메뉴 건너뛰기




Volumn 51, Issue 4, 2010, Pages 671-679

Effects of enzastaurin, alone or in combination, on signaling pathway controlling growth and survival of B-cell lymphoma cell lines

Author keywords

Apoptosis; B cell lines; Indolent lymphoma; PI3K AKT; PKC; Signaling pathways

Indexed keywords

CHLORAMBUCIL; ENZASTAURIN; FLUDARABINE; PROTEIN BAD; PROTEIN KINASE B; PROTEIN KINASE C;

EID: 77953212331     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428191003637290     Document Type: Article
Times cited : (13)

References (30)
  • 2
    • 33645733104 scopus 로고    scopus 로고
    • Improvement of overall and failure-free survival in stage IV follicular lymphoma: 25 years of treatment experience
    • The University of Texas M.D. Anderson Cancer Center
    • Liu Q, Fayad L, Cabanillas F, et al. Improvement of overall and failure-free survival in stage IV follicular lymphoma: 25 years of treatment experience at The University of Texas M.D. Anderson Cancer Center. J Clin Oncol 2006;24: 1582-1589.
    • (2006) J Clin Oncol , vol.24 , pp. 1582-1589
    • Liu, Q.1    Fayad, L.2    Cabanillas, F.3
  • 3
    • 34248398358 scopus 로고    scopus 로고
    • Introduction of rituximab in front-line and salvage therapies has improved outcome of advanced-stage follicular lymphoma patients
    • Italian Lymphoma Study Group
    • Sacchi S, Pozzi S, Marcheselli L, et al.; Italian Lymphoma Study Group. Introduction of rituximab in front-line and salvage therapies has improved outcome of advanced-stage follicular lymphoma patients. Cancer 2007;109:2077-2082.
    • (2007) Cancer , vol.109 , pp. 2077-2082
    • Sacchi, S.1    Pozzi, S.2    Marcheselli, L.3
  • 4
    • 25644448853 scopus 로고    scopus 로고
    • Management of nodal indolent (non marginal-zone) non-Hodgkin's lymphomas: Practice guidelines from the Italian Society of Hematology
    • Italian Society of Experimental Hematology and Italian Group for Bone Marrow Transplantation
    • Barosi G, Carella A, Lazzarino M, et al. Management of nodal indolent (non marginal-zone) non-Hodgkin's lymphomas: practice guidelines from the Italian Society of Hematology, Italian Society of Experimental Hematology and Italian Group for Bone Marrow Transplantation. Haematologica 2005;90: 1236-1257.
    • (2005) Haematologica , vol.90 , pp. 1236-1257
    • Barosi, G.1    Carella, A.2    Lazzarino, M.3
  • 5
    • 0038518616 scopus 로고    scopus 로고
    • Treatment of indolent B-cell nonfollicular lymphomas: Final results of the LL01 randomized trial of the Gruppo Italiano per lo Studio dei Linfomi
    • Gruppo Italiano per lo Studio dei Linfomi
    • Baldini L, Brugiatelli M, Luminari S, et al.; Gruppo Italiano per lo Studio dei Linfomi. Treatment of indolent B-cell nonfollicular lymphomas: final results of the LL01 randomized trial of the Gruppo Italiano per lo Studio dei Linfomi. J Clin Oncol 2003;21:1459-1465.
    • (2003) J Clin Oncol , vol.21 , pp. 1459-1465
    • Baldini, L.1    Brugiatelli, M.2    Luminari, S.3
  • 6
    • 77953190015 scopus 로고    scopus 로고
    • Front-line treatment of low-grade non-follicular non-Hodgkin lymphoma (final report of Gisl LL02 trial)
    • Abstract 2332
    • Goldaniga M, Merli F, Stelitano C, et al. Front-line treatment of low-grade non-follicular non-Hodgkin lymphoma (final report of Gisl LL02 trial). Blood 2007;110(Suppl. 1):690a (Abstract 2332).
    • (2007) Blood , vol.110 , Issue.SUPPL. 1
    • Goldaniga, M.1    Merli, F.2    Stelitano, C.3
  • 7
    • 77953197621 scopus 로고    scopus 로고
    • Front-line chemoimmunotherapy rituximab-FCprituximab maintenance in patients with untreated advanced stage non follicular lymphoma (INFL) preliminary results of a prospective study of the Intergruppo Italiano Linfomi and Roche (ML18324)
    • Abstract 2686
    • Baldini L, Pulsoni A, Rossi G, et al. Front-line chemoimmunotherapy rituximab-FCprituximab maintenance in patients with untreated advanced stage non follicular lymphoma (INFL): preliminary results of a prospective study of the Intergruppo Italiano Linfomi and Roche (ML18324). Blood 2008;112(Suppl. 1):709 (Abstract 2686).
    • (2008) Blood , vol.112 , Issue.SUPPL. 1 , pp. 709
    • Baldini, L.1    Pulsoni, A.2    Rossi, G.3
  • 8
    • 0031452745 scopus 로고    scopus 로고
    • T(14;18), a journey to eternity
    • Meijerink JP. t(14;18), a journey to eternity. Leukemia 1997; 11:2175-2187.
    • (1997) Leukemia , vol.11 , pp. 2175-2187
    • Meijerink, J.P.1
  • 9
    • 0036177115 scopus 로고    scopus 로고
    • Targeting protein kinase C: New therapeutic opportunities against high-grade malignant gliomas?
    • da Rocha AB, Mans DR, Regner A, Schwartsmann G. Targeting protein kinase C: new therapeutic opportunities against high-grade malignant gliomas? Oncologist 2002;7: 17-33.
    • (2002) Oncologist , vol.7 , pp. 17-33
    • Da Rocha, A.B.1    Mans, D.R.2    Regner, A.3    Schwartsmann, G.4
  • 10
    • 18244409933 scopus 로고    scopus 로고
    • Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning
    • Shipp MA, Ross KN, Tamayo P, et al. Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning. Nat Med 2002;8:68-74.
    • (2002) Nat Med , vol.8 , pp. 68-74
    • Shipp, M.A.1    Ross, K.N.2    Tamayo, P.3
  • 11
    • 34248151884 scopus 로고    scopus 로고
    • Retrospective analysis of protein kinase C-beta (PKC-beta) expression in lymphoid malignancies and its association with survival in diffuse large B cell lymphomas
    • Li S, Phong M, Lahn M, et al. Retrospective analysis of protein kinase C-beta (PKC-beta) expression in lymphoid malignancies and its association with survival in diffuse large B cell lymphomas. Biol Direct 2007;21:2-8.
    • (2007) Biol Direct , vol.21 , pp. 2-8
    • Li, S.1    Phong, M.2    Lahn, M.3
  • 12
    • 0029739626 scopus 로고    scopus 로고
    • Immunodeficiency in protein kinase cbeta-deficient mice
    • Leitges M, Schmedt C, Guinamard R, et al. Immunodeficiency in protein kinase cbeta-deficient mice. Science 1996; 273:788-791.
    • (1996) Science , vol.273 , pp. 788-791
    • Leitges, M.1    Schmedt, C.2    Guinamard, R.3
  • 13
    • 0038394537 scopus 로고    scopus 로고
    • Acyclic N-(azacycloalkyl)bisindolylmaleimides: Isozyme selective inhibitors of PKCb
    • Faul MM, Gillig JR, Jirousek MR, et al. Acyclic N-(azacycloalkyl) bisindolylmaleimides: isozyme selective inhibitors of PKCb. Bioorg Med Chem Lett 2003;13:1857-1859.
    • (2003) Bioorg Med Chem Lett , vol.13 , pp. 1857-1859
    • Faul, M.M.1    Gillig, J.R.2    Jirousek, M.R.3
  • 14
    • 0033199874 scopus 로고    scopus 로고
    • Protein kinase C lies on the signaling pathway for vascular endothelial growth factor-mediated tumor development and angiogenesis
    • Yoshiji H, Kuriyama S, Ways DH, et al. Protein kinase C lies on the signaling pathway for vascular endothelial growth factor-mediated tumor development and angiogenesis. Cancer Res 1999;59:4413-4418.
    • (1999) Cancer Res , vol.59 , pp. 4413-4418
    • Yoshiji, H.1    Kuriyama, S.2    Ways, D.H.3
  • 15
    • 0019051838 scopus 로고
    • Long-term culture of human bone marrow cells
    • Gartner S, Kaplan HS. Long-term culture of human bone marrow cells. Proc Natl Acad Sci USA 1980;77:4756-4759.
    • (1980) Proc Natl Acad Sci USA , vol.77 , pp. 4756-4759
    • Gartner, S.1    Kaplan, H.S.2
  • 16
    • 0023691590 scopus 로고
    • Detection of chromosome aberrations in metaphase and interphase tumor cells by in situ hybridization using chromosome-specific library probes
    • Cremer T, Lichter P, Borden J, Ward DC, Manuelidis L. Detection of chromosome aberrations in metaphase and interphase tumor cells by in situ hybridization using chromosome-specific library probes. Hum Genet 1988;80:235-246.
    • (1988) Hum Genet , vol.80 , pp. 235-246
    • Cremer, T.1    Lichter, P.2    Borden, J.3    Ward, D.C.4    Manuelidis, L.5
  • 17
    • 0026353797 scopus 로고
    • All advanced stage non-Hodgkin's lymphomas with a polymerase chain reaction amplifiable breakpoint of bcl-2 have residual cells containing the bcl-2 rearrangement at evaluation and after treatment
    • Gribben JG, Freedman A, Woo SD, et al. All advanced stage non-Hodgkin's lymphomas with a polymerase chain reaction amplifiable breakpoint of bcl-2 have residual cells containing the bcl-2 rearrangement at evaluation and after treatment. Blood 1991;78:3275-3280.
    • (1991) Blood , vol.78 , pp. 3275-3280
    • Gribben, J.G.1    Freedman, A.2    Woo, S.D.3
  • 18
    • 0021118703 scopus 로고
    • Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
    • Chou TC, Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 1984;22:27-55.
    • (1984) Adv Enzyme Regul , vol.22 , pp. 27-55
    • Chou, T.C.1    Talalay, P.2
  • 19
    • 33748794547 scopus 로고    scopus 로고
    • Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies
    • Chou TC. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev 2006;58:621-681.
    • (2006) Pharmacol Rev , vol.58 , pp. 621-681
    • Chou, T.C.1
  • 20
    • 23844521568 scopus 로고    scopus 로고
    • The protein kinase C beta selective inhibitor, enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts
    • Graff JR, McNulty AM, Hanna KR, et al. The protein kinase C beta selective inhibitor, enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. Cancer Res 2005;65:7462-7469.
    • (2005) Cancer Res , vol.65 , pp. 7462-7469
    • Graff, J.R.1    McNulty, A.M.2    Hanna, K.R.3
  • 21
    • 33846914141 scopus 로고    scopus 로고
    • Targeting PKC in multiple myeloma: In vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615. HCl)
    • Podar K, Raab MS, Zhang J, et al. Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615. HCl). Blood 2007;109:1669-1677.
    • (2007) Blood , vol.109 , pp. 1669-1677
    • Podar, K.1    Raab, M.S.2    Zhang, J.3
  • 22
    • 49849099068 scopus 로고    scopus 로고
    • Sequencedependent, synergistic antiproliferative and proapoptotic effects of the combination of cytotoxic drugs and enzastaurin, a protein kinase C beta inhibitor, in non-small cell lung cancer cells
    • Morgillo F, Martinelli E, Troiani T, et al. Sequencedependent, synergistic antiproliferative and proapoptotic effects of the combination of cytotoxic drugs and enzastaurin, a protein kinase C beta inhibitor, in non-small cell lung cancer cells. Mol Cancer Ther 2008;7:1698-1707.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1698-1707
    • Morgillo, F.1    Martinelli, E.2    Troiani, T.3
  • 23
    • 33745207996 scopus 로고    scopus 로고
    • The selective protein kinase C beta inhibitor enzastaurin induces apoptosis in cutaneous T-cell lymphoma cell lines through the AKT pathway
    • Querfeld C, Rizvi MA, Kuzel TM, et al. The selective protein kinase C beta inhibitor enzastaurin induces apoptosis in cutaneous T-cell lymphoma cell lines through the AKT pathway. J Invest Dermatol 2006;126:1641-1647.
    • (2006) J Invest Dermatol , vol.126 , pp. 1641-1647
    • Querfeld, C.1    Rizvi, M.A.2    Kuzel, T.M.3
  • 24
    • 33748328365 scopus 로고    scopus 로고
    • Enzastaurin (LY317615), a protein kinase Cbeta inhibitor, inhibits the AKT pathway and induces apoptosis in multiple myeloma cell lines
    • Rizvi MA, Ghias K, Davies KM, et al. Enzastaurin (LY317615), a protein kinase Cbeta inhibitor, inhibits the AKT pathway and induces apoptosis in multiple myeloma cell lines. Mol Cancer Ther 2006;5:1783-1789.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1783-1789
    • Rizvi, M.A.1    Ghias, K.2    Davies, K.M.3
  • 25
    • 47649103741 scopus 로고    scopus 로고
    • The oral protein-kinase C beta inhibitor enzastaurin (LY317615) suppresses signalling through the AKT pathway, inhibits proliferation and induces apoptosis in multiple myeloma cell lines
    • Neri A, Marmiroli S, Tassone P, et al. The oral protein-kinase C beta inhibitor enzastaurin (LY317615) suppresses signalling through the AKT pathway, inhibits proliferation and induces apoptosis in multiple myeloma cell lines. Leuk Lymphoma 2008;49:1374-1383.
    • (2008) Leuk Lymphoma , vol.49 , pp. 1374-1383
    • Neri, A.1    Marmiroli, S.2    Tassone, P.3
  • 26
    • 0030584088 scopus 로고    scopus 로고
    • Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
    • Zha J, Harada H, Yang E, Jockel J, Korsmeyer SJ. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L) Cell 1996;87:619-628.
    • (1996) Cell , vol.87 , pp. 619-628
    • Zha, J.1    Harada, H.2    Yang, E.3    Jockel, J.4    Korsmeyer, S.J.5
  • 27
    • 0033520937 scopus 로고    scopus 로고
    • P90(RSK) blocks bad-mediated cell death via a protein kinase C-dependent pathway
    • Tan Y, Ruan H, Demeter MR, Comb MJ. p90(RSK) blocks bad-mediated cell death via a protein kinase C-dependent pathway. J Biol Chem 1999;274:34859- 34867.
    • (1999) J Biol Chem , vol.274 , pp. 34859-34867
    • Tan, Y.1    Ruan, H.2    Demeter, M.R.3    Comb, M.J.4
  • 28
    • 21244461138 scopus 로고    scopus 로고
    • Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Baxand Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells
    • Hurbin A, Coll JL, Dubrez-Daloz L, et al. Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Baxand Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells. J Biol Chem 2005;280:19757-19767.
    • (2005) J Biol Chem , vol.280 , pp. 19757-19767
    • Hurbin, A.1    Coll, J.L.2    Dubrez-Daloz, L.3
  • 29
    • 40949101463 scopus 로고    scopus 로고
    • Enzastaurin, a protein kinase C beta inhibitor, suppresses signaling through the ribosomal S6 kinase and bad pathways and induces apoptosis in human gastric cancer cells
    • Lee KW, Kim SG, KimHP, et al. Enzastaurin, a protein kinase C beta inhibitor, suppresses signaling through the ribosomal S6 kinase and bad pathways and induces apoptosis in human gastric cancer cells. Cancer Res 2008;68:1916-1926.
    • (2008) Cancer Res , vol.68 , pp. 1916-1926
    • Lee, K.W.1    Kim, S.G.2    Kim, H.P.3
  • 30
    • 33748670455 scopus 로고    scopus 로고
    • Phase i dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase Cb inhibitor, in patients with advanced cancer
    • Carducci MA, Musib L, Kies MS, et al. Phase I dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase Cb inhibitor, in patients with advanced cancer. J Clin Oncol 2006;24:4092-4099.
    • (2006) J Clin Oncol , vol.24 , pp. 4092-4099
    • Carducci, M.A.1    Musib, L.2    Kies, M.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.