Protein Kinase C Promotes Apoptosis in LNCaP Prostate Cancer Cells through Activation of p38 MAPK and Inhibition of the Akt Survival Pathway

Journal of Biological Chemistry

Volumn 278, Issue 36, 2003, Pages 33753-33762

  Tanaka, Yuichi ^a   Gavrielides, M Veronica ^a   Mitsuuchi, Yasuhiro ^b   Fujii, Teruhiko ^c   Kazanietz, Marcelo G ^a,d  

^a Center for Experimental Therapeutics   (United States)

^b FOX CHASE CANCER CENTER   (United States)

^c KURUME UNIVERSITY   (Japan)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENZYME INHIBITION; ENZYMES; ESTERS; GLYCEROL; TUMORS;

DEPHOSPHORYLATION;

BIOCHEMISTRY;

ANDROGEN; DIACYLGLYCEROL; MITOGEN ACTIVATED PROTEIN KINASE; OKADAIC ACID; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE B; PROTEIN KINASE C; SYNAPTOPHYSIN; ANDROSTANE DERIVATIVE; ENZYME INHIBITOR; ISOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PRKCA PROTEIN, HUMAN; PRKCD PROTEIN, HUMAN; PROTEIN KINASE C ALPHA; PROTEIN KINASE C DELTA; WORTMANNIN;

ARTICLE; CANCER CELL; CELL SURVIVAL; DEPHOSPHORYLATION; EFFECTOR CELL; ENZYME ACTIVATION; ENZYME REGULATION; GENE; GROWTH INHIBITION; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; MITOGENESIS; MULTIGENE FAMILY; PRIORITY JOURNAL; PROSTATE CANCER; PTEN GENE; TARGET CELL; TUMOR GROWTH; APOPTOSIS; BIOLOGICAL MODEL; CELL CULTURE; DOSE RESPONSE; DOWN REGULATION; GENETIC TRANSFECTION; MALE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PROSTATE TUMOR; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME; WESTERN BLOTTING;

GARCIA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; APOPTOSIS; BLOTTING, WESTERN; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; OKADAIC ACID; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTEIN ISOFORMS; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; PROTEIN KINASE C-DELTA; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE; TIME FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0141594871     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M303313200     Document Type: Article

References (51)

1. Ron, D., and Kazanietz, M. G. (1999) FASEB J. 13, 1658-1676
2. Dempsey, E. C., Newton, A. C., Mochly-Rosen, D., Fields, A. P., Reyland, M. E., Insel, P. A., and Messing, R. O. (2000) Am. J. Physiol. 279, L429-L438
3. Newton, A. C. (2001) Chem. Rev. 101, 2353-2364
4. Kazanietz, M. G. (2002) Mol. Pharmacol. 61, 759-767
5. Mischak, H., Goodnight, J. A., Kolch, W., Martiny-Baron, G., Schaechtle, C., Kazanietz, M. G., Blumberg, P. M., Pierce, J. H., and Mushinski, J. F. (1993) J. Biol. Chem. 268, 6090-6096
6. Weinstein, I. B., Kahn, S. M., O'Driscoll, K., Borner, C., Bang, D., Jiang, W., Blackwood, A., and Nomoto, K. (1997) Adv. Exp. Med. Biol. 400, 313-321
7. Jaken, S., and Parker, P. J. (2000) Bioessays 22, 245-254
8. Schechtman, D., and Mochly-Rosen, D. (2001) Oncogene 20, 6339-6347
9. Powell, C. T., Brittis, N. J., Stec, D., Hug, H., Heston, W. D., and Fair, W. R. (1996) Cell Growth Differ. 7, 419-428
10. Zhao, X., Gschwend, J. E., Powell, C. T., Foster, R. G., Day, K. C., and Day, M. L. (1997) J. Biol. Chem. 272, 22751-22757
11. Garzotto, M., White-Jones, M., Jiang, Y., Ehleiter, D., Liao, W. C., Haimovitz-Friedman, A., Fuks, Z., and Kolesnick, R. (1998) Cancer Res. 58, 2260-2264
12. Fujii, T., García-Bermejo, M. L., Bernabö, J. L., Caamaño, J., Ohba, M., Kuroki, T., Li, L., Yuspa, S. H., and Kazanietz, M. G. (2000) J. Biol. Chem. 275, 7574-7582
13. Garcia-Bermejo, M. L., Leskow, F. C., Fujii, T., Wang, Q., Blumberg, P. M., Ohba, M., Kuroki, T., Han, K. C., Lee, J., Marquez, V. E., and Kazanietz, M. G. (2002) J. Biol. Chem. 277, 645-655
14. Schonwasser, D. C., Marais, R. M., Marshall, C. J., and Parker, P. J. (1998) Mol. Cell. Biol. 18, 790-798
15. Barry, O. P., Kazanietz, M. G., Pratico, D., and FitzGerald, G. A. (1999) J. Biol. Chem. 274, 7545-7556
16. Soh, J. W., Lee, E. H., Prywes, R., and Weinstein, I. B. (1999) Mol. Cell. Biol. 19, 1313-1324
17. Datta, R., Yoshinaga, K., Kaneki, M., Pandey, P., and Kufe, D. (2000) J. Biol. Chem. 275, 41000-41003
18. Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., and Greenberg, M. E. (1995) Science 270, 1326-1331
19. De Zutter, G. S., and Davis, R. J. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 6168-6173
20. Murillo, H., Schmidt, L. J., and Tindall, D. J. (2001) Cancer Res. 61, 7408-7412
21. Carson, J. P., Kulik, G., and Weber, M. J. (1999) Cancer Res. 59, 1449-1453
22. McMenamin, M. E., Soung, P., Perera, S., Kaplan, I., Loda, M., and Sellers, W. R. (1999) Cancer Res. 69, 4291-4296
23. Chen, X., Thakkar, H., Tyan, F., Gim, S., Robinson, H., Lee, C., Pandey, S. K., Nwokorie, C., Onwudiwe, N., and Srivastava, R. K. (2001) Oncogene 20, 6073-6083
24. Malik, S. N., Brattain, M., Ghosh, P. M., Troyer, D. A., Prihoda, T., Bedolla, R., and Kreisberg, J. I. (2002) Clin. Cancer Res. 8, 1168-1171
25. Fujio, Y., Guo, K., Mano, T., Mitsuuchi, Y., Testa, J. R., and Walsh, K. (1999) Mol. Cell. Biol. 19, 5073-5082
26. Berkner, K. L. (1992) Curr. Top. Microbiol. Immunol. 158, 39-66
27. Cuenda, A., Rouse, J., Doza, Y. N., Meier, R., Cohen, P., Gallagher, T. F., Young, P. R., and Lee, J. C. (1995) FEBS Lett. 364, 229-233
28. Young, P. R., McLaughlin, M. M., Kumar, S., Kassis, S., Doyle, M. L., McNulty, D., Gallagher, T. F., Fisher, S., McDonnell, P. C., Carr, S. A., Huddleston, M. J., Seibel, G., Porter, T. G., Livi, G. P., Adams, J. L., and Lee, J. C. (1997) J. Biol. Chem. 272, 12116-12121
29. Bennett, B. L., Sasaki, D. T., Murray, B. W., O'Leary, E. C., Sakata, S. T., Xu, W., Leisten, J. C., Motiwala, A., Pierce, S., Satoh, Y., Bhagwat, S. S., Manning, A. M., and Anderson, D. W. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 13681-62001
30. Wu, D., Foreman, T. L., Gregory, C. W., McJilton, M. A., Wescott, G. G., Ford, O. H., Alvey, R. F., Mohler, J. L., and Terrian, D. M. (2002) Cancer Res. 62, 2423-2429
31. Emoto, Y., Manome, Y., Meinhardt, G., Kisaki, H., Kharbanda, S., Robertson, M., Ghayur, T., Wong, W. W., Kamen, R., and Weichselbaum, R. (1995) EMBO J. 14, 6148-6156
32. Ghayur, T., Hugunin, M., Talanian, R. V., Ratnofsky, S., Quinlan, C., Emoto, Y., Pandey, P., Datta, R., Huang, Y., Kharbanda, S., Allen, H., Kamen, R., Wong, W., and Kufe, D. (1996) J. Exp. Med. 184, 2399-2404
33. Denning, M. F., Wang, Y., Nickoloff, B. J., and Wrone-Smith, T. (1998) J. Biol. Chem. 273, 29995-30002
34. Reyland, M. E., Anderson, S. M., Matassa, A. A., Barzen, K. A., and Quissell, D. O. (1999) J. Biol. Chem. 274, 19115-19123
35. Cerda, S. R., Bissonnette, M., Scaglione-Sewell, B., Lyons, M. R., Khare, S., Mustafi, R., and Brasitus, T. A. (2001) Gastroenterology 120, 1700-1712
36. Goerke, A., Sakai, N., Gutjahr, E., Schlapkohl, W. A., Mushinski, J. F., Haller, H., Kolch, W., Saito, N., and Mischak, H. (2002) J. Biol. Chem. 277, 32054-32062
37. Li, L., Lorenzo, P. S., Bogi, K., Blumberg, P. M., and Yuspa, S. H. (1999) Mol. Cell. Biol. 19, 8547-8558
38. Sumitomo, M., Ohba, M., Asakuma, J., Asano, T., Kuroki, T., Asano, T., and Hayakawa, M. (2002) J. Clin. Invest. 109, 827-836
39. Livneh, E., and Fishman, D. D. (1997) Eur. J. Biochem. 248, 1-9
40. Okuda, H., Adachi, M., Miyazawa, M., Hinoda, Y., and Imai, K. (1999) Oncogene 18, 5604-5609
41. Black, J. D. (2000) Front. Biosci. 5, D406-D423
42. Ito, T., Kozawa, O., Tanabe, K., Niwa, M., Matsuno, H., Sakai, N., Ito, H., Kato, K., and Uematsu, T. (2000) Hypertension 35, 673-678
43. Kanda, Y., Nishio, E., Kuroki, Y., Mizuno, K., and Watanabe, Y. (2001) Life Sci. 68, 1989-2000
44. Yashima, R., Abe, M., Tanaka, K., Ueno, H., Shitara, K., Takenoshita, S., and Sato, Y. (2001) J. Cell. Physiol. 188, 201-210
45. Kumar, S., McDonnell, P. C., Gum, R. J., Hand, A. T., Lee, J. C., and Young, P. R. (1997) Biochem. Biophys. Res. Commun. 235, 533-538
46. Efimova, T., Deucher, A., Kuroki, T., Ohba, M., and Eckert, R. L. (2002) J. Biol. Chem. 277, 31753-31760
47. Gschwend, J. E., Fair, W. R., and Powell, C. T. (2000) Mol. Pharmacol. 57, 1224-1234
48. Gioeli, D., Mandell, J. W., Petroni, G. R., Frierson, H. F., and Weber, M. J. (1999) Cancer Res. 59, 279-284
49. Motley, E. D., Kabir, S. M., Gardner, C. D., Eguchi, K., Frank, G. D., Kuroki, T., Ohba, M., Yamakawa, T., and Eguchi, S. (2002) Hypertension 39, 508-512
50. Cazzolli, R., Carpenter, L., Biden, T. J., and Schmitz-Peiffer, C. (2001) Diabetes 50, 2210-2218
51. Teruel, T., Hernandez, R., and Lorenzo, M. (2001) Diabetes 50, 2563-2571