-
1
-
-
2342496710
-
Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells
-
Amsen, D., J. M. Blander, G. R. Lee, K. Tanigaki, T. Honjo, and R. A. Flavell. 2004. Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell 117:515-526.
-
(2004)
Cell
, vol.117
, pp. 515-526
-
-
Amsen, D.1
Blander, J.M.2
Lee, G.R.3
Tanigaki, K.4
Honjo, T.5
Flavell, R.A.6
-
2
-
-
34447506658
-
Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis
-
Ancrile, B., K. H. Lim, and C. M. Counter. 2007. Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis. Genes Dev. 21:1714-1719.
-
(2007)
Genes Dev
, vol.21
, pp. 1714-1719
-
-
Ancrile, B.1
Lim, K.H.2
Counter, C.M.3
-
3
-
-
17644394616
-
Smoldering and polarized inflammation in the initiation and promotion of malignant disease
-
Balkwill, F., K. A. Charles, and A. Mantovani. 2005. Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell 7:211-217.
-
(2005)
Cancer Cell
, vol.7
, pp. 211-217
-
-
Balkwill, F.1
Charles, K.A.2
Mantovani, A.3
-
4
-
-
0033570912
-
The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression
-
Barradas, M., A. Monjas, M. T. Diaz-Meco, M. Serrano, and J. Moscat. 1999. The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression. EMBO J. 18:6362-6369.
-
(1999)
EMBO J
, vol.18
, pp. 6362-6369
-
-
Barradas, M.1
Monjas, A.2
Diaz-Meco, M.T.3
Serrano, M.4
Moscat, J.5
-
5
-
-
0027178812
-
Protein kinase C zeta isoform is critical for mitogenic signal transduction
-
Berra, E., M. T. Diaz-Meco, I. Dominguez, M. M. Municio, L. Sanz, J. Lozano, R. S. Chapkin, and J. Moscat. 1993. Protein kinase C zeta isoform is critical for mitogenic signal transduction. Cell 74:555-563.
-
(1993)
Cell
, vol.74
, pp. 555-563
-
-
Berra, E.1
Diaz-Meco, M.T.2
Dominguez, I.3
Municio, M.M.4
Sanz, L.5
Lozano, J.6
Chapkin, R.S.7
Moscat, J.8
-
6
-
-
0024376173
-
ras oncogenes in human cancer: A review
-
Bos, J. L. 1989. ras oncogenes in human cancer: a review. Cancer Res. 49:4682-4689.
-
(1989)
Cancer Res
, vol.49
, pp. 4682-4689
-
-
Bos, J.L.1
-
7
-
-
0028063391
-
Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta
-
Diaz-Meco, M. T., J. Lozano, M. M. Municio, E. Berra, S. Frutos, L. Sanz, and J. Moscat. 1994. Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta. J. Biol. Chem. 269:31706-31710.
-
(1994)
J. Biol. Chem
, vol.269
, pp. 31706-31710
-
-
Diaz-Meco, M.T.1
Lozano, J.2
Municio, M.M.3
Berra, E.4
Frutos, S.5
Sanz, L.6
Moscat, J.7
-
8
-
-
0042525909
-
Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation
-
Duran, A., M. T. Diaz-Meco, and J. Moscat. 2003. Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation. EMBO J. 22:3910-3918.
-
(2003)
EMBO J
, vol.22
, pp. 3910-3918
-
-
Duran, A.1
Diaz-Meco, M.T.2
Moscat, J.3
-
9
-
-
41249084239
-
The signaling adaptor p62 is an important NF-[kappa]B mediator in tumorigenesis
-
Duran, A., J. F. Linares, A. S. Galvez, K. Wikenheiser, J. M. Flores, M. T. Diaz-Meco, and J. Moscat. 2008. The signaling adaptor p62 is an important NF-[kappa]B mediator in tumorigenesis. Cancer Cell 13:343-354.
-
(2008)
Cancer Cell
, vol.13
, pp. 343-354
-
-
Duran, A.1
Linares, J.F.2
Galvez, A.S.3
Wikenheiser, K.4
Flores, J.M.5
Diaz-Meco, M.T.6
Moscat, J.7
-
10
-
-
0442325388
-
The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis
-
Duran, A., M. Serrano, M. Leitges, J. M. Flores, S. Picard, J. P. Brown, J. Moscat, and M. T. Diaz-Meco. 2004. The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Dev. Cell 6:303-309.
-
(2004)
Dev. Cell
, vol.6
, pp. 303-309
-
-
Duran, A.1
Serrano, M.2
Leitges, M.3
Flores, J.M.4
Picard, S.5
Brown, J.P.6
Moscat, J.7
Diaz-Meco, M.T.8
-
11
-
-
0035893318
-
Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes
-
Fisher, G. H., S. L. Wellen, D. Klimstra, J. M. Lenczowski, J. W. Tichelaar, M. J. Lizak, J. A. Whitsett, A. Koretsky, and H. E. Varmus. 2001. Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Genes Dev. 15:3249-3262.
-
(2001)
Genes Dev
, vol.15
, pp. 3249-3262
-
-
Fisher, G.H.1
Wellen, S.L.2
Klimstra, D.3
Lenczowski, J.M.4
Tichelaar, J.W.5
Lizak, M.J.6
Whitsett, J.A.7
Koretsky, A.8
Varmus, H.E.9
-
12
-
-
0035380478
-
The carboxyl terminus of protein kinase C provides a switch to regulate its interaction with the phosphoinosi-tide-dependent kinase, PDK-1
-
Gao, T., A. Toker, and A. C. Newton. 2001. The carboxyl terminus of protein kinase C provides a switch to regulate its interaction with the phosphoinosi-tide-dependent kinase, PDK-1. J. Biol. Chem. 276:19588- 19596.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 19588-19596
-
-
Gao, T.1
Toker, A.2
Newton, A.C.3
-
13
-
-
0242585506
-
Genetic inactivation of Par4 results in hyperactivation of NF-kB and impairment of JNK and p38
-
Garcia-Cao, I., M. Lafuente, L. Criado, M. Diaz-Meco, M. Serrano, and J. Moscat. 2003. Genetic inactivation of Par4 results in hyperactivation of NF-kB and impairment of JNK and p38. EMBO Rep. 4:307-312.
-
(2003)
EMBO Rep
, vol.4
, pp. 307-312
-
-
Garcia-Cao, I.1
Lafuente, M.2
Criado, L.3
Diaz-Meco, M.4
Serrano, M.5
Moscat, J.6
-
14
-
-
37349098725
-
Autocrine IL-6 signaling: A key event in tumorigenesis?
-
Grivennikov, S., and M. Karin. 2008. Autocrine IL-6 signaling: a key event in tumorigenesis? Cancer Cell 13:7-9.
-
(2008)
Cancer Cell
, vol.13
, pp. 7-9
-
-
Grivennikov, S.1
Karin, M.2
-
15
-
-
0041883654
-
Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context
-
Guerra, C., N. Mijimolle, A. Dhawahir, P. Dubus, M. Barradas, M. Serrano, V. Campuzano, and M. Barbacid. 2003. Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context. Cancer Cell 4:111-120.
-
(2003)
Cancer Cell
, vol.4
, pp. 111-120
-
-
Guerra, C.1
Mijimolle, N.2
Dhawahir, A.3
Dubus, P.4
Barradas, M.5
Serrano, M.6
Campuzano, V.7
Barbacid, M.8
-
16
-
-
45149134605
-
Re-educating tumor-associated macrophages by targeting NF-kB
-
Hagemann, T., T. Lawrence, I. McNeish, K. A. Charles, H. Kulbe, R. G. Thompson, S. C. Robinson, and F. R. Balkwill. 2008. "Re-educating" tumor-associated macrophages by targeting NF-kB. J. Exp. Med. 205:1261-1268.
-
(2008)
J. Exp. Med
, vol.205
, pp. 1261-1268
-
-
Hagemann, T.1
Lawrence, T.2
McNeish, I.3
Charles, K.A.4
Kulbe, H.5
Thompson, R.G.6
Robinson, S.C.7
Balkwill, F.R.8
-
17
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan, D., and R. A. Weinberg. 2000. The hallmarks of cancer. Cell 100:57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
18
-
-
38849199203
-
Shared principles in NF-kappaB signaling
-
Hayden, M. S., and S. Ghosh. 2008. Shared principles in NF-kappaB signaling. Cell 132:344-362.
-
(2008)
Cell
, vol.132
, pp. 344-362
-
-
Hayden, M.S.1
Ghosh, S.2
-
19
-
-
33751501696
-
Requirement of androgen-dependent activation of protein kinase Czeta for androgen-depen-dent cell proliferation in LNCaP Cells and its roles in transition to androgen-independent cells
-
Inoue, T., T. Yoshida, Y. Shimizu, T. Kobayashi, T. Yamasaki, Y. Toda, T. Segawa, T. Kamoto, E. Nakamura, and O. Ogawa. 2006. Requirement of androgen-dependent activation of protein kinase Czeta for androgen-depen-dent cell proliferation in LNCaP Cells and its roles in transition to androgen-independent cells. Mol. Endocrinol. 20:3053-3069.
-
(2006)
Mol. Endocrinol
, vol.20
, pp. 3053-3069
-
-
Inoue, T.1
Yoshida, T.2
Shimizu, Y.3
Kobayashi, T.4
Yamasaki, T.5
Toda, Y.6
Segawa, T.7
Kamoto, T.8
Nakamura, E.9
Ogawa, O.10
-
20
-
-
44649101304
-
Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network
-
Kuilman, T., C. Michaloglou, L. C. Vredeveld, S. Douma, R. van Doorn, C. J. Desmet, L. A. Aarden, W. J. Mooi, and D. S. Peeper. 2008. Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell 133:1019-1031.
-
(2008)
Cell
, vol.133
, pp. 1019-1031
-
-
Kuilman, T.1
Michaloglou, C.2
Vredeveld, L.C.3
Douma, S.4
van Doorn, R.5
Desmet, C.J.6
Aarden, L.A.7
Mooi, W.J.8
Peeper, D.S.9
-
21
-
-
13944253118
-
Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway
-
Leitges, M., L. Sanz, P. Martin, A. Duran, U. Braun, J. F. Garcia, F. Camacho, M. T. Diaz-Meco, P. D. Rennert, and J. Moscat. 2001. Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway. Mol. Cell 8:771-780.
-
(2001)
Mol. Cell
, vol.8
, pp. 771-780
-
-
Leitges, M.1
Sanz, L.2
Martin, P.3
Duran, A.4
Braun, U.5
Garcia, J.F.6
Camacho, F.7
Diaz-Meco, M.T.8
Rennert, P.D.9
Moscat, J.10
-
22
-
-
0026063529
-
Promoters, co-carcinogens and inhibitors of pulmonary carcinogenesis in mice: An overview
-
Malkinson, A. M. 1991. Promoters, co-carcinogens and inhibitors of pulmonary carcinogenesis in mice: an overview. Exp. Lung Res. 17:435-437.
-
(1991)
Exp. Lung Res
, vol.17
, pp. 435-437
-
-
Malkinson, A.M.1
-
23
-
-
0030612937
-
-
Mayo, M. W., C. Y. Wang, P. C. Cogswell, K. S. Rogers-Graham, S. W. Lowe, C. J. Der, and A. S. Baldwin, Jr. 1997. Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras. Science 278:1812-1815.
-
Mayo, M. W., C. Y. Wang, P. C. Cogswell, K. S. Rogers-Graham, S. W. Lowe, C. J. Der, and A. S. Baldwin, Jr. 1997. Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras. Science 278:1812-1815.
-
-
-
-
24
-
-
15444374561
-
Mouse models for human lung cancer
-
Meuwissen, R., and A. Berns. 2005. Mouse models for human lung cancer. Genes Dev. 19:643-664.
-
(2005)
Genes Dev
, vol.19
, pp. 643-664
-
-
Meuwissen, R.1
Berns, A.2
-
25
-
-
33747886310
-
Cell signaling and function organized by PB1 domain interactions
-
Moscat, J., M. T. Diaz-Meco, A. Albert, and S. Campuzano. 2006. Cell signaling and function organized by PB1 domain interactions. Mol. Cell 23:631-640.
-
(2006)
Mol. Cell
, vol.23
, pp. 631-640
-
-
Moscat, J.1
Diaz-Meco, M.T.2
Albert, A.3
Campuzano, S.4
-
26
-
-
33846692198
-
Signal integration and diversification through the p62 scaffold protein
-
Moscat, J., M. T. Diaz-Meco, and M. W. Wooten. 2007. Signal integration and diversification through the p62 scaffold protein. Trends Biochem. Sci. 32:95-100.
-
(2007)
Trends Biochem. Sci
, vol.32
, pp. 95-100
-
-
Moscat, J.1
Diaz-Meco, M.T.2
Wooten, M.W.3
-
27
-
-
33645960166
-
PKCzeta at the crossroad of NF-kappaB and Jak1/Stat6 signaling pathways
-
Moscat, J., P. Rennert, and M. T. Diaz-Meco. 2006. PKCzeta at the crossroad of NF-kappaB and Jak1/Stat6 signaling pathways. Cell Death Differ. 13:702-711.
-
(2006)
Cell Death Differ
, vol.13
, pp. 702-711
-
-
Moscat, J.1
Rennert, P.2
Diaz-Meco, M.T.3
-
28
-
-
34447327216
-
Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
-
Naugler, W. E., T. Sakurai, S. Kim, S. Maeda, K. Kim, A. M. Elsharkawy, and M. Karin. 2007. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 317:121-124.
-
(2007)
Science
, vol.317
, pp. 121-124
-
-
Naugler, W.E.1
Sakurai, T.2
Kim, S.3
Maeda, S.4
Kim, K.5
Elsharkawy, A.M.6
Karin, M.7
-
29
-
-
0347123433
-
Tumour-educated macrophages promote tumour progression and metastasis
-
Pollard, J. W. 2004. Tumour-educated macrophages promote tumour progression and metastasis. Nat. Rev. Cancer 4:71-78.
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 71-78
-
-
Pollard, J.W.1
-
30
-
-
33847246805
-
Oncomine 3.0: Genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles
-
Rhodes, D. R., S. Kalyana-Sundaram, V. Mahavisno, R. Varambally, J. Yu, B. B. Briggs, T. R. Barrette, M. J. Anstet, C. Kincead-Beal, P. Kulkarni, S. Varambally, D. Ghosh, and A. M. Chinnaiyan. 2007. Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles. Neoplasia 9:166-180.
-
(2007)
Neoplasia
, vol.9
, pp. 166-180
-
-
Rhodes, D.R.1
Kalyana-Sundaram, S.2
Mahavisno, V.3
Varambally, R.4
Yu, J.5
Briggs, B.B.6
Barrette, T.R.7
Anstet, M.J.8
Kincead-Beal, C.9
Kulkarni, P.10
Varambally, S.11
Ghosh, D.12
Chinnaiyan, A.M.13
-
31
-
-
36849039660
-
IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland
-
Sansone, P., G. Storci, S. Tavolari, T. Guarnieri, C. Giovannini, M. Taf-furelli, C. Ceccarelli, D. Santini, P. Paterini, K. B. Marcu, P. Chieco, and M. Bonafe. 2007. IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. J. Clin. Investig. 117:3988-4002.
-
(2007)
J. Clin. Investig
, vol.117
, pp. 3988-4002
-
-
Sansone, P.1
Storci, G.2
Tavolari, S.3
Guarnieri, T.4
Giovannini, C.5
Taf-furelli, M.6
Ceccarelli, C.7
Santini, D.8
Paterini, P.9
Marcu, K.B.10
Chieco, P.11
Bonafe, M.12
-
32
-
-
0034599476
-
The atypical PKC-interacting protein p62 channels NF-kappaB activation by the TRAF6 pathway
-
Sanz, L., M. T. Diaz-Meco, H. Nakano, and J. Moscat. 2000. The atypical PKC-interacting protein p62 channels NF-kappaB activation by the TRAF6 pathway. EMBO J. 19:1576-1586.
-
(2000)
EMBO J
, vol.19
, pp. 1576-1586
-
-
Sanz, L.1
Diaz-Meco, M.T.2
Nakano, H.3
Moscat, J.4
-
33
-
-
11144356354
-
Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects
-
Tuveson, D. A., A. T. Shaw, N. A. Willis, D. P. Silver, E. L. Jackson, S. Chang, K. L. Mercer, R. Grochow, H. Hock, D. Crowley, S. R. Hingorani, T. Zaks, C. King, M. A. Jacobetz, L. Wang, R. T. Bronson, S. H. Orkin, R. A. DePinho, and T. Jacks. 2004. Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell 5:375-387.
-
(2004)
Cancer Cell
, vol.5
, pp. 375-387
-
-
Tuveson, D.A.1
Shaw, A.T.2
Willis, N.A.3
Silver, D.P.4
Jackson, E.L.5
Chang, S.6
Mercer, K.L.7
Grochow, R.8
Hock, H.9
Crowley, D.10
Hingorani, S.R.11
Zaks, T.12
King, C.13
Jacobetz, M.A.14
Wang, L.15
Bronson, R.T.16
Orkin, S.H.17
DePinho, R.A.18
Jacks, T.19
-
34
-
-
36248962105
-
-
Wood, L. D., D. W. Parsons, S. Jones, J. Lin, T. Sjoblom, R. J. Leary, D. Shen, S. M. Boca, T. Barber, J. Ptak, N. Silliman, S. Szabo, Z. Dezso, V. Ustyanksky, T. Nikolskaya, Y. Nikolsky, R. Karchin, P. A. Wilson, J. S. Kaminker, Z. Zhang, R. Croshaw, J. Willis, D. Dawson, M. Shipitsin, J. K. V. Willson, S. Sukumar, K. Polyak, B. H. Park, C. L. Pethiyagoda, P. V. K. Pant, D. G. Ballinger, A. B. Sparks, J. Hartigan, D. R. Smith, E. Suh, N. Papadopoulos, P. Buckhaults, S. D. Markowitz, G. Parmigiani, K. W. Kinzler, V. E. Velculescu, and B. Vogelstein. 2007. The genomic landscapes of human breast and colorectal cancers. Science 318:1108-1113.
-
Wood, L. D., D. W. Parsons, S. Jones, J. Lin, T. Sjoblom, R. J. Leary, D. Shen, S. M. Boca, T. Barber, J. Ptak, N. Silliman, S. Szabo, Z. Dezso, V. Ustyanksky, T. Nikolskaya, Y. Nikolsky, R. Karchin, P. A. Wilson, J. S. Kaminker, Z. Zhang, R. Croshaw, J. Willis, D. Dawson, M. Shipitsin, J. K. V. Willson, S. Sukumar, K. Polyak, B. H. Park, C. L. Pethiyagoda, P. V. K. Pant, D. G. Ballinger, A. B. Sparks, J. Hartigan, D. R. Smith, E. Suh, N. Papadopoulos, P. Buckhaults, S. D. Markowitz, G. Parmigiani, K. W. Kinzler, V. E. Velculescu, and B. Vogelstein. 2007. The genomic landscapes of human breast and colorectal cancers. Science 318:1108-1113.
-
-
-
-
35
-
-
27444433045
-
The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination
-
Wooten, M. W., T. Geetha, M. L. Seibenhener, J. R. Babu, M. T. Diaz-Meco, and J. Moscat. 2005. The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination. J. Biol. Chem. 280:35625-35629.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 35625-35629
-
-
Wooten, M.W.1
Geetha, T.2
Seibenhener, M.L.3
Babu, J.R.4
Diaz-Meco, M.T.5
Moscat, J.6
|