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Volumn 66, Issue 19, 2006, Pages 9379-9384

Targeted disruption of protein kinase Cε reduces cell invasion and motility through inactivation of RhoA and RhoC GTPases in head and neck squamous cell carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; NUCLEOTIDE BINDING PROTEIN; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C EPSILON; PROTEIN KINASE C GAMMA; PROTEIN KINASE C ZETA; RHOA GTPASE; RHOC GTPASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 33750379275     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-2646     Document Type: Article
Times cited : (72)

References (24)
  • 2
    • 0027458280 scopus 로고
    • Overview of combined modality therapies for head and neck cancer
    • Dimery IW, Hong WK. Overview of combined modality therapies for head and neck cancer. J Natl Cancer Inst 1993;85:95-111.
    • (1993) J Natl Cancer Inst , vol.85 , pp. 95-111
    • Dimery, I.W.1    Hong, W.K.2
  • 3
    • 0034280331 scopus 로고    scopus 로고
    • Protein kinase C as a drug target: Implications for drug or diet prevention and treatment of cancer
    • Carter CA. Protein kinase C as a drug target: implications for drug or diet prevention and treatment of cancer. Curr Drug Targets 2000;1:163-83.
    • (2000) Curr Drug Targets , vol.1 , pp. 163-183
    • Carter, C.A.1
  • 4
    • 0027182090 scopus 로고
    • The ε isoform of protein kinase C is an oncogene when overexpressed in rat fibroblasts
    • Cacace AM, Guadagno SN, Krauss RS, Fabbro D, Weinstein IB. The ε isoform of protein kinase C is an oncogene when overexpressed in rat fibroblasts. Oncogene 1993;8:2095-104.
    • (1993) Oncogene , vol.8 , pp. 2095-2104
    • Cacace, A.M.1    Guadagno, S.N.2    Krauss, R.S.3    Fabbro, D.4    Weinstein, I.B.5
  • 5
    • 0027418816 scopus 로고
    • Overexpression of protein kinase C-δ and -ε in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity
    • Mischak H, Goodnight JA, Kolch W, et al. Overexpression of protein kinase C-δ and -ε in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity. J Biol Chem 1993;268:6090-6.
    • (1993) J Biol Chem , vol.268 , pp. 6090-6096
    • Mischak, H.1    Goodnight, J.A.2    Kolch, W.3
  • 6
    • 0035110896 scopus 로고    scopus 로고
    • Protein kinase C-ε transgenic mice: A unique model for metastatic squamous cell carcinoma
    • Jansen AP, Verwiebe EG, Dreckschmidt NE, et al. Protein kinase C-ε transgenic mice: a unique model for metastatic squamous cell carcinoma. Cancer Res 2001;61:808-12.
    • (2001) Cancer Res , vol.61 , pp. 808-812
    • Jansen, A.P.1    Verwiebe, E.G.2    Dreckschmidt, N.E.3
  • 7
    • 4344694684 scopus 로고    scopus 로고
    • Metastatic squamous cell carcinoma cells that overexpress c-Met exhibit enhanced angiogenesis factor expression, scattering, and metastasis in response to hepatocyte growth factor
    • Dong G, Lee TL, Yeh NT, et al. Metastatic squamous cell carcinoma cells that overexpress c-Met exhibit enhanced angiogenesis factor expression, scattering, and metastasis in response to hepatocyte growth factor. Oncogene 2004;23:6199-208.
    • (2004) Oncogene , vol.23 , pp. 6199-6208
    • Dong, G.1    Lee, T.L.2    Yeh, N.T.3
  • 8
    • 23844435559 scopus 로고    scopus 로고
    • Hepatocyte growth factor/scatter factor differentially regulates expression of proangiogenic factors through Egr-1 in head and neck squamous cell carcinoma
    • Worden B, Yang XP, Lee TL, et al. Hepatocyte growth factor/scatter factor differentially regulates expression of proangiogenic factors through Egr-1 in head and neck squamous cell carcinoma. Cancer Res 2005;65:7071-80.
    • (2005) Cancer Res , vol.65 , pp. 7071-7080
    • Worden, B.1    Yang, X.P.2    Lee, T.L.3
  • 9
    • 6344248651 scopus 로고    scopus 로고
    • PKC controls HGF-dependent c-Met traffic, signalling, and cell migration
    • Kermorgant S, Zicha D, Parker PJ. PKC controls HGF-dependent c-Met traffic, signalling, and cell migration. EMBO J 2004;23:3721-34.
    • (2004) EMBO J , vol.23 , pp. 3721-3734
    • Kermorgant, S.1    Zicha, D.2    Parker, P.J.3
  • 10
    • 24944563309 scopus 로고    scopus 로고
    • Protein kinase Cε is a predictive biomarker of aggressive breast cancer and a validated target for RNA interference anti-cancer therapy
    • Pan Q, Bao LW, Kleer CG, et al. Protein kinase Cε is a predictive biomarker of aggressive breast cancer and a validated target for RNA interference anti-cancer therapy. Cancer Res 2005;65:8366-71.
    • (2005) Cancer Res , vol.65 , pp. 8366-8371
    • Pan, Q.1    Bao, L.W.2    Kleer, C.G.3
  • 11
    • 0028826715 scopus 로고
    • Alterations in levels of different protein kinase C isotypes and their influence on behavior of squamous cell carcinoma of the oral cavity: εPKC, a novel prognostic factor for relapse and survival
    • Martinez-Gimeno C, Diaz-Meco MT, Dominguez I, Moscat J. Alterations in levels of different protein kinase C isotypes and their influence on behavior of squamous cell carcinoma of the oral cavity: εPKC, a novel prognostic factor for relapse and survival. Head Neck 1995;17:516-25.
    • (1995) Head Neck , vol.17 , pp. 516-525
    • Martinez-Gimeno, C.1    Diaz-Meco, M.T.2    Dominguez, I.3    Moscat, J.4
  • 12
    • 0344305784 scopus 로고    scopus 로고
    • Cell migration: Integrating signals from front to back
    • Ridley AJ, Schwartz MA, Burridge K, et al. Cell migration: integrating signals from front to back. Science 2003;302:1704-9.
    • (2003) Science , vol.302 , pp. 1704-1709
    • Ridley, A.J.1    Schwartz, M.A.2    Burridge, K.3
  • 13
    • 0028961293 scopus 로고
    • Rho, rac, cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
    • Nobes CD, Hall A. Rho, rac, cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 1995;81:53-62.
    • (1995) Cell , vol.81 , pp. 53-62
    • Nobes, C.D.1    Hall, A.2
  • 15
    • 0036168355 scopus 로고    scopus 로고
    • Characterization of RhoC expression in benign and malignant breast disease: A potential new marker for small breast carcinomas with metastatic ability
    • Kleer CG, van Golen KL, Zhang Y, Wu ZF, Rubin MA, Merajver SD. Characterization of RhoC expression in benign and malignant breast disease: a potential new marker for small breast carcinomas with metastatic ability. Am J Pathol 2002;160:579-84.
    • (2002) Am J Pathol , vol.160 , pp. 579-584
    • Kleer, C.G.1    Van Golen, K.L.2    Zhang, Y.3    Wu, Z.F.4    Rubin, M.A.5    Merajver, S.D.6
  • 16
    • 0032939619 scopus 로고    scopus 로고
    • Rho GTPases are overexpressed in human tumors
    • Fritz G, Just I, Kaina B. Rho GTPases are overexpressed in human tumors. Int J Cancer 1999;81:682-7.
    • (1999) Int J Cancer , vol.81 , pp. 682-687
    • Fritz, G.1    Just, I.2    Kaina, B.3
  • 17
    • 0037048326 scopus 로고    scopus 로고
    • Rho GTPases in human breast tumours: Expression and mutation analyses and correlation with clinical parameters
    • Fritz G, Brachetti C, Bahlmann F, Schmidt M, Kaina B. Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters. Br J Cancer 2002;87:635-44.
    • (2002) Br J Cancer , vol.87 , pp. 635-644
    • Fritz, G.1    Brachetti, C.2    Bahlmann, F.3    Schmidt, M.4    Kaina, B.5
  • 18
    • 0034930411 scopus 로고    scopus 로고
    • Motility-related proteins as markers for head and neck squamous cell carcinoma
    • Abraham MT, Kuriakose MA, Sacks PG, et al. Motility-related proteins as markers for head and neck squamous cell carcinoma. Laryngoscope 2001;111:1285-9.
    • (2001) Laryngoscope , vol.111 , pp. 1285-1289
    • Abraham, M.T.1    Kuriakose, M.A.2    Sacks, P.G.3
  • 19
    • 33748038365 scopus 로고    scopus 로고
    • RhoC-GTPase expression as a potential marker of lymph node metastasis in squamous cell carcinoma of the head and neck
    • Kleer CG, Teknos TN, Islam M, et al. RhoC-GTPase expression as a potential marker of lymph node metastasis in squamous cell carcinoma of the head and neck. Clin Cancer Res 2006;12:4485-90.
    • (2006) Clin Cancer Res , vol.12 , pp. 4485-4490
    • Kleer, C.G.1    Teknos, T.N.2    Islam, M.3
  • 20
    • 20444480169 scopus 로고    scopus 로고
    • Phosphorylation of serine 188 protects RhoA from ubiquitin/proteasome- mediated degradation in vascular smooth muscle cells
    • Rolli-Derkinderen M, Sauzeau V, Boyer L, et al. Phosphorylation of serine 188 protects RhoA from ubiquitin/proteasome-mediated degradation in vascular smooth muscle cells. Circ Res 2005;96:1152-60.
    • (2005) Circ Res , vol.96 , pp. 1152-1160
    • Rolli-Derkinderen, M.1    Sauzeau, V.2    Boyer, L.3
  • 21
    • 0034602690 scopus 로고    scopus 로고
    • Endogenous, hyperactive Rac3 controls the proliferation of breast cancer cells by a p21-aclivated kinase-dependent pathway
    • Mira JP, Benard V, Groffen J, Sanders LC, Knaus UG. Endogenous, hyperactive Rac3 controls the proliferation of breast cancer cells by a p21-aclivated kinase-dependent pathway. Proc Natl Acad Sci U S A 2000;97:185-9.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 185-189
    • Mira, J.P.1    Benard, V.2    Groffen, J.3    Sanders, L.C.4    Knaus, U.G.5
  • 22
    • 0035933870 scopus 로고    scopus 로고
    • Protein kinase C-α signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function
    • Mehta D, Rahman A, Malik AB. Protein kinase C-α signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function. J Biol Chem 2001;25:22614-20.
    • (2001) J Biol Chem , vol.25 , pp. 22614-22620
    • Mehta, D.1    Rahman, A.2    Malik, A.B.3
  • 23
    • 0043237427 scopus 로고    scopus 로고
    • Protein kinase Cα-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement
    • Holinstat M, Mehta D, Kozasa T, Minshall RD, Malik AB. Protein kinase Cα-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement. J Biol Chem 2003;278:28793-8.
    • (2003) J Biol Chem , vol.278 , pp. 28793-28798
    • Holinstat, M.1    Mehta, D.2    Kozasa, T.3    Minshall, R.D.4    Malik, A.B.5
  • 24
    • 0033636507 scopus 로고    scopus 로고
    • The adhesion signaling molecule p190 RhoGAP is required for morphogenetic processes in neural development
    • Brouns MR, Matheson SF, Hu KQ, et al. The adhesion signaling molecule p190 RhoGAP is required for morphogenetic processes in neural development. Development 2000;127:4891-903.
    • (2000) Development , vol.127 , pp. 4891-4903
    • Brouns, M.R.1    Matheson, S.F.2    Hu, K.Q.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.