C-Myc phosphorylation by PKCζ represses prostate tumorigenesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 16, 2013, Pages 6418-6423

  Kim, Ji Young ^a   Valencia, Tania ^a   Abu Baker, Shadi ^b   Linares, Juan ^a   Lee, Sang Jun ^a   Yajima, Tomoko ^a   Chen, Jing ^b   Eroshkin, Alexey ^a   Castilla, Elias A ^b   Brill, Laurence M ^a   Medvedovic, Mario ^b   Leitges, Michael ^c   Moscat, Jorge ^a   Diaz Meco, Maria T ^a  

^a BURNHAM INSTITUTE   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MYC PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE C ZETA; SERINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOINFORMATICS; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CANCER INVASION; CANCER TISSUE; CELL LEVEL; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GENE INACTIVATION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROTEIN PHOSPHORYLATION; REGULATOR GENE; TRANSCRIPTION INITIATION; TUMOR SUPPRESSOR GENE; TUMOR XENOGRAFT;

ANIMALS; BLOTTING, WESTERN; CELL TRANSFORMATION, NEOPLASTIC; COMPUTATIONAL BIOLOGY; GENE EXPRESSION REGULATION, NEOPLASTIC; LUCIFERASES; MALE; MICE; MICROARRAY ANALYSIS; NEOPLASM METASTASIS; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-MYC; PTEN PHOSPHOHYDROLASE; REAL-TIME POLYMERASE CHAIN REACTION;

MUS;

EID: 84876213030     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1221799110     Document Type: Article

References (25)

1. Moscat J, Diaz-Meco MT, Wooten MW (2009) Of the atypical PKCs, Par-4 and p62: Recent understandings of the biology and pathology of a PB1-dominated complex. Cell Death Differ 16(11):1426-1437.
2. Moscat J, Diaz-Meco MT (2009) p62 at the crossroads of autophagy, apoptosis, and cancer. Cell 137(6):1001-1004.
3. Moscat J, Diaz-Meco MT, Albert A, Campuzano S (2006) Cell signaling and function organized by PB1 domain interactions. Mol Cell 23(5):631-640.
4. Díaz-Meco MT, et al. (1996) The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C. Cell 86(5):777-786.
5. Moscat J, Diaz-Meco MT (2000) The atypical protein kinase Cs. Functional specificity mediated by specific protein adapters. EMBO Rep 1(5):399-403.
6. Galvez AS, et al. (2009) Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo. Mol Cell Biol 29(1):104-115.
7. Fernandez-Marcos PJ, et al. (2009) Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-kappaB activation and invasive prostate carcinoma. Proc Natl Acad Sci USA 106(31):12962-12967.
8. Trotman LC, et al. (2006) Identification of a tumour suppressor network opposing nuclear Akt function. Nature 441(7092):523-527.
9. Rhodes DR, et al. (2007) Oncomine 3.0: Genes, pathways, and networks in a collection of 18, 000 cancer gene expression profiles. Neoplasia 9(2):166-180.
10. Yao S, et al. (2010) PRKC-ζ expression promotes the aggressive phenotype of human prostate cancer cells and is a novel target for therapeutic intervention. Genes Cancer 1(5):444-464.
11. Ishiguro H, et al. (2009) aPKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6. Proc Natl Acad Sci USA 106(38):16369-16374.
12. Murray NR, Kalari KR, Fields AP (2011) Protein kinase Cι expression and oncogenic signaling mechanisms in cancer. J Cell Physiol 226(4):879-887.
13. Yu YP, et al. (2004) Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancy. J Clin Oncol 22(14):2790-2799.
14. Taylor BS, et al. (2010) Integrative genomic profiling of human prostate cancer. Cancer Cell 18(1):11-22.
15. Powell CT, et al. (1996) Overexpression of protein kinase C-zeta (PKC-zeta) inhibits invasive and metastatic abilities of Dunning R-3327 MAT-LyLu rat prostate cancer cells. Cancer Res 56(18):4137-4141.
16. Koh CM, et al. (2010) MYC and prostate cancer. Genes Cancer 1(6):617-628.
17. Dang CV (2012) MYC on the path to cancer. Cell 149(1):22-35.
18. Chen X, et al. (2008) Integration of external signaling pathways with the core tran-scriptional network in embryonic stem cells. Cell 133(6):1106-1117.
19. Ouyang Z, Zhou Q, Wong WH (2009) ChIP-Seq of transcription factors predicts absolute and differential gene expression in embryonic stem cells. Proc Natl Acad Sci USA 106(51):21521-21526.
20. Mootha VK, et al. (2003) PGC-1alpha-responsive genes involved in oxidative phos-phorylation are coordinately downregulated in human diabetes. Nat Genet 34(3): 267-273.
21. Diouf B, et al. (2011) Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells. Nat Med 17(10):1298-1303.
22. Pu YS, et al. (2012) Down-regulation of PKCζ in renal cell carcinoma and its clinico-pathological implications. J Biomed Sci 19:39.
23. Ma L, et al. (2013) Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis. Cell 152(3):599-611.
24. Huang Z (2004) Stress signaling and Myc downregulation: Implications for cancer. Cell Cycle 3(5):593-596.
25. Huang Z, Traugh JA, Bishop JM (2004) Negative control of the Myc protein by the stress-responsive kinase Pak2. Mol Cell Biol 24(4):1582-1594.