Overexpression of protein kinase Cζ confers protection against antileukemic drugs by inhibiting the redox-dependent sphingomyelinase activation

Molecular Pharmacology

Volumn 62, Issue 6, 2002, Pages 1446-1455

  Bezombes, Christine ^a   De Thonel, Auriélie ^a   Apostolou, Andriana ^a   Louat, Thierry ^a   Jaffrézou, Jean Pierre ^a   Laurent, Guy ^b   Quillet Mary, Anne ^a  

^a INSTITUT CLAUDIUS REGAUD   (France)

^b CHU PURPAN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTILEUKEMIC AGENT; CERAMIDE; CYTARABINE; DAUNORUBICIN; PROTEIN KINASE C ZETA; PROTEIN P53; PROTEIN P56; REACTIVE OXYGEN METABOLITE; SPHINGOMYELIN PHOSPHODIESTERASE;

APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; OXIDATION REDUCTION POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ANTINEOPLASTIC AGENTS; CELL SURVIVAL; CERAMIDES; CYTARABINE; DAUNORUBICIN; HUMANS; HYDROGEN PEROXIDE; METABOLIC DETOXICATION, DRUG; OXIDATION-REDUCTION; PHOSPHORYLATION; PROTECTIVE AGENTS; PROTEIN KINASE C; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SPHINGOMYELIN PHOSPHODIESTERASE; SRC-FAMILY KINASES; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; U937 CELLS;

EID: 0036893717     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.62.6.1446     Document Type: Article

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