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Volumn 32, Issue 38, 2013, Pages 4539-4548

PKCδ-mediated phosphorylation of BAG3 at Ser187 site induces epithelial-mesenchymal transition and enhances invasiveness in thyroid cancer FRO cells

Author keywords

BAG3; EMT; invasion; PKCd

Indexed keywords

BCL 2 ASSOCIATED ATHANOGENE 3; PHOSPHOPROTEIN; PROTEIN BCL 2; PROTEIN KINASE C DELTA; UNCLASSIFIED DRUG;

EID: 84884588730     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.466     Document Type: Article
Times cited : (35)

References (43)
  • 1
    • 0030987070 scopus 로고    scopus 로고
    • Regulation of protein kinase C
    • Newton AC. Regulation of protein kinase C. Curr Opin Cell Biol 1997; 9: 161-167.
    • (1997) Curr Opin Cell Biol , vol.9 , pp. 161-167
    • Newton, A.C.1
  • 2
    • 0027292678 scopus 로고
    • Phorbol ester-induced myeloid differentiation is mediated by protein kinase C-alpha and -delta and not by protein kinase C-beta II, -epsilon, -zeta, and -eta
    • Mischak H, Pierce JH, Goodnight J, Kazanietz MG, Blumberg PM, Mushinski JF. Phorbol ester-induced myeloid differentiation is mediated by protein kinase C-alpha and -delta and not by protein kinase C-beta II, -epsilon, -zeta, and -eta. J Biol Chem 1993; 268: 20110-20115.
    • (1993) J Biol Chem , vol.268 , pp. 20110-20115
    • Mischak, H.1    Pierce, J.H.2    Goodnight, J.3    Kazanietz, M.G.4    Blumberg, P.M.5    Mushinski, J.F.6
  • 3
    • 0036947279 scopus 로고    scopus 로고
    • Protein kinase C delta (PKC delta): Activation mechanisms and functions
    • Kikkawa U, Matsuzaki H, Yamamoto T. Protein kinase C delta (PKC delta): Activation mechanisms and functions. J Biochem 2002; 132: 831-839.
    • (2002) J Biochem , vol.132 , pp. 831-839
    • Kikkawa, U.1    Matsuzaki, H.2    Yamamoto, T.3
  • 4
    • 10944238407 scopus 로고    scopus 로고
    • Distinctive activation mechanisms and functions for protein kinase Cdelta
    • Steinberg SF. Distinctive activation mechanisms and functions for protein kinase Cdelta. Biochem J 2004; 384: 449-459.
    • (2004) Biochem J , vol.384 , pp. 449-459
    • Steinberg, S.F.1
  • 5
    • 0026472991 scopus 로고
    • Cell division arrest induced by phorbol ester in CHO cells overexpressing protein kinase C-delta subspecies
    • Watanabe T, Ono Y, Taniyama Y, Hazama K, Igarashi K, Ogita K et al. Cell division arrest induced by phorbol ester in CHO cells overexpressing protein kinase C-delta subspecies. Proc Natl Acad Sci USA 1992; 89: 10159-10163.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 10159-10163
    • Watanabe, T.1    Ono, Y.2    Taniyama, Y.3    Hazama, K.4    Igarashi, K.5    Ogita, K.6
  • 6
    • 0642303674 scopus 로고    scopus 로고
    • Mechanical stress-activated PKCdelta regulates smooth muscle cell migration
    • Li C, Wernig F, Leitges M, Hu Y, Xu Q. Mechanical stress-activated PKCdelta regulates smooth muscle cell migration. Faseb J 2003; 17: 2106-2108.
    • (2003) Faseb J , vol.17 , pp. 2106-2108
    • Li, C.1    Wernig, F.2    Leitges, M.3    Hu, Y.4    Xu, Q.5
  • 8
    • 0033523874 scopus 로고    scopus 로고
    • Bis a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death
    • Lee JH, Takahashi T, Yasuhara N, Inazawa J, Kamada S, Tsujimoto Y. Bis a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death. Oncogene 1999; 18: 6183-6190.
    • (1999) Oncogene , vol.18 , pp. 6183-6190
    • Lee, J.H.1    Takahashi, T.2    Yasuhara, N.3    Inazawa, J.4    Kamada, S.5    Tsujimoto, Y.6
  • 9
    • 0033534588 scopus 로고    scopus 로고
    • An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators
    • Takayama S, Xie Z, Reed JC. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. J Biol Chem 1999; 274: 781-786.
    • (1999) J Biol Chem , vol.274 , pp. 781-786
    • Takayama, S.1    Xie, Z.2    Reed, J.C.3
  • 10
    • 0034618385 scopus 로고    scopus 로고
    • CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gamma and Hsp70/Hsc70
    • Doong H, Price J, Kim YS, Gasbarre C, Probst J, Liotta LA et al. CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gamma and Hsp70/Hsc70. Oncogene 2000; 19: 4385-4395.
    • (2000) Oncogene , vol.19 , pp. 4385-4395
    • Doong, H.1    Price, J.2    Kim, Y.S.3    Gasbarre, C.4    Probst, J.5    Liotta, L.A.6
  • 11
    • 33947542628 scopus 로고    scopus 로고
    • The antiapoptotic protein BAG3 is expressed in thyroid carcinomas and modulates apoptosis mediated by tumor necrosis factor-related apoptosis-inducing ligand
    • Chiappetta G, Ammirante M, Basile A, Rosati A, Festa M, Monaco M et al. The antiapoptotic protein BAG3 is expressed in thyroid carcinomas and modulates apoptosis mediated by tumor necrosis factor-related apoptosis-inducing ligand. J Clin Endocrinol Metab 2007; 92: 1159-1163.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 1159-1163
    • Chiappetta, G.1    Ammirante, M.2    Basile, A.3    Rosati, A.4    Festa, M.5    Monaco, M.6
  • 12
    • 0035902997 scopus 로고    scopus 로고
    • The antiapoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines
    • Liao Q, Ozawa F, Friess H, Zimmermann A, Takayama S, Reed JC et al. The antiapoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines. FEBS Lett 2001; 503: 151-157.
    • (2001) FEBS Lett , vol.503 , pp. 151-157
    • Liao, Q.1    Ozawa, F.2    Friess, H.3    Zimmermann, A.4    Takayama, S.5    Reed, J.C.6
  • 14
  • 15
    • 58149494120 scopus 로고    scopus 로고
    • BAG3 gene silencing sensitizes leukemic cells to Bortezomib-induced apoptosis
    • Liu P, Xu B, Li J, Lu H. BAG3 gene silencing sensitizes leukemic cells to Bortezomib-induced apoptosis. FEBS Lett 2009; 583: 401-406.
    • (2009) FEBS Lett , vol.583 , pp. 401-406
    • Liu, P.1    Xu, B.2    Li, J.3    Lu, H.4
  • 16
    • 79951857812 scopus 로고    scopus 로고
    • BAG3 (BCL2-associated athanogene 3) interacts with MMP-2 to positively regulate invasion by ovarian carcinoma cells
    • Suzuki M, Iwasaki M, Sugio A, Hishiya A, Tanaka R, Endo T et al. BAG3 (BCL2-associated athanogene 3) interacts with MMP-2 to positively regulate invasion by ovarian carcinoma cells. Cancer Lett 2011; 303: 65-71.
    • (2011) Cancer Lett , vol.303 , pp. 65-71
    • Suzuki, M.1    Iwasaki, M.2    Sugio, A.3    Hishiya, A.4    Tanaka, R.5    Endo, T.6
  • 17
    • 41149104785 scopus 로고    scopus 로고
    • Caspase-dependent cleavage of BAG3 in proteasome inhibitors-induced apoptosis in thyroid cancer cells
    • Du ZX, Meng X, Zhang HY, Guan Y, Wang HQ. Caspase-dependent cleavage of BAG3 in proteasome inhibitors-induced apoptosis in thyroid cancer cells. Biochem Biophys Res Commun 2008; 369: 894-898.
    • (2008) Biochem Biophys Res Commun , vol.369 , pp. 894-898
    • Du, Z.X.1    Meng, X.2    Zhang, H.Y.3    Guan, Y.4    Wang, H.Q.5
  • 18
    • 79955647069 scopus 로고    scopus 로고
    • Proteasome inhibition induces a p38 MAPK pathway-dependent antiapoptotic program via Nrf2 in thyroid cancer cells
    • Du ZX, Yan Y, Zhang HY, Liu BQ, Gao YY, Niu XF et al. Proteasome inhibition induces a p38 MAPK pathway-dependent antiapoptotic program via Nrf2 in thyroid cancer cells. J Clin Endocrinol Metab 2011; 96: E763-E771.
    • (2011) J Clin Endocrinol Metab , vol.96
    • Du, Z.X.1    Yan, Y.2    Zhang, H.Y.3    Liu, B.Q.4    Gao, Y.Y.5    Niu, X.F.6
  • 19
    • 58149375078 scopus 로고    scopus 로고
    • Proteasome inhibitor MG132 induces BAG3 expression through activation of heat shock factor 1
    • Du ZX, Zhang HY, Meng X, Gao YY, Zou RL, Liu BQ et al. Proteasome inhibitor MG132 induces BAG3 expression through activation of heat shock factor 1. J Cell Physiol 2009; 218: 631-637.
    • (2009) J Cell Physiol , vol.218 , pp. 631-637
    • Du, Z.X.1    Zhang, H.Y.2    Meng, X.3    Gao, Y.Y.4    Zou, R.L.5    Liu, B.Q.6
  • 21
    • 33747376303 scopus 로고    scopus 로고
    • CAIR-1/BAG-3 modulates cell adhesion and migration by downregulating activity of focal adhesion proteins
    • Kassis JN, Guancial EA, Doong H, Virador V, Kohn EC. CAIR-1/BAG-3 modulates cell adhesion and migration by downregulating activity of focal adhesion proteins. Exp Cell Res 2006; 312: 2962-2971.
    • (2006) Exp Cell Res , vol.312 , pp. 2962-2971
    • Kassis, J.N.1    Guancial, E.A.2    Doong, H.3    Virador, V.4    Kohn, E.C.5
  • 22
    • 32844465932 scopus 로고    scopus 로고
    • BAG-1 expression in hyperplastic and neoplastic prostate tissue: Is there any relationship with BCL-related proteins and androgen receptor status?
    • Bozdogan O, Atasoy P, Bozdogan N, Erekul S, Batislam E, Yilmaz E et al. BAG-1 expression in hyperplastic and neoplastic prostate tissue: Is there any relationship with BCL-related proteins and androgen receptor status? Tumori 2005; 91: 539-545.
    • (2005) Tumori , vol.91 , pp. 539-545
    • Bozdogan, O.1    Atasoy, P.2    Bozdogan, N.3    Erekul, S.4    Batislam, E.5    Yilmaz, E.6
  • 23
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009; 139: 871-890.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 26
    • 38949113714 scopus 로고    scopus 로고
    • Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell-mediated lysis of myeloma
    • Shi J, Tricot GJ, Garg TK, Malaviarachchi PA, Szmania SM, Kellum RE et al. Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell-mediated lysis of myeloma. Blood 2008; 111: 1309-1317.
    • (2008) Blood , vol.111 , pp. 1309-1317
    • Shi, J.1    Tricot, G.J.2    Garg, T.K.3    Malaviarachchi, P.A.4    Szmania, S.M.5    Kellum, R.E.6
  • 27
    • 67650996754 scopus 로고    scopus 로고
    • Biomarkers for epithelial-mesenchymal transitions
    • Zeisberg M, Neilson EG. Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 2009; 119: 1429-1437.
    • (2009) J Clin Invest , vol.119 , pp. 1429-1437
    • Zeisberg, M.1    Neilson, E.G.2
  • 28
    • 0037114358 scopus 로고    scopus 로고
    • What's in the 'BAG'?-A functional domain analysis of the BAG-family proteins
    • Doong H, Vrailas A, Kohn EC. What's in the 'BAG'?-A functional domain analysis of the BAG-family proteins. Cancer Lett 2002; 188: 25-32.
    • (2002) Cancer Lett , vol.188 , pp. 25-32
    • Doong, H.1    Vrailas, A.2    Kohn, E.C.3
  • 30
    • 0037464447 scopus 로고    scopus 로고
    • Regulation by heavy metals and temperature of the human BAG-3 gene, a modulator of Hsp70 activity
    • Pagliuca MG, Lerose R, Cigliano S, Leone A. Regulation by heavy metals and temperature of the human BAG-3 gene, a modulator of Hsp70 activity. FEBS Lett 2003; 541: 11-15.
    • (2003) FEBS Lett , vol.541 , pp. 11-15
    • Pagliuca, M.G.1    Lerose, R.2    Cigliano, S.3    Leone, A.4
  • 32
    • 65249153614 scopus 로고    scopus 로고
    • The stress-inducible HspB8-Bag3 complex induces the eIF2alpha kinase pathway: Implications for protein quality control and viral factory degradation?
    • Carra S. The stress-inducible HspB8-Bag3 complex induces the eIF2alpha kinase pathway: Implications for protein quality control and viral factory degradation? Autophagy 2009; 5: 428-429.
    • (2009) Autophagy , vol.5 , pp. 428-429
    • Carra, S.1
  • 33
    • 65549101724 scopus 로고    scopus 로고
    • HspB8 participates in protein quality control by a non-chaperone-like mechanism that requires eIF2{alpha} phosphorylation
    • Carra S, Brunsting JF, Lambert H, Landry J, Kampinga HH. HspB8 participates in protein quality control by a non-chaperone-like mechanism that requires eIF2{alpha} phosphorylation. J Biol Chem 2009; 284: 5523-5532.
    • (2009) J Biol Chem , vol.284 , pp. 5523-5532
    • Carra, S.1    Brunsting, J.F.2    Lambert, H.3    Landry, J.4    Kampinga, H.H.5
  • 34
    • 38349105324 scopus 로고    scopus 로고
    • HSPB8 chaperone activity towards poly-Q containing proteins depends on its association with BAG3, a stimulator of macroautophagy
    • Carra S, Seguin SJ, Lambert H, Landry J. HSPB8 chaperone activity towards poly-Q containing proteins depends on its association with BAG3, a stimulator of macroautophagy. J Biol Chem 2008; 283: 1437-1444.
    • (2008) J Biol Chem , vol.283 , pp. 1437-1444
    • Carra, S.1    Seguin, S.J.2    Lambert, H.3    Landry, J.4
  • 35
    • 24644480749 scopus 로고    scopus 로고
    • Molecular requirements for epithelial-mesenchymal transition during tumor progression
    • Huber MA, Kraut N, Beug H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr Opin Cell Biol 2005; 17: 548-558.
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 548-558
    • Huber, M.A.1    Kraut, N.2    Beug, H.3
  • 36
    • 0035906987 scopus 로고    scopus 로고
    • Epithelial mesenchymal interactions in cancer and development
    • Arias AM. Epithelial mesenchymal interactions in cancer and development. Cell 2001; 105: 425-431.
    • (2001) Cell , vol.105 , pp. 425-431
    • Arias, A.M.1
  • 37
    • 84655163784 scopus 로고    scopus 로고
    • Emerging roles of molecular chaperones and cochaperones in selective autophagy: Focus on BAG proteins
    • Gamerdinger M, Carra S, Behl C. Emerging roles of molecular chaperones and cochaperones in selective autophagy: Focus on BAG proteins. J Mol Med 2011; 89: 1175-1182.
    • (2011) J Mol Med , vol.89 , pp. 1175-1182
    • Gamerdinger, M.1    Carra, S.2    Behl, C.3
  • 38
    • 65449117176 scopus 로고    scopus 로고
    • Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3
    • Gamerdinger M, Hajieva P, Kaya AM, Wolfrum U, Hartl FU, Behl C. Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3. EMBO J 2009; 28: 889-901.
    • (2009) EMBO J , vol.28 , pp. 889-901
    • Gamerdinger, M.1    Hajieva, P.2    Kaya, A.M.3    Wolfrum, U.4    Hartl, F.U.5    Behl, C.6
  • 39
    • 33751514601 scopus 로고    scopus 로고
    • A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells
    • Yook JI, Li XY, Ota I, Hu C, Kim HS, Kim NH et al. A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Nat Cell Biol 2006; 8: 1398-1406.
    • (2006) Nat Cell Biol , vol.8 , pp. 1398-1406
    • Yook, J.I.1    Li, X.Y.2    Ota, I.3    Hu, C.4    Kim, H.S.5    Kim, N.H.6
  • 40
    • 0031727409 scopus 로고    scopus 로고
    • Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front
    • Brabletz T, Jung A, Hermann K, Gunther K, Hohenberger W, Kirchner T. Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front. Pathol Res Pract 1998; 194: 701-704.
    • (1998) Pathol Res Pract , vol.194 , pp. 701-704
    • Brabletz, T.1    Jung, A.2    Hermann, K.3    Gunther, K.4    Hohenberger, W.5    Kirchner, T.6
  • 41
    • 35648949978 scopus 로고    scopus 로고
    • Beta-Catenin signaling in biological control and cancer
    • Gavert N, Ben-Ze'ev A. beta-Catenin signaling in biological control and cancer. J Cell Biochem 2007; 102: 820-828.
    • (2007) J Cell Biochem , vol.102 , pp. 820-828
    • Gavert, N.1    Ben-Ze'ev, A.2
  • 42
    • 33745516898 scopus 로고    scopus 로고
    • PKCdelta clustering at the leading edge and mediating growth factor-enhanced, but not ecm-initiated, dermal fibroblast migration
    • Fan J, Guan S, Cheng CF, Cho M, Fields JW, Chen M et al. PKCdelta clustering at the leading edge and mediating growth factor-enhanced, but not ecm-initiated, dermal fibroblast migration. J Invest Dermatol 2006; 126: 1233-1243.
    • (2006) J Invest Dermatol , vol.126 , pp. 1233-1243
    • Fan, J.1    Guan, S.2    Cheng, C.F.3    Cho, M.4    Fields, J.W.5    Chen, M.6
  • 43
    • 84055176150 scopus 로고    scopus 로고
    • Dynamic actin remodeling during epithelial-mesenchymal transition depends on increased moesin expression
    • Haynes J, Srivastava J, Madson N, Wittmann T, Barber DL. Dynamic actin remodeling during epithelial-mesenchymal transition depends on increased moesin expression. Mol Biol Cell 22: 4750-4764.
    • Mol Biol Cell , vol.22 , pp. 4750-4764
    • Haynes, J.1    Srivastava, J.2    Madson, N.3    Wittmann, T.4    Barber, D.L.5


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