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Volumn 7, Issue 2, 2012, Pages

Non-small cell lung carcinoma cell motility, Rac activation and metastatic dissemination are mediated by protein kinase C epsilon

Author keywords

[No Author keywords available]

Indexed keywords

ADAMTS1 PROTEIN; CLUSTERIN; COLLAGENASE 3; EPIDERMAL GROWTH FACTOR; GELATINASE A; GELATINASE B; INTERSTITIAL COLLAGENASE; MATRILYSIN; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 15; MATRIX METALLOPROTEINASE 16; NEUTROPHIL COLLAGENASE; PROTEIN KINASE C EPSILON; PROTEINASE; PROTEINASE INHIBITOR; RAC PROTEIN; STROMELYSIN; STROMELYSIN 2; STROMELYSIN 3; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 3; VON WILLEBRAND FACTOR CLEAVING PROTEINASE; GUANOSINE TRIPHOSPHATE;

EID: 84857578369     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031714     Document Type: Article
Times cited : (43)

References (66)
  • 1
    • 8444248738 scopus 로고    scopus 로고
    • Molecular oncology-perspectives in lung cancer
    • Huber RM, Stratakis DF, (2004) Molecular oncology-perspectives in lung cancer. Lung Cancer 45 (Suppl 2): S209-213.
    • (2004) Lung Cancer , vol.45 , Issue.SUPPL. 2
    • Huber, R.M.1    Stratakis, D.F.2
  • 4
    • 33947603008 scopus 로고    scopus 로고
    • Protein kinase C and other diacylglycerol effectors in cancer
    • Griner EM, Kazanietz MG, (2007) Protein kinase C and other diacylglycerol effectors in cancer. Nat Rev Cancer 7: 281.
    • (2007) Nat Rev Cancer , vol.7 , pp. 281
    • Griner, E.M.1    Kazanietz, M.G.2
  • 5
    • 0242321186 scopus 로고    scopus 로고
    • Divergence and complexities in DAG signaling: looking beyond PKC
    • Yang C, Kazanietz MG, (2003) Divergence and complexities in DAG signaling: looking beyond PKC. Trends Pharmacol Sci 24: 602-608.
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 602-608
    • Yang, C.1    Kazanietz, M.G.2
  • 6
    • 77952761391 scopus 로고    scopus 로고
    • A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation
    • Griner EM, Caino MC, Soledad Sosa M, Colon-Gonzalez F, Chalmers MJ, et al. (2010) A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation. J Biol Chem 285: 16931-16941.
    • (2010) J Biol Chem , vol.285 , pp. 16931-16941
    • Griner, E.M.1    Caino, M.C.2    Soledad Sosa, M.3    Colon-Gonzalez, F.4    Chalmers, M.J.5
  • 7
    • 62449114700 scopus 로고    scopus 로고
    • Hallmarks for senescence in carcinogenesis: novel signaling players
    • Caino MC, Meshki J, Kazanietz MG, (2009) Hallmarks for senescence in carcinogenesis: novel signaling players. Apoptosis 14: 392-408.
    • (2009) Apoptosis , vol.14 , pp. 392-408
    • Caino, M.C.1    Meshki, J.2    Kazanietz, M.G.3
  • 8
    • 26644461205 scopus 로고    scopus 로고
    • Phorbol ester-induced G1 phase arrest selectively mediated by protein kinase Cdelta-dependent induction of p21
    • Nakagawa M, Oliva JL, Kothapalli D, Fournier A, Assoian RK, et al. (2005) Phorbol ester-induced G1 phase arrest selectively mediated by protein kinase Cdelta-dependent induction of p21. J Biol Chem 280: 33926-33934.
    • (2005) J Biol Chem , vol.280 , pp. 33926-33934
    • Nakagawa, M.1    Oliva, J.L.2    Kothapalli, D.3    Fournier, A.4    Assoian, R.K.5
  • 9
    • 41949140742 scopus 로고    scopus 로고
    • S-Phase-specific Activation of PKC{alpha} Induces Senescence in Non-small Cell Lung Cancer Cells
    • Oliva JL, Caino MC, Senderowicz AM, Kazanietz MG, (2008) S-Phase-specific Activation of PKC{alpha} Induces Senescence in Non-small Cell Lung Cancer Cells. J Biol Chem 283: 5466-5476.
    • (2008) J Biol Chem , vol.283 , pp. 5466-5476
    • Oliva, J.L.1    Caino, M.C.2    Senderowicz, A.M.3    Kazanietz, M.G.4
  • 10
    • 34447119557 scopus 로고    scopus 로고
    • Protein kinase C epsilon is overexpressed in primary human non-small cell lung cancers and functionally required for proliferation of non-small cell lung cancer cells in a p21/Cip1-dependent manner
    • Bae KM, Wang H, Jiang G, Chen MG, Lu L, et al. (2007) Protein kinase C epsilon is overexpressed in primary human non-small cell lung cancers and functionally required for proliferation of non-small cell lung cancer cells in a p21/Cip1-dependent manner. Cancer Res 67: 6053-6063.
    • (2007) Cancer Res , vol.67 , pp. 6053-6063
    • Bae, K.M.1    Wang, H.2    Jiang, G.3    Chen, M.G.4    Lu, L.5
  • 11
    • 34250669166 scopus 로고    scopus 로고
    • Protein kinase Cepsilon makes the life and death decision
    • Basu A, Sivaprasad U, (2007) Protein kinase Cepsilon makes the life and death decision. Cell Signal 19: 1633-1642.
    • (2007) Cell Signal , vol.19 , pp. 1633-1642
    • Basu, A.1    Sivaprasad, U.2
  • 12
    • 0037144492 scopus 로고    scopus 로고
    • Protein Kinase C-epsilon Promotes Survival of Lung Cancer Cells by Suppressing Apoptosis through Dysregulation of the Mitochondrial Caspase Pathway
    • Ding L, Wang H, Lang W, Xiao L, (2002) Protein Kinase C-epsilon Promotes Survival of Lung Cancer Cells by Suppressing Apoptosis through Dysregulation of the Mitochondrial Caspase Pathway. J Biol Chem 277: 35305-35313.
    • (2002) J Biol Chem , vol.277 , pp. 35305-35313
    • Ding, L.1    Wang, H.2    Lang, W.3    Xiao, L.4
  • 13
    • 39649094089 scopus 로고    scopus 로고
    • Inhibition of novel protein kinase C-epsilon augments TRAIL-induced cell death in A549 lung cancer cells
    • Felber M, Sonnemann J, Beck JF, (2007) Inhibition of novel protein kinase C-epsilon augments TRAIL-induced cell death in A549 lung cancer cells. Pathol Oncol Res 13: 295-301.
    • (2007) Pathol Oncol Res , vol.13 , pp. 295-301
    • Felber, M.1    Sonnemann, J.2    Beck, J.F.3
  • 14
    • 61649084727 scopus 로고    scopus 로고
    • Protein kinase C epsilon: an oncogene and emerging tumor biomarker
    • Gorin MA, Pan Q, (2009) Protein kinase C epsilon: an oncogene and emerging tumor biomarker. Mol Cancer 8: 9.
    • (2009) Mol Cancer , vol.8 , pp. 9
    • Gorin, M.A.1    Pan, Q.2
  • 15
    • 0027418816 scopus 로고
    • Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity
    • Mischak H, Goodnight JA, Kolch W, Martiny-Baron G, Schaechtle C, et al. (1993) Overexpression of protein kinase C-delta and-epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity. J Biol Chem 268: 6090-6096.
    • (1993) J Biol Chem , vol.268 , pp. 6090-6096
    • Mischak, H.1    Goodnight, J.A.2    Kolch, W.3    Martiny-Baron, G.4    Schaechtle, C.5
  • 16
    • 0030050822 scopus 로고    scopus 로고
    • Overexpression of protein kinase C epsilon is oncogenic in rat colonic epithelial cells
    • Perletti GP, Folini M, Lin HC, Mischak H, Piccinini F, et al. (1996) Overexpression of protein kinase C epsilon is oncogenic in rat colonic epithelial cells. Oncogene 12: 847-854.
    • (1996) Oncogene , vol.12 , pp. 847-854
    • Perletti, G.P.1    Folini, M.2    Lin, H.C.3    Mischak, H.4    Piccinini, F.5
  • 18
    • 70449553663 scopus 로고    scopus 로고
    • Opposite effects of protein kinase C beta1 (PKCbeta1) and PKCepsilon in the metastatic potential of a breast cancer murine model
    • Grossoni VC, Todaro LB, Kazanietz MG, de Kier Joffe ED, Urtreger AJ, (2009) Opposite effects of protein kinase C beta1 (PKCbeta1) and PKCepsilon in the metastatic potential of a breast cancer murine model. Breast Cancer Res Treat 118: 469-480.
    • (2009) Breast Cancer Res Treat , vol.118 , pp. 469-480
    • Grossoni, V.C.1    Todaro, L.B.2    Kazanietz, M.G.3    de Kier Joffe, E.D.4    Urtreger, A.J.5
  • 19
    • 33750379275 scopus 로고    scopus 로고
    • Targeted Disruption of Protein Kinase C{varepsilon} Reduces Cell Invasion and Motility through Inactivation of RhoA and RhoC GTPases in Head and Neck Squamous Cell Carcinoma
    • Pan Q, Bao LW, Teknos TN, Merajver SD, (2006) Targeted Disruption of Protein Kinase C{varepsilon} Reduces Cell Invasion and Motility through Inactivation of RhoA and RhoC GTPases in Head and Neck Squamous Cell Carcinoma. Cancer Res 66: 9379-9384.
    • (2006) Cancer Res , vol.66 , pp. 9379-9384
    • Pan, Q.1    Bao, L.W.2    Teknos, T.N.3    Merajver, S.D.4
  • 20
    • 0036237907 scopus 로고    scopus 로고
    • Regulation of tumor invasion and metastasis in protein kinase C epsilon-transformed NIH3T3 fibroblasts
    • Tachado SD, Mayhew MW, Wescott GG, Foreman TL, Goodwin CD, et al. (2002) Regulation of tumor invasion and metastasis in protein kinase C epsilon-transformed NIH3T3 fibroblasts. J Cell Biochem 85: 785-797.
    • (2002) J Cell Biochem , vol.85 , pp. 785-797
    • Tachado, S.D.1    Mayhew, M.W.2    Wescott, G.G.3    Foreman, T.L.4    Goodwin, C.D.5
  • 21
    • 69849101598 scopus 로고    scopus 로고
    • PKCepsilon regulation of an alpha5 integrin-ZO-1 complex controls lamellae formation in migrating cancer cells
    • Tuomi S, Mai A, Nevo J, Laine JO, Vilkki V, et al. (2009) PKCepsilon regulation of an alpha5 integrin-ZO-1 complex controls lamellae formation in migrating cancer cells. Sci Signal 2: ra32.
    • (2009) Sci Signal , vol.2
    • Tuomi, S.1    Mai, A.2    Nevo, J.3    Laine, J.O.4    Vilkki, V.5
  • 22
    • 0037345097 scopus 로고    scopus 로고
    • Phorbol ester-induced migration of HepG2 cells is accompanied by intensive stress fibre formation, enhanced integrin expression and transient down-regulation of p21-activated kinase 1
    • Gujdar A, Sipeki S, Bander E, Buday L, Farago A, (2003) Phorbol ester-induced migration of HepG2 cells is accompanied by intensive stress fibre formation, enhanced integrin expression and transient down-regulation of p21-activated kinase 1. Cell Signal 15: 307-318.
    • (2003) Cell Signal , vol.15 , pp. 307-318
    • Gujdar, A.1    Sipeki, S.2    Bander, E.3    Buday, L.4    Farago, A.5
  • 23
    • 58149229989 scopus 로고    scopus 로고
    • Phorbol ester-induced podosomes in normal human bronchial epithelial cells
    • Xiao H, Eves R, Yeh C, Kan W, Xu F, et al. (2009) Phorbol ester-induced podosomes in normal human bronchial epithelial cells. J Cell Physiol 218: 366-375.
    • (2009) J Cell Physiol , vol.218 , pp. 366-375
    • Xiao, H.1    Eves, R.2    Yeh, C.3    Kan, W.4    Xu, F.5
  • 25
    • 11144273927 scopus 로고    scopus 로고
    • Atypical protein kinase C-zeta modulates clonogenicity, motility, and secretion of proteolytic enzymes in murine mammary cells
    • Urtreger AJ, Grossoni VC, Falbo KB, Kazanietz MG, Bal de Kier Joffe ED, (2005) Atypical protein kinase C-zeta modulates clonogenicity, motility, and secretion of proteolytic enzymes in murine mammary cells. Mol Carcinog 42: 29-39.
    • (2005) Mol Carcinog , vol.42 , pp. 29-39
    • Urtreger, A.J.1    Grossoni, V.C.2    Falbo, K.B.3    Kazanietz, M.G.4    Bal de Kier Joffe, E.D.5
  • 26
    • 78650235523 scopus 로고    scopus 로고
    • Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer
    • Sosa MS, Lopez-Haber C, Yang C, Wang H, Lemmon MA, et al. (2010) Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer. Mol Cell 40: 877-892.
    • (2010) Mol Cell , vol.40 , pp. 877-892
    • Sosa, M.S.1    Lopez-Haber, C.2    Yang, C.3    Wang, H.4    Lemmon, M.A.5
  • 27
    • 31344467784 scopus 로고    scopus 로고
    • Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4
    • Yang C, Liu Y, Lemmon MA, Kazanietz MG, (2006) Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4. Mol Cell Biol 26: 831-842.
    • (2006) Mol Cell Biol , vol.26 , pp. 831-842
    • Yang, C.1    Liu, Y.2    Lemmon, M.A.3    Kazanietz, M.G.4
  • 28
    • 79953182359 scopus 로고    scopus 로고
    • Differential Regulation of Gene Expression by Protein Kinase C Isozymes as Determined by Genome-wide Expression Analysis
    • Caino MC, von Burstin VA, Lopez-Haber C, Kazanietz MG, (2011) Differential Regulation of Gene Expression by Protein Kinase C Isozymes as Determined by Genome-wide Expression Analysis. J Biol Chem 286: 11254-11264.
    • (2011) J Biol Chem , vol.286 , pp. 11254-11264
    • Caino, M.C.1    von Burstin, V.A.2    Lopez-Haber, C.3    Kazanietz, M.G.4
  • 29
    • 0035953403 scopus 로고    scopus 로고
    • Inhibition of anchorage-independent growth and lung metastasis of A549 lung carcinoma cells by IkappaBbeta
    • Jiang Y, Cui L, Yie TA, Rom WN, Cheng H, et al. (2001) Inhibition of anchorage-independent growth and lung metastasis of A549 lung carcinoma cells by IkappaBbeta. Oncogene 20: 2254-2263.
    • (2001) Oncogene , vol.20 , pp. 2254-2263
    • Jiang, Y.1    Cui, L.2    Yie, T.A.3    Rom, W.N.4    Cheng, H.5
  • 30
    • 0034981225 scopus 로고    scopus 로고
    • Successful treatment of primary and disseminated human lung cancers by systemic delivery of tumor suppressor genes using an improved liposome vector
    • Ramesh R, Saeki T, Templeton NS, Ji L, Stephens LC, et al. (2001) Successful treatment of primary and disseminated human lung cancers by systemic delivery of tumor suppressor genes using an improved liposome vector. Mol Ther 3: 337-350.
    • (2001) Mol Ther , vol.3 , pp. 337-350
    • Ramesh, R.1    Saeki, T.2    Templeton, N.S.3    Ji, L.4    Stephens, L.C.5
  • 31
    • 72849125358 scopus 로고    scopus 로고
    • Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice
    • Santos AM, Jung J, Aziz N, Kissil JL, Pure E, (2009) Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice. J Clin Invest 119: 3613-3625.
    • (2009) J Clin Invest , vol.119 , pp. 3613-3625
    • Santos, A.M.1    Jung, J.2    Aziz, N.3    Kissil, J.L.4    Pure, E.5
  • 32
    • 0034776809 scopus 로고    scopus 로고
    • Protein kinase C isozymes, novel phorbol ester receptors and cancer chemotherapy
    • Barry OP, Kazanietz MG, (2001) Protein kinase C isozymes, novel phorbol ester receptors and cancer chemotherapy. Curr Pharm Des 7: 1725-1744.
    • (2001) Curr Pharm Des , vol.7 , pp. 1725-1744
    • Barry, O.P.1    Kazanietz, M.G.2
  • 33
    • 0037069690 scopus 로고    scopus 로고
    • Rho GTPases in cell biology
    • Etienne-Manneville S, Hall A, (2002) Rho GTPases in cell biology. Nature 420: 629-635.
    • (2002) Nature , vol.420 , pp. 629-635
    • Etienne-Manneville, S.1    Hall, A.2
  • 34
    • 0032559362 scopus 로고    scopus 로고
    • Rho GTPases and the actin cytoskeleton
    • Hall A, (1998) Rho GTPases and the actin cytoskeleton. Science 279: 509-514.
    • (1998) Science , vol.279 , pp. 509-514
    • Hall, A.1
  • 35
    • 0142169536 scopus 로고    scopus 로고
    • Characterization of the Rac-GAP (Rac-GTPase-activating protein) activity of beta2-chimaerin, a 'non-protein kinase C' phorbol ester receptor
    • Caloca MJ, Wang H, Kazanietz MG, (2003) Characterization of the Rac-GAP (Rac-GTPase-activating protein) activity of beta2-chimaerin, a 'non-protein kinase C' phorbol ester receptor. Biochem J 375: 313-321.
    • (2003) Biochem J , vol.375 , pp. 313-321
    • Caloca, M.J.1    Wang, H.2    Kazanietz, M.G.3
  • 36
    • 0023784627 scopus 로고
    • Induction of circular membrane ruffling on human fibroblasts by platelet-derived growth factor
    • Mellstrom K, Heldin CH, Westermark B, (1988) Induction of circular membrane ruffling on human fibroblasts by platelet-derived growth factor. Exp Cell Res 177: 347-359.
    • (1988) Exp Cell Res , vol.177 , pp. 347-359
    • Mellstrom, K.1    Heldin, C.H.2    Westermark, B.3
  • 37
    • 0033568349 scopus 로고    scopus 로고
    • c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF
    • Plattner R, Kadlec L, DeMali KA, Kazlauskas A, Pendergast AM, (1999) c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF. Genes Dev 13: 2400-2411.
    • (1999) Genes Dev , vol.13 , pp. 2400-2411
    • Plattner, R.1    Kadlec, L.2    DeMali, K.A.3    Kazlauskas, A.4    Pendergast, A.M.5
  • 38
    • 41249094587 scopus 로고    scopus 로고
    • Role of phospholipase Cgamma-induced activation of protein kinase Cepsilon (PKCepsilon) and PKCbetaI in epidermal growth factor-mediated protection of tight junctions from acetaldehyde in Caco-2 cell monolayers
    • Suzuki T, Seth A, Rao R, (2008) Role of phospholipase Cgamma-induced activation of protein kinase Cepsilon (PKCepsilon) and PKCbetaI in epidermal growth factor-mediated protection of tight junctions from acetaldehyde in Caco-2 cell monolayers. J Biol Chem 283: 3574-3583.
    • (2008) J Biol Chem , vol.283 , pp. 3574-3583
    • Suzuki, T.1    Seth, A.2    Rao, R.3
  • 39
    • 0032209522 scopus 로고    scopus 로고
    • Signaling through protein kinase C
    • Toker A, (1998) Signaling through protein kinase C. Front Biosci 3: D1134-1147.
    • (1998) Front Biosci , vol.3
    • Toker, A.1
  • 40
    • 36749081143 scopus 로고    scopus 로고
    • Competitive inhibitors and allosteric activators of protein kinase C isoenzymes: a personal account and progress report on transferring academic discoveries to the clinic
    • Budas GR, Koyanagi T, Churchill EN, Mochly-Rosen D, (2007) Competitive inhibitors and allosteric activators of protein kinase C isoenzymes: a personal account and progress report on transferring academic discoveries to the clinic. Biochem Soc Trans 35: 1021-1026.
    • (2007) Biochem Soc Trans , vol.35 , pp. 1021-1026
    • Budas, G.R.1    Koyanagi, T.2    Churchill, E.N.3    Mochly-Rosen, D.4
  • 41
    • 0030609162 scopus 로고    scopus 로고
    • A selective epsilon-protein kinase C antagonist inhibits protection of cardiac myocytes from hypoxia-induced cell death
    • Gray MO, Karliner JS, Mochly-Rosen D, (1997) A selective epsilon-protein kinase C antagonist inhibits protection of cardiac myocytes from hypoxia-induced cell death. J Biol Chem 272: 30945-30951.
    • (1997) J Biol Chem , vol.272 , pp. 30945-30951
    • Gray, M.O.1    Karliner, J.S.2    Mochly-Rosen, D.3
  • 42
    • 11244310899 scopus 로고    scopus 로고
    • Cardioprotection by epsilon-protein kinase C activation from ischemia: continuous delivery and antiarrhythmic effect of an epsilon-protein kinase C-activating peptide
    • Inagaki K, Begley R, Ikeno F, Mochly-Rosen D, (2005) Cardioprotection by epsilon-protein kinase C activation from ischemia: continuous delivery and antiarrhythmic effect of an epsilon-protein kinase C-activating peptide. Circulation 111: 44-50.
    • (2005) Circulation , vol.111 , pp. 44-50
    • Inagaki, K.1    Begley, R.2    Ikeno, F.3    Mochly-Rosen, D.4
  • 43
    • 34548815897 scopus 로고    scopus 로고
    • Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model
    • Koyanagi T, Noguchi K, Ootani A, Inagaki K, Robbins RC, et al. (2007) Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model. J Mol Cell Cardiol 43: 517-522.
    • (2007) J Mol Cell Cardiol , vol.43 , pp. 517-522
    • Koyanagi, T.1    Noguchi, K.2    Ootani, A.3    Inagaki, K.4    Robbins, R.C.5
  • 44
    • 0027333411 scopus 로고
    • Tumor cell interactions with the extracellular matrix during invasion and metastasis
    • Stetler-Stevenson WG, Aznavoorian S, Liotta LA, (1993) Tumor cell interactions with the extracellular matrix during invasion and metastasis. Annu Rev Cell Biol 9: 541-573.
    • (1993) Annu Rev Cell Biol , vol.9 , pp. 541-573
    • Stetler-Stevenson, W.G.1    Aznavoorian, S.2    Liotta, L.A.3
  • 45
    • 0035003212 scopus 로고    scopus 로고
    • Regulation of the cytoskeleton by Rho-family GTPases: implications for tumour cell invasion
    • Price LS, Collard JG, (2001) Regulation of the cytoskeleton by Rho-family GTPases: implications for tumour cell invasion. Semin Cancer Biol 11: 167-173.
    • (2001) Semin Cancer Biol , vol.11 , pp. 167-173
    • Price, L.S.1    Collard, J.G.2
  • 46
    • 24744459073 scopus 로고    scopus 로고
    • Involvement of the RASSF1A tumor suppressor gene in controlling cell migration
    • Dallol A, Agathanggelou A, Tommasi S, Pfeifer GP, Maher ER, et al. (2005) Involvement of the RASSF1A tumor suppressor gene in controlling cell migration. Cancer Res 65: 7653-7659.
    • (2005) Cancer Res , vol.65 , pp. 7653-7659
    • Dallol, A.1    Agathanggelou, A.2    Tommasi, S.3    Pfeifer, G.P.4    Maher, E.R.5
  • 47
    • 66349098157 scopus 로고    scopus 로고
    • Host deficiency in Vav2/3 guanine nucleotide exchange factors impairs tumor growth, survival, and angiogenesis in vivo
    • Brantley-Sieders DM, Zhuang G, Vaught D, Freeman T, Hwang Y, et al. (2009) Host deficiency in Vav2/3 guanine nucleotide exchange factors impairs tumor growth, survival, and angiogenesis in vivo. Mol Cancer Res 7: 615-623.
    • (2009) Mol Cancer Res , vol.7 , pp. 615-623
    • Brantley-Sieders, D.M.1    Zhuang, G.2    Vaught, D.3    Freeman, T.4    Hwang, Y.5
  • 48
    • 70350074501 scopus 로고    scopus 로고
    • Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation
    • Justilien V, Fields AP, (2009) Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation. Oncogene 28: 3597-3607.
    • (2009) Oncogene , vol.28 , pp. 3597-3607
    • Justilien, V.1    Fields, A.P.2
  • 49
    • 68849084686 scopus 로고    scopus 로고
    • The haematopoietic specific signal transducer Vav1 is aberrantly expressed in lung cancer and plays a role in tumourigenesis
    • Lazer G, Idelchuk Y, Schapira V, Pikarsky E, Katzav S, (2009) The haematopoietic specific signal transducer Vav1 is aberrantly expressed in lung cancer and plays a role in tumourigenesis. J Pathol 219: 25-34.
    • (2009) J Pathol , vol.219 , pp. 25-34
    • Lazer, G.1    Idelchuk, Y.2    Schapira, V.3    Pikarsky, E.4    Katzav, S.5
  • 50
    • 24944563309 scopus 로고    scopus 로고
    • Protein kinase C epsilon is a predictive biomarker of aggressive breast cancer and a validated target for RNA interference anticancer therapy
    • Pan Q, Bao LW, Kleer CG, Sabel MS, Griffith KA, et al. (2005) Protein kinase C epsilon is a predictive biomarker of aggressive breast cancer and a validated target for RNA interference anticancer therapy. Cancer Res 65: 8366-8371.
    • (2005) Cancer Res , vol.65 , pp. 8366-8371
    • Pan, Q.1    Bao, L.W.2    Kleer, C.G.3    Sabel, M.S.4    Griffith, K.A.5
  • 51
    • 0035110896 scopus 로고    scopus 로고
    • Protein kinase C-epsilon transgenic mice: a unique model for metastatic squamous cell carcinoma
    • Jansen AP, Verwiebe EG, Dreckschmidt NE, Wheeler DL, Oberley TD, et al. (2001) Protein kinase C-epsilon transgenic mice: a unique model for metastatic squamous cell carcinoma. Cancer Res 61: 808-812.
    • (2001) Cancer Res , vol.61 , pp. 808-812
    • Jansen, A.P.1    Verwiebe, E.G.2    Dreckschmidt, N.E.3    Wheeler, D.L.4    Oberley, T.D.5
  • 52
    • 45549098906 scopus 로고    scopus 로고
    • Protein kinase C-epsilon regulates sphingosine 1-phosphate-mediated migration of human lung endothelial cells through activation of phospholipase D2, protein kinase C-zeta, and Rac1
    • Gorshkova I, He D, Berdyshev E, Usatuyk P, Burns M, et al. (2008) Protein kinase C-epsilon regulates sphingosine 1-phosphate-mediated migration of human lung endothelial cells through activation of phospholipase D2, protein kinase C-zeta, and Rac1. J Biol Chem 283: 11794-11806.
    • (2008) J Biol Chem , vol.283 , pp. 11794-11806
    • Gorshkova, I.1    He, D.2    Berdyshev, E.3    Usatuyk, P.4    Burns, M.5
  • 54
    • 34247347733 scopus 로고    scopus 로고
    • Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation
    • Ferri N, Colombo G, Ferrandi C, Raines EW, Levkau B, et al. (2007) Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation. Arterioscler Thromb Vasc Biol 27: 1043-1049.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 1043-1049
    • Ferri, N.1    Colombo, G.2    Ferrandi, C.3    Raines, E.W.4    Levkau, B.5
  • 55
    • 77952956960 scopus 로고    scopus 로고
    • Rac1 modulates TGF-beta1-mediated epithelial cell plasticity and MMP9 production in transformed keratinocytes
    • Santibanez JF, Kocic J, Fabra A, Cano A, Quintanilla M, (2010) Rac1 modulates TGF-beta1-mediated epithelial cell plasticity and MMP9 production in transformed keratinocytes. FEBS Lett 584: 2305-2310.
    • (2010) FEBS Lett , vol.584 , pp. 2305-2310
    • Santibanez, J.F.1    Kocic, J.2    Fabra, A.3    Cano, A.4    Quintanilla, M.5
  • 56
    • 49649126819 scopus 로고    scopus 로고
    • Matrix metalloproteinase-10 is a critical effector of protein kinase Ciota-Par6alpha-mediated lung cancer
    • Frederick LA, Matthews JA, Jamieson L, Justilien V, Thompson EA, et al. (2008) Matrix metalloproteinase-10 is a critical effector of protein kinase Ciota-Par6alpha-mediated lung cancer. Oncogene 27: 4841-4853.
    • (2008) Oncogene , vol.27 , pp. 4841-4853
    • Frederick, L.A.1    Matthews, J.A.2    Jamieson, L.3    Justilien, V.4    Thompson, E.A.5
  • 57
    • 13444252631 scopus 로고    scopus 로고
    • GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
    • Rossman KL, Der CJ, Sondek J, (2005) GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat Rev Mol Cell Biol 6: 167-180.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 167-180
    • Rossman, K.L.1    Der, C.J.2    Sondek, J.3
  • 58
    • 77954817588 scopus 로고    scopus 로고
    • Alteration of the PKC theta-Vav1 complex and phosphorylation of Vav1 in TCDD-induced apoptosis in the lymphoblastic T cell line, L-MAT
    • Ishida M, Itsukaichi T, Kobayashi D, Kikuchi H, (2010) Alteration of the PKC theta-Vav1 complex and phosphorylation of Vav1 in TCDD-induced apoptosis in the lymphoblastic T cell line, L-MAT. Toxicology 275: 72-78.
    • (2010) Toxicology , vol.275 , pp. 72-78
    • Ishida, M.1    Itsukaichi, T.2    Kobayashi, D.3    Kikuchi, H.4
  • 59
    • 34247615185 scopus 로고    scopus 로고
    • GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases
    • Birkenfeld J, Nalbant P, Bohl BP, Pertz O, Hahn KM, et al. (2007) GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases. Dev Cell 12: 699-712.
    • (2007) Dev Cell , vol.12 , pp. 699-712
    • Birkenfeld, J.1    Nalbant, P.2    Bohl, B.P.3    Pertz, O.4    Hahn, K.M.5
  • 60
    • 40749160955 scopus 로고    scopus 로고
    • Protein kinase A-dependent phosphorylation modulates beta1Pix guanine nucleotide exchange factor activity through 14-3-3beta binding
    • Chahdi A, Sorokin A, (2008) Protein kinase A-dependent phosphorylation modulates beta1Pix guanine nucleotide exchange factor activity through 14-3-3beta binding. Mol Cell Biol 28: 1679-1687.
    • (2008) Mol Cell Biol , vol.28 , pp. 1679-1687
    • Chahdi, A.1    Sorokin, A.2
  • 61
    • 33847305415 scopus 로고    scopus 로고
    • Rho-kinase modulates the function of STEF, a Rac GEF, through its phosphorylation
    • Takefuji M, Mori K, Morita Y, Arimura N, Nishimura T, et al. (2007) Rho-kinase modulates the function of STEF, a Rac GEF, through its phosphorylation. Biochem Biophys Res Commun 355: 788-794.
    • (2007) Biochem Biophys Res Commun , vol.355 , pp. 788-794
    • Takefuji, M.1    Mori, K.2    Morita, Y.3    Arimura, N.4    Nishimura, T.5
  • 62
    • 33750970854 scopus 로고    scopus 로고
    • Contribution of guanine exchange factor H1 in phorbol ester-induced apoptosis
    • Chang YC, Lee HH, Chen YJ, Bokoch GM, Chang ZF, (2006) Contribution of guanine exchange factor H1 in phorbol ester-induced apoptosis. Cell Death Differ 13: 2023-2032.
    • (2006) Cell Death Differ , vol.13 , pp. 2023-2032
    • Chang, Y.C.1    Lee, H.H.2    Chen, Y.J.3    Bokoch, G.M.4    Chang, Z.F.5
  • 63
    • 0035933870 scopus 로고    scopus 로고
    • Protein kinase C-alpha signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function
    • Mehta D, Rahman A, Malik AB, (2001) Protein kinase C-alpha signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function. J Biol Chem 276: 22614-22620.
    • (2001) J Biol Chem , vol.276 , pp. 22614-22620
    • Mehta, D.1    Rahman, A.2    Malik, A.B.3
  • 64
    • 62149105253 scopus 로고    scopus 로고
    • DLC1 interacts with 14-3-3 proteins to inhibit RhoGAP activity and block nucleocytoplasmic shuttling
    • Scholz RP, Regner J, Theil A, Erlmann P, Holeiter G, et al. (2009) DLC1 interacts with 14-3-3 proteins to inhibit RhoGAP activity and block nucleocytoplasmic shuttling. J Cell Sci 122: 92-102.
    • (2009) J Cell Sci , vol.122 , pp. 92-102
    • Scholz, R.P.1    Regner, J.2    Theil, A.3    Erlmann, P.4    Holeiter, G.5
  • 65
    • 0035657643 scopus 로고    scopus 로고
    • Protein kinase C inhibitors as novel anticancer drugs
    • Goekjian PG, Jirousek MR, (2001) Protein kinase C inhibitors as novel anticancer drugs. Expert Opin Investig Drugs 10: 2117-2140.
    • (2001) Expert Opin Investig Drugs , vol.10 , pp. 2117-2140
    • Goekjian, P.G.1    Jirousek, M.R.2
  • 66
    • 33746753299 scopus 로고    scopus 로고
    • Preclinical and clinical development of novel agents that target the protein kinase C family
    • Serova M, Ghoul A, Benhadji KA, Cvitkovic E, Faivre S, et al. (2006) Preclinical and clinical development of novel agents that target the protein kinase C family. Semin Oncol 33: 466-478.
    • (2006) Semin Oncol , vol.33 , pp. 466-478
    • Serova, M.1    Ghoul, A.2    Benhadji, K.A.3    Cvitkovic, E.4    Faivre, S.5


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