Protein kinase Cι is required for pancreatic cancer cell transformed growth and tumorigenesis

Cancer Research

Volumn 70, Issue 5, 2010, Pages 2064-2074

  Scotti, Michele L ^a   Bamlet, William R ^b   Smyrk, Thomas C ^b   Fields, Alan P ^a   Murray, Nicole R ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b Mayo Clinic   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN KINASE C IOTA; RAC1 PROTEIN; ISOENZYME; MESSENGER RNA; PROTEIN KINASE C; PROTEIN KINASE C LAMBDA;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CARCINOGENESIS; CARCINOGENICITY; CELL INVASION; CONTROLLED STUDY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; METASTASIS; MOUSE; NONHUMAN; PANCREAS ADENOCARCINOMA; PANCREAS CANCER; PANCREAS TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SURVIVAL; BIOSYNTHESIS; CANCER INVASION; CELL GROWTH; CELL TRANSFORMATION; ENZYMOLOGY; GENETICS; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE; VASCULARIZATION;

CELL GROWTH PROCESSES; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; ISOENZYMES; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOVASCULARIZATION, PATHOLOGIC; PANCREATIC NEOPLASMS; PROTEIN KINASE C; RAC1 GTP-BINDING PROTEIN; RNA, MESSENGER;

EID: 77950250455     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-2684     Document Type: Article

References (38)

1. Lebedeva IV, Sarkar D, Su ZZ, et al. Molecular target-based therapy of pancreatic cancer. Cancer Res 2006;66:2403-13.
2. Klimstra DS, Longnecker DS. K-ras mutations in pancreatic ductal proliferative lesions. Am J Pathol 1994;145:1547-50.
3. Aoki K, Yoshida T, Matsumoto N, Ide H, Sugimura T, Terada M. Suppression of Ki-ras p21 levels leading to growth inhibition of pancreatic cancer cell lines with Ki-ras mutation but not those without Ki-ras mutation. Mol Carcinog 1997;20:251-8.
4. Saad ED, Hoff PM. Molecular-targeted agents in pancreatic cancer. Cancer Control 2004;11:32-8.
5. Murray NR, Jamieson L, Yu W, et al. Protein kinase Cι is required for Ras transformation and colon carcinogenesis in vivo. J Cell Biol 2004;164:797-802.
6. Zhang J, Anastasiadis PZ, Liu Y, Thompson EA, Fields AP. Protein kinase C (PKC) βII induces cell invasion through a Ras/Mek-, PKCι/Rac 1-dependent signaling pathway. J Biol Chem 2004;279:22118-23.
7. Bjorkoy G, Perander M, Overvatn A, Johansen T. Reversion of Ras-and phosphatidylcholine-hydrolyzing phospholipase C-mediated transformation of NIH 3T3 cells by a dominant interfering mutant of protein kinase Cλ is accompanied by the loss of constitutive nuclear mitogen-activated protein kinase/extracellular signal-regulated kinase activity. J Biol Chem 1997;272:11557-65.
8. Kampfer S, Windegger M, Hochholdinger F, et al. Protein kinase C isoforms involved in the transcriptional activation of cyclin D1 by transforming Ha-Ras. J Biol Chem 2001;276:42834-42.
9. Uberall F, Hellbert K, Kampfer S, et al. Evidence that atypical protein kinase C-λ and atypical protein kinase C-ζ participate in Ras-mediated reorganization of the F-actin cytoskeleton. J Cell Biol 1999;144:413-25.
10. Coghlan MP, Chou MM, Carpenter CL. Atypical protein kinases Cλ and -ζ associate with the GTP-binding protein Cdc42 and mediate stress fiber loss. Mol Cell Biol 2000;20:2880-9.
11. Regala RP, Davis RK, Kunz A, Khoor A, Leitges M, Fields AP. Atypical protein kinase Cι is required for bronchioalveolar stem cell expansion and lung tumorigenesis. Cancer Res 2009;69:7603-11.
12. Hasegawa K, Nakamura T, Harvey M, et al. The use of a tropismmodified measles virus in folate receptor-targeted virotherapy of ovarian cancer. Clin Cancer Res 2006;12:6170-8.
13. Pongprasobchai S, Pannala R, Smyrk TC, et al. Long-term survival and prognostic indicators in small (< or =2 cm) pancreatic cancer. Pancreatology 2008;8:587-92.
14. Calcagno SR, Li S, Colon M, et al. Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon. Int J Cancer 2008;122:2462-70.
15. Frederick LA, Matthews JA, Jamieson L, et al. Matrix metalloproteinase-10 is a critical effector of protein kinase Cι-Par6α-mediated lung cancer. Oncogene 2008;27:4841-53.
16. Regala RP, Weems C, Jamieson L, Copland JA, Thompson EA, Fields AP. Atypical protein kinase Cι plays a critical role in human lung cancer cell growth and tumorigenicity. J Biol Chem 2005;280:31109-15.
17. Stallings-Mann M, Jamieson L, Regala RP, Weems C, Murray NR, Fields AP. A novel small-molecule inhibitor of protein kinase Cι blocks transformed growth of non-small-cell lung cancer cells. Cancer Res 2006;66:1767-74.
18. Murray NR, Weems C, Chen L, et al. Protein kinase CβII and TGFβRII in ω-3 fatty acid-mediated inhibition of colon carcinogenesis. J Cell Biol 2002;157:915-20.
19. Fields AP, Calcagno SR, Krishna M, Rak S, Leitges M, Murray NR. Protein kinase Cβ is an effective target for chemoprevention of colon cancer. Cancer Res 2009;69:1643-50.
20. Regala RP, Thompson EA, Fields AP. Atypical protein kinase Cι expression and aurothiomalate sensitivity in human lung cancer cells. Cancer Res 2008;68:5888-95.
21. Missiaglia E, Blaveri E, Terris B, et al. Analysis of gene expression in cancer cell lines identifies candidate markers for pancreatic tumori-genesis and metastasis. Int J Cancer 2004;112:100-12.
22. Giroux V, Malicet C, Barthet M, et al. p8 is a new target of gemcitabine in pancreatic cancer cells. Clin Cancer Res 2006;12:235-41.
23. Sato N, Maehara N, Mizumoto K, et al. Telomerase activity of cultured human pancreatic carcinoma cell lines correlates with their potential for migration and invasion. Cancer 2001;91:496-504.
24. Win HY, Acevedo-Duncan M. Role of protein kinase C-ι in transformed non-malignant RWPE-1 cells and androgen-independent prostate carcinoma DU-145 cells. Cell Prolif 2009;42:182-94.
25. Staiger K, Schatz U, Staiger H, et al. Protein kinase C-ι mediates lipid-induced apoptosis of human coronary artery endothelial cells. Microvasc Res 2009;78:40-4.
26. Zhang L, Huang J, Yang N, et al. Integrative genomic analysis of protein kinase C (PKC) family identifies PKCι as a biomarker and potential oncogene in ovarian carcinoma. Cancer Res 2006;66:4627-35.
27. Ray S, Lu Y, Kaufmann SH, et al. Genomic mechanisms of p210BCR-ABL signaling: induction of heat shock protein 70 through the GATA response element confers resistance to paclitaxel-induced apoptosis. J Biol Chem 2004;279:35604-15.
28. Guha S, Lunn JA, Santiskulvong C, Rozengurt E. Neurotensin stimulates protein kinase C-dependent mitogenic signaling in human pancreatic carcinoma cell line PANC-1. Cancer Res 2003;63:2379-87.
29. Bruns CJ, Harbison MT, Kuniyasu H, Eue I, Fidler IJ. In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice. Neoplasia 1999;1:50-62.
30. Kunnumakkara AB, Guha S, Krishnan S, Diagaradjane P, Gelovani J, Aggarwal BB. Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-κB-regulated gene products. Cancer Res 2007;67:3853-61.
31. Chadha KS, Khoury T, Yu J, et al. Activated Akt and Erk expression and survival after surgery in pancreatic carcinoma. Ann Surg Oncol 2006;13:933-9.
32. Javle MM, Gibbs JF, Iwata KK, et al. Epithelial-mesenchymal transition (EMT) and activated extracellular signal-regulated kinase (p-Erk) in surgically resected pancreatic cancer. Ann Surg Oncol 2007;14:3527-33.
33. Billadeau DD, Chatterjee S, Bramati P, et al. Characterization of the CXCR4 signaling in pancreatic cancer cells. Int J Gastrointest Cancer 2006;37:110-9.
34. Loukopoulos P, Kanetaka K, Takamura M, Shibata T, Sakamoto M, Hirohashi S. Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity. Pancreas 2004;29:193-203.
35. Fukasawa M, Korc M. Vascular endothelial growth factor-trap suppresses tumorigenicity of multiple pancreatic cancer cell lines. Clin Cancer Res 2004;10:3327-32.
36. Erdogan E, Lamark T, Stallings-Mann M, et al. Aurothiomalate inhibits transformed growth by targeting the PB1 domain of protein kinase Cι. J Biol Chem 2006;281:28450-9.
37. Guo W, Wu S, Liu J, Fang B. Identification of a small molecule with synthetic lethality for K-ras and protein kinase Cι. Cancer Res 2008;68:7403-8.
38. Regala RP, Weems C, Jamieson L, et al. Atypical protein kinase Cι is an oncogene in human non-small cell lung cancer. Cancer Res 2005;65:8905-11.