Proteasome inhibitors sensitize glioma cells and glioma stem cells to TRAIL-induced apoptosis by PKCε-dependent downregulation of AKT and XIAP expressions

Cellular Signalling

Volumn 23, Issue 8, 2011, Pages 1348-1357

  Kahana, Sarit ^a   Finniss, Susan ^b   Cazacu, Simona ^b   Xiang, Cunli ^b   Lee, Hae Kyung ^b   Brodie, Shlomit ^b   Goldstein, Ronald S ^a   Roitman, Vered ^a   Slavin, Shimon ^c   Mikkelsen, Tom ^b   Brodie, Chaya ^a,b  

^a BAR ILAN UNIVERSITY   (Israel)

^b HENRY FORD HOSPITAL   (United States)

^c CTCI ^*  (Israel)

Author keywords

Apoptosis; Glioma; Glioma stem cells; PKC ; Proteasome inhibitors; TRAIL

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BORTEZOMIB; CASPASE; MESSENGER RNA; PROTEIN KINASE B; PROTEIN KINASE C EPSILON; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; CATALYSIS; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME INHIBITION; GENE OVEREXPRESSION; GLIOMA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SENSITIZATION; STEM CELL;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; ASTROCYTES; BORONIC ACIDS; CELL LINE, TUMOR; DOWN-REGULATION; GLIOMA; HUMANS; LEUPEPTINS; MUTAGENESIS, SITE-DIRECTED; NEOPLASTIC STEM CELLS; PROTEASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN KINASE C-EPSILON; PROTO-ONCOGENE PROTEINS C-AKT; PYRAZINES; TNF-RELATED APOPTOSIS-INDUCING LIGAND; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 79955843451     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellsig.2011.03.017     Document Type: Article

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