Enzastaurin renders MCF-7 breast cancer cells sensitive to radiation through reversal of radiation-induced activation of protein kinase C

European Journal of Cancer

Volumn 44, Issue 9, 2008, Pages 1315-1322

  Jasinski, Piotr ^a,b   Terai, Kaoru ^a   Zwolak, Pawel ^a   Dudek, Arkadiusz Z ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

, , Isoforms; Apoptosis; Breast cancer; Clonogenic survival; Enzastaurin; Protein kinase C; Radiotherapy

Indexed keywords

7 AMINODACTINOMYCIN; ACTIN; CASPASE 3; CASPASE 9; ENZASTAURIN; EPIDERMAL GROWTH FACTOR RECEPTOR; GLYCOGEN SYNTHASE KINASE 3BETA; ISOENZYME; LIPOCORTIN 5; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETAII; PROTEIN KINASE C EPSILON; PROTEIN KINASE C INHIBITOR; RADIOSENSITIZING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER MODEL; CELL STRAIN MCF 7; CELL SURVIVAL; CLONOGENESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; GAMMA IRRADIATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOSENSITIVITY; TUMOR XENOGRAFT;

ANNEXIN A5; APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CASPASE 3; CASPASE 9; CELL SURVIVAL; CYTOSOL; DACTINOMYCIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; GAMMA RAYS; HUMANS; INDOLES; PHOSPHORYLATION; PROTEIN KINASE C; RADIATION-SENSITIZING AGENTS; REPRESSOR PROTEINS; TUMOR CELLS, CULTURED;

EID: 44449102550     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2008.03.024     Document Type: Article

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