P. Protein kinase C-a question of specificity. Trends Biochem Sci 1994; 19:73-77 (Pubitemid 24055564)
5. Blobe GC, Obeid LM, Hannun YA. Regulation of protein kinase C and role in cancer biology. Cancer metastasis reviews 1994; 13:411-431
6. Jarvis W, Turner AJ, Porvick LF, Traylor RS, Grant S. Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. Cancer research 1994; 54:1707-1714 (Pubitemid 24116174)
7. Obeid LM, Linardic CM, Karolak LA, Hannun YA. Programmed cell death induced by ceramide. Science (New York, NY) 1993; 259:1769-1771 (Pubitemid 23114667)
8. Grant S, Jarvis W, Swerdlow P, Turner A, Traylor R, Wallace H, Lin P, Pettit G, Gerwitz D. Potentiation of the activity of 1-β-D- arabinofuranosylcytosine by the protein kinase C activator bryostatin 1 in HL-60 cells: association with enhanced fragmentation of mature DNA. Cancer research 1992; 52:6270-6278
9. Lotem J, Cragoe EJ, Sachs L. Rescue from programmed cell death in leukemic and normal myeloid cells. Blood 1991; 78:953-960
10. Haimovitz-Friedman A, Balaban NA, McLoughlin M, Ehleiter D, Michaeli J, Vlodavsky I, Fuks Z. Protein kinase C mediates basic fibroblast growth factor protection of endothelial cells against radiation-induced apoptosis. Cancer research 1994; 54:2591-2597 (Pubitemid 24173743)
11. Ishii H, Gobe G. Epstein-Barr virus infection is associated with increased apoptosis in untreated and phorbol ester-treated human Burkitt's lymphoma (AW-Ramos) cells. Biochem Biophys Res Comm 1993; 192:1415-1423 (Pubitemid 223022239)
12. Kizaki H, Tadakuma T, Okada C, Maramatsu J, Ishimura Y. Activation of a suicide process of thymocytes through DNA fragmentation by calcium and phorbol esters. Journal of Immunology 1989; 143:1790-1794 (Pubitemid 19241189)
13. Reyland ME, Barzen KA, Anderson SM, Quisseli DO, Matassa AA. Activation of PKC is sufficient to induce an apoptotic program in salivary gland acinar cells. Cell death and differentiation 2000; 7:1200-1209 (Pubitemid 32042227)
14. Li Y, Bhuiyan M, Mohammad RM, Sarkar FH. Induction of apoptosis in breast cancer cells by TPA. Oncogene 1998; 17:2915-2920 (Pubitemid 29010061)
15. Garzotto M, White-Jones M, Jiang Y, Ehleiter D, Liao WC, Haimovitz-Friedman A, Fuks Z, Kolesnick R. 12-O-tetradecanoylphorbol-13-acetate- induced apoptosis in LNCaP cells is mediated through ceramide synthase. Cancer research 1998; 58:2260-2264 (Pubitemid 28232917)
16. Garzotto M, Haimovitz-Friedman A, Liao WC, White-Jones M, Huryk R, Heston DWW, Cardon-Cardo C, Kolesnick R, Fuks Z. Reversal of radiation resistance in LNCaP cells by targeting apoptosis through ceramide synthase. Cancer research 1999; 59:5194-5201 (Pubitemid 29503982)
17. Lavin MF, Birrell G, Chen P, Kozlov S, Scott S, Gueven N. ATM signaling and genomic stability in response to DNA damage. Mutat Res 2005; 569:123-132 (Pubitemid 39643262)
18. Liao W-C, Haimovitz-Friedman A, Persaud R, McLoughlin M, Ehleiter D, Zhang N, Gatei M, Lavin M, Kolesnick R, Fuks Z. Ataxia Telangiectasia-mutated gene product inhibits DNA damage-induced apoptosis via ceramide synthase. The Journal of biological chemistry 1999; 274:17908-17917 (Pubitemid 129519151)
19. Kang JH, Siddiqui MA, Sigano DM, Krajewski K, Lewin NE, Pu Y, Blumberg PM, Lee J, Marquez VE. Conformationally constrained analogues of diacylglycerol 24. Asymmetric synthesis of a chiral (R)-DAG-lactone template as a versatile precursor for highly functionalized DAG-lactones. Org Lett 2004; 6:2413-2416
20. Choi Y, Kang JH, Lewin NE, Blumberg PM, Lee J, Marquez VE. Conformationally constrained analogues of diacylglycerol 19. Synthesis and protein kinase C binding affinity of diacylglycerol lactones bearing an N-hydroxylamide side chain. J Med Chem 2003; 46:2790-2793 (Pubitemid 36702546)
21. Sramkoski RM, Pretlow TG, 2nd, Giaconia JM, Pretlow TP, Schwartz S, Sy MS, Marengo SR, Rhim JS, Zhang D, Jacobberger JW. A new human prostate carcinoma cell line, 22Rv1. In Vitro Cell Dev Biol Anim 1999; 35:403-409
22. Haimovitz-Friedman A, Balaban N, McLoughlin M, Ehleiter D, Michaeli J, Vlodavsky I, Fuks Z. Protein kinase C mediates basic fibroblast growth factor protection of endothelial cells against radiation-induced apoptosis. Cancer research 1994; 54:2591-2597 (Pubitemid 24173743)
23. Makowske M, Rosen OM. Complete activation of protein kinase C by an antipeptide antibody directed against the pseudosubstrate prototope. The Journal of biological chemistry 1989; 264:16155-16159 (Pubitemid 19238378)
24. Niles RM, Loewy BP. Induction of protein kinase C in mouse melanoma cells by retinoic acid. Cancer research 1989; 49:4483-4487 (Pubitemid 19208349)
25. Sullivan RM, Stone M, Marshall JF, Uberall F, Rotenberg SA. Photo-induced inactivation of protein kinase calpha by dequalinium inhibits motility of murine melanoma cells. Mol Pharmacol 2000; 58:729-737
26. Truman J, Liao W-C, Ehleiter D, Kolesnick R, Lavin M, Leibel SA, Fuks Z, Haimovitz-Friedman A. Transcriptional downregulation of Ataxia-Telangiectasia Mutated protein (ATM) radiosensitizes human prostate cancer cells. Proceedings of the AACR 2004; 45.
27. Keating KE, Gueven N, Watters D, Rodemann HP, Lavin MF. Transcriptional downregulation of ATM by EGF is defective in ataxia-telangiectasia cells expressing mutant protein. Oncogene 2001; 20:4281-4290 (Pubitemid 32726869)
28. Albright N. Computer programs for the analysis of cellular survival data. Radiat Res 1987; 112:331-340 (Pubitemid 18015902)
29. Stephenson RA, Dinney CP, Gohji K, Ordonez NG, Killion JJ, Fidler IJ. Metastatic model for human prostate cancer using orthotopic implantation in nude mice. J Natl Cancer Inst 1992; 84:951-957
30. Gleave ME, Hsieh JT, Wu HC, von Eschenbach AC, Chung LW. Serum prostate specific antigen levels in mice bearing human prostate LNCaP tumors are determined by tumor volume and endocrine and growth factors. Cancer research 1992; 52:1598-1605
31. Powell CT, Brittis NJ, Stec D, Hug H, Heston WD, Fair WR. Persistent membrane translocation of protein kinase C alpha during 12-0- tetradecanoylphorbol-13-acetate-induced apoptosis of LNCaP human prostate cancer cells. Cell Growth & Differentiation 1996; 7:419-428 (Pubitemid 26362086)
32. Berenblum I. A re-evaluation of the concept of cocarciongenesis. Prog Exp Tumor Res 1969; 11:21-30.
33. Slaga TJ, Fischer SM, Nelson K, Gleason GL. Studies on the mechanism of skin tumor promotion: evidence for stages in promotion. Proceedings of the National Academy of Sciences of the United States of America 1980; 77:3659-3663 (Pubitemid 10012917)
34. Furstenberger G, Berry DL, Sorg B, Marks F. Skin tumor promotion by phorbol esters is a two-stage process. Proceedings of the National Academy of Sciences of the United States of America 1981; 78:7722-7726 (Pubitemid 12186634)
35. Han ZT, Zhu XX, Yang RY, Sun JZ, Tian GF, Liu XJ, Cao GS, Newmark HL, Conney AH, Chang RL. Effect of intravenous infusions of 12-O- tetradecanoylphorbol-13-acetate (TPA) in patients with myelocytic leukemia: preliminary studies on therapeutic efficacy and toxicity. Proceedings of the National Academy of Sciences of the United States of America 1998; 95:5357-5361 (Pubitemid 28208602)
36. Han ZT, Tong YK, He LM, Zhang Y, Sun JZ, Wang TY, Zhang H, Cui YL, Newmark HL, Conney AH, Chang RL. 12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced increase in depressed white blood cell counts in patients treated with cytotoxic cancer chemotherapeutic drugs. Proceedings of the National Academy of Sciences of the United States of America 1998; 95:5362-5365 (Pubitemid 28208603)